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"As for what we gained from attending the conference, there are so many things As for what we gained from attending the conference, there are so many things that it's difficult to mention them all. However, we feel that the entire weekend that it's difficult to mention them all. However, we feel that the entire weekend can be summed up in one word: can be summed up in one word: hope hope . Upon learning what my wife was facing, . Upon learning what my wife was facing, hope is the one thing that we've found it very difficult to maintain throughout the hope is the one thing that we've found it very difficult to maintain throughout the whole process of chemo and radiation. With the help of the Richard Farrell whole process of chemo and radiation. With the help of the Richard Farrell Memorial Scholarship Fund we were able to attend the conference which helped Memorial Scholarship Fund we were able to attend ...

Get Checked for Colon Cancer 4 1 1 2 2 2 If you’re 50 or older,or at high risk,get a colonoscopy to prevent colon cancer . Other Colon Cancer Tests There are other colon cancer tests, which, while not as effective as colonoscopy, are much better than no test at all. A positive result on any of these tests should be followed up with colonoscopy. Fecal Occult Blood Test (FOBT) • FOBT is an acceptable alternative to colonoscopy for people who are not at high risk for colon cancer . • It finds small amounts of hidden (occult) blood in stool. • FOBT includes instructions on taking stool samples at home and returning them for testing. Sigmoidoscopy • Is similar to colonoscopy, but with several differences. • Sigmoidoscopy examines less than half of the colon (not the entire colon , as colonoscopy does). ...

National Cancer Institute SEER Program 40 COLON AND RECTUM C ancers of the colon and rectum are the fourth most commonly diagnosed cancers and rank second among cancer deaths in the United States. The incidence rates show wide divergence by racial/ethnic group, with rates in the Alaska Native population that are over four times as high as rates in the American Indian population (New Mexico) for both men and women. There are only minor differences, between men and women, in the order of incidence rates by racial/ethnic group. After Alaska Natives, the next highest rates in men are among Japanese, black and non-Hispanic white populations. These are followed by Chinese, Hawaiians and white Hispanics; and then Filipinos, Koreans and Vietnamese. In women, Alaska Natives are followed by black, Japanese and white non- Hispanic ...

July/August 2005 ¦ COMMUNITY ONCOLOGY 331 Volume 2/Number 4 Adjuvant therapy for colon cancer in the elderly: treat or don’t treat? Jason S. Levitz, MD, 1 and Stuart M. Lichtman, MD 2 1 Don Monti Division of Oncology, North Shore University Hospital, Manhasset, NY 2 Memorial Sloan-Kettering Cancer Center at Suffolk, Commack, NY The changing demographics of the population have emphasized the importance of the care of older cancer patients. Many recent advances have also occurred in the treatment of colon cancer , particularly in the role of adjuvant therapy. These changes have included the addition of new drugs and schedules and the increasing recognition that older patients benefit from adjuvant therapy. In facing a decision regarding which particular regimen to use in the older patient, clinicians must take into account ...

This information provided is for informational purposes, and not to be considered a substitute for physician care or instructions . @Gastrocor, 6/05 Cancer of the colon or rectum (colorectal) develops in the digestive tract, also known as the gastrointestinal or GI tract. The colon , or large bowel, is a muscular tube about 5 feet long and is divided into 4 parts: Ascending, transverse descending and the sigmoid colon . The rectum connects the sigmoid colon to the anus and is six inches in length. Cancer can develop in any of sections in the colon and or rectum. Depending on the location, the symptoms differ, as well as the tests to detect the cancer . What is colon (colorectal) cancer ? How many people are affected by colon cancer ? Colorectal cancer is the third most common cancer diagnosed in both men and women, and the second leading cause of death in the United States. ...

ver. 2cs 1/15/99 NORTH CAROLINA COLON CANCER STUDY University of North Carolina Chapel Hill, North Carolina Participant Questionnaire STUDY ID DATE OF INTERVIEW / / MM/DD/YY Page 2 ver. 2cs 1/15/991/15/99 1 A. Background Characteristics Time began: : Since many people have never been in an interview exactly like this one, let me start by telling you a little bit about how it works. I am going to read you a set of questions exactly as they are worded so that everybody in the study will be answering the same questions. You will be asked to answer two kinds of questions. In some cases you will answer in your own words, and I will write down your answers word for word. For other questions you will be given a list of choices and asked to pick the one that fits best. If at any time during the interview ...

