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INDEX INDEX Colon Cancer information p information p ack ack Index Index Section Section T T itle itle Page(s) Page(s) 1 General information General information 1-2 2 2.1 2.2 2.3 2.4 T T ypes of colon cancer ypes of colon cancer sporadic colon cancer familial colon cancer HNPCC FAP 3-7 4 4 4 6 3 Mut Mut ationDiscovery ationDiscovery .com and colon cancer .com and colon cancer 7-9 4 Key W Key W A A VE / DHPLC references VE / DHPLC references 10 5 Useful websites Useful websites 11 6 Existing W Existing W A A VE System Users ...

FIGURE 5 Average Annual Age-Adjusted Incidence and Mortality Rates* by Sex and Race, Pennsylvania Residents, 1996-2000 There were 8,795 cases of invasive colon and rectum cancers diagnosed among residents in 2000, the fourth highest annual number for the ten-year period of 1991-2000. It was also the third most common cancer site among males and females, accounting for almost 13 percent of all of the new invasive cancer cases recorded for 2000. The average annual age-adjusted incidence rate for colon and rectum cancers during the period of 1996-2000 was almost 42 percent higher among males than for females. Black males had the highest average annual age-adjusted incidence rate among the four sex/race groups. Annual age-adjusted incidence rates during the ten years from 1991 to 2000 showed no discernible trend among white males, white females or black males; however, the rates for black females have been on the ...

434 Am J Epidemiol 2003;157:434–445 American Journal of Epidemiology Copyright © 2003 by the Johns Hopkins Bloomberg School of Public Health All rights reserved Vol. 157, No. 5 Printed in U.S.A. DOI: 10.1093/aje/kwf221 Heterocyclic Amines, Meat Intake, and Association with Colon Cancer in a Population-based Study L. M. Butler 1 , R. Sinha 2 , R. C. Millikan 3 , C. F. Martin 3,4 , B. Newman 5 , M. D. Gammon 3 , A. S. Ammerman 6 , and R. S. Sandler 3,4 1 Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC. 2 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD. 3 Department of Epidemiology, ...

colon cancer COLON CANCER GEORGE QIAO WHAT IS COLON CANCER Colorectal cancer is cancer of the large intestine ( colon ). More than 90% of patients are over age 40, affecting about 1 in every 20 people in North America. Annually colon cancer strikes 140,000 people and killing 60,000 people in the US. A family with history of colon polyps are at greater risk to develop colon cancer . Colon cancer has many causes which remain to be unknown. Who’s at risk? 90% of patients over age 40. A person who's family has a history of polyps. TREATMENTS Colonoscopy Looking for symptoms Having a diet low in fat and high in fiber Bibliography www.pubmed.gov/articles/colorectalcancer/ www.encyclopedia.com/colorectalcancer/ www.worldbook.com/colorectalcancer/ ...

Genetic testing for colon cancer : Joint statement of the American College of Medical Genetics and American Society of Human Genetics Joint Test and Technology Transfer Committee Working Group Colorectal cancer (CRC) is the second leading cause of can- cer death in the United States. Annually, approximately 130,200 individuals will be diagnosed and 56,300 will die from this disease. 1 In general, CRC evolves in an “adenoma to car- cinoma” sequence during which a series of somatic alterations accumulate in the DNA of the tumor tissue. Since 1987, signif- icant strides have been made in characterizing the genetic events that lead to colorectal cancer . This work has been based on detailed clinical and molecular genetic studies of colorectal tumors. Acquired genetic alterations seen in tumors include APC and MCC on chromosome 5q, KRAS on chromosome 12p, DCC on chromosome ...

