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1 BREAST CANCER FACT SHEET The lifetime risk for women of developing breast cancer across the world is 1 in 7, with far-reaching consequences on their personal lives, and those of their family and friends. In addition, breast cancer is the second most common cancer among women, accounting for nearly 1 in 3 cancers diagnosed in U.S. women. To understand the full impact of breast cancer , it is helpful first to understand what breast cancer is, and to examine its epidemiology and prevalence. Listed below are key facts and figures of today’s breast cancer landscape. BREAST CANCER WORLDWIDE • The incidence of breast cancer worldwide is increasing every year and is responsible for approximately 23% of all new cancer cases among women • More than 1,100,000 women across the world are diagnosed with breast cancer each year • Each year around 410,000 ...

Modelling molecular mechanisms of breast cancer and invasion: lessons from the normal gland Mina J. Bissell Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720 Having developed a versatile 3D culture assay that allows normal breast cells to make acini and could be distinguished from malignant colonies of breast cancer cells, we were able to show that the microenvironment is dominant over the genome, a finding that is compatible with nature of tissue- and organ-specificity. We have shown that malignant breast cells can become phenotypically normal if we manipulate the microenvironment, and we can make normal cells malignant if we destroy cell and tissue architecture using inappropriate expression of MMPs in vivo or in culture . We have shown that once the basement membrane (BM) is lost by MMP action, cells produce ROS, leading to genomic instability. Thus the use of ...

Mauri Ora: Maori Health Symposium 2006 Breast Cancer Disparities: Is it all just screening, bad tumours, treatment or what? Dr Elana Taipapaki Curtis Ngati Rongomai, Ngati Pikiao (Te Arawa) Public Health Medicine Specialist Page 2 Mauri Ora: Maori Health Symposium 2006 Ko wai tenei? Page 3 Mauri Ora: Maori Health Symposium 2006 Ko wai tenei? Te Ropu Rangahau Hauora a Eru Pomare Page 4 Mauri Ora: Maori Health Symposium 2006 Ko wai tenei? Harkness Felllow in Healthcare Policy, 2004-2005 Based at UCSF, San Francisco Investigating ethnic disparities in breast cancer mortality and survival. Ko wai tenei? Page 5 Mauri Ora: Maori Health Symposium 2006 Outline ...

Editors N. Perry M. Broeders C. de Wolf S. Törnberg R. Holland L. von Karsa Technical editor E. Puthaar European guidelines for quality assurance in breast cancer screening and diagnosis F o u r t h E d i t i o n Page 2 This document has been prepared with financial support from the European Commission [grant agreement SPC.2002482]. The contents of this document do not necessarily reflect the views of the European Commission and are in no way an indication of the Commission’s future position in this area. Neither the Commission nor any person acting on its behalf can be held responsible for any use that may be made of the information in this document. A great deal of additional information on the European Union is available on the Internet. It can be accessed through the Europa server (http://europa.eu.int). Further information ...

Breast Cancer Facts & Figures 2001-2002 Page 2 Table of Contents What is breast cancer ? 1 Who gets breast cancer ? 1 How has the occurrence of breast cancer changed over time? 3 What factors influence breast cancer survival? 5 What are the known risk factors for breast cancer ? 7 Can breast cancer be prevented? 9 How can breast cancer be detected early? 10 How is breast cancer treated? 11 What research is currently being done on breast cancer ? 14 What resources are available in your community? 15 What is the American Cancer Society doing about breast cancer ? 16 Sources of Statistics 17 References 18 Acknowledgments The production of this report would not have been possible without the efforts of: Cheryll Cardinez, MSPH, ...

breast cancer Breast Cancer Prevention: The STAR Trial in East Tennessee In the mid-1990s we learned that Tamoxifen could decrease the risk of breast cancer by approximately 50% in women at increased risk for the disease. But this reduction in risk of breast cancer was accompanied by many side effects. These included increased hot flashes, blood clots, cataracts, and an increase in uterine cancer . These side effects certainly affected the willingness of women to take tamoxifen as a preventive strategy. Investigators at Thompson Cancer Survival Center, members of the National Surgical Adjuvant Breast and Bowel Project (NSABP), participated in the initial prevention trial that demonstrated the effectiveness of Tamoxifen and led to its approval for use in breast cancer prevention in 1998. “An option that avoided some of Tamoxifen’s side effects would perhaps lead ...

