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BREAST CANCER AND DIET 1: Eur J Cancer , 2000;36:335-340. Low Alpha-Linolenic Acid Content of Adipose Breast Tissue Is Associated With an Increased Risk of Breast Cancer Klein V, Chajès V, Germain E, et al One hundred and twenty-three women with biopsies of adipose breast tissue at the time of diagnosis of invasive non-metastatic breast cancer compared with 59 women with benign breast disease who served as controls were evaluated. Results showed there was no association between fatty acids and disease, except for alpha-linolenic acid, which showed an inverse association with the risk of breast cancer . The relative risk of breast cancer in women in the highest quartile of adipose breast tissue alpha-linolenic acid level was 64% lower than those who consumed the least linolenic acid. Flax is nature’s richest source of linolenic ...

December 20, 2001 Tamoxifen and Breast Cancer Incidence Among Women with Inherited Mutations in BRCA1 and BRCA2 Bruce K. Lin and Paula Yoon Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention Past issues e-journal abstract template on King et al The Health Outcome As many as 192,200 new cases of invasive breast cancer will be diagnosed among women in the United States in 2001, making it the most common form of cancer in women this year. Three to five% of these breast cancer cases will be associated with mutations within the BRCA1 or BRCA2 genes. Despite declining mortality rates among women during 1990-1997, breast cancer remains the second-leading cause of cancer deaths among women. In addition to mutations found in the breast cancer susceptibility genes, several environmental, ...

Breast Cancer Clinical Trial Announcement The Eastern Cooperative Oncology Group (ECOG) would like to share information about a clinical trial for people with recently diagnosed locally recurrent or metastatic breast cancer . A Randomized Phase III Trial of Paclitaxel (Taxol) vs. Paclitaxel and Bevacizumab (Avastin) as First Line Therapy for Locally Recurrent or Metastatic Breast Cancer (E2100) What is Bevacizumab (Avastin) and why add it to Taxol? Tumors need an increased blood supply in order to grow. The process of growing new blood vessels is called angiogenesis and tumors have the ability to trigger this process. Avastin is a monoclonal antibody (anti VEGF) that can block signals to the blood vessels that tell them to grow. Researchers believe that adding an anti-angiogenesis drug like Avastin to a chemotherapy drug that is known to be effective (Taxol) in women ...

breast cancer SUMMARY: Postmenopausal Hormone Therapy and Breast Cancer The WHI agrees with some case-control and cohort studies indicating that long-term (about five years) current use of combined estrogen and progestin has a slightly increased risk of breast cancer . It is possible that this finding is due to an effect of hormonal therapy on pre-existing tumors. The evidence certainly does not indicate a major impact on the risk of breast cancer . The epidemiologic data indicate that a positive family history of breast cancer should not be a contraindication to the use of postmenopausal hormone therapy. Women who develop breast cancer while using postmenopausal hormone therapy have a reduced risk of dying from breast cancer . This is probably because of two factors: 1) development of a more differentiated tumor so that tumors appear ...

H:\MHRA\Epinet\MillionWomenStudy\Aug2003FINAL HORMONE REPLACEMENT THERAPY (HRT) AND BREAST CANCER – IMPORTANT NEW INFORMATION You may have seen in the news that a large study in the UK, the Million Women Study, has just published its results on the risk of breast cancer with various types of HRT. This study shows that the level of risk associated with use of combined (oestrogen plus progestogen) HRT products is substantially higher than previously thought. If, after reading the information below, you are concerned, make a routine appointment to see your doctor. Use of HRT In the UK, HRT products are licensed for helping relieve the unpleasant symptoms of the menopause, including hot flushes, vaginal dryness and night sweats. Some HRT products are also licensed for the longer-term prevention of osteoporosis, which can cause bone fractures. Million Women Study findings This ...

MHRA\Epinet\MillionWomenStudy\Aug2003FINAL Hormone replacement therapy (HRT) and breast cancer – results of the UK Million Women Study Dear Health Professional This message provides information to help you advise women who are using HRT and who may be concerned about their risk of breast cancer following today’s publication in the Lancet of the UK Million Women Study. The Committee on Safety of Medicines (CSM) and its expert working group (EWG) on HRT have reviewed this study. The key points are: · The previously described small increase in risk of breast cancer in association with oestrogen-only products has been confirmed. · The increased risk of breast cancer in association with use of combined (oestrogen plus progestogen – both continuous and sequential regimens) HRT is substantially higher than with oestrogen-only therapy (see table below). ...