An Orthotopic Mouse Model of Remetastasis of Human Colon Cancer Liver Metastasis Babak Rashidi, Reza Gamagami, Aaron Sasson, Fang Xian Sun, Jack Geller, A. R. Moossa, and Robert M. Hoffman 1 AntiCancer, Inc., San Diego, California 92111 [B. R., F. X. S., J. G., R. M. H.], and Department of Surgery, University of California, San Diego, California 92103-8220 [B. R., R. G., A. S., A. R. M., R. M. H.] ABSTRACT Whether liver metastases from colon cancer are capa- ble of metastasizing to other sites is an important question in surgical oncology. To answer this question, we have devel- oped a highly metastatic orthotopic transplant model of a liver metastasis from a human colon cancer patient in nude mice that targets the liver and lymph nodes. The metastatic human tumor was transplanted in athymic nude mice by surgical ...

colon cancer Fiber May Prevent Colon Cancer After All 2 Studies Contradict Earlier Research Showing No Benefit of Fiber on Colon Cancer By Sid Kirchheimer, WebMD Medical News Reviewed By Brunilda Nazario, MD There has been evidence that dietary fiber helps prevent heart disease, diabetes, diverticulosis, and other diseases. However, studies have shown mixed results in its role in reducing the risk of the second most common cancer in the United States, colon cancer . Some find that a high-fiber diet lowers colon cancer risk, while others indicate it offers no protection. In two new studies, dietary fiber is shown to help reduce the risk of colon cancer . Also, the people who ate a higher-fiber diet were more likely to exercise, smoke less, drink less alcohol, and ate less red meat. Fiber is believed ...

31 American Journal of Epidemiology Copyright © 2001 by The Johns Hopkins University School of Hygiene and Public Health All rights reserved Vol. 153, No. 1 Printed in U.S.A. Bone Mass and Colon Cancer Zhang et al. Bone Mass and the Risk of Colon Cancer among Postmenopausal Women The Framingham Study Yuqing Zhang, 1,2 David T. Felson, 1 R. Curtis Ellison, 2 Bernard E. Kreger, 2–5 Arthur Schatzkin, 6 Joanne F. Dorgan, 7 L. Adrienne Cupples, 8 Daniel Levy, 3,4 and Douglas P. Kiel 9,10 Although postmenopausal estrogen use has been associated with a lower risk of colon cancer in women, some studies do not confirm such findings. No known study has examined the effect of cumulative estrogen exposure on colon ...

Dietary Factors and Risk of Colon Cancer in Shanghai, China Brian C-H. Chiu, 1 Bu-Tian Ji, Qi Dai, Gloria Gridley, Joseph K. McLaughlin, Yu-Tang Gao, Joseph F. Fraumeni, Jr., and Wong-Ho Chow Department of Preventive and Societal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-4350 [B. C-H. C.]; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland [B-T. J., G. G., J. F. F., W-H. C.]; Shanghai Cancer Institute, Shanghai, China [Q. D., Y-T. G.]; International Epidemiology Institute, Rockville, Maryland [J. K. M.]; and Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, Tennessee [J. K. M.] Abstract Colon cancer incidence rates have risen sharply in Shanghai, China, since the early 1970s, and diet may have contributed ...

P.O.Box 2345, Beijing 100023,China World J Gastroenterol 2003;9(6):1241-1245 Fax: +86-10-85381893 World Journal of Gastroenterology E-mail: wjg@wjgnet.com www.wjgnet.com Copyright © 2003 by The WJG Press ISSN 1007-9327 • COLORECTAL CANCER • Synergistic antitumor effect of TRAIL and doxorubicin on colon cancer cell line SW480 Li-Hong Xu, Chang-Sheng Deng, You-Qing Zhu, Shi-Quan Liu, Dong-Zhou Liu Li-Hong Xu, Chang-Sheng Deng, You-Qing Zhu, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province China Shi-Quan Liu, Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province China Dong-Zhou Liu, Department of Nephrology, Renmin Hospotal of Wuhan University, Wuhan 430060, Hubei Province China Correspondence to: Li-Hong Xu, Department of Gastroenterology, Zhongnan Hospital ...

Colon Cancer Colorectal/ Colon cancer strikes more than 148,300 men and women in this country each year, claiming over 57,100 lives! It is the second leading cause of cancer -death in America. Are you at risk? Nearly 90 percent of colorectal cancers occur in people over the age of 50. Ask yourself these questions to see if you are at risk for developing colorectal cancer . 1) Do I eat a high-fat diet? 2) Am I overweight or obese? 3) Do I live an inactive lifestyle? 4) Is there a personal or family history of colon polyps or cancer in my family? 5) Have I suffered from long-standing inflammatory conditions, such as Crohn’s Disease or ulcerative colitis? Warning signs for colorectal cancer Changes in bowel habits: diarrhea, constipation, change in stool consistency Rectal bleeding, blood in your stool A feeling that your bowel ...

