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Institute for Breast Cancer Research – Fast Facts The Institute for Breast Cancer Research (IBCR) is located at Princess Margaret Hospital, in Toronto. The Vision: To create a world-leading program in breast cancer research by leveraging basic, translational and clinical research opportunities. Also, to develop new mechanistically based treatments that will offer the potential of dramatic improvements in clinical outcomes. The Program Elements: Target Discoveries : Use transgenics and knock-out mice, Drosophila screening tumor and tissue banks/human samples, signal transduction, cancer immunolotherapy, in order to identify best genetic targets for breast cancer therapies Pre-clinical Developments : Use in vitro and in vivo screens, animal models, and translational development for novel surgical and radiation technologies as well as potential ...

Fact Sheet 2004 - The Weekend to End Breast Cancer History: • 2003 was the inaugural event in Toronto (September 19-21,2003) • More than 3900 women and men participated • Each participant was required to raise a minimum of $2,000 and walked 60 km over two days to support Princess Margaret Hospital (PMH) • More than 400 Volunteers spent their entire weekend in service to the event. More than 1000 Volunteers helped throughout the year to make the event a success. • The support from men, women and children in the Toronto community was phenomenal. They lined the route cheering the walkers on, congratulating them for their incredible efforts. • The 2003 Weekend to End Breast Cancer was the most successful first-time fundraising event in Canadian history. • More than $8,500,000 (net proceeds) went to support three innovative breast cancer programs at PMH: 1) The ...

Institute for Breast Cancer Research – Dr. Tak W. Mak Biography Born in southern China in 1946 and raised in Hong Kong, Tak Wah Mak studied biochemistry and biophysics at the University of Wisconsin. In the early 1970s, he earned his PhD in biochemistry from the University of Alberta, in Edmonton. After he obtained his degree, Dr. Mak became a Canadian citizen. Following his postdoctoral fellowship at the Ontario Cancer Institute, the research arm of Princess Margaret Hospital in Toronto, Dr. Mak became a faculty member and later a full professor at University of Toronto’s Departments of Medical Biophysics and Immunology. He was named a University Professor at University of Toronto in 1997, an honour reserved for one per cent of the university’s faculty at any given time. Dr. Mak changed the world of science and research in 1984 when he published a landmark scientific paper on the cloning of ...

Institute for Breast Cancer Research – Backgrounder The Institute for Breast Cancer Research (IBCR) is located at Princess Margaret Hospital, in Toronto and will be led by Dr. Tak W. Mak, world-renowned and award-winning scientist. Focus of Discovery: We are entering an important era of discovery. Decades of investment in basic science have given scientists new understanding of the mechanisms that fuel cancer growth. It is yielding important new targets for cancer research into developing mechanistically based drugs ? ones that pinpoint a specific genetic or cellular process in the cancerous cell ? including examples of the newest generation such as Gleevac and Avestin. The focus of IBCR will be to apply these lessons to breast cancer and develop new drugs and surgical and radiation therapies that are more effective, less toxic and can increase a patient’s quality and length ...

The Weekend to End Breast Cancer Benefiting Princess Margaret Hospital Walker Quotes “The event last year, was the most rewarding experience of my life. The energy, emotion and pure dedication of my fellow walkers was absolutely overwhelming.” -Cindy Lewis “My hope is that my children and all future generations will grow up in a world that no longer has Breast Cancer as a threat and is a thing of the past! I have never challenged myself in this way and as I will be turning 40 the week of the walk, I hope to make ‘the new decade in my life’ the decade that ends breast cancer !” -Karen Sinden “I never thought about Breast Cancer much before Sue tearfully told me that she had it. It suddenly became all that I thought about. Someone so young. She is in the prime of her life. I kept hearing all of the radio adds for the Weekend to End ...

March 9, 2004 – Press Release Micromet Starts Phase II Trial in Breast Cancer with Fully Human Antibody MT201 MT201 to offer biological treatment to new segment of breast cancer patients Munich, Germany -- Micromet AG has initiated a randomized, open-label, international, phase II trial to investigate the efficacy and safety of MT201 for the treatment of breast cancer patients who experienced a metastatic relapse. The trial will evaluate the clinical response to two different dose levels of MT201 in two parallel treatment groups. The study is being conducted at multiple sites in Europe and will enroll approximately 100 patients. Breast cancer is the second indication after prostate cancer that is being evaluated in the context of Micromet’s phase II program on MT201. Breast cancer is the most common cancer in the world. Notwithstanding substantial ...