This factsheet is for those who would like more information about breast cancer that runs in families, known as familial or hereditary breast cancer . It describes what familial breast cancer is, how it is passed on and gives some general guidance about what might be considered a significant family history. It also outlines what you can do if you think you are at risk of familial breast cancer . Although this factsheet is aimed at women, much of the information is relevant to men. We hope it answers some of your questions and directs you to further sources of information and support. What is familial breast cancer ? Breast cancer is a common disease, and the vast majority of breast cancers are not due to inherited (genetic) factors. For most women, increasing age is the greatest risk factor. However, in some cases breast cancer does run ...

SEMM – European School of Molecular Medicine University of Milan IFOM – The FIRC Insitute of Molecular Oncology Foundation IEO – European Institute of Oncology EVERYTHING YOU ALWAYS WANTED TO KNOW ABOUT BREAST CANCER An innovative, multidisciplinary translational research programme for breast cancer , which aims to build an integrated database collection within the next ten to twelve years. Large-scale clinical trials. These are the topics discussed yesterday at the 2 nd IFOM-IEO Cancer Meeting. Early diagnosis, patient stratification for tailored prognoses and chemoprevention. With these goals in mind, Julio Celis, director of the Institute of Cancer Biology of the Danish Cancer Society, has given the go-ahead to the Danish Centre for Translational Breast Cancer Research. The research programme aims to build an integrated ...

117 Proclamations Proc. 7936 Proclamation 7936 of September 30, 2005 National Breast Cancer Awareness Month, 2005 By the President of the United States of America A Proclamation Breast cancer is the second most common kind of cancer and the second leading cause of cancer deaths among women in the United States. During National Breast Cancer Awareness Month, we renew our commitment to making progress in the fight to prevent, detect, treat, and cure this deadly disease. Although we do not yet know the exact causes of breast cancer , researchers have discovered several factors that can increase a person’s risk of devel- oping the disease, including age, characteristics of certain genes, and a fam- ily history of breast cancer . It is important for individuals to seek medical advice about risk factors and screening methods. Because treatment ...

FOR IMMEDIATE RELEASE Contact: Community Relations May 9, 2006 202-268-2155 Stamp News Release No. 06-024 www.usps.com U.S. POSTAL SERVICE RAISES OVER $50 MILLION FOR BREAST CANCER RESEARCH WASHINGTON – The U.S. Postal Service announced today that the Breast Cancer Research semipostal stamp has raised over $50.3 million for research. With Mother’s Day just around the corner, the Postal Service encourages consumers to use this stamp on Mother’s Day cards to further increase funding for research. The U.S. Postal Service’s Breast Cancer Research stamp was first issued in 1998 pursuant to legislation enacted by Congress and over 695 million stamps have been sold. As a “semipostal”stamp, the U.S. Postal Service’s Breast Cancer Research stamp sells for 45-cents and is valid for postage at the prevailing 39-cent First-Class Mail® letter rate. Seventy percent ...

Senator Feinstein Urges Children to Use Breast Cancer Research Stamps to Send Their Mother’s Day Cards - Stamp has so far raised over $50 million for cancer research - May 8, 2006 Washington, DC – With Mother’s Day fast approaching, U.S. Senator Dianne Feinstein (D-Calif.) today called on sons and daughters to use the Breast Cancer Research Stamp when sending greeting cards to their mothers. “Using the Breast Cancer Research Stamp to send your Mother’s Day cards shows that you are committed to finding a cure for this devastating disease,” Senator Feinstein said. “Sales of the stamp have already raised over $50 million for breast cancer research. More and more people today are becoming cancer survivors, rather than cancer victims, thanks to breakthroughs in cancer research. And until a cure is found, the money from the sales of this extraordinary stamp will continue ...

Related terms Estrogen — A hormone produced primarily by the ovaries that aids in developing female sex organs and in regulating monthly menstrual cycles Hormone — A substance that helps regulate body functions Hormone Therapy (HRT) — Hormone-based drugs given to women to help control the effects of menopause Menopause — The time in a woman’s life when menstrual cycles stop and the level of estrogen in her body decreases Oral Contraceptive — Hormone-based drugs used to prevent pregnancy or help regulate a woman’s menstrual cycle Osteoporosis — A disease in which bones become less dense and may break more easily Progesterone — A hormone that is released by the ovaries during every menstrual cycle and helps prepare a woman’s body for pregnancy Progestin — A synthetic progesterone-like ingredient found in HRT drugs. For more information about ...