8 (NAPSA)—At the 2003 Interna- tional Conference on the Mediter- ranean Diet, significant emphasis was placed on the value of fat in the diet. Of course, not all fats are good for us. Nutrition and health science leaders detailed the protec- tive powers of the essential polyun- saturated fatty acids found in fish, seafood, nuts, seeds and broad- leafed greens. When used in combi- nation with the monounsaturated fats in olive oil, these fatty acids provide a diet of balanced fat. Dietary changes can be made one step at a time, and there’s no reason that we can’t hold onto the comfort foods we’ve grown accus- tomed to eating. It’s simply a mat- ter of making smarter choices in the preparation. For example, when homemade bread or rolls are on the menu, make your time-hon- ored recipes and substitute olive oil for butter or other shortening. The ...

28820 Single Oak Drive • Temecula, CA 92590 Phone: 909-676-8080 • 800-437-7500 • Fax: 909-676-9209 custserv@chemicon.com • techserv@chemicon.com • www.chemicon.com Material Safety Data Sheet SECTION 1. IDENTIFICATION Catalog Number: TMA1203 Product Name: Human Colon Cancer with Normal Colon MANUFACTURER: EMERGENCY TELEPHONE NUMBERS: Chemicon International, Inc. (800) 437-7500 28820 Single Oak Dr. (909) 676-8080 Temecula, CA 92590 SECTION 2. COMPOSITION/INFORMATION ON INGREDIENTS HAZARDOUS INGREDIENTS: No hazardous ingredients are contained in this product. SECTION 3. HAZARDS IDENTIFICATION To the best of our knowledge, no toxicity hazards are associated with this product. SECTION 4. FIRST-AID ...

Section 1 Gastrointestinal: Colon Cancer 23 Thrombocytopenia 1% Diarrhea 15.4% Hand-Foot Syndrome 18.1% Hyperbilirubinemia 17.3% Stomatitis 3% Hyperglycemia 8.7% Diarrhea* 22% Stomatitis* 31% Hand-Foot Syndrome* 14% *Grade II–IV toxicity Nausea* 10% Vomiting* 9% Diarrhea * 14% Stomatitis* 26% Alopecia 34% *Toxicity ungraded, but listed as severe Days 1–14— level 1 Days 1–7— level 2 Days 1–5— level 2 11.4% of patients hospitalized, the most common reasons being dehydration and diarrhea Minimal toxicity Approximately 2 out of every 3 patients experienced Grade II–IV toxicity Grade III–IV 1.3% Anemia Toxicity Other Grade III–IV Toxicities Emetogenic Potential Consequences of Adverse Event(s) ...

0% 10% 20% 30% 40% 50% Source: California Facts & Figures, 2003 Source: California Facts & Figures, 2003 Asians Have the Lowest Rate of Colon Cancer Screening in California Sigmoidoscopy/Colonoscopy Use Among Persons Ages 50 and Older by Race/Ethnicity in California, 2001 1.800.ACS.2345 www. cancer .org Hope.Progress.Answers

colon cancer Colo-Rectal Cancer A Clinical Practice Perspective Klaus Gottlieb, MD FACP,FACG Spokane, Washington K. Gotttlieb, MD www.gi-guy.com Outline of Presentation Colon Cancer : Etiology, epidemiology, syndromes What’s new: Chemoprevention, genetic testing, PET, new Medicare screening benefits Rectal cancer is different and how endoscopic ultrasound (EUS) can help K. Gotttlieb, MD www.gi-guy.com In 1997, an estimated 131,000 Americans were diagnosed with colorectal cancer , and 55,000 died of the disease.1 Without undergoing screening or taking preventive action, approximately one in 17 persons in this country will develop colorectal cancer at some point in life. K. Gotttlieb, MD www.gi-guy.com Colon cancer : highest ...

