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Breast Cancer and Environmental Risk Factors FACT SHEET #16 Q & A’s from the Cornell University Program on Breast Cancer and Environmental Risk Factors in New York State March 1998 Pesticides and Breast Cancer Risk, An Evaluation of Simazine What is simazine? Simazine (2-chloro-4,6-bis(ethylamino)- s -triazine) is a synthetic chemical that is widely used as an herbicide to control the growth of weeds. Simazine is in the family of s - triazine herbicides. Some of the common trade names of simazine include: Simazina Atanor, Gesatop, Princep, Caliber 90, Drexel Simazine, Simanex, Sim-Trol, and Nezitec. Simazine is also available commercially in combination with other pesticides including paraquat, diuron, glyphosate, metolachlor, ametryn, amitrole, terbutryn, diquate dibromide and another s -triazine herbicide called atrazine. ...

Cornell University Program on Breast Cancer and Environmental Risk Factors in New York State (BCERF) FACT SHEET #39 June 2000 Institute for Comparative and Environmental Toxicology Cornell Center for the Environment Meat, Poultry and Fish and the Risk of Breast Cancer Current research suggests that there is a possible relationship between eating meat, especially beef and cured meats, and an increase in the risk of breast cancer . This relationship is uncertain for eating other meats such as pork and poultry. Eating fish appears to be unrelated to breast cancer risk. Some studies suggest that cancer -causing chemicals are formed when meat is cooked at high temperatures and for a long time. The results of this research are not entirely clear because of limits in the studies that have been published so far. Does eating meat, in general, affect a woman’s ...

Cornell University Program on Breast Cancer and Environmental Risk Factors in New York State (BCERF) FACT SHEET #20 Institute for Comparative and Environmental Toxicology Cornell Center for the Environment January 1999 Pesticides and Breast Cancer Risk, An Evaluation of Dichlorvos This fact sheet reviews the science-based information on whether or not dichlorvos affects breast cancer risk. Dichlorvos was once a very popular insecticide for use in homes and offices and many people may have come in contact with it in the past. Whether or not dichlorvos affects breast cancer risk cannot be determined from the studies that have been done so far. However, there is evidence that dichlorvos causes other cancers and toxic effects in laboratory animals. We have included information about dichlorvos use, how people may have come in contact with it and steps that you can ...

Breast Cancer and Environmental Risk Factors FACT SHEET #12 Q & A’s from the Cornell University Program on Breast Cancer and Environmental Risk Factors in New York State March 1998 Pesticides and Breast Cancer Risk, An Evaluation of Heptachlor What is heptachlor? Heptachlor is a mixture of synthetic chemicals widely used as an insecticide in the United States (U.S.). Heptachlor and its partial breakdown product heptachlor epoxide, are resistant to being broken down in the environment and can still be found in some soils. Some of the common trade names of heptachlor sold in the U.S. were Fennotox, Cupincida, Velsicol 104 and Biarbinex. These products were mixtures and included chlordane, another persistent insecticide that is no longer in use. Similarly, the chlordane used to treat buildings for termites contained 10-20% heptachlor ...

FACT SHEET #44 Institute for Comparative and Environmental Toxicology Cornell Center for the Environment May 2002 Cornell University Program on Breast Cancer and Environmental Risk Factors in New York State (BCERF) Diet and Lifestyle and Survival from Breast Cancer While diet and lifestyle have been associated with the risk of getting breast cancer , little is known about the effect of diet and lifestyle on breast cancer survival. Understanding the consequences of diet and lifestyle on breast cancer survival is important to survivors of breast cancer who want to make choices to improve the length and quality of their lives. Far too little is known about the effects of diet and lifestyle after diagnosis on breast cancer survival. Nonetheless, the results of studies examining these effects are promising although still preliminary. What is the survival ...