E d i t o r i a l Singapore Med J 2002 Vol 43(5) : 221 Mount Elizabeth Medical Centre Singapore 228510 S B Wee, MBBS, FAMS, MMed (Surg), FRCS (Edin) Consultant Surgeon Correspondence to: Dr Wee Siew Bock Tel: (65) 6732 7755 Fax: (65) 6732 0829 Email: weesbock@ singnet.com.sg Permit No MITA (P) 073/09/2001 ISSN 0037 - 5675 JOURNAL OF THE SINGAPORE MEDICAL ASSOCIATION Editor A/Prof C Rajasoorya Deputy Editor Prof Wilfred C G Peh A/Prof Sonny Wang Yee Tang Corresponding Editors Prof Azrul Azwar (Indonesia) Prof Myo Myint (Myanmar) Prof Neil Pride (UK) Prof Tan Chong Tin (Malaysia) Prof Teh Bin Tean (USA) Prof Victor Yu (Australia) Editorial Board Dr Chin Jing Jih Dr Chow Wan Cheng A/Prof Ho Nai Kiong Prof Kua Ee Heok Dr Kenneth Lyen Dr Denis Nyam A/Prof Paul Ananth Tambyah ...

411 Research Program H Genome Research and Bioinformatics H0602 Molecular Genetics of Breast Cancer DKFZ 2003: Research Report 2001/2002 Visiting Scientist Prof. Rodney J. Scott (11/02 -) University of Newcastle, Newcastle, Australia Graduate Student Usman Rashid (5/02 -) Technicians Michaela Schleicher (- 9/00) Antje Seidel-Renkert Karin Schüssler (11/02 -) Michael Gilbert Molecular Genetics of Breast Cancer U. Hamann In cooperation with: S. Würtz, J. Hoheisel, C. Hoff, J. Mollenhauer, A. Poustka, DKFZ; H. Frenzel, H.U. Ulmer, Städtisches Klinikum Karlsruhe; H.-P. Sinn, Pathologisches Institut der Universität, Sektion Gynäkologische Pathologie, Heidelberg; H. Brauch, IKP, Stuttgart; T. Brüning, Berufsgenos- senschaftliches Forschungsinstitut für Arbeitsmedizin der Ruhr- Universität, Bochum; Y. Ko, Med. Poliklinik, ...

breast cancer For Immediate Release Rethink Breast Cancer Launches Innovative Breast Health Awareness Series TORONTO, ON ? November 2003 - Rethink Breast Cancer , the charity that thinks differently about breast cancer , is thrilled to present An Evening Devoted to the Health of your Breasts. This hip breast health event will debunk myths and set the record straight on nutrition, exercise and real ways to be breast health savvy. Guests are invited to listen, discuss and ask questions in a casual and intimate setting, with a team of leading experts, including Balance TV?s resident health and lifestyle guru Dr. Marla Shapiro The event is taking place on November 18 in the stylish Fluid Living loft in Toronto?s hot distillery district. ?We want to educate people about breast cancer in a way that is accessible ...

After beating breast cancer , possible risk of brittle bones Experts at OHSU are studying why survivors, especially young ones, seem more prone to break bones 09/24/03 ANDY DWORKIN Facing cancer before 50 is burden enough for any person. But scientists at Oregon Health & Science University fear younger women who have beaten breast cancer may carry an additional load -- an increased risk of breaking their bones. Kerri Winters, an OHSU exercise physiologist, said some evidence indicates women who are treated for breast cancer before they hit menopause may be more likely to break their wrists and perhaps their hips. And "Women who have gone through chemotherapy for breast cancer have about a five-times- greater risk of spine fracture than their healthy counterparts," Winters said. Winters and her co-workers have launched two separate studies trying to figure ...

OCTOBER: National Breast Cancer Awareness Month? NationalCancerIndustryMonth NationalCancerIndustryMonth Cancer is big business. The Cancer Industry consists of the polluting industries, public relations firms, and agencies that fail to protect our health and divert attention away from the need to prevent cancer by finding the causes. Not enough is being done to look into the environ- mental links to cancer . After all, what profit is there in preventing cancer ? Some who cause cancer also profit from it. Du Pont produces various pesticides, some of which contain ingredients known to cause cancer . Du Pont also makes drugs to treat cancer . General Electric owns nuclear reactors and sells mammography equipment, both of which create ionizing radiation, a known carcinogen (cause ...