colon cancer DIALOGUE FOR ACTION: BRINGING COLORECTAL CANCER SCREENING HOME March 11, 2003 Harold P. Freeman, MD Medical Director, Ralph Lauren Center for Cancer Care and Prevention Associate Director, National Cancer Institute (NCI) Director, NCI Center to Reduce Cancer Health Disparities Director of Surgery, North General Hospital Colon & Rectum Cancer Incidence & Mortality by Race and Ethnicity, US, 1992-1999 *Per 100,000, age-adjusted to the 2000 US standard population. Hispanics are not mutually exclusive from other racial/ethnic categories. Source: American Cancer Society, Surveillance Research, 2003 Harlem and East Harlem COLORECTAL CARCINOMA ...

colon cancer Colon Cancer Surveillance & Evaluation Lorna Thorpe, Ph.D. NYC DOHMH – Division of Epidemiology CDC - Nat’l Center for Chronic Disease Prevention and Health Promotion Objectives Review cancer surveillance goals Identify measurable indicators related to colorectal cancer Summarize national and local surveillance findings Discuss strengths and weaknesses of available indicators Lead group discussion on local surveillance opportunities Objectives Review cancer surveillance goals Identify measurable indicators related to colorectal cancer Summarize national and local surveillance findings Discuss strengths and weaknesses of available indicators Lead group discussion on local surveillance opportunities Objectives Review cancer surveillance goals Identify ...

MGX ™ 4D Colon Cancer Array M etri G enix M etri G enix 708 Quince Orchard Road • Gaithersburg, Maryland 20878 phone 301-987-1716 • fax 301-987-1717 info@metrigenix.com • www.metrigenix.com Colon cancer is the second leading cause of cancer related deaths in the United States. It is also one of the most common inherited cancer syndromes known. Estimates are that there were about 148,300 new cases of colon cancer diagnosed in the U.S. in 2002, with about 56,600 resulting deaths. Reports indicate that the incidence rate is similar among men and women until the age of 50, after which it increases in men. Prevention of colon cancer is primarily by screening and early detection. Colon cancer develops ...

45 Retinol inhibits the growth of Retinoic Acid-resistant colon cancer cells Presenter Jessica Leland Collaborators Professor Michelle Lane, Alice Dillard, and Erik Wilder, Department of Human Ecology Department Nutrition Abstract Retinoids, derivatives of Vitamin A, are responsible for inducing differentiation and inhibiting cell growth in colon cancer . Retinoic Acid (RA) is unable to inhibit the growth of cells that become RA-resistant through alteration in metabolism or the loss of retinoic acid or retinoic “X” receptor activity. We investigated the ability of the more physiologically relevant retinoid, retinol, to inhibit the growth of RA-resistant colon cancer cell lines, determined the bioactive metabolites produced within these cells, and the mechanism by which growth is inhibited. HCT-116, SW620, and WiDr cells were treated with 0 (control), ...

1 DNA repair defects in colon cancer Josef Jiricny* and Giancarlo Marra Defects in DNA-repair pathways lead to an accumulation of mutations in genomic DNA that result from non-repair or mis-repair of modifications introduced into the DNA by endogenous or exogenous agents or by the malfunction of DNA metabolic pathways. Until recently, only two repair pathways, postreplicative mismatch repair and nucleotide excision repair, have been linked to cancer in mammals, but these have been joined in recent months also by the damage-reversal and base-excision-repair processes, which have been shown to be inactivated, either through mutation or epigenetically, in human cancer . Addresses Institute of Molecular Cancer Research, University of Zürich, August Forel Strasse 7, CH-8008, Zürich, Switzerland *Correspondence: e-mail: jiricny@imr.unizh.ch Current Opinion in Genetics & Development 2003, 13:XXX–XXX ...

page 1 of 2 All images and text in this document are the sole property of the University of Maryland. For more information contact the Office of the Associate Director, 301.405.2462 (MAES) Maryland Agricultural Experiment Station 1201 Symons Hall, University of Maryland, College Park, MD 20742 “Maryland Dividends” Maryland Agricultural Experiment Station College of Agriculture & Natural Resources Premiums returned on investments in research, education and outreach. 19 December 2002 magnuson1 For more information about this research project please contact: Bernadene Magnuson Assistant Professor Nutrition and Food Sci 3301 Marie Mount Hall, Univ of Maryland College Park, MD, 20472 301.405.4523 bm150@umail.umd.edu Researcher Team: Dr. Bernadene Magnuson (U of M), Dr. Monica Guisti (U of M), Dr. Norberta Schoene (USDA), Dr. Tom ...