FACT SHEET #23 Institute for Comparative and Environmental Toxicology Cornell Center for the Environment February 1999 Pesticides and Breast Cancer Risk, An Evaluation of Atrazine Why is there concern about atrazine and the risk of breast cancer ? BCERF chose to review atrazine because of its wide- spread use in agriculture, history of water contamination, and evidence of causing tumors in laboratory animal studies. What is atrazine and how is it used? Atrazine is an herbicide used to control weeds on agricultural crops, especially corn. It is the most used agricultural herbicide in the United States (U.S.) and New York State. It is usually applied to the soil once a year in the spring before the young corn plants emerge from the ground. It is also used on other agricultural crops including sorghum, sugar cane, guava and macadamia nuts. ...

FACT SHEET #41 July 2001 Cornell University Program on Breast Cancer and Environmental Risk Factors in New York State (BCERF) Institute for Comparative and Environmental Toxicology Cornell Center for the Environment Polycyclic Aromatic Hydrocarbons and Breast Cancer Risk Polycyclic aromatic hydrocarbons (PAHs) are a group of over 200 different chemicals formed when coal, wood, gasoline, oil, tobacco or other organic materials are burned. They can be formed in food when fish or meats are charbroiled. Several PAHs have been identified as chemicals that can cause mammary ( breast ) cancer in laboratory rats and mice. Whether PAHs found in the environment affect breast cancer risk in humans is an active area of research. Workplace exposure to mixtures containing PAHs and other chemicals has been associated with a higher risk of other types of cancers. This ...

FACT SHEET #26 Institute for Comparative and Environmental Toxicology Cornell Center for the Environment March 1999 Cornell University Program on Breast Cancer and Environmental Risk Factors in New York State (BCERF) Pesticides and Breast Cancer Risk, An Evaluation of Chlorpyrifos This fact sheet reviews the information currently available on whether or not chlorpyrifos affects the risk of breast cancer . It also includes information on how chlorpyrifos is used, different ways by which people can come in contact with it, and how you can minimize your exposure to this chemical. What is chlorpyrifos? Chlorpyrifos is a synthetic chemical used to kill insects (insecticide). It belongs to the group of chemicals called “organophosphate pesticides.” Dursban ® and Lorsban ® are two common trade names of insecticides ...

FACT SHEET #40 Updated July 2002 Cornell University Program on Breast Cancer and Environmental Risk Factors in New York State (BCERF) Institute for Comparative and Environmental Toxicology Cornell Center for the Environment 1) Hormone Treatment After Menopause and the Risk of Breast Cancer Hormone Treatments and the Risk of Breast Cancer 1) Hormone Treatment After Menopause and the Risk of Breast Cancer 2) Use of Birth Control Pills and the Risk of Breast Cancer Three recent clinical trials have changed the way postmenopausal hormone treatment is viewed. One of the trials was ended because of increases in breast cancer risk related to the treatment. Further, the decrease in the risk of heart and blood vessel disease, that was expected, was not found in any of these trials. Major health organizations have responded and suggested that ...

Breast Cancer Research Council Meeting Minutes May 21, 2004: Funding Meeting Oakland, CA Members present: Kim Pierce, Elaine Ashby, Debra Oto-Kent, Georjean Stoodt, Carol D’Onofrio, Janet Howard-Espinoza, Michael Figueroa, Vicki Boriak, Christine White, Dorothy Bainton, Diana Chingos, Kathryn Phillips, Jacquline Papkoff, John Morgan, Kathy Walters, Dee Bainton, James Ford Members not present: Diana Chingos, Georjean Stoodt Guests: M. Ellen Mahoney, Bobbie Head, Barbara Brenner, Sandra Walsh Staff: Mhel Kavanaugh-Lynch, Charles L. Gruder, Walter Price, Larry Fitzgerald, Janna Cordeiro, Katie McKenzie, Lyn Dunagan, Jill Stark, Cathyn Fan, David Betts, Joyce Price, Sharon Simms, Brenda Dixon-Coby, Eric Noguchi I. Call to Order The meeting was called to order at 8:21am and introductions were exchanged. Deb Oto- Kent briefly reviewed the steps of the programmatic review process. ...