What You Should Know About the Environment and Breast Cancer 1 Powerful evidence from experimental, body burden and ecological research indicates that there is a connection between chemicals and breast cancer . While we pursue the research that will lead to even more defi nitive answers, we will lead to even more defi niti will lead to even more defi niti can and should reduce our exposure to substances should we believe cause cancer . Why we believe there is a link between the environment and breast cancer : • 70% of the people with breast cancer have none of the known risk factors. The so-called known risk factors, like late menopause, having children late in life, and family history are present in only 30% of breast cancer cases. 1 • Non-industrialized countries have lower breast ...

Breast Cancer Prevention: Searching for Causes/ Implementing the Precautionary Principle It will not be possible to truly “prevent” breast cancer – in the common meaning of the word – unless and until we understand the causes of the disease. Accordingly, Breast Cancer Action advocates redirecting a significant portion of the funds devoted to breast cancer research toward research into possible causes of the disease, with particular emphasis on those environmental contaminants for which evidence exists that they contribute to the risk for developing breast cancer and other cancers. This campaign takes several forms: – Educational efforts through publication and distribution of a substantive, science-based bimonthly newsletter, including articles on environmental links to breast cancer – Communication with public policy makers including the NCI and the Environmental ...

Breast Cancer —Beating The Odds November 2002 Heart disease is still the number one cause of death for women in the United States, but cancer comes in a close second. Statistics show that breast cancer will strike one out of every eight women in the United States, with the incidence rate increasing with age. Can diet help you to prevent breast cancer ? Here’s what the American Institute for Cancer Research (AICR) and the American Cancer Society (ACS) have to say. Get Moving! Research is showing that the risk of cancer of the breast , prostate, endometrium, kidney, colon and rectum are all reduced in people who exercise. Exercise, it seems, is beneficial in reducing breast cancer risk for two reasons. First, it helps to prevent weight gain and excess weight is a risk factor in the development of breast cancer . Second, it moderates the levels of ...

This leaflet is about radiotherapy to the chest for Hodgkin’s disease (Hodgkin lymphoma) and the increased risk of breast cancer in women who have had this type of treatment. It describes: • who might be at risk • what is meant by ‘increased risk’ • what is likely to be offered to those at risk • what you should do if you are worried. Increased risk of breast cancer following radiotherapy for Hodgkin’s disease Lymphoma Association PO Box 386, Aylesbury HP20 2GA www.lymphoma.org.uk Registered charity number 1068395 November 2003 Page 2 Introduction Radiotherapy has been used for many years to treat people with Hodgkin’s disease. Most of these people are now completely cured. Because people are living longer, doctors now know more ...

breast cancer Increased risk of breast cancer following radiotherapy for Hodgkin?s disease Produced by: The Lymphoma Association PO Box 386, Aylesbury HP20 2GA www.lymphoma.org.uk Registered charity number 1068395 November 2003 This document is about radiotherapy to the chest for Hodgkin?s disease (Hodgkin lymphoma) and the increased risk of breast cancer in women who have had this type of treatment. It describes: ? who might be at risk ? what is meant by ?increased risk? ? what is likely to be offered to those at risk ? what you should do if you are worried. Introduction Radiotherapy has been used for many years to treat people with Hodgkin?s disease. Most of these people are now completely cured. Because people are living longer, doctors now know more about the long-term side effects ...

Vinorelbine in Stage IV Breast Cancer Evidence Summary #1-4 Members of the Breast Cancer Disease Site Group ORIGINAL EVIDENCE SUMMARY: November 11, 1998 MOST RECENT LITERATURE SEARCH: April 24, 2003 NEW EVIDENCE ADDED TO EVIDENCE SUMMARY: November 2003 An evidence summary report is a systematic overview of the best evidence available on a specific clinical question when there is insufficient high-quality evidence on which to base a practice guideline. SUMMARY Question What is the evidence for vinorelbine as second-line chemotherapy in stage IV (metastatic) breast cancer ? Target Population Women with stage IV breast cancer who have failed first-line chemotherapy for metastatic disease. Methods Entries to the MEDLINE (to April 2003) and Cochrane Library (Issue 1, 2003) databases and abstracts published in the ...