Avon Foundation-AACR International Scholar Awards in Breast Cancer Research Scholar Program Detailed Description --------------------------------------------------------------------------------------- Functional Significance of the brca1/Xist Interaction: Reactivation of Silenced X-Linked Genes in Breast and Ovarian Cancer PI’s Name David M. Livingston, M.D. Title Emil Frei Professor of Genetics and Cancer Name of Research Group Department of Cancer Biology Name of Organization Dana-Farber Cancer Institute Internet Homepage of Research Group http://www.dana-farber.org/ ------------------------------------------------------------------------------------------------------------------------------- DESCRIPTION OF RESEARCH PROGRAM The Scholar will explore the significance in BRCA1 breast cancers of the common ...

General Practitioner in Oncology Self-directed Learning Program BREAST CANCER MODULE Page 2 Breast Cancer Case Scenario 1 Mrs. Jones is a 48-year-old woman who found a lump in her left breast on routine breast self-examination. She reported this to her family doctor. 1. What would your differential diagnosis be for a breast lump found in a 48-year- old woman? 2. How would you investigate this? Her family physician ordered an ultrasound and mammogram. These investigations confirmed a 1.5cm mass at 3 o’clock in the left breast . 1. Are these appropriate investigations? 2. Does she require both an ultrasound and mammogram? 3. How would you proceed next? She subsequently saw a surgeon who performed a fine needle aspirate. The cytology revealed cells suspicious for adenocarcinoma. 1. What are the indications ...

Page 1 of 6 Avon Foundation-AACR International Scholar Awards in Breast Cancer Research Application for Scholars I NSTRUCTIONS Confirm that you meet the following eligibility requirements before submitting an application: Applicants must be nationals or permanent residents of countries where opportunities for specialized scientific training and advancement for physicians and scientists are limited, including those in Asia, Latin America, and Eastern Europe, and must currently be residing and conducting research within these targeted countries; Applicants must be holding a first faculty appointment at the level of Instructor, Acting Assistant Professor, or Assistant Professor, and have held this appointment for no longer than five (5) years by December 31 of the application year. An applicant whose title is not Instructor, Acting Assistant Professor, or Assistant ...

Every Woman’s Guide to Breast Cancer Page 2 i Acknowledgments Every Woman’s Guide to Breast Cancer is a revision of our 1995 publication, For Single Women With Breast Cancer . The idea of transforming the “Singles” booklet into Every Woman’s Guide was well received, since for many years staff, volunteers and callers have told us they read the “Singles” book even though they have partners. Breast cancer support group leaders from hospitals and organizations throughout the Chicagoland area enabled us to reach many women who completed a questionnaire, responded to early drafts and answered additional questions. Y-ME Hotline staff and volunteers provided assistance and insight. Our medical advisors and other physicians reviewed the booklet for clarity as well as accuracy. We thank them for their valuable contributions. Original Research ...

Avon Foundation-AACR International Scholar Awards in Breast Cancer Research Scholar Program Detailed Description --------------------------------------------------------------------------------------------------- Validation of Proteases as Therapeutic Targets in Breast Cancer : Functional Imaging of Protease Expression, Activity and Inhibition PI’s Name Bonnie F. Sloane, Ph.D. Title Professor and Chair Name of Research Group Protease Breast Cancer Center of Excellence Name of Organization Wayne State University Internet Homepage of Research Group http://www.med.wayne.edu/pharm/bccoe.htm ------------------------------------------------------------------------------------------------------------------------------- DESCRIPTION OF RESEARCH PROGRAM The Scholar will participate in the research program funded by a DOD Breast ...

Fact Sheet: Breast Cancer Registry of Greater Cincinnati Contact: Susan Pinney, PhD Department of Environmental Health University of Cincinnati College of Medicine Phone: 513-558-0854 Susan.Pinney@UC.edu Breast cancer is the second leading cause of cancer deaths among women in the US, claiming 40,110 lives per year. Although the incidence (new case) rate in African Americans is lower than that for Caucasians, mortality (death) rates are higher. In 2000, the age adjusted breast cancer death rate among black women in the US was 34.6/100,000, compared to 26.3/100,000 for white women. In Greater Cincinnati, there are approximately 14,000 white women and 1,300 African-American women who have been diagnosed with breast cancer at some point in their lifetime. Very few males develop breast cancer ; less than 1% of all cases are males. A ...