Colon Cancer Alliance | 175 Ninth Avenue. | New York, NY 10011. | 212.627.7451. | www.CCAlliance.org what is the colon cancer alliance? what is CCA? The Colon Cancer Alliance (CCA) is an alliance of colon and rectal cancer survivors, their families, caregivers, people with a genetic predisposition to colorectal cancer , and members of the medical community. CCA is the official patient support partner of the National Colorectal Cancer Research Alliance (NCCRA), co-founded by Katie Couric. what is the CCA’s mission? The Colon Cancer Alliance brings the voice of survivors to battle colorectal cancer through patient support, education, research and advocacy. what support services does the CCA offer? The Colon Cancer Alliance offers a variety of support and informational services that include: • Brochures • A series of booklets • An ...

Colon Cancer Alliance | 175 Ninth Avenue. | New York, NY 10011. | 212.627.7451. | www.CCAlliance.org The Connections Program offers information and support services for patients, their families and friends. We offer this information and support from our own experience – from the experience of CRC survivors and others whose lives have been touched by this disease. Please visit our web- site at www.CCAlliance.org or call our toll-free Helpline at 1-877-422-2030 for more information. The Colon Cancer Alliance thanks the following sponsors for making our Connections program possible: Colon Cancer Connections: Peer Support for Survivors and Caregivers colon cancer connections: peer support for survivors and caregivers support Personal Stories | The Colon Cancer Alliance website presents a collection of stories ...

Targeted Agents for Adjuvant Therapy of Colon Cancer Aimery de Gramont Hôpital Saint-Antoine Paris, France Recent phase III studies have shown that targeted agents improved survival in patients with advanced colorectal cancer . Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor (VEGF), is the first drug to have performed successful first- and second-line studies in combination with irinotecan and oxaliplatin in a FOLFOX regimen. 1,2 Cetuximab, another monoclonal antibody targeting epidermal growth factor receptor (EGF- R) has shown efficacy in third-line therapy and promising results in first-line phase II studies. 3 On the other hand, tyrosine kinase inhibitors (TKIs) and other targeted therapies have not yet achieved the successful trials in advanced disease allowing to start adjuvant studies. The role of angiogenesis and VEGF ...

Molecular Mechanisms of Colon Cancer Metastasis: Diagnostic, Prognostic, and Therapeutic Implications Anton Wellstein Lombardi Comprehensive Cancer Center at Georgetown University Washington, DC Tumor metastasis initiates with cancer cell evasion from the primary site, and progresses with seeding into a distant organ site. Distinct surface molecules on the vascular bed of target tissues that match with their counterparts on tumor cells are thought to contribute to organ-specific spreading of cancers. Furthermore, survival signals in the host organ of a metastatic tumor support growth and expansion of the metastatic seed. Identification and function of genes that can support gastrointestinal cancer metastasis will be discussed with respect to their use in tumor prognosis, as well as the potential for therapeutic targeting of disseminated tumors. NOTES: ...

July/August 2005 ¦ COMMUNITY ONCOLOGY 11 Volume 2/Number 4/Supplement 3 T HE X-ACT AND TREE TRIALS provide important clinical in- formation on therapeutic options for patients with stage III and IV colon cancer . Superior survival benefit It is clear from the results of the X-ACT trial that not only is capecitabine (Xeloda) an alterna- tive to 5-fluorouracil in the adju- vant therapy of colon cancer , but it is, in fact, superior by most objective criteria and also offers safety and convenience advantages. It is im- portant to remember that although this trial was designed to demon- strate equivalence between oral capecitabine and intravenous 5-FU plus leucovorin (Mayo Clinic regi- men), capecitabine actually showed a statistically superior benefit for re- lapse-free ...

1672 Main St. Ste. E #264 • Ramona, CA 92065 • Tel: 760.789.8928 • Fax: 760.789.8929 • Toll Free: 800.475.1955 • www.proteinbiotechnologies.com HUMAN COLON CANCER TISSUE MICROARRAY Catalog Number: TMA-004 Each core represents one specimen selected and pathologically confirmed. Normal matched or unmatched colon tissue is provided for comparison to the cancer tissue. Cases : 40 Cores : 80 Diameter : 1.5 mm Thickness: 5 µm Standard IHC: Cytokeratin confirmed Layout : 8 x 10 1 2 3 4 5 6 7 8 9 10 A 1 2 3 4 5 6 7 8 9 10 B 11 12 13 14 15 16 17 18 19 20 C 21 22 23 24 25 26 27 28 29 30 D ...

