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RISK FACTOR INFORMATION FOR SELECTED CANCER TYPES Source: Community Assessment Program, Center for Environmental Health, Massachusetts Department of Public Health March, 2005 Brain and CNS Cancer Brain and central nervous system (CNS) tumors can be either malignant (cancerous) or benign (non-cancerous). Primary brain tumors (i.e., brain cancer ) comprise two main types: gliomas and malignant meningiomas. Gliomas are a general classification of malignant tumors that include a variety of types, named for the cells from which they arise: astrocytomas, oligodendrogliomas, and ependymomas. Meningiomas arise from the meninges, which are tissues that surround the outer part of the spinal cord and brain . Although meningiomas are not technically brain tumors, as they occur outside of the brain , they account for about 50% of all reported primary brain and spinal cord tumors. ...

brain cancer Leukemia Leukemia is the general term that includes a group of different cancers that occur in the blood forming organs and result in the formation of abnormal amounts and types of white blood cells in the blood and bone marrow. Individuals with leukemia generally maintain abnormally high amounts of leukocytes or white blood cells in their blood. This condition results in an individual's inability to maintain certain body functions, particularly a person's ability to combat infection. In 2005, leukemia is expected to affect approximately 34,810 individuals (19,640 males and 15,170 females) in the United States, resulting in 22,570 deaths. In Massachusetts, approximately 770 individuals will be diagnosed with the disease in 2005, representing more than 2% of all cancer diagnoses. There are four major types of leukemia: acute lymphoid leukemia (ALL), acute myeloid leukemia ...

BRAIN CANCER Brain Cancer Spring 2005 / THE ONCOLOGY REPORT 11 For more meeting reports, visit www.OncologyReport.com © 2005 Elsevier Inc. All rights reserved. Brain Cancer Commentary by Henry S. Friedman, MD James B. Powell, Jr. Professor of Neuro-Oncology and Co-Director of the Clinical Neuro-Oncology Program of the Brain Tumor Center at Duke, Duke University Medical Center, Durham, North Carolina INDEX Brain tumor stem cell, 14 MGMT, 11 O6-BG, 12 Radiation sensitizer (Efaproxiral [RSR-13]), 14, 16 Radiation therapy, whole brain , 14 Temozolomide (Temodar), 11, 12 Vaccine, 13 Adding temozolomide to radiation improves survival in patients with glioblastoma Two-year survival rate is more than twice as high with combination therapy AMERICAN SOCIETY ...

X. Statistical Tables 88 Oregon State Cancer Registry Average Percent Average Percent Invasive Age Annual Malignant Age Annual Cases Adjusted Trend Deaths Adjusted Trend OREGON COUNTY INCIDENCE MORTALITY Per Year 1 Rate (APC) Per Year Rate (APC) 1996 - 2000 Rates are per 100,000 and age-adjusted to the 2000 U.S. (5-year groups) standard. * Trend is statistically stable. 1 Counts may not match state tables due to cases in unknown counties. ^ Rate not calculated due to instability of small numbers. APC = Average Annual Percent Change DATA Table 3b: Malignant Brain Cancer State of Oregon 229 6.9 -3.4 186 5.5 -2.9 ...

16 th EORTC – NCI – AACR Symposium on Molecular Targets and Cancer Therapeutics Geneva, Switzerland, 28 September – 1 October 2004 Conference secretariat: EORTC-NCI-AACR 2004, FECS – Federation of European Cancer Societies Avenue E. Mounier 83, B-1200 Brussels T: +32 (0) 2 775 02 01 – F: +32 (0) 2 775 02 00 – E-mail: ENA2004@fecs.be – www.fecs.be Embargoed: 12.30 hrs CET Wednesday 29 September 2004 Trial shows which brain cancer patients benefit from temozolomide Genetic predictive test clears way for targeted drug treatment Geneva, Switzerland: An international team of scientists and cancer specialists has identified which patients with the deadly form of brain tumours called glioblastomas are likely to live longer if they are treated with temozolomide, and which patients are likely to get only marginal, if any, benefit. The genetic predictive ...

Inhibition of breast and brain cancer cell growth by BCCIP a , an evolutionarily conserved nuclear protein that interacts with BRCA2 Jingmei Liu 1 , Yuan Yuan 1,2 , Juan Huan 2 and Zhiyuan Shen* ,1 1 Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center; 915 Camino de Salud, NE. Albuquerque, New Mexico, NM 87131, USA; 2 Graduate Program of Molecular Genetics, College of Medicine, University of Illinois at Chicago, 900 S. Ashland Ave. Chicago, Illinois, IL 60607, USA BRCA2 is a tumor suppressor gene involved in mammary tumorigenesis. Although important functions have been assigned to a few conserved domains of BRCA2, little is known about the longest internal conserved domain encoded by exons 14 ± 24. We identi®ed a novel protein, designated ...