MJA Vol 178 16 June 2003 651 CANCER SCREENING The Medical Journal of Australia ISSN: 0025-729X 16 June 2003 178 12 651-652 ©The Medical Journal of Australia 2003 www.mja.com.au Cancer screening B REAST CANCER is the most common cancer in women and the most common cause of cancer death in Australian women. Factors affecting mortality from breast cancer are earlier detection through screening, earlier presentation with symptoms, and improved treatments. For many years, pub- lic-health messages have promoted the importance of both mammographic screening and systematic, regular breast self examination for the early detection of breast cancer . More recently, both of these screening tests have been strongly challenged, necessitating a review of their role by primary care providers. Mammographic ...

breast cancer Expression of Interest for Specific Targeted Research Project (STREP) for Fp6 Identification and Characterization of Breast Cancer Cell Populations with the putative role of Tumorigenic Stem Cells (BRECASTEM) Background and Relevance Breast cancer is one of the leading causes of cancer mortality in women and remains difficult to cure despite advances in surgery and adjuvant therapy. Its outcome is frequently difficult to predict, as breast tumors sharing similar morphology and phenotype can have very different prognosis and response to treatment. Most of current research on breast cancer is focused on the bulk tumor mass. However there is overwhelming evidence in some malignancies that the population of neoplastic cells exhibits marked heterogeneity with respect to proliferation, differentiation and phenotype. It is still ...

340 MJA Vol 177 7 October 2002 EDITORIALS The Medical Journal of Australia ISSN: 0025-729X 7 October 2002 177 7 340-341 ©The Medical Journal of Australia 2002 www.mja.com.au Editorials Probably in the short term, but results of ongoing trials are needed to determine longer-term safety O ESTROGENS PLAY AN IMPORTANT ROLE in the develop- ment of breast cancer . This is most evident in postmenopau- sal women: circulating levels of endogenous oestradiol are higher in those who develop breast cancer , 1 while use of hormone replacement therapy (HRT) increases breast can- cer risk. 2 Recent results from the Women’s Health Initiative randomised trial showed a 26% excess rate of breast cancer development in women who took combined continuous equine oestrogens and ...

MJA Vol 176 18 March 2002 247 EDITORIALS The Medical Journal of Australia ISSN: 0025-729X 18 March 2002 176 6 247-248 ©The Medical Journal of Australia 2002 www.mja.com.au EDITORIALS Screening by high-quality programs successfully detects cancers at an earlier stage I N 2002, the 10th anniversary of Australia’s national program of mammographic screening for breast cancer , it is perhaps timely to reflect and review. The need for reassessment is highlighted by the recent furore in the breast -screening world 1-4 precipi- tated by a Cochrane review by Olsen and Gøtzsche. 1 In this issue of the Journal, the article by Barratt et al 5 ( page 45) also encourages us to review breast -screening policies — in this case for women 70 years and over who are no longer in the target group ...

232 Breast Cancer Research Vol 5 No 5 Whittemore Introduction Two articles previously published in Breast Cancer Research provide another example of the political/social/ psychological/scientific quandary presented by regional cancer clusters [1,2]. A community is concerned by what it perceives to be its high incidence of cancer , and a group of activists collaborates with epidemiologists to investigate the reasons for the cluster. They launch a study that considers every conceivable cause, but cannot come up with an answer because of limitations in their study design. Findings of the articles Marin County is a small urban county north of San Francisco. Its 250,000 predominantly white, non-Hispanic residents have breast cancer rates approximately 38% higher than those of the United States as a whole [1]. In response to concerns about ...

Revised, 10/01 FACT SHEET — Breast Cancer Breast cancer is the most common form of cancer among American women, accounting for more than 30 percent of all cancers. Scientists do not know what causes breast cancer , and why one person gets the disease, and another does not. Risk Factors for Breast Cancer ? Age 40 or older — The risk for breast cancer increases as a woman ages. Most breast cancers occur in women over the age of 50; the risk is especially high for women over 60. ? Family history — The risk of getting breast cancer increases for a woman whose mother, sister or daughter has had the disease. The risk increases if the relative's cancer developed before menopause or if it affected both breasts. ? Personal history — Women who have had breast cancer are at high risk for developing the disease ...