Offering New Options for Colon &Rectal Cancer Surgery In keeping with University Hospital’s commitment to excellence in patient care, the colorectal surgery team provides the most ad- vanced care to patients with cancer . Now they not only use the latest minimally invasive pro- cedures for treating colon cancer , they also give patients the opportunity to benefit from the latest advances in rectal surgery that dramatically enhance quality of life. Abdominal incisions for traditional colectomy can be as long as 10 to 12 inches, but with laparoscopic surgery, each small incision is usually less than 1 inch. This approach helps to minimize patient trauma and enhance recovery for most patients. LAPAROSCOPIC COLECTOMY IS LESS PAINFUL WITH A FASTER RECOVERY Open colectomy is the standard form of surgery for colon cancer patients, ...

Division of General Surgery: Information on Colorectal Conditions Colon Cancer The primary treatment for colon cancer is surgery. Usually, the affected segment of intestine and its surrounding lymph nodes are removed, and the two ends are stitched or stapled together again. The removed colon is subsequently analyzed by the MGH Pathology Department, and 7- 10 days later a report is provided about the "stage" of the tumor. This is a determination of the degree to which the cancer has advanced. In patients in whom the surrounding lymph nodes are found to contain cancer , experience has shown that the likelihood of cure is better if a course of chemotherapy is given after recovery from surgery, usually for about six months. In that case, the patient is referred to a medical oncologist for this treatment. If the lymph nodes are negative, then surgery alone is sufficient. Rectal Cancer ...

© The Ulster Medical Society, 2005. 14 The Ulster Medical Journal The Ulster Medical Journal, Volume 74 No. 1, pp. 14-21, May 2005. Review Hereditary Non-Polyposis colon cancer LA Devlin, JH Price, PJ Morrison Belfast City Hospital, Lisburn Road, Belfast BT9 7AB. Department of Medical Genetics: LA Devlin, MB, BCh, MRCPCH, Research Fellow. PJ Morrison, MD, FRCPCH, FFPHMI, Professor of Human Genetics. Department of Gynaecological Surgery: JH Price, MD, FRCOG, Consultant Gynaecologist. Correspondence to Professor Morrison. INTRODUCTION Colorectal cancer is the second most common cause of cancer related death and the third most common cancer in the United Kingdom. 1, 2 Around 80% of cases present with spread to the bowel wall. Early diagnosis and recognition of symptoms can now be achieved by screening asymptomatic ...

Colon Cancer in Pregnancy Alex Minter, MD, Rohit Malik, MD, Leslie Ledbetter, RN, Thomas S. Winokur, MD, Mary T. Hawn, MD, and M. Wasif Saif, MD Introduction Colorectal cancer in pregnancy is rare, with a reported incidence of 0.002%. 1 Approximately 275 cases of colon cancer associated with pregnancy have been reported in the literature. 2 A review of 205 of these cases performed by Bernstein et al 3 demonstrated that 85% of these cancers were located below the peritoneal reflection. The symp- toms of colorectal cancer include nausea, vomiting, abdominal pain, altered bowel movements, and rectal bleeding. Since these symptoms are commonly found in the pregnant population as a whole, physicians and patients usually attribute them to the usual manifestations of pregnancy without an appropriate evaluation. The delay ...

Effects of dietary supplements in young and aged rats Drs. Magnuson and Malik University of Maryland Drs. Franke-Carroll, Hines & Alam FDA Page 2 Background • Estimated that 40% of US population uses dietary supplements often • Over 80% have tried at least 1 of 29,000 supplements on the market • Safety concerns for special populations – Children,elderly – Pregnant women,healthcompromised • Evaluated curcumin and soy isoflavones Page 3 Curcumin • Claims include: • Anti-inflammatory • Antioxidant • Anticarcinogenic • Anti-aging Page 4 Curcumin • Colorectal cancer prevention in rodent studies with young rats • Phase 1 Clinical trials in ...

The Canadian Association of Gastroenterology Guidelines on Colon Cancer Screening 1 first-degree relative with cancer or polyp at age < 60 or 2 or more first-degree relatives affected with polyp or colon cancer at any age Colonoscopy every 5 years beginning at age 40 years or 10 years earlier than the youngest diagnosis of polyp or cancer in the family, whichever comes first. 1 first-degree relative affected at age > 60 or 2 or more second- degree relatives with cancer Average-risk screening, but beginning at age 40. Could include F.O.B.T., X-Ray, Endoscopy or a combination. 1 second-degree relative or third- degree relative affected Average-risk screening beginning at age 50. Could include F.O.B.T., X-Ray, Endoscopy or a combination. ...