Health column 857 words BREAST CANCER UPDATE October is Breast Cancer Awareness month. In the United States, a woman’s lifetime risk of developing breast cancer is about 10 percent. More than half of these breast cancers will occur in women over age 65. But perhaps it is more important to understand the specific risk at a certain age. A woman aged 35, until age 55, without any other significant risk factors, has only a 2.5 percent potential risk of developing breast cancer over the next two decades. A woman who is 50 has a five percent chance of developing cancer over the next 25 years. An American woman who develops breast cancer has about a 3.5 percent chance of dying from breast cancer . Family, or genetic, risk factors appear to play a role in the development of breast cancer , however, in fact, a family history for breast cancer is ...

Report on the National Breast Cancer Coalition Fund Annual Advocacy Training Conference: “Stop Breast Cancer . It’s in Our Power!”, Washington DC 3 rd – 6 th May, 2003 Pamela Williams, BCNA Representative, Victoria The National Breast Cancer Coalition’s Annual Training Conference brings together breast cancer advocates from around the US and offers scholarships to international participants. Those advocates are breast cancer survivors, and people who have been directly affected by a friend or relative having breast cancer , and people who work in organisations that support women with breast cancer . The very full conference program included plenary sessions: • Tools for the Future of Breast Cancer Advocacy An introduction to the conference by Fran Visco, President, NBCCF • ...

Report on the National Breast Cancer Coalition’s (USA) Annual Advocacy Training Conference: “Stop Breast Cancer . It’s in Our Power!”, Washington DC 3 rd – 6 th May, 2003 Mary Bartlett, BCNA Representative, Victoria I attended this 3 day conference with a very full program, including 3 workshop sessions. I attended the following workshops: • Current Advocacy Issues in Clinical Trial: The Role of Trial Endpoints in Drug Evaluation • The Long Island Breast Cancer Study Project: Where Do We Go From Here? (this was an interesting epidemiological study of 2 areas with a higher then average incidence of breast cancer – Long Island and Cape Cod) • Evidence-Based Complementary and Alternative Medicine The fourth day was the annual Lobby Day, where the offices of all congressmen/women and senators on ...

Increased risk of breast cancer following radiotherapy for Hodgkin’s disease This leaflet is about radiotherapy to the chest for Hodgkin’s disease (Hodgkin lymphoma) and the increased risk of breast cancer in women who have had this type of treatment. It describes: • who might be at risk • what is meant by ‘increased risk’ • what is likely to be offered to those at risk • what you should do if you are worried. Lymphoma Association PO Box 386, Aylesbury HP20 2GA www.lymphoma.org.uk Registered charity number 1068395 November 2003 Introduction Radiotherapy has been used for many years to treat people with Hodgkin’s disease. Most of these people are now completely cured. Because people are living longer, doctors now know more about the long-term side effects of radiotherapy. Recent research ...

This leaflet is about radiotherapy to the chest for Hodgkin’s disease (Hodgkin lymphoma) and the increased risk of breast cancer in women who have had this type of treatment. It describes: • who might be at risk • what is meant by ‘increased risk’ • what is likely to be offered to those at risk • what you should do if you are worried. Increased risk of breast cancer following radiotherapy for Hodgkin’s disease Lymphoma Association PO Box 386, Aylesbury HP20 2GA www.lymphoma.org.uk Registered charity number 1068395 November 2003 What if I am having radiotherapy for Hodgkin’s disease now? Modern treatment for Stage I and II Hodgkin’s disease has changed. Radiotherapy is still used, but instead of treating the whole chest, doctors now tend to direct it only ...

Volume 3 Issue 2 Winter 1998 Environmental Organochlorine Exposure and Risk of Breast Cancer Polychlorobiphenyls (PCB’s) and dichlorodiphenyl- trichloroethane (DDT) are persistent organic pollutants in the Great Lakes and other aquatic ecosystems. Currently in North America, human exposure to these compounds occurs primarily through the ingestion of contaminated fish, meat and dairy products. Many of these compounds have interacted with the estrogen receptor, but the interactions are complex. Some congeners of both PCB and DDT, as well as other organochlorine pollutants, have weakly estrogenic activity, stimulating estrogen receptors in both animal and human tissue. Yet others of these compounds have anti-estrogenic capacity. Consequences of the estrogenic effect of xenobiotics in wildlife include an altered male:female sex ratio among California gulls exposed ...

