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W F R I E N D S F O R L I F E MARCH-APRIL 2004 6 V OLUME SIX 3202 North Meridian Street Indianapolis, IN 46208 • Joseph E. Walther, M.D. President / CEO Emeritus • Visit our web site at www.walther.org Nonprofit Organization U.S. Postage PAID Indianapolis, IN Permit No. 399 Eliminating cancer as a cause of suffering and death Walther Cancer Institute Eliminating Cancer as a Cause of Suffering and Death There have long been behavioral studies examining the effects of provid- ing care on caregivers of persons with cancer . There have also been many studies researching the effects of caring for someone debilitated by demen- tia or brain injury. However, few studies exist to study the relationship between the two. What happens to the caregiver ...

Brain cancer The brain controls our thoughts, intelligence, memory and emotions. It weighs about one and a half kilograms and is made up of nerve cells (neurones). Along with the spinal cord, the brain makes up the central nervous system. This system helps all the different parts of the body to communicate with each other. Types of brain tumours There are different types of benign and malignant brain tumours. • Benign brain tumour – can press on and damage the surrounding brain tissue. Usually, this type of tumour can be successfully removed. • Malignant brain tumour – some are contained inside a capsule and are easy to remove, while others have thin filaments spreading through the brain . Many malignant brain tumours are secondary cancers, which means they developed from a cancer somewhere else in the body. ...

Public release date: 28-Aug-2006 [ Print Article | E-mail Article | Close Window ] Contact: Leslie Orr leslie_orr@urmc.rochester.edu 585-275-5774 University of Rochester Medical Center Study links lead exposure to brain cancer in adults People who are routinely exposed to lead on the job are 50 percent more likely to die from brain cancer than people who are not exposed, according to a University of Rochester Medical Center study. More than 18,000 brain and spinal cord tumors will be diagnosed in the United States this year. Yet little is known about what causes brain cancer ; the only established risk factor is radiation, according to the American Cancer Society. Results of other studies attempting to show a clear link between lead and cancer have been inconclusive. The new data, based on information from the U.S. Census Bureau and the National Death Index, ...

Public release date: 15-Aug-2006 [ Print Article | E-mail Article | Close Window ] Contact: Warren Froelich froelich@aacr.org 215-440-9300 American Association for Cancer Research Cancer stem cells spur glioma angiogenesis, could hold key to brain tumor therapy Philadelphia -- Stem cell-like glioma cancer cells that share many characteristics with normal stem cells propel the lethal growth of brain cancers by promoting tumor blood vessel formation, and may hold the key to treating these deadly cancers, a research team reported in the August 15th issue of Cancer Research. Led by Jeremy Rich, M.D., associate professor at the Preston Robert Tisch Brain Tumor Center at Duke University, the researchers found that a small subset of glioma cells expressed higher levels of a growth factor associated with cancer cell growth. They believe this subset could be a target ...

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Venom protein may lead to brain cancer cure- study Doctors seeking treatments for malignant brain tumors have found promise in the venom of scorpions, according to a study released on Friday. The study showed that a synthetic version of a protein found in the venom of giant yellow Israeli scorpions targeted tumor cells but did not harm the healthy cells of brain cancer patients. "We're testing a new agent that has a lot of potential for patients who have had no meaningful treatments thus far," said Dr. Adam Mamelak, lead author on an article to appear in the August issue of the Journal of Clinical Oncology. In the study, 18 patients first had surgery to remove malignant gliomas, a lethal kind of brain tumor. Then doctors injected their brains with a solution of radioactive iodine and TM-601, the synthetic protein. The solution bound almost exclusively to leftover tumor cells, suggesting that it ...

Invasive Cancer Incidence by Race Illinois, 1986-2003 Brain and Other Nervous System, Both Sexes All Races Whites Years Count Rate SE LCI UCI Count Rate SE LCI UCI 1986-2003 13,148 6.3 0.1 6.2 6.4 11,836 6.7 0.1 6.6 6.8 1986 640 5.8 0.2 5.4 6.3 584 6.2 0.3 5.7 6.7 1987 673 6.2 0.2 5.8 6.7 600 6.5 0.3 6.0 7.1 1988 696 6.3 0.2 5.8 6.8 625 6.6 0.3 6.1 7.2 1989 750 6.8 0.3 6.3 7.3 676 7.1 0.3 6.6 7.7 1990 662 5.9 0.2 5.5 6.4 608 6.4 0.3 5.9 6.9 1991 ...