Book Recommendations BOOK AUTHOR PUBLISHER & YEAR Advanced Breast Cancer : A Guide to Living with Metastatic Disease Musa Mayer O'Reilly Media 2003 After Breast Cancer : Answers to Questions You're Afraid to Ask Musa Mayer O'Reilly Media 2003 After Breast Cancer : A Common Sense Guide to Life After Treatment Hester Hill Schnipper Random House 2005 Anatomy of Hope Jerome Groopman Random House 2005 Another Morning: Voices of Truth & Hope from Mothers with Cancer Linda Blachman Seal Press 2006 Be a Survivor: Your Guide to Breast Cancer Treatments Vladimir Lange, MD Lange Productions 2005 Best News About Radiation Therapy Carol Kornmehl Evans & Co 2004 Between Heaven & Earth Harriet Beinfield Ballatine Books 1992 B.O.O.B.S: A Bunch of Outrageous ...

1 Predicting Breast Cancer Survivability Using Data Mining Techniques Abdelghani Bellaachia, Erhan Guven Department of Computer Science The George Washington University Washington DC 20052 {bell, eguven}@gwu.edu Abstract In this paper we present an analysis of the prediction of survivability rate of breast cancer patients using data mining techniques. The data used is the SEER Public-Use Data. The preprocessed data set consists of 151,886 records, which have all the available 16 fields from the SEER database. We have investigated three data mining techniques: the Naïve Bayes, the back-propagated neural network, and the C4.5 decision tree algorithms. Several experiments were conducted using these algorithms. The achieved prediction performances are comparable to existing techniques. However, we found out that C4.5 algorithm has a much better ...

A fact sheet from the Greater Bay Area Cancer Registry Breast Cancer in the San Francisco Bay Area 1988-1999 March 2002 Breast cancer was the most common cancer in the San Francisco Bay Area with nearly 15,000 invasive and 3,000 in situ cases diagnosed among women between 1995 and 1999. During this period, age-adjusted incidence rates of invasive and in situ breast cancer were 137 and 29 cases per 100,000 females, respec- tively, similar to rates in the neighboring Santa Clara Region. Figure 1. Age-adjusted incidence rates of invasive and in situ breast cancer , by year of diagnosis, 1988-1999. Since 1988, rates of invasive breast cancer remained stable, but rates increased slightly for in situ cases, which may partly reflect increased use of early detection methods, such as mammography (Figure 1, above). Figure 2. Average annual age-specific ...

Breast Cancer Genetics and Clinical Trials Dr James Mackay Consultant Clinical Genetic Oncologist Page 2 Inherited genetic variation and treatment outcome Clinical Pharmaco-genetics Page 3 Summary • Current practice in BRCA testing • Genetic Breast Cancer Trial • Acquiring new knowledge from routinely collected clinical oncology data • A national structure for investigating pharmaco-genetics Page 4 High Risk High Risk DDD DDD DDD DDD DDD DDD BrCa 51 OvCa 55 BrCa 38 37 BrCa 32 Page 5 Genetic Testing Genetic Testing A 2 step process: 1. identify mutation in affected family member then 2. offer direct gene ...

A Woman’s Guide to Breast Care Y-ME National Breast Cancer Organization TM Page 2 Breast self-examination (BSE) takes just a few minutes, and you only do it once a month. As you do your examination, keep in mind that your goal is to become acquainted with how your breasts normally LOOK and FEEL. You will become more familiar with your breasts if you perform BSE on a regular basis. This knowledge may help you identify a change, which should be reported to your medical professional. What changes should I look for? • Lump or thickening in or near the breast or underarm area • Change in the size and/or shape of the breast • Puckering, dimpling and/or redness of the breast skin • Scaliness, redness, itching and/or swelling of the nipple or surrounding area When should I perform BSE? • ...

GINGER BRAUER BREAST CANCER SUPPORT AWARD The Susan G. Komen Breast Cancer Foundation Brainerd Lakes Affiliate established the annual Breast Cancer Support Award in 2000. The first winner, Ginger Brauer, lost her battle in 2001 and the award was subsequently named in her honor. Ginger Brauer exemplified the selfless giving of time and energy in support of local breast cancer activities and was an active member of the Race for the Cure ® committee from its inception. Each year the Komen Brainerd Lakes Affiliate will accept nominations from the general public from Cass and Crow Wing Counties. Criteria for this annual award are listed below. The winner will be announced at the Komen Brainerd Lakes Race for the Cure ® event on July 1, 2006 in Brainerd, MN. Criteria for this award • All nominees must reside in Cass or Crow Wing Counties. • All nominees ...