TRANSLATIONAL PHYSIOLOGY LPA 2 receptor mediates mitogenic signals in human colon cancer cells C. Chris Yun, 1 Hong Sun, 1 Dongsheng Wang, 1 Raluca Rusovici, 1 Amanda Castleberry, 2 Randy A. Hall, 2 and Hyunsuk Shim 3 1 Departments of Medicine and Physiology, 2 Department of Pharmacology, and 3 Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia Submitted 14 December 2004; accepted in final form 15 February 2005 Yun, C. Chris, Hong Sun, Dongsheng Wang, Raluca Rusovici, Amanda Castleberry, Randy A. Hall, and Hyunsuk Shim. LPA 2 receptor mediates mitogenic signals in human colon cancer cells. Am J Physiol Cell Physiol 289: C2–C11, 2005. First published ...

Page 1 of 3 How to Talk To Family and Loved Ones About Colon Cancer -- Conversation and Dialogue Starters -- For the vast majority of people, cancer can seem like a foreign word, something that affects other people, or other families, but not their own. Cancer , in general, is not a common subject we talk about with family or friends – either because it seems irrelevant or because the specifics of the disease are awkward to talk about. However, talking about cancer is the only way we can take steps to treat and prevent it. Colon cancer , in particular, is the second leading cause of cancer death among men and women in the United States, yet it is rarely discussed because it involves parts of the body that are embarrassing or uncomfortable to talk about, like the colon and the rectum. However, colon cancer can be treated and even prevented if diagnosed early, but only if we make it part of the ...

676 N ORTH S T . C LAIR , S UITE 1200 C HICAGO , I LLINOIS 60611-3013 (312) 695-1300 Contact: Amanda Widtfeldt awidtfel@nmh.org 312-926-2955 Northwestern Memorial Hospital Northwestern's cancer genetics program ID's gene variant that increases colon cancer risk CHICAGO – A paper published in this week's Journal of Clinical Oncology says Transforming Growth Factor Beta Receptor 1*6A (TGFBR1*6A) – a mutated gene present in nearly one in eight people and the most commonly inherited cancer susceptibility gene identified so far – might be responsible for a significant proportion of familial colorectal cancers. The study, published by researchers at Northwestern Memorial Hospital and Northwestern University's Robert H. Lurie Comprehensive Cancer Center, says 15 to 20 percent ...

Lutein-Containing Foods Can Help Prevent Colon Cancer Carotenoids, substances found in many fruits and vegetables, have biological properties that offer protection against cancer . A new study examined how specific carotenoids protect against particular types and stages of colon cancer . Of all the carotenoids tested, lutein had the greatest protective effect. An inverse relationship between lutein intake and colon cancer was found for all subjects, meaning that the more lutein-containing foods that were consumed, the less of a risk of colon cancer . This was especially the case for those who were younger when their cancer was diagnosed. Lutein is found in spinach, broccoli, lettuce, tomatoes, carrots, oranges and orange juice, celery, greens and eggs. The study, led by Martha Slattery of the Health Research Center in Salt Lake City, Utah, looked at 1,993 subjects ages 30 to 79 years ...

To date, 2005 has been a year of increased exposure for the Foundation. From ra- dio and television broadcasts, to lectures and events, we continue to grow our presence in Central Pennsylvania. With the addition of a new staff member, the Foundation is primed for another year of progress. In this edition, you will find several valuable opportunities that will enhance your business while helping us educate the public about colorectal cancer prevention. Take a look, and enjoy the issue. Fundraising Coordinator, Torrey Nasrallah, comes to the Foundation with a wide range of skills that include fundraising, volunteer work and providing exceptional customer service. Torrey, born and raised in Hollidaysburg, obtained her B.S. degree from Penn State University and went on to work in the corporate world creating software training materials. Once the company downsized, Torrey went to work in the staffing indus- ...