Review of Primary Investigation of Suspected Brain Cancer Cluster in RMIT Building 108, Levels 16 & 17, Specifically reviewing the following primary investigators’ reports: Medical Investigation of Tumours Detected in RMIT Building 108, Levels 16 & 17: Final Report, conducted by Southern Medical Services and Environmental/Exposure Assessment reports conducted under the direction of Sustainable Risk Management Australia This Secondary-Level Peer Review was conducted by a Panel of Experts Jointly Nominated by RMIT University, the National Tertiary Education Union (NTEU), and the Australian Education Union (AEU): A/Prof Anthony D. LaMontagne (Secondary Review Panel Chair) Centre for Health & Society, School of Population Health University of Melbourne Melbourne, VIC Dr. Deborah Glass Centre for Occupational and Environmental ...

Cancer in Northern Ireland 1993 - 2001: A Comprehensive Report 115 20: Cancer of the Brain (C71) Incidence In 2001, malignant primary cancer of the brain was the fifteenth most common cancer in males and twentieth commonest in females. On average, 60 males and 45 females were diagnosed as having cancer of the brain each year i.e. approximately 1% of all cancers registered. Age The median age at diagnosis was 56 years for males and 57 years for females. Given the levels of disease in 2001, the risk of getting cancer of the brain before the age of 75 years was 1 in 151 for males and 1 in 210 for females (Table 20a). Examination of the age-specific incidence rates show that males twenty years and older had consistently higher levels of this cancer than females (Figure 20a). Prevalence In Northern Ireland on 31st December 2001, there were 121 males and 117 females alive who ...

Validation of Functional Assessment of Cancer Therapy- Brain (FACT-Br) Questionnaire and FACT-Br Symptom Index (FBrSI) in Patients with Recurrent High-Grade Gliomas PA-31 Angel Nickolov 1 , Jennifer L. Beaumont 1 , David Victorson 1 , Amy H. Peterman 2 , David Cella 1 , Astra M. Liepa 3 , Howard A. Fine 4 1 Center on Outcomes, Research and Education (CORE), Evanston Northwestern Healthcare, Evanston, IL; 2 University of North Carolina, Charlotte, NC; 3 Eli Lilly and Company, Indianapolis, IN; 4 Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD The Functional Assessment of Cancer Therapy- Brain (FACT- Br) has been previously validated in a mixed sample ...

APPENDIX A SECTION 1. SHORT TITLE. This Act may be cited as the `Benign Brain Tumor Cancer Registries Amendment Act'. SEC. 2. NATIONAL PROGRAM OF CANCER REGISTRIES; BENIGN BRAIN - RELATED TUMORS AS ADDITIONAL CATEGORY OF DATA COLLECTED. (a) IN GENERAL- Section 399B of the Public Health Service Act (42 U.S.C. 280e), as redesignated by section 502(2)(A) of Public Law 106-310 (114 Stat. 1115), is amended in subsection (a)-- (1) by redesignating paragraphs (1) through (5) as subparagraphs (A) through (E), respectively, and indenting appropriately; (2) by striking `(a) IN GENERAL- The Secretary' and inserting the following: `(a) IN GENERAL- `(1) STATEWIDE CANCER REGISTRIES- The Secretary'; (3) in the matter preceding subparagraph (A) (as so redesignated), by striking `population-based' and all that follows through `data' and inserting the following: `population-based, ...

The GSM Association (GSMA) is the global trade association that exists to promote, protect and enhance the interests of GSM mobile operators throughout the world. www.gsmworld.com The MMF is an international association of wireless communications manufacturers established to support scientific research in relation to mobile telephony and health www.mmfai.info INTERPHONE: Mobile phone brain cancer study in the UK As part of the INTERPHONE project, UK medical researchers have published a large epidemiological study on the association between mobile phone use and the brain cancer , glioma * . The researchers were mostly medical statisticians and epidemiologists from various Centres and Institutes in England. The study was published on line in the British Medical Journal in January 2006. Study Design The study used a population based case-control design. The cases consisted ...

