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I Gastrointestinal (GI) malignancies account for a large percentage of the cancer burden in the United States. Although the majority of cancer cases are sporadic, approximately 5% to 10% of cancer results from inherited genetic mutations. There are several hereditary cancer syndromes of the GI tract that have been identified. To date, the genetics of colorectal cancer and its associated hereditary cancer syndromes have been characterized in detail, and effective screening modalities and recommendations have been incorporated into standards of care. Today, scientists are beginning to understand the genetic basis of pancreatic and gastric cancer , and in some cases have identified a number of their associated inherited cancer syndromes. Information about cancer genetics and hereditary cancer syndromes not only will provide advanced practice ...

RAPID COMMUNICATION On attitudes about colorectal cancer screening among gastrointestinal specialists and general practitioners in the Netherlands JS Terhaar sive Droste, GDN Heine, ME Craanen, H Boot, CJJ Mulder www.wjgnet.com JS Terhaar sive Droste, GDN Heine, ME Craanen, CJJ Mulder, Department of Gastroenterology and Hepatology, VU University Medical Centre, Amsterdam, The Netherlands H Boot, Department of Gastroenterology and Hepatology, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands Correspondence to: Professor Dr. CJJ Mulder, Department of Gastroenterology and Hepatology, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands. cjmulder@vumc.nl Telephone: +31-20-4440613 Fax: +31-20-4440554 Received: 2006-02-28 Accepted: 2006-03-27 Abstract AIM: To find out whether there are differences in at- titudes ...

Fox Chase Cancer Center 2005 Scientific Report 1 Elin R. Sigurdson, M.D., Ph.D., Senior Member John P. Hoffman, M.D., F.A.C.S., Senior Member Natalie E. Joseph, M.D ., Associate Member Neal S.Topham, M.D., Associate Member James C. Watson, M.D., Associate Member Cathy O’Hare, Senior Medical Secretary Susan Davis, Medical Secretary In the United States in the last year, there were more than 250,000 cases of gastrointestinal cancer , with more than 135,000 deaths from these diseases. Gastrointestinal malignancies include cancers of the esophagus, stomach, hepatobiliary system, pancreas, and small and large intestines. The most common gastrointestinal cancer in men and women is colorectal cancer , and is the second leading cause of cancer death in the United States, with 56,000 deaths anticipated annually. While less common, more than 30,000 ...

Fox Chase Cancer Center 2005 Scientific Report 1 Monica Morrow, M.D., F.A. Elin R. Sigurdson, M.D., Ph.D., Senior Member John P. Hoffman, M.D., F.A.C.S., Senior Member Natalie E. Joseph, M.D ., Associate Member Neal S.Topham, M.D., Associate Member James C. Watson, M.D., Associate Member Cathy O’Hare, Senior Medical Secretary Susan Davis, Medical Secretary In the United States in the last year, there were more than 250,000 cases of gastrointestinal cancer , with more than 135,000 deaths from these diseases. Gastrointestinal malignancies include cancers of the esophagus, stomach, hepatobiliary system, pancreas, and small and large intestines. The most common gastrointestinal cancer in men and women is colorectal cancer , and is the second leading cause of ...

Fox Chase Cancer Center 2005 Scientific Report 1 Neal J. Meropol, M.D., Senior Member, Director, Gastrointestinal Cancer Program, Director, Gastrointestinal Tumor Risk Assessment Program Elin R. Sigurdson, M.D., Ph.D., Senior Member, Surgical Co-Director, Gastrointestinal Cancer Program Clinical Investigators: Medical Oncology Paul F. Engstrom, M.D., Senior Member Louis M. Weiner, M.D., Senior Member Barbara A. Burtness, M.D., Member Jonathan D. Cheng, M.D., Associate Member Steven J. Cohen, M.D., Associate Member Nevena Damjanov, M.D., Associate Member Nancy L. Lewis, M.D., Associate Member Radiation Oncology Gary M. Freedman, M.D., Member Andre A. Konski, M.D., M.P.H., ...

synthesis of this substance. These low serum carnitine levels also contribute to the progression of cachexia in cancer patients. © 2006 The WJG Press. All rights reserved. Key words: Acetyl carnitine; Nutritional status; Anorexia; Malnutrition; Fatigue Malaguarnera M, Risino C, Gargante MP, Oreste G, Barone G, Tomasello AV, Costanzo M, Cannizzaro MA. Decrease of serum carnitine levels in patients with or without gastrointestinal cancer cachexia. World J Gastroenterol 2006; 12(28): 4541-4545 http://www.wjgnet.com/1007-9327/12/4541.asp INTRODUCTION Cancer cachexia is a condition characterized by anorexia, chronic nausea, early satiety, muscle wasting, involuntary weight loss, lipolysis, weakness, fatigue, impaired mental and physical performance, decreased capacity of wound healing, impaired immunological function, and compromized quality ...

18 th Asia Pacific Cancer Conference - 6- Minimally Invasive and Individualized Management for Gastrointestinal Cancer Using Highly Advanced Technologies Masaki Kitajima, M.D., FACS Department of Surgery, Keio University School of Medicine, Tokyo, Japan Since 1992 we have introduced endoscopic surgery into the field of GI cancer surgery as minimally invasive procedures. Although endoscopic surgery is a less invasive approach for patients, it is a relatively difficult pro- cedure for surgeons because of a lack of freedom and tactile sensation. To overcome this issue we have been investigating surgical robotics. We have developed a novel type of master-slave manipulator, in which we put master controller and slave arm together to make a single structure as conventional laparoscopic forceps. In this manipulator, movement of the shaft of the forceps is ...

gastrointestinal cancer 1146 JOINT AUGIS/ALS POSITION STATEMENT ON LAPAROSCOPIC UPPER GASTROINTESTINAL CANCER SURGERY Laparoscopic cancer surgery has developed rapidly in the last few years, and techniques continue to evolve. Although most published series of resectional surgery have focussed on operations performed for relatively early stage tumours, it is important that more extensive laparoscopic procedures which include a radical lymphadenectomy, are carried out safely and with the same regard to oncological principles that have been established at “open” surgery. The extent to which encouraging initial results can be applied to the generality of UK patients where more advanced tumours and obesity play important roles, merits careful evaluation in oesophago-gastric and HPB cancer by upper gastrointestinal surgeons. Meticulous prospective audit of results is essential to ensure that complications ...

8th World Congress on Gastrointestinal Cancer 8th World Congress on Gastrointestinal Cancer - Author Index André T P-026 Bouché O P-027 Gil-Negrete A P-163 Hatoum H P-158 Julié C P-026 Karaboué A P-026 Lagarde S P-027 Louvet C P-026 Lévi F P-026 Park D P-024 Rougier P P-026 Sevillano Capeán M P-075 Zalcberg J PD-013 Aballea S P-140 Abbrederis K P-074 Abbruzzese J P-171 Abdel Salam M P-066 Abdel-Khalik Z P-167 abe k P-236 Abruzzo L P-260 Acciolli A PD-006 Ackland S PD-012 Aderka D P-141 Adinin R P-171 Aerts M P-179 Afchain P P-026, P-129 Agostini M P-304 Agresta S P-286 Ahadova N P-204 Ahmadi R P-067 Aigner ...

8th World Congress on Gastrointestinal Cancer 8th World Congress on Gastrointestinal Cancer - Table of Contents O-001. Preliminary results of the Polish clinical trial on extended D2 (D2+) vs. standard D2 lymphadenectomy in gastric cancer patients Popiela T , Kulig J, Kolodziejczyk P, Sierzega M, Szczepanik A Ist Department of Surgery, Jagiellonian University, Krakow, Poland O-002. Irinotecan / capecitabine versus cisplatin / capecitabine in advanced adenocarcinoma of the stomach or gastroesophageal junction: Interimsanalysis of a randomized German AIO phase II study Moehler M 1 , Kanzler S 1 , Geissler M 2 , Raedle J 3 , Ebert M 4 , Scherubl h 5 , Flieger D 6 , Seufferlein T 7 , Galle P 1 , Hoehler T 8 1 University ...

TUMOR M2-PK IN THE DIAGNOSIS OF GASTROINTESTINAL CANCER B.K. NGOUMOU, J. RUPP, P.D. HARDT, H. SCHNELL-KRETSCHMER and H.-U. KLOER Third Medical Department, Justus-Liebig-University, Giessen, Germany Introduction: Tumor M2-PK is the dimeric isoform of the tetrameric glycolytic enzyme pyruvate kinase. It is strongly overexpressed in tumor cells due to their modified metabolic state. It can be quantified in EDTA plasma with a commercially available ELISA test kit. Recent reports indicate that Tumor M2-PK is a marker for renal cell carcinoma and lung cancer [1,2]. It has also been investigated in pancreatic cancer and gastric cancer with promising results [3]. This study was designed to evaluate the use of this marker in gastrointestinal cancer . Because elevation of tumor markers sometimes can be observed in inflammatory diseases, ...

PO Box 2345, Beijing 100023, China World J Gastroenterol 2006 February 7; 12(5):815-817 www.wjgnet.com World Journal of Gastroenterology ISSN 1007-9327 wjg@wjgnet.com © 2006 The WJG Press. All rights reserved. CASE REPORT Small gastrointestinal stromal tumor concomitant with early gastric cancer : A case report Ying-Lung Lin, Jeh-En Tzeng, Chang-Kou Wei, Chih-Wen Lin www.wjgnet.com Ying-Lung Lin, Jeh-En Tzeng, Chang-Kou Wei, Chih-Wen Lin, Department of Family Medicine, Pathology, General Surgery, Radiology, Buddhist Dalin Tzu Chi General Hospital, Chia Yi, Taiwan, China Correspondence to: Dr Jeh-En Tzeng, Department of Pathology, Buddhist Dalin Tzu Chi General Hospital, 2, Min Sheng Road, Dalin, Chia Yi, Taiwan, China. p121521@tzuchi.com.tw Telephone: +886-5-2648000-5725 Received: 2005-06-07 Accepted: 2005-08-03 Abstract ...

07. Gastrointestinal Cancer including Liver OP170 LOSS OF THE „COXSACKIE UND ADENOVIRUS RECEPTOR (CAR)“ EXPRESSION CORRELATES WITH POOR CLINICAL OUTCOME, TUMOR DEDIFFERENTIATION, INCREASED PROLIFERATION, AND OCCURRENCE OF DISTANT METASTASIS IN GASTRIC ADENOCARCINOMAS Anders, M. 1 ; Vieth, M. 3 ; Koschel, A. 1 ; Wiedenmann, B. 2 ; Röcken, C. 4 ; Ebert, M. 5 ; Kemmner, W. 6 ; Höcker, M. 1 1 Laboratory for Angiogenesis and Tumor Metastasis, Charité, Campus Virchow-Klinikum, Berlin; 2 Department of Internal Medicine, Divisions of Gastroenterology and Hepatology, Charite Medical School - Campus Virchow, Berlin; 3 Institut für Pathologie, Bayreuth; 4 Otto-von-Guericke-Universität, ...

07. Gastrointestinal Cancer including Liver OP171 ROLE OF SRC-FAMILY KINASES IN GASTROINTESTINAL STROMAL TUMORS Bauer, S. 1 ; Demetri, G.D. 3 ; Fletcher, J.A. 2 1 Westdeutsches Tumorzentrum, Universitätsklinikum, Essen; 2 Brigham & Womens Hospital, Harvard Medical School, Boston, MA, USA; 3 Dana Farber Cancer Institute, Boston, MA, USA Background: Inhibition of KIT oncoproteins by imatinib mesylate (IM) induces clinical responses in most GIST patients. However, many patients develop IM-resistance due to secondary KIT mutations and none of the novel KIT inhibitors inhibits all known IM-resistance mutations. Src-family kinases (SFK) are important signaling intermediates in related kinase-driven tumor models (ALL, CML) and dual-specific Src/Abl-inhibitors show promising activity in IM-resistant ...

07. Gastrointestinal Cancer including Liver OP169 COMBINATION ANALYSIS OF ACTIVATOR PROTEIN-1 FAMILY MEMBERS, SP1AND AN ACTIVATOR PROTEIN-2 ? -RELATED FACTOR BINDING TO DIFFERENT REGIONS OF THE UROKINASE RECEPTOR (U-PAR) GENE IN RESECTED COLORECTAL CANCERS Schewe, D. 1 ; Biller, T. 2 