Breast Cancer Therapy: Cure, Chronic Disease and Complications Richard J. Pietras, PhD, MD Stiles Program in Integrative Oncology UCLA-Jonsson Comprehensive Cancer Center Page 2 Breast Cancer • 215,000 new cases - 40,000 deaths/year in US • Risk factors • Personal history • Family history (5-10%) • Benign breast disease ( atypical hyperplasia) • Endocrine ( late menopause, early menarche, OCP > 10 yr, pm-HRT > 15 yr, late pregnancy ) • Environment ( diet, alcohol, carcinogens ) • No attributable risk ( 70-75% ) Page 3 Breast Cancer : Declining death rates Page 4 Reasons for Declining Deaths Earlier detection - more but smaller tumors (1975- 2000, 65% of new breast cancers early stage Improved therapy ...

FACT SHEET The Biologic Cause of the Abortion Breast Cancer Link: The Physiology of the Breast The physiology of the breast provides the strongest evidence of the causal link between abortion and breast cancer . The same biology that accounts for 90% of all risk factors for breast cancer accounts for the ABC link. Simply stated, the biology rests on two principles. 1. The more estrogen a woman is exposed to in her lifetime, the higher her risk for breast cancer . It is well established that estrogen is implicated in the formation of three cancers: uterine, germ cell and breast . 1 Estrogen can induce cancers to form in two ways, as a genotoxin and a mitogen . A genotoxin or mutagen directly damages the DNA (causes mutations), initiating a process that leads to the formation of cancer cells. Certain natural metabolites of estrogen have been shown to cause mutations ...

Breast Cancer : A Canadian Snapshot Overview • Over 22,000 women and 160 men will be diagnosed with breast cancer in 2006; 5,300 women and 45 men will die of it • On average, 429 women will be diagnosed with breast cancer every week • Breast cancer is the most common cancer among Canadian women • Breast cancer deaths comprise the second highest cancer death rate, after lung cancer , among Canadian women. • One in nine Canadian women is expected to develop breast cancer during her lifetime, and one in 27 will die of it. Incidence by age group: • Less than 1% of breast cancer cases occur in women aged 29 or younger. • 20% of breast cancer cases occur in women aged 30-49. • 28% of breast cancer cases occur in women aged 50 to 59. • 23% of cases occur in women aged 60-69. • 29% of cases occur in women aged 70 and over. Mortality by age group: ...

Control of Selective Estrogen Receptor Modulators: Prevention of Hormonal-Dependant Breast Cancer Use of a Progestinally Active Compound to Facilitate Broader and Safer use of SERMs for Breast Cancer Prevention Intellectual Property ID Number 66 Contact Robert F. Williams, Ph.D., M.B.A. Director, Office of Technology Transfer (757) 446-5099 WilliaRF@evms.edu Inventor Gary D. Hodgen, Ph.D. Field Breast Cancer Prevention Technology Use of a progestin (such as clomiphene) to ameliorate the side effects of a SERM (such as tamoxifen) used for breast cancer prevention. Key Features • Broadens the safe use of SERMs for prevention of breast cancer • Some early validation provided by clinical studies ...

Women’s Health Forum Monash University December 1 st 2005 Breast Cancer A/Professor Robin Bell Women’s Health Program Department of Medicine (CECS) Monash University This presentation is restricted to a discussion of: 1. The extent of the problem of breast cancer in Australia 2. Some issues about “risk” – the WHI study 3. After Breast Cancer study - Women’s Health Program, Monash University ? Breast cancer is the commonest cancer (29.1%) and the most common cause of cancer death in Australian women (16.3%) ? 11,791 new cases and 2,594 deaths in 2001 ? Lifetime risk 1 in 11 (cumulative rate 9%) ? 5 year survival 85% 1994-1997 and survival is improving The number of new cases diagnosed each year increased in the mid-1990’s at the time that screening mammography was introduced. The incidence seems ...