1 Immunity & Brain Cancer & reversible determinants of age-associated clinical outcome MDNSI Immunology Program Problem Current therapies are insufficient to treat late- stage gliomas • Local and systemic barriers to effective anti-tumor immunity • Highly invasive, difficult to treat focally • Inherently resistant to cytotoxic agents • Highly mutable and heterogeneous • Age is a better predictor of clinical outcome • Time vs. process dependent? Prins et al., J Immunol 172:1602 C o u n ts Tumor alone Tumor + L-Kb 22.7% 94.5% C o u n ts A B C CD4/8 CD4/8 0 10 20 30 40 50 % D N T I L 0 10 20 30 40 50 % D N T I L GL26 B16 ...

FOR IMMEDIATE RELEASE CONTACT Rob Tufel 415.834.9970 ext. 107 Beating Brain Cancer by Marathon Running (San Francisco, June 6, 2006) - “When I was diagnosed with a brain tumor, the only thought in my mind was, ‘this is not my time!’”, says Diane Levin” the Team Captain of the Racing Ahead for the National Brain Tumor Foundation team at the S.F. Marathon. “I think it was my naivete and sense of strength that kept me going. Marathons had become a new passion in my life, and I saw no reason to change my thinking.” It is this passion and positive thinking that motivated Diane to run in the S.F. Marathon but this time with she is running with a new attitude. “When in college, I enjoyed running, but it was not until I was 30 that marathons interested me. It became an addiction! Now, however, speed, testing myself, and timing are no longer my reasons for signing up to run. Now, there is a true joyand ...

customer focus University of Alabama Research into Personalized Treatment for Brain and Pancreatic Cancer Using the TaqMan ® Low Density Arrays and the Applied Biosystems 7900HT Fast Real-Time PCR System Dr. Martin Johnson at the University of Alabama is a passionate researcher striving to improve treatment for patients with pancreatic and brain tumors, two of the most commonly known incurable cancers. Dr. Johnson explains, “Right now, the treatments we have were developed empirically, and for these two types of cancer , the approach has been disappointing. Median survival is one year or less, and there has been very little improvement in overall median survival.” Dr. Johnson hopes that combining information from the human genome project with microfluidic gene-expression analysis cards such as TaqMan ® Low Density Arrays will finally ...

Page 2 Mortality trends in England; ICD9 (191), ICD10 (C71); File: Sepho 96-04 V2 Brain cancer in England 1996 to 2004. Mortality trends Authors: Michael Goldacre, Marie Duncan, Paula Cook-Mozaffari, Matthew Davidson, Henry McGuiness, Daniel Meddings Published by: Unit of Health-Care Epidemiology, Oxford University, and South-East England Public Health Observatory, 2006 This document provides a profile of trends in mortality for brain cancer in England. The period covered is January 1 1996 to December 31 2004. The data are analysed from mortality files supplied to the South East England Public Health Observatories (SEPHO) by the Office for National Statistics (ONS). Mortality rates were calculated for the condition certified as the underlying cause of death and for the disease certified as any mention on the death certificates. Age-specific ...

For research use only A221( ? )- Brain cancer tissues (formalin fixed) Specifications: • No. of cases: 30 • Tissue type: Brain cancer tissues • No. of spots: 2 spots from each cancer case (60 spots) 4 non-neoplastic spots (4 spots) •Total spots: 64 • Corresponding normal tissues with cancers: Yes • Diameter: 1. 5 mm Documents : • Product specification: layout, summary of tissue spots • H&E stained images • Detailed pathological information Layout: 1 2 3 4 5 6 7 8 9 10 A B C D E F G WHO and St.Anne/Mato grading system WHO designation St.Anne/Mayo designation : I Pilocytic astrocytoma : II Diffuse astrocytoma Astrocytoma grade 2 : III Anaplastic astrocytoma Astrocytoma ...