This information sheet is to help women work out if they have an increased chance of developing breast cancer because of a family history of the disease and if so what they can do. This information is adapted from ‘Advice about familial aspects of breast cancer and ovarian cancer – a guide for health professionals’ (iSource National Breast Cancer Centre). A questionnaire about risk based on breast cancer family history is included – this is only for women without a personal history of breast cancer . Please see the flip side of this pad for information for women about breast changes. Do you have breast cancer in your family? Take action for life Page 2 DO YOU HAVE BREAST CANCER IN YOUR FAMILY? This information sheet is to help you work out if you have an increased ...

Breast Cancer Screening Definition: The percentage of women 52 through 69 years of age using the HMO who received a mammogram during the past two years. Breast cancer is the second most common form of cancer among American women. More than 180,000 women are diagnosed each year with breast cancer (National Cancer Institute, CancerNet 2001). The earlier breast cancer is found, the better the chance for successful treatment. Mammogram is one of the best ways to detect breast cancer at an early stage. A mammogram is an X-ray of the breast that identifies tumors that are too small to be detected by self-examination. The International Agency for Research on Cancer , an agency of the WHO, has concluded in its 2002 report that mammograms, through early detection, can prevent breast cancer death by 35 percent among women aged 50 to 69. The ...

team of Canadian researchers, in a study partly funded by the Canadian Genetic Diseases Network, has discovered that the behavior of cer- tain breast cancers is not as easily predicted as once thought. Led by Network Investigators Drs. Steven Narod and William Foulkes , the team discovered that the presence of either the BRCA 1 or BRCA 2 gene mutation in a patient will significantly impact the pattern of metastasis. Traditionally, it was believed that the larger a tumor in a breast cancer patient, the more likely it was that the cancer cells had metastasized into the lymph system. The results of this study, which were published in the October 15th, 2003 issue of CANCER , demonstrate that the tumor size in a breast cancer patient with the BRCA1 gene mutation is not necessarily correlated with local dis- ease progression. “This discovery ...

This information sheet is to assist general practitioners in managing the clinical and psychosocial aspects of care of the woman with metastatic breast cancer and her family. This guide provides evidence based recommendations relevant to general practice adapted from the Clinical practice guidelines for the management of advanced breast cancer (National Breast Cancer Centre 2001). A chart detailing symptoms a woman with metastatic breast cancer may experience requiring urgent treatment is included. This guide is designed to be kept in the woman’s file for easy referencing. The management of the woman with metastatic breast cancer A guide for GPs NATIONAL BREAST CANCER CENTRE Incorporating the Ovarian Cancer Program Symbol of quality information in women’s cancer ...

Every woman is at risk for breast cancer , but your risk climbs with age. Eighty percent of all breast cancer occurs in women over 50 years of age. Fortunately, mammograms are highly effective for this age group. That’s why provincial screening programs recommend a mammogram every two years for women 50 and older. Provincial screening programs are for women with no symptoms of breast cancer . They are designed to detect the disease at the earliest possible stage and, therefore, greatly increase the chances of survival. Provincial screening programs have established screening services that specialize in providing breast screening in a quality, caring environment. If you are 50 or older and aren’t currently involved in a screening program, do yourself a favour. Start now. Call your nearest screening program today, and talk to your family physician. For more information call the Cancer ...

A G U I D E F O R W O M E N W I T H Early breast cancer N AT I O N A L B R E A S T C A N C E R C E N T R E Incorporating the Ovarian Cancer Program Page 2 Every woman’s situation and needs are different. Not all the information in this book will be relevant to you and your current situation. This book is intended to be used as a resource as required, rather than a book to be read from cover to cover. The contents pages can be used as a guide to the information in each chapter. Page 3 i A guide for women with early breast cancer Page 4 ii A guide for women with early breast cancer was prepared with input from the National Breast Cancer Centre’s Early Breast Cancer Consumer Information Review Group, and ...

Trastuzumab Use in Breast Cancer : Clinical Issues John Horton, MB, ChB Background: Overexpression of the epidermal growth factor 2 HER2 in breast cancer tissue is associated with shorter survival. Trastuzumab, a monoclonal antibody against HER2, can induce tumor responses when given alone and enhances the effectiveness of several chemotherapeutic agents. Methods: The recent clinical data on outcomes regarding testing for HER2 overexpression and the tolerance, toxicity, and antitumor effects of trastuzumab are reviewed. Results: Trastuzumab use is indicated either alone or with chemotherapy only in patients with IHC 3+ or FISH+ test results and survival is prolonged in patients with metastatic disease. Cardiac toxicity differs from anthracycline cardiac toxicity and is often reversible. Conclusions: The safety and efficacy profile of trastuzumab in patients with metastatic ...