Cornell University Program on Breast Cancer and Environmental Risk Factors in New York State (BCERF) FACT SHEET #1 Revised July 2001 Institute for Comparative and Environmental Toxicology Cornell Center for the Environment Phytoestrogens and the Risk of Breast Cancer Phytoestrogens are estrogen-like chemicals found in plant foods such as beans, seeds, and grains. Foods made from soybeans have some of the highest levels of phytoestrogens and have been studied the most. In spite of initial optimism, it is not clear whether eating foods rich in phytoestrogens decreases breast cancer risk. This is an active area of research with much work needed to resolve this issue. This fact sheet presents the most current information and indicates where more research would be helpful. What are phytoestrogens? Phytoestrogens are a group of chemicals found in plants ...

Institute for Breast Cancer Research â€“ Fast Facts The Institute for Breast Cancer Research (IBCR) is located at Princess Margaret Hospital, in Toronto. The Vision: To create a world-leading program in breast cancer research by leveraging basic, translational and clinical research opportunities. Also, to develop new mechanistically based treatments that will offer the potential of dramatic improvements in clinical outcomes. The Program Elements: Target Discoveries : Use transgenics and knock-out mice, Drosophila screening tumor and tissue banks/human samples, signal transduction, cancer immunolotherapy, in order to identify best genetic targets for breast cancer therapies Pre-clinical Developments : Use in vitro and in vivo screens, animal models, and translational development for novel surgical and radiation technologies as well as potential new drugs aimed ...

test Sexuality and Breast Cancer - Addressing the taboo subject D. Akkerman, Director, Cancer Information and Support Service, Anti- Cancer Council of Victoria, Australia. A. Hordern, R.N., B.N., Grad. Dip., M.Ed., MRCNA Anti- Cancer Council of Victoria, 1 Rathdowne St, Carlton, Victoria 3053 Australia Abstract Despite the integral role sexuality plays throughout the continuum of breast cancer , sexual needs of a woman with breast cancer are very rarely addressed in the clinical setting. Health professionals frequently express an uncertainty about 'not knowing where to begin' or, they presume that post-menopausal women are no longer sexually active. The Cancer Information and Support Service (CISS) have addressed this gap in service through the development of workshops “Sexuality and Cancer - Addressing the taboo subject" for both health professionals and patients. ...

test IMPROVING SERVICES FOR WOMEN WITH BREAST CANCER BY ESTABLISHING THE ROLE OF BREAST CARE NURSE IN AUSTRALIA THROUGH A TERTIARY BASED DISTANCE EDUCATION PROGRAM Amanda Hordern, R.N., B.N., Grad. Dip. Ed., M. Ed., MRCNA. Doreen Akkerman, Director, Cancer Information and Support Service Anti- Cancer Council of Victoria 1 Rathdowne St Carlton, Victoria 3053 Australia Abstract The Anti- Cancer Council of Victoria Cancer Information and Support Service (CISS) responds to over 36,000 calls per year. In 1999 20,000 calls were concerning female breast cancer . In the same period, there were three hundred women matched with a trained Breast Cancer Support Service Volunteer, 218 Cancer Support Groups and 39 Breast Cancer Support Groups were coordinated by this service. CISS is not only a means of disseminating information, it also has a finger on the ...

MJA Vol 178 16 June 2003 651 CANCER SCREENING The Medical Journal of Australia ISSN: 0025-729X 16 June 2003 178 12 651-652 ©The Medical Journal of Australia 2003 www.mja.com.au Cancer screening B REAST CANCER is the most common cancer in women and the most common cause of cancer death in Australian women. Factors affecting mortality from breast cancer are earlier detection through screening, earlier presentation with symptoms, and improved treatments. For many years, pub- lic-health messages have promoted the importance of both mammographic screening and systematic, regular breast self examination for the early detection of breast cancer . More recently, both of these screening tests have been strongly challenged, necessitating a review of their role by primary care providers. Mammographic screening Mammographic ...