Cancer Dataset Cancer Data Manual – Brain and CNS Cancer Appendix Appendix for Brain and CNS Cancer Table of contents Cancer Care Spell..2 Brain and CNS Cancer Specific Codes.3 Additional Data Items for Brain and CNS Cancer 12 Version 4.0 Page 1 of 12 Issue Date: 11.08.03 Page 2 Cancer Dataset Cancer Data Manual – Brain and CNS Cancer Appendix Cancer Care Spell A new Cancer Care Spell for • each different three-character ICD-10 code • different histology with the same three-character ICD-10 code However, a single lesion of one histologic type is considered a single primary (i.e. one Cancer Care Spell), even if the lesion crosses site boundaries. Differences in histologic type refer to differences in the first three digits of ...

March 11, 2005 Volume 2 No. 19 USE YOUR HEAD How students are using tattoos to solicit blood donations Page 4 THE BIG PICTURE How ‘Mr. Small Science’ links science and society Page 5 INSIDE THE CCIT Take a quiz on your knowledge of CCIT activities Pages 6 & 7 D I S C O V E R Y E N E R G Y C R E A T I V I T Y C O M M U N I T Y HOPE FOR BRAIN CANCER VICTIMS HOPE FOR BRAIN CANCER VICTIMS Page 3 Dr. Greg Cairncross and patient Don McHenry examine MRIs of McHenry’s brain . / Photo by Ken Bendiktsen Page 2 2 MARCH 11, 2005 on CAMPUS Volume 2, Number 18 OnCampus is published 31 times a year by the office of the Vice President (External Relations.) ...

B R E A S T C A N C E R C A R E K I L N H O U S E , 2 1 0 N E W K I N G S R O A D , L O N D O N S W 6 4 N Z . T E L : 0 2 0 7 3 8 4 2 9 8 4 H E L P L I N E 0 8 0 8 8 0 0 6 0 0 0 W E B S I T E W W W . B R E A S T C A N C E R C A R E . O R G . U K R E G I S T E R E D I N E N G L A N D C O M P A N Y N O . 2 4 4 7 1 8 2 . R E G I S T E R E D C H A R I T Y N O . 1 0 1 7 6 5 8 Secondary brain cancer February 2005 This factsheet is for those who have been diagnosed with secondary cancer in the brain that has spread from the breast. It describes what secondary brain cancer is, what the symptoms are and the treatments used. Being told that your cancer has spread to the brain can be particularly distressing and one of the common fears people have is of not knowing what effects this will have on their life. We hope this factsheet answers some of your questions and helps ...

Molecular Imaging of Pediatric Brain Cancer Raymond W. Sze, M.D. Assistant Professor of Radiology Page 2 Outline of Talk • Why is Pediatric Brain Cancer Important? • What advances are being made in Pediatric Brain Cancer Research? • What is Molecular Imaging? • What are “smart” nanoparticle contrast agents? • How can we use these agents for Pediatric Brain Cancer ? Page 3 I. Why is Pediatric Brain Cancer Important? Page 4 Pediatric Brain Cancer • Most common solid tumor in children • 1700 new diagnosis in USA • 20% of all childhood cancer deaths • Medulloblastoma is most common type of Pediatric Brain Cancer ...

BRAIN CANCER 12 THE ONCOLOGY REPORT / Fall 2004 www.OncologyReport.com © 2004 Elsevier Inc. All rights reserved. C hemotherapy has played a limited role in the treatment of patients with glioblastoma multiforme—but findings discussed at the 2004 American Society of Clinical Oncology’s annual meeting showed that concomitant use of temozolomide Temozolomide/radiotherapy may become a new standard of care for glioblastoma multiforme Study shows a ‘clinically meaningful’ survival advantage for chemotherapy radiation in vitro, and temozolomide has shown some activity against re- current glioma. Results of a phase II study released 2 years ago showed that the combination of temozolomide and radiotherapy had promising clinical efficacy (Stupp R et al: J Clin Oncol 2002;20:1375–1382). In this randomized phase III ...