For research use only A221( ? ) Brain cancer tissues: grade ? ~ ? (formalin fixed) Specifications: • No. of cases: 30 • Tissue type: Brain cancer tissues: grade ?~? • No. of spots: 2 spots from each cancer case (60 spots) 2 non-neoplastic spots (2 spots) •Total spots: 62 • Corresponding normal tissues with cancers: Yes • Diameter: 1. 0 mm Documents : • Product specification: layout, summary of tissue spots • H&E stained images • Detailed pathological information Layout: 1 2 3 4 5 6 7 8 A B C D E F G H I WHO and St.Anne/Mato grading system WHO designation St.Anne/Mayo designation : III Anaplastic astrocytoma Astrocytoma grade 3 : IV Glioblastoma multiforme Astrocytoma grade 4 ...

A221(I) : Brain cancer tissues: Glioblastoma (formalin fixed) For research use only Specifications: • No. of cases: 30 • Tissue type: Brain cancer tissues: Glioblastoma • No. of spots: 2 spots from each cancer case (60 spots) 2 non-neoplastic spots (2 spots) • Total spots: 62 • Corresponding normal tissues with cancers: Yes • Diameter: 1. 0 mm Documents : • Product specification: layout, summary of tissue spots • H&E stained images • Detailed pathological information Layout: Page 2 Summary of tissue spots A221(I) : Brain cancer tissues: Glioblastoma (formalin fixed) For research use only No. Sex Age Key Word 1 1, 2 f 68 glioblastoma 2 3, 4 f 67 glioblastoma 3 5, 6 m 54 ...

Brain cancer Introduction In South Australia there were 66 men and 65 women diagnosed with brain cancer in 2002. Brain cancers can occur at any age. Although they become more common after the age of 50 they can occur in relatively young adults and are one of the most common cancers found in children. They are slightly more common in males than in females. The cause(s) of brain cancer are unknown at present. Structure and function of the brain The average brain weighs about one and a half kilograms and is surrounded and protected by the skull. As the body's control centre the brain governs how the body functions. Centres within the brain control mechanical tasks such as body movement, circulation of the blood and breathing. There are also areas which enable us to feel sensations such as pleasure or pain. The brain controls speech, memory, learning ...

Headaches The most common problems associated with raised intracranial pressure are early morning headaches, which may be worse on coughing or straining. The doctor can prescribe pain medication, which should be able to control the headache effectively. There are other medications such as steroids, that can be used to reduce the swelling due to accumulation of fluid. Disturbances in speech, vision, balance Changes in these areas should be reported to the doctor so the symptoms can be treated. Domiciliary and palliative care agencies may offer specific support and home visits. For more information phone The Cancer Council Helpline 13 11 20 . Personality changes Changes in personality can be confronting. It is important to understand that counselling the affected person will not improve their behaviour. Changes should be reported to the doctor so this symptom can ...

Brain metastases are an increasingly important cause of morbidity and mortality among patients with metastatic breast cancer (MBC).This clinical situation represents a therapeutic challenge for the treating physician and an emotionally and physically debilitating experience for the patient.While significant advances have been achieved in the treatment of MBC,more research is necessary to determine appropriate protocols for early diagnosis,proper surveillance,and effective treatments for MBC that has spread to the brain . Brain metastases are the most common brain tumors seen in clinical practice today,comprising well over half of all brain tumors.The annual incidence of brain metastases in the United States is nearly 170,000 cases,compared with only 17,000 for primary brain tumors. i The risk of developing brain metastases varies according to primary tumor type.Approximately 15 percent ...

MDS Nordion Signs Agreement with Bradmer Pharmaceuticals Inc. for Novel Brain Cancer Therapeutic Ottawa, Canada, April 19, 2006 – MDS Nordion, the world’s leading provider of medical isotopes and radiopharmaceutical services, has signed a three-year contract with Bradmer Pharmaceuticals Inc. for the development and clinical trial supply of Neuradiab, a monoclonal antibody conjugated to iodine-131 used to treat glioblastoma multiforme (GBM), the most common and deadly form of brain cancer . “MDS Nordion is thrilled to team up with Bradmer Pharmaceuticals in their fight against this terrible disease,” said Steve West, President of MDS Nordion. “We are pleased that our world-class cGMP facilities, wealth of expertise and dedication to bringing products to market quickly will contribute to Neuradiab’s development and its potential success.” According to the World Health Organization, GBM is usually fatal ...