National Breast Cancer Awareness Month What is Breast Cancer ? Breast cancer is a malignant (cancerous) tumor that starts from cells of the breast . The disease occurs mostly in women, but men can get breast cancer as well. The information here refers only to breast cancer in women. The breast is made up of lobules, ducts, fatty and connective tissue, blood vessels, and lymph vessels. Lymph vessels are like veins, except that they carry lymph fluid instead of blood. Inside the breasts are glands that produce and release milk after a woman has a baby. The glands that make the milk are called lobules and the tubes that connect them to the nipple are called ducts. Lymph is a clear fluid that contains immune system cells and tissue waste products. The fluid is carried in lymph vessels that lead to small, pea-sized collections of tissue called lymph nodes. ...

Breast Cancer When it comes to cancer , knowledge is good medicine. The most common cancer among American women is breast cancer . Almost one-third of all new cancer diagnoses in women is for breast cancer . Signs and symptoms of breast cancer include changes in the breast , such as: • A non-painful lump located in the breast , but sometimes in the armpit • Discharge from the nipple • Dimpling of the skin • An abnormal density seen on a mammogram • Discoloration of the breast The risk of breast cancer increases with age. Forty-eight percent of new breast cancers occur in women over the age of 65, but that means that more than half are diagnosed in younger women. In addition, the risk is higher in women who have the following conditions: • A personal or family risk of breast cancer • Some forms of benign (non-cancerous) breast ...

Sunday, May 23, 2004 8:00 a.m. – 12:00 p.m. Philadelphia Museum of Art (East Entrance Steps) Yoga Unites for Living Beyond Breast Cancer A unique open-air yoga class and Healthy Living Expo to benefit women with breast cancer ! All proceeds benefit Living Beyond Breast Cancer ’s education and support programs. Special thanks to the Yoga Unites sponsors whose generous contri- butions make this program possible. A l l a g e s a n d s k i l l l e v e l s w e l c o m e . List incomplete Pre-Registration fee: $25 for adults, $10 - children 6-16 (Register by May 21) Walk-In Registration: $30 for adults, $15 - children Experience being at peace with your body and improve community awareness of breast cancer issues at this basic yoga practice ...

Frequently Asked Questions about Breast Cancer Why should I be concerned about breast cancer ? It seems like we’ve all been affected by breast cancer at some point in our lives, whether we have had it, or have had a family member or friend who’s battled it. Every woman has a chance of getting breast cancer . Other than skin cancer , breast cancer is the most common cancer in American women and the disease we fear most. As scared as we are, you can try to remember that if you find breast cancer early, it can often be treated successfully. Many women have overcome breast cancer and are living life to its fullest! Where can I learn more about breast cancer ? The National Cancer Institute (NCI) is the federal government's authority on breast cancer . Contact them at 800-4- CANCER (800-422-6237) or go to the following ...

UW Breast Center State-of-the-art care, tailored for you The Breast Center at University of Wisconsin Hospital and Clinics offers all the breast health answers and care in a single beautiful location. To schedule an appointment please call (608) 266-6400 . CC6810-0404A uwhealth.org Sunday, May 16, 2004 RACE FOR THE CURE Page 5 By Jeanine Maguire for Capital Newspapers Readers, you are not about to embark on a journey through the “Twilight Zone.” The following stories are true, and they offer us two valuable lessons: trust your instincts and hire physicians that listen to you. Fire the ones that don’t! Sue Joy-Sobota wasn’t sitting around feeling morbid when suddenly she was struck with a grim omen of her future. “I had a premonition that I was going to die of breast ...

Breast Cancer UCLA breast surgeons offer ductal lavage for patients at high-risk for breast cancer as a diagnostic adjunct to mammography. Program News The Ductal Lavage Clinic, an integral part of the Revlon-UCLA Breast Center, is one of a limited number of such clinics nationally with the goal of providing women at high risk of developing breast cancer a new screening tool that evaluates ductal fluid, where most breast cancer begins. Background Breast cancer originates in breast epithelium and women with atypical breast ductal epithelial cells are at increased risk of breast cancer . UCLA researchers at the Jonsson Comprehensive Cancer Center at UCLA participated in a 19 medical center study that compared ductal lavage to nipple aspiration with regard to safety, tolerability and sensitivity for detecting abnormal breast ...