288 www.SupportiveOncology.net T HE J OURNAL OF S UPPORTIVE O NCOLOGY O B S E R V A T I O N S New Study to Probe Effects of Methionine on Brain Cancer T he Cancer Treatment Research Foundation (CTRF) has an- nounced that it is funding a 2-year studyinvestigatingwhethertheelimina- tion of the amino acid methionine from the diet, coupled with chemotherapy, provides increased survival for patients suffering from glioblastoma multiforme. Morris D. Groves, MD, Assistant Professor of Neuro-Oncology at The University of Texas M. D. Anderson Cancer Center, Houston, will conduct the study, which will treat patients with standard chemotherapy combined with a special methionine-free diet. The diet alone should cause some tumor cells to die, but when the diet is combined with ...

brain cancer Air Pollution & Brain Cancer CURWOOD: California state legislators say it?s their way or the highway when it comes to protect ing school children from air pollution. Concerns over childhood asthma and lung cancer have led to the passage of a bill will block the building of new schools near major freeways and busy roads. Tiny particles from passing diesel vehicle pose some of the biggest dangers to health. Now, an emerging study may show that air pollution is not only linked to respiratory problems, but may also to brain cancer . Dr. Keith Black is heading up this study and directs neurosurgery at Cedar Sinai Medical Center. He joins me now from his Los Angeles office. Dr. Black, welcome. BLACK: Thank you. CURWOOD: Tell me, Doctor, what?s the best evidence to date that there may be a link between specific types of air pollution and brain ...

Groundbreaking National Program Helps Families of Brain Cancer Patients A new program developed by the National Brain Tumor Foundation offers information and training to families caring for a loved one with a brain tumor. The free caregiver workshops, offered in partnership with hospitals across the US, include vital information on treatment, managing symptoms at home, coping with side effects, and finding supportive resources in the community. San Francisco, CA (PRWEB) March 29, 2005 -- Families across the United States faced with the challenges of caring for loved ones with brain tumors will now have an opportunity to learn critical care giving skills thanks to a unique program offered by the National Brain Tumor Foundation (NBTF). The National Brain Tumor Family Caregiver Program was launched this year and provides a free day-long training workshop for family caregivers to give ...

Center for Environmental Health Studies (617) 482-9485 44 Farnsworth Street, Boston, MA 02210 http://www.jsi.com * Findings were statistically significant (strong evidence) + Evidence of a dose-response relationship (strongest evidence) Page 21 Brain Cancer and Exposure to Ionizing Radiation Summary: There is strong evidence that brain cancer may be associated with exposure to ionizing radiation. This evidence is based upon studies conducted at Los Alamos National Laboratory, studies of nuclear workers at other sites, and others exposed to ionizing radiation. This is consistent with the National Research Council’s finding that brain tissue is sensitive to ionizing radiation. There remains some scientific debate as to whether brain cancer in nuclear workers may be due to radiation or chemical exposures. Brain ...

Editor Halle C.F. Moore, MD Department of Hematology/Oncology, The Cleveland Clinic Foundation, R30, 9500 Euclid Avenue, Cleveland, OH 44195, USA. E-mail: mooreh1@ccf.org Brain Tumor Society http://www.tbts.org The stated missions of the Brain Tumor Society are research, education, and support. The website provides general information about both primary and metastatic tumors of the brain and spinal cord. Issues addressed include diagnosis, symptoms, treatment, and rehabilitation. The site also provides information on resources for patients and their families. Stories of long-term survivors of brain tumors are available on the site. Other features include answers to frequently asked questions, a newsletter, book lists, and a variety of links to related sites. Resources for medical professionals as well as conference and event information are also included. Site last updated : August ...

[ CANCER RESEARCH 63, 5821–5828, September 15, 2003] Identification of a Cancer Stem Cell in Human Brain Tumors Sheila K. Singh, Ian D. Clarke, Mizuhiko Terasaki, Victoria E. Bonn, Cynthia Hawkins, Jeremy Squire, and Peter B. Dirks The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada [S. K. S., I. D. C., M. T., V. E. B., P. B. D.], and Program in Developmental Biology [S. K. S., I. D. C., M. T., V. E. B., P. B. D.], Division of Neurosurgery [S. K. S., P. B. D.], Department of Pediatric Laboratory Medicine [C. H.], and Department of Laboratory Medicine and Pathobiology [J. S.], University of Toronto, Toronto, Ontario M5G 1X8 Canada ABSTRACT Most current research on human brain tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However, there is overwhelming evidence in some ...

24509 N.E. 27 th Place, Sammamish, WA 98074 www.ChrisElliottFund.org Christopher S. Elliott Memorial Glioblastoma Brain Tumor Research Fund is a 501 (c) 3 non-profit organization Tax Exempt # 042-263-040 White Copy (Office), Canary Copy (File), Pink Copy (Donor Tax Receipt) 4 th Annual Christopher S. Elliott Memorial Golf Scramble Benefiting Glioblastoma Brain Cancer Research Bear Creek Country Club ? 13737 202 nd Ave. NE ? Woodinville ? WA Monday, September 12 th , 2005 ? GOLF REGISTRATION FORM ? (Pre-registration required by: August 20, 2005) Team Captain :_HCP Player #2 : HCP _ Address _ Address City, State, Zip _ City, State, Zip __ Email address __ Email ...