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[ CANCER RESEARCH 62, 1030–1035, February 15, 2002] Circulating Insulin-like Growth Factor-I Levels Regulate Colon Cancer Growth and Metastasis Yiping Wu, Shoshana Yakar, Ling Zhao, Lothar Hennighausen, and Derek LeRoith 1 Section of Cellular and Molecular Physiology, Cellular Endocrinology Branch [Y. W., S. Y., D. L.] and Laboratory of Genetics and Physiology [L. Z., L. H.], National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892-1758 ABSTRACT It has been shown previously that slight elevations in serum levels of insulin-like growth factor-I (IGF-I) are correlated with an increased risk for developing prostate, breast, colon , and lung cancer . The aim of this study was to determine the role of serum IGF-I levels in the process of stimulating tumor growth and metastasis in a mouse model of colon cancer ...

USC CLINICAL GENETICS UNDERSTANDING YOUR FAMILY HISTORY OF COLON CANCER UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE DEPARTMENT OF OBSTETRICS AND GYNECOLOGY DIVISION OF GENETICS Location: Two Medical Park Suite 301 Columbia, SC 29203 Phone: 803-779-4928 ext. 228 Toll free in SC: 800-544-9866 Fax: 803-434-6852 (laboratory) Fax: 803-434-4596 (genetic counselors) E-mail: uscgenetics@medpark.sc.edu Web: www.med.sc.edu/uscgenetics 13 C olorectal cancer is the third most common cancer diagnosed in the United States. In 2000 alone, an estimated 135,000 new cases were diagnosed. The chance that a person will develop colorectal cancer in his or her lifetime approaches 6%. Family History: Most cases of colorectal cancer occur by chance in individ- ...

121 “The paper cited was an attempt to show not only that large bowel cancer was more closely associated with the life-style characteristic of modern western culture than is any other form of cancer , but also, that its geographical and socioeconomic distribution is very closely related to that of other characteristically Western diseases. “These observations indicate that large bowel tumours must be potentially preventable, could causative factors be identified and reduced or eradicated, and in addition that clues to their causation might be provided by studying other diseases that flourish in the same environment and might therefore share common causative factors. “Bowel cancer and its related diseases are uncommon throughout the Third World and both there and in some Western countries have higher prevalences in urban than in rural communities. “The ...

Cancers of the colon and rectum made up 12.4 percent of the incident (newly diagnosed) cancers reported to the Ohio Cancer Incidence Surveillance System (OCISS) for the years 1996 through 2000 (Table 1). The average annual age-adjusted colon and rectum cancer incidence rate during this time period was 57.6 cases per 100,000 residents, which is about 6 percent higher than the average annual age-adjusted U.S. (SEER 1 ) incidence rate of 54.2 cases per 100,000 residents. Average annual numbers and rates represent the number of cases diagnosed per year on average, not the total number of cases diagnosed during the five-year time period. Completeness of reporting of colon and rectum cancer is estimated to be 94 percent for 1996- 2000, which is slightly less than the national standard of 95 percent for complete case ascertainment. Therefore, the colon and rectum ...

Chin J Radiol 2002; 27: 73-77 73 Calcification within the lesion of liver metastases is a well-known phenomenon. It occurs in 12-27% of hepatic colorectal metastases, but its clinical significance and its influence on prognosis are controversial. The calcification is either produced by the tumor itself or represents dystrophic calcification secondary to necrosis and/or haemorrhage within the tumor before or during chemotherapy. We here present the image findings of a case of colon cancer with liver metastases which calcified following 5- fluorouracil chemotherapy. Key words: calcification, colorectal cancer , 5-fluorouracil, liver metastases Colorectal carcinoma is one of the most common cause of cancer -related death in Taiwan. In recent years, cytotoxic chemotherapy using 5-fluorouracil has been the treatment of choice ...

LifePro Financial Services Inc. 225 West Plaza – Solana Beach, CA 92075 – PH: 888-543-3776 – FAX: 858-259-1742 – Email: greg@lifepro.net Cancer – Colon LifePro Finacial Services, Inc. – Phone: 888-543-3776 – FAX: 858-259-1742 – email: greg@lifepro.net (1) Date of first diagnosis: __ (2) Date of last treatment: (3) Type of treatment: Surgery Radiation Chemotherapy (4) Stage of Cancer : In Situ (Caner present in mucosa – no lymph node involvement) Dukes Stage A ( Cancer has penetrated to teh submucosa – no lymph node involvement) Dukes’ Stage B1 ( Cancer has penetrated to the muscularis – no lymph node involvement) Dukes’ Stage B2 ( Cancer has penetrated to the serosa – no lymph node involvement) Dukes’ Stage C1 ( Cancer has penetrated to the muscularis – lymph nodes involved) Dukes’ Stage C2 ( Cancer has penetrated to the serosa – lymph nodes involved) ...

Cancer Patients Improve from Receiving Colon Treatment Cancer Patients Improve from Receiving Colon Treatment "I have found over the years that cancer patients who are not doing well usually are toxic and not being cleansed. They certainly are in need of colon hydrotherapy," advises oncologist and homeopath Douglas Brodie, MD, of Reno, Nevada. Dr. Brodie has developed CAM methods for treating cancer and other degenerative diseases aimed at strengthening the immune system. He emphasizes natural and humane approaches to these conditions with colon hydrotherapy being among them. "I do recommend that most of my cancer patients take colon hydrotherapy, or colonic irrigations, because they often improve by having such treatment. Liver cancer in particular shows benefit from colon hydrotherapy, but any internal tumors show effectual change, too," Dr. ...

CANCER COUNTDOWN – Colon & Rectum (Colorectal) Cancer In the US, colon and rectum cancer (colorectal) is the fourth most common site of new cancer cases and the second leading cause of cancer deaths. Many of these are preventable by improvements in nutrition, physical activity and timely screening tests. Colorectal cancer usually affects people over the age of 50 (90%). Men and women have the same rate until after age 50 when it becomes higher in men than women (because women live longer than men, the total number of cases and deaths is higher in women than men). Signs and Symptoms In it’s early stages; colorectal cancer usually has no symptoms. Later stage symptoms include: Bleeding from rectum Blood in your stool Change in bowel habits Cramping pain in your lower stomach Risk Factors About 90% of colorectal cancer cases and ...