National Breast Cancer Awareness Month What is Breast Cancer ? Breast cancer is a malignant (cancerous) tumor that starts from cells of the breast . The disease occurs mostly in women, but men can get breast cancer as well. The information here refers only to breast cancer in women. The breast is made up of lobules, ducts, fatty and connective tissue, blood vessels, and lymph vessels. Lymph vessels are like veins, except that they carry lymph fluid instead of blood. Inside the breasts are glands that produce and release milk after a woman has a baby. The glands that make the milk are called lobules and the tubes that connect them to the nipple are called ducts. Lymph is a clear fluid that contains immune system cells and tissue waste products. The fluid is carried in lymph vessels that lead to small, pea-sized collections of tissue called lymph nodes. Most lymphatic vessels of ...

1 From the publishers of F A C U L T Y : Patrick I Borgen, MD Robert W Carlson, MD Kevin R Fox, MD Generosa Grana, MD Gabriel N Hortobagyi, MD, FACP Peter Ravdin, MD, PhD Eva Singletary, MD Debu Tripathy, MD Marisa C Weiss, MD E D I T O R : Neil Love, MD S P E C I A L R E P O R T May 18, 2003, New York, New York September 14, 2003, Miami, Florida November 16, 2003, Houston, Texas A summary of the proceedings from three breast cancer patient town hall meetings Breast Cancer Patient Perspectives Project Page 2 2 Faculty and Affiliations 3 Prologue: A snapshot of what it was like 6 Editor’s Note: Freedom of choice 9 Breast Cancer Update faculty participants 11 ...

Mar 2004 National Committee on Cancer Care Ministry of Health MOH Clinical Practice Guidelines 4/2004 Page 2 Levels of evidence and grades of recommendation A (evidence levels Ia, Ib) B (evidence levels IIa, IIb, III) C (evidence level IV) GPP (good practice points) Requires at least one randomised controlled trial, as part of the body of literature of overall good quality and consistency addressing the specific recommendation. Requires availability of well conducted clinical studies but no randomised clinical trials on the topic of recommendation. Requires evidence obtained from expert committee reports or opinions and/or clinical experiences of respected authorities. Indicates absence of directly applicable clinical studies of good quality. Recommended best practice based ...

Novartis International AG Novartis Communications CH-4002 Basel Switzerland Tel + 41 61 324 2200 Fax + 41 61 324 3300 Internet Address: http://www.novartis.com 1/3 MEDIA RELEASE • COMMUNIQUE AUX MEDIA • MEDIENMITTEILUNG Compelling disease-free survival results in breast cancer trial prompt independent researchers to offer patients the opportunity to switch to Femara ® , as reported in New England Journal of Medicine Interim results from first study to explore post-tamoxifen use of Femara ® (letrozole) in postmenopausal women with early breast cancer showed dramatically reduced risk of recurrence (43%) and significantly improved disease-free survival Basel, Switzerland, 9 October 2003—Postmenopausal women with early breast cancer who completed five years of post-surgical hormonal therapy with tamoxifen benefited ...

Prof. Chris Robertson Age at any birth and Breast Cancer Risk This project will review previously published models of the effect of parity and age at any birth on breast cancer risk. These models are conceptually similar and one aim is to write a general model such that various restrictions on the parameters of the general model yield the specific models. A second aim is to apply these models to a large series of Case Control studies. I expect that there will be developments in the areas of using spline functions and other flexible curves to improve the validity of the models. Background. Parity and age at first birth have long been identified as risk factors for breast cancer . Relative to nulliparous women, parous women have a decreased risk of breast cancer . The risk of developing breast cancer is greater among women with a later age at first birth compared to women who had ...

115 Proclamations Proc. 7711 Americans to celebrate this week with appropriate programs, ceremonies, and activities to recognize the many contributions of our Nation’s minority enterprises. IN WITNESS WHEREOF, I have hereunto set my hand this twenty-six day of September, in the year of our Lord two thousand three, and of the Inde- pendence of the United States of America the two hundred and twenty- eighth. GEORGE W. BUSH Proclamation 7711 of October 3, 2003 National Breast Cancer Awareness Month, 2003 By the President of the United States of America A Proclamation Breast cancer touches the lives of many Americans, either directly or through the diagnosis of a family member or friend. We have made consid- erable progress in diagnosing this disease and improving treatments, but we have not ended it. While overall death rates are declining, ...

K ENTUCKY B REAST C ANCER T ASK F ORCE R EPORT C ARD O CTOBER 2003 This report card was prepared by Gilbert H. Friedell, M.D., Linda Linville, Ph.D., Connie Sorrell, M.P.H., Bin Huang, M.S., and Joe Petrik, M.A., M.Sc. Dr. Friedell is Director Emeritus of the Markey Cancer Center, University of Kentucky and Executive Director of the Kentucky Breast Cancer Task Force. Dr. Linville is Director, Cancer Control Practice, Markey Cancer Control Program, University of Kentucky and Co-Director of the Kentucky Breast Cancer Task Force. Ms. Sorrell is Director, Kentucky Cancer Program, Brown Cancer Center, University of Louisville and Co-Director of the Kentucky Breast Cancer Task Force. ...

About Rethink Breast Cancer Rethink Breast Cancer is fighting breast cancer and expanding support for the cause through innovative research and awareness. We are a national volunteer-driven charity with a bold, enterprising and entrepreneurial approach. Rethink uses creative and unconventional ways to communicate about breast cancer in order to transform attitudes, debunk myths and reach women and men who feel unaffected by the breast cancer cause. Rethink is tapping into the art, entertainment and fashion communities to re-energize the breast cancer movement and tackle the serious issues of breast cancer in a creative and strongly positive way. Our Audience Rethink Breast Cancer ’s target audience is modern, bold, youthful minded, upbeat, media savvy, highly interactive and culturally aware. These are people who may not be currently responding to the breast cancer community’s ...

1 of 21 Annex 1 to CC/98/23 REVIEW OF ALCOHOL: ASSOCIATION WITH BREAST CANCER A possible association between alcohol consumption and breast cancer has been identified in CC95/4 and CC95/12. In CC95/4, the need for a more detailed review of this topic was identified. This paper reviews and updates the available epidemiological data. A summary of the most recent data is provided in Appendix 1. Introduction 1. There is an extensive literature available on the epidemiology of breast cancer . Known risk factors for breast cancer include age, ethnic group, family history of the disease, age at birth of first child, menarche and at menopause, history of biopsy for benign breast disease, socio-economic status, obesity and, in premenopausal breast cancer , history of lactation. Other proposed risk factors have been cited, such as parity (in addition to age at birth of first ...

New breast cancer gene mechanism found http://web.mit.edu/newsoffice/tt/2003/oct29/yaffe.html 1 of 3 2/19/04 3:13 PM Published by the MIT News Office at the Massachusetts Institute of Technology, Cambridge, Mass. October 29 | 2003 | Tech Talk | Search | MIT News | Comments | MIT New breast cancer gene mechanism found Deborah Halber, News Office PHOTO / DONNA COVENEY Professor Michael Yaffe loads a tiny protein crystal onto an X-ray diffractometer machine to study its structure. Eighty-five percent of women who inherit mutations in a gene called BRCA develop breast cancer , and 65 percent with the same mutation develop ovarian cancer . Despite intense study, the exact way the gene predisposes patients to breast and ovarian cancer remained a mystery—until now. MIT researchers report in the Oct. 24 issue of Science a ...

Scientists do not currently know what causes breast cancer or how to prevent it. Research completed over the past twenty years indicates the existence of several risk factors that seem to increase an individual's chance of getting the disease. The two most significant risk factors for breast cancer currently identified are gender and age- In addition, family history and in a small number of cases, genetics can indicate an increased risk for breast cancer . All women and men are born with two copies of the so-called " breast cancer genes," BRCA-1 and BRCA-2. When functioning properly, these genes are thought to protect against cancer by suppressing abnormal cell growth. If one copy of these tumor suppressor genes becomes damaged, the other copy can act as a "brake" on uncontrolled cell growth. Scientists have identified at least four other genes that may play a ...

BREAST CANCER FACT SHEET Breast Cancer Statistics • One in nine women is expected to develop breast cancer during her lifetime; one in 27 will die of it. 1 • Breast cancer is the most frequently diagnosed cancer in Canadian women. 2 • Breast cancer continues to lead in incidence among Canadian women, with more than twice as many new cases as lung cancer . 1 • Since 1988, breast cancer incidence rates have risen by 10% but death rates have dropped by 19%. 2 • Breast , lung and colorectal cancers account for at least 50% of the new cancer cases in women. 1 • Incidence by age group: 3 · 22% of breast cancer cases occur in women under age 50 · 48% of cases occur in women ages 50 to 69 · 30% of cases occur in women age 70 and over • Mortality ...

BREAST Swimming has been Laurine Schuler’s favorite activity since childhood, so naturally she got back in the pool after surgery for breast cancer more than a decade ago. Since then, she set records in Senior Olympic and Masters’ swim competitions. Just the Facts Breast Cancer Your best chance for surviving breast cancer is detecting it early. When found early,there is a 96 percent chance for cure. Symptoms Symptoms of breast cancer may vary from woman to woman. Women should examine their breasts monthly so that they know what feels and looks normal for them. Many cancers are found by regular mammography after age 40 – before any symptoms are felt. Symptoms include • lump or mass in your breast • enlarged lymph nodes in the armpit • changes in breast size, shape, skin texture or color • skin redness • dimpling or ...

Breast Cancer Research Council Meeting Minutes November 20, 2003 San Francisco, CA Members Present: Dorothy Bainton, Kathryn Phillips, Georjean Stoodt, Michael Figueroa, Kim Pierce, Diana Chingos, John Morgan, James Ford, Christine White, Vicki Boriak, Carol D’Onofrio, Debra Oto-Kent, Kathy Walters Members Absent: Jacqueline Papkoff, Elaine Ashby, Janet Howard-Espinoza Staff Present: Mhel Kavanaugh-Lynch, Katherine McKenzie, Larry Fitzgerald, Walter Price, Charles Gruder, Roslyn Roberts, Janna Cordeiro, Lyn Dunagan Guests: Peggy Reynolds, Ngina Lythcott, Robert Millikan, Musa Mayer I. Call to Order and Introductions The meeting was called to order at 9:15 a.m. by Chair Debbie Oto-Kent. General introductions followed. II. Approval of 10/17/03 Minutes The October 17 minutes were unanimously approved as written. III. Priority-Setting Presentations, ...

Spring 2000 1 Early Detection of Breast Cancer in Counties Participating in the Illinois Breast and Cervical Cancer Program The Illinois Breast and Cervical Cancer Program (IBCCP) provides free or reduced cost mammograms, Pap tests, and other related screening and diagnostic services to income-eligible Illinois women. Funded through the U.S. Centers for Disease Control and Prevention’s National Breast and Cervical Cancer Early Detection Program, it began as a demonstration program in 1995 in DuPage, Lake and Peoria counties. Illinois continued to receive federal funding to augment IBCCP in 1996 and 1997. In 1999, IBCCP was able to begin providing screening services to eligible women living in all 102 Illinois counties. The IBCCP targets women who are at or below 200 percent of the federal poverty guideline. Women eligible for breast ...