page 1 of 2 All images and text in this document are the sole property of the University of Maryland. For more information contact the Office of the Associate Director, 301.405.2462 (MAES) Maryland Agricultural Experiment Station 1201 Symons Hall, University of Maryland, College Park, MD 20742 “Maryland Dividends” Maryland Agricultural Experiment Station College of Agriculture & Natural Resources Premiums returned on investments in research, education and outreach. 19 December 2002 magnuson2 For more information about this research project please contact: Bernadene Magnuson Assistant Professor Nutrition and Food Sci 3301 Marie Mount Hall, Univ of Maryland College Park, MD, 20472 301.405.4523 bm150@umail.umd.edu Research Team: Dr. Bernadene Magnuson (U of M), Youngjoo Kwon (U of M), and Dr. Minnie Malik (U of M), and Dr. ...

stimuli, leading to uncontrolled transcrip- tion of the hTcf-4 target genes. The appar- ent de novo expression of other members of the Tcf family in some colon carcinoma cell lines might lead to a further deregulation of Tcf target gene expression by the same mechanism. The control of -catenin–Tcf signaling is likely to be an important part of the gatekeeper function of APC ( 19 ), and its disruption may be an early step in ma- lignant transformation. REFERENCES AND NOTES 1. B. Rubinfeld et al. , Science 262, 1731 (1993); L.-K. Su, B. Vogelstein, K. W. Kinzler, ibid. , p. 1734. 2. B. Gumbiner, Curr. Opin. Cell Biol. 7, 634 (1995). 3. B. Rubinfeld et al. , Science 272, 1023 (1996). 4. J. Papkoff, B. Rubinfeld, B. Schryver, P. Polakis, Mol. Cell. Biol. 16, 2128 (1996). 5. S. Munemitsa, B. Souza, I. Albert, B. Rubinfeld, P. Polakis, Proc. Natl. ...

Genetic disruption of PPAR decreases the tumorigenicity of human colon cancer cells Ben Ho Park*, Bert Vogelstein* † , and Kenneth W. Kinzler* ‡ *Johns Hopkins Oncology Center and † Howard Hughes Medical Institute, 1650 Orleans Street, Room 590, Baltimore, MD 21231 Contributed by Bert Vogelstein, December 29, 2000 Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that have been implicated in a variety of biologic processes. The PPAR isotype was recently proposed as a downstream target of the adenomatous polyposis coli (APC) - catenin pathway in colorectal carcinogenesis. To evaluate its role in tumorigenesis, a PPAR null cell line was created by targeted homologous recombination. When inoculated as xenografts in nude mice, PPAR cells exhibited a decreased ability ...

CANCER COUNTDOWN – Colon & Rectum (Colorectal) Cancer In the US, colon and rectum cancer (colorectal) is the fourth most common site of new cancer cases and the second leading cause of cancer deaths. Many of these are preventable by improvements in nutrition, physical activity and timely screening tests. Colorectal cancer usually affects people over the age of 50 (90%). Men and women have the same rate until after age 50 when it becomes higher in men than women (because women live longer than men, the total number of cases and deaths is higher in women than men). Signs and Symptoms In it’s early stages; colorectal cancer usually has no symptoms. Later stage symptoms include: Bleeding from rectum Blood in your stool Change in bowel habits Cramping pain in your lower stomach Risk Factors About 90% of colorectal cancer cases and ...

MEDIA ADVISORY: For Tuesday, March 18 th NEW FINDINGS ON COLON CANCER SCREENING TO BE RELEASED Contact: Kathryn Cervino, Associate Director of Communications 212.822.7285 kcervino@nyam.org WHAT: Important new findings regarding colon cancer screening in New York City, especially among minority populations, will be presented by the New York’s leaders in public health, health care and medical research. WHEN: Tuesday, March 18, 2003 10:00 a.m. Contact: Sandra Mullin, Associate Commissioner Office of Communications 212.788.5290 smullin@health.nyc.gov WHERE: Harlem Hospital – enter at 506 Lenox Avenue (at 135 th Street) Auditorium on 2nd Floor of Martin ...