DEPARTMENT OF VETERANS AFFAIRS Veterans Health Administration Washington DC 20420 IL 10-2005-020 In Reply Refer To: 131 September 15, 2005 UNDER SECRETARY FOR HEALTH’S INFORMATION LETTER NEW STUDY REPORTING INCREASED RISK OF BRAIN CANCER DEATHS AMONG 1991 GULF WAR VETERANS POSSIBLY EXPOSED TO SARIN CHEMICAL WARFARE AGENT AT KHAMISIYAH, IRAQ 1. Purpose. This Under Secretary for Health’s Information Letter provides information to clinicians who: a. Examine and provide care to veterans who may have been exposed to low levels of chemical warfare nerve agents including sarin during March 1991 weapons demolitions at Khamisiyah, Iraq, and b. May have concerns about how such exposures may have affected the veteran’s health. 2. Background a. A recent scientific study (“Mortality in US Army Gulf War Veterans Exposed to 1991 Khamisiyah Chemical ...

This factsheet is for those who have been diagnosed with secondary cancer in the brain that has spread from the breast. It describes what secondary brain cancer is, what the symptoms are and the treatments used. Being told that your cancer has spread to the brain can be particularly distressing and one of the common fears people have is of not knowing what effects this will have on their life. We hope this factsheet answers some of your questions and helps you to discuss your options with your specialist team. You may also find it helpful to read our Secondary breast cancer booklet, which looks at the physical and emotional impact of living with secondary breast cancer . What is secondary brain cancer ? Secondary brain cancer occurs when cancer cells from the breast spread through the lymph or blood system to the brain . This may ...

Technology in Cancer Research and Treatment ISSN 1533-0346 Volume 5, Number 3, June (2006) ©Adenine Press (2006) Future Prospects for the Cure of Brain Cancer www.tcrt.org Treatment of cancer of the brain is one of the most challenging problems in oncology as well as neurosurgery. Despite all the advances in understanding of pathomechanism, diagnosis by imaging and availability of powerful thera- peutic tools, the life expectancy of patients with GBM has been prolonged only slightly and cure remains elusive. None of the currently available surgical tools, including operative microscopes, lasers and image guided surgery enable detection and removal of all of the tumor tissue. Considerable efforts are being made to find a cure for glioblastoma multiforme (GBM) and over 100 research projects, mostly clinical trials, are underway worldwide. A sampling of inno- vative approaches ...

Childhood Brain Cancer and Potential Residential Exposure to Toxics Release Inventory Chemicals during Pregnancy Authors: Hannah Choi 1 , Youn Shim 2 , Wendy Kaye 2 , P. Barry Ryan 1 1 Department of Environmental and Occupational Health, Rollins School of Pubic Health, Emory University 2 Division of Health Studies, Agency for Toxic Substances and Disease Registry (ATSDR) Keywords: children’s health, brain cancer , toxics release inventory, air emissions, pregnancy Background: We examined whether mothers of children with brain cancer had greater potential residential exposure to Toxics Release Inventory (TRI) chemicals during pregnancy than mothers of children without any cancer (controls). Methods: Cases included 382 children born after 1987 and diagnosed with first primary brain cancer before age ten ...

TABLE III - 41 (Page 1 of 2) Douglas County, Nebraska 1990-2004 2004* 2003* 2002* 2001* 2000* 1999* 1998 1997 1996 1995 1994 1993 1992 1991 1990 Deaths 21 19 15 23 20 15 25 21 18 25 27 23 27 16 19 Rates per 100,000 Population* Crude Rate 4.4 4.0 3.2 4.9 4.3 3.3 5.5 4.7 4.0 5.7 6.2 5.3 6.3 3.8 4.6 2000 Age-adjusted Rate 4.5 4.2 3.5 5.2 4.7 3.5 6.1 5.1 4.3 6.5 6.8 5.6 7.2 4.0 4.8 By Sex Male 12 13 8 10 10 7 11 13 12 15 9 14 9 9 11 Female 9 6 7 13 10 8 14 8 6 10 18 9 18 7 8 By Race/Ethnicity White, not Hispanic 17 19 ...