Breast Cancer Research New UCLA clinical trial tests two targeted therapies against advanced breast cancer . Program News For the first time, a new, early phase study at UCLA’s Jonsson Cancer Center pairs two molecularly targeted drugs, Herceptin and Avastin, as a “one-two punch” to fight metastatic breast cancer . The drugs attack only the cancer and the blood vessel cells, and leave the healthy cells unharmed. This study will not use chemotherapy or other conventional treatments. Background Other research on advanced cancers using the monoclonal antibody Herceptin and the angiogenesis inhibitor Avastin has shown potential survival benefit for subjects. This research has led to the UCLA study to test these drugs in combination against advanced breast cancer without chemotherapy. Avastin recently made national headlines after positive results ...

Breast cancer and hair loss Page 2 Breast Cancer Care is the UK’s leading provider of information, practical assistance and emotional support for anyone affected by breast cancer . Every year we reach over 750,000 people with breast cancer or breast health concerns. All our services are free. For more information call the Breast Cancer Care helpline free on 0808 800 6000 (textphone 0808 800 6001) or visit www.breastcancercare.org.uk. Page 3 Contents Introduction 2 Coping with losing your hair 3 Other people’s reactions 5 Treatments and hair loss 6 Chemotherapy 6 Radiotherapy 7 Preventing hair loss 8 Looking after your hair 9 During treatment 9 When you lose your hair 10 When ...

Novartis International AG Novartis Communications CH-4002 Basel Switzerland Tel + 41 61 324 2200 Fax + 41 61 324 3300 Internet Address: http://www.novartis.com 1/3 MEDIA RELEASE • COMMUNIQUE AUX MEDIA • MEDIENMITTEILUNG Compelling disease-free survival results in breast cancer trial prompt independent researchers to offer patients the opportunity to switch to Femara ‚ , as reported in New England Journal of Medicine Interim results from first study to explore post-tamoxifen use of Femara ‚ (letrozole) in postmenopausal women with early breast cancer showed dramatically reduced risk of recurrence (43%) and significantly improved disease-free survival Basel, Switzerland, 9 October 2003—Postmenopausal women with early breast cancer who completed five years of post-surgical hormonal ...

Attitudes and risk perception concerning breast cancer and predictive genetic testing ( AttRisk ) Background Inherited mutations in the BRCA1 and BRCA2 genes are associated with a high risk of breast and ovarian cancer . Genetic tests for breast cancer susceptibility are now available in research settings and may enter medical practice in Germany shortly. It is important to under- stand the potential demand of genetic testing for breast cancer risk as well as the characteristics of those who seek testing and their expectations about benefits and risks (Ulrich et al ., 1998). However, so far little is known about awareness, knowledge and attitudes of German women concerning this test. This study focuses on psy- chosocial aspects of human genetics and the general aim is to investigate women’s attitudes toward genetic test- ing for breast cancer risk ...

Case magazine Beth Overmoyer functions under many titles: medical oncologist, breast cancer researcher, advocate, administrator, clinician. Whatever her role is on a given day, patient care remains at the fore. Page 2 FEATURE Fight for the Cure spring 2004 | 23 by Patricia Faller Beth Overmoyer views the dual nature of her work a “beautiful fit” that allows her to be deeply involved with breast cancer from two perspectives. The medical oncologist divides her time between breast cancer research and patient care. She serves as director of breast cancer research at the Case Comprehensive Cancer Center, the link between research and patient care known as clinical ...

R A D I A T I O N T H E R A P Y f o r BREAST CANCER A Patient’s Guide to Understanding Treatment ABOUT ASTRO The American Society for Therapeutic Radiology and Oncology is the largest radiation oncology society in the world. ASTRO's mission is to advance radiation oncology by promoting excellence in patient care, supporting cancer research and distributing the results of clinical trials. LEARNING ABOUT CLINICAL TRIALS The radiation oncology team is always exploring new ways to treat cancer patients through studies called clinical trials. Today's radiation therapy treatments are the result of clinical trials completed many years ago proving that radiation ther- apy kills cancer cells and is safe long-term. For more infor- mation on current clinical trials, please visit the following Web sites of the following organizations: ...