Colon Cancer There’s no gentle way to say that colon cancer is one of the most deadly diseases that we deal with. But there are simple things that you can do for prevention, and early detection of this cancer is critical. Colon cancer can strike at any age, and it can hit a man or a woman, as you’re about to see in Karen’s story. KAREN MANCUSO, WHO WAS ONCE A NATIONAL CHAMPION AND OLYMPIC- LEVEL ATHLETE, IS FAMILIAR WITH FATIGUE AFTER LONG WORKOUTS. BUT IT WAS A TWO-YEAR EXHAUSTION THAT WAS HER ONLY CLUE THAT SOMETHING WAS WRONG. Karen Mancuso/ colon cancer patient “A lack of energy, tiredness, my hands and my feet hurt, my skin deteriorated.” AFTER ANEMIA AND OTHER MEDICAL CONDITIONS WERE RULED OUT, FINALLY A COLONOSCOPY REVEALED THAT KAREN HAD COLON CANCER AT THE AGE OF 44. Mancuso “Third-stage cancer , huge tumor, upper right side.” KAREN NEVER EXPECTED THE NEWS TO BE ...

NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property? Raymond K. Yeh a , Jie Chen a , Jennie L. Williams a , Mehdi Baluch a , Thomas R. Hundley a , Raphael E. Rosenbaum a , Srinivas Kalala a , Frank Traganos b , Francesca Benardini c , Piero del Soldato c , Khosrow Kashfi d , Basil Rigas a ,* a American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 06595, USA b Department of Medicine, Brader Cancer Research Institute, New York Medical College, Valhalla, NY 06595, USA c NicOx, SA, Sophia Antipolis, France ...

A R T I C L E Genetics supersedes epigenetics in colon cancer phenotype Kentaro Yamashita, Tomoko Dai, Yuichi Dai, Fumiichiro Yamamoto, and Manuel Perucho* The Burnham Institute, La Jolla Cancer Center, Cancer Genetics and Epigenetics Program 10901 North Torrey Pines Road, La Jolla, California 92037 *Correspondence: mperucho@burnham.org Summary A CpG island DNA methylator phenotype has been postulated to explain silencing of the hMLH1 DNA mismatch repair gene in cancer of the microsatellite mutator phenotype. To evaluate this model, we analyzed methylation in CpG islands from six mutator and suppressor genes, and thirty random genomic sites, in a panel of colorectal cancers. Tumor-specific somatic hypermethylation was a widespread age-dependent process that followed a normal Gaussian distribution. Because there was no discontinuity in methylation rate, our results challenge the ...

Reference Section a report by Richard L Nelson , MD Professor and Head, Division of Colon and Rectal Surgery, University of Illinois, Chicago Many famous individuals have excited the public’s imagination and concern, who have suffered from colorectal cancer , such as Vince Lombardi, Audrey Hepburn, Darryl Strawberry, or Ronald Reagan.The fundamentals relating to the diagnosis and treatments of colon and rectal cancer are familiar even to most members of lay public and certainly in much greater detail to those who specialize in gastrointestinal disease. This review will attempt to steer away from the familiar and cover, in a field that has always been fast moving, newer developments related to colorectal cancer .It will be broadly divided into three categories; the first being risk modification and prevention, the second being screening, and ...

E MPLOYERS H EALTH C OOPERATIVE SPRING 2005 I N T HIS I SSUE 1 Colon cancer awareness 2 WI hospital charges now online Meet EHC’s new provider contact Health risk appraisals Spring “Stress Less” Section: 3 Think healthy, be healthy Increase your energy Learn to be lucky 4 Fast Facts: Stress Customer Service Corner EHC Contacts 5 EHC Membership P A G E 1 Colon Cancer Awareness Prevent Wisconsin’s second-leading killer: Get screened olon cancer is among the most curable forms of cancer and screening tests exist that can result in not only early detection of colorectal cancer , but also prevention! Unfortunately, only 4 in 10 Americans over 50 follow the American Cancer Society recommended ...

Volume II, Issue 2 April 2005 Cohn Helps Colon Cancer Cause S AN J OSE – March was Colon Cancer Awareness Month and Assemblymember Rebecca Cohn joined in the efforts to raise awareness about the deadly disease. Colon cancer is the third most common type of cancer diagnosed. More than 14,000 Californians will be diagnosed with colon cancer during 2005 and nearly half will die from it. (See Colon Cancer Free Zone, Page 3) I NSIDE T HIS I SSUE Cohn’s Comment (page 1) Heath Faire (page 1) In-Home Supportive Services Hearing (page 1) Baseball in San Jose (page 2) Domestic Violence Bill Package (page 3) Legislative Update s (page 4) 4 ) Cohn to Host Health Faire in Willow Glen Please join Assemblymember Rebecca ...