FOR IMMEDIATE RELEASE Contact: Machie Madden LandersMadden 212.292.8560 ext. 216 machie.madden@landersmadden.com NATIONAL PHILANTHROPIC TRUST BREAST CANCER FUND AWARDS GRANTS TO THE NATIONAL BREAST CANCER COALITION FUND AND THE ONCOLOGY NURSING SOCIETY FOUNDATION JENKINTOWN, PA – April 11, 2006 – The National Philanthropic Trust (NPT), one of the nation’s 100 largest charities and among the top 35 grant makers in the United States, today announced grants from its Breast Cancer Fund to the Oncology Nursing Society Foundation (ONSF) and the National Breast Cancer Coalition Fund (NBCCF). The NPT Breast Cancer Fund provides long-term support for breast cancer initiatives including research, treatment, prevention and education. Consistent with those objectives, the grant money will be applied toward programs of education, support and research ...

Genetic testing can help determine breast cancer risk By Markian Hawryluk / Published in the Bend Bulletin Newspaper on 11-24-05 Knowledge can be a wonderful asset. It can also be a terrible burden. In the 1990s, researchers discovered that genetic mutations found in one out of every 500 women substantially increase their risk for breast cancer . Women with a mutation in the BRCA 1 or 2 genes have an 80 percent to 85 percent chance of being stricken. A genetic test can now determine which women have the mutation. But many struggle with the decision to have the test and must carefully weigh the ramifications of finding out. For two Bend women, the decision of whether to pull open that door and get a vision of what their fate may hold in store for them may have been the toughest of their lives. Shari Harris-Dunning grew up knowing she was at high risk for cancer . "That was always the cloud hanging over ...

Breast Cancer Awareness Patch Breast Cancer has special significance for all Girl Scouts, not only because we are female, but also because our founder, Juliette Gordon Low, died from it. Today, modern medical advances make detecting and treating breast cancer a lot easier than it was back in 1927. Girl Scouts of Indian Waters Council is teaming up with the American Cancer Society to educate young women about breast cancer . This is an opportunity to learn about breast cancer —something all girls and women (and men) need to know about. In this case, knowledge is power and responsibility! Who is at risk for breast cancer ? All women are at risk for breast cancer . It now causes more deaths among women than any other form of cancer except lung cancer . Many breast cancers may be curable if they are found early. Who can earn the Breast Cancer Awareness Patch? The ...

What Cannot Be Controlled? Age. The older a woman is, the more likely she is to get breast cancer . Family History. Having a family member (mother, sister) with breast cancer increases a woman’s chance of breast cancer . Previous Breast Cancer . Having been diagnosed with breast cancer or any other cancer in the past is a risk factor for breast cancer . Breast Density. Studies have found that as breast density increases (as seen on a mammogram), so does the risk of cancer . Radiation Exposure in Childhood and Young Adulthood. Radiation exposure at an early age (for Hodgkins disease or Scoliosis) can increase breast cancer risk Reproductive Factors. These include a first period before age 12, giving birth at a later age, breastfeeding, and menopause after the age of 55. Breast cancer is a type of cancer where cells divide ...

676 N ORTH S T . C LAIR , S UITE 1200 C HICAGO , I LLINOIS 60611-3013 (312) 695-1304 For immediate release: January 4, 2006 For more information, contact: Elizabeth Crown at (312) 503-8928 or at e-crown@northwestern.edu Broadcast Media: Mary Jane Twohey at 847-491-4887 or at mjtwhohey@northwestern.edu CELL STRESS PROTEIN LINKED TO AGGRESSIVE BREAST CANCER CHICAGO --- A groundbreaking study led by Northwestern University researchers has demonstrated that a protein called alphaB-crystallin, which normally protects cells from stress damage, triggers events that may cause breast cancer when overactive. Breast cancer is the most common cancer in women and is responsible for over 400,000 deaths annually in women throughout the world. Most ...

Tax Check-off Grants Researchers funded by contributions to line 57 are undertaking studies to eliminate breast cancer and its effects by investigating its potential causes, devising ways to prevent and cure it, and pursuing ways to live well after a breast cancer diagnosis. The following list of grants received funding through the tax check-off program. African American Women and Breast Cancer : What Works? ¹Priscilla Banks, M.A., ²Carol Somkin, Ph.D. ¹African American Advisory Committee, ²Kaiser Foundation Research Institute Award Type: Community Research Collaboration, Pilot Award Duration: 1.5 years $132,055 Apogossypol Derivatives for Breast Cancer Therapy Maurizo Pellecchia, Ph.D. The Burnham Institute Award Type: STEP Duration: 2 years $285,764 Breast Cancer Functional Imaging with Optics and MRI ¹Bruce Tromberg, Ph.D., ²Nola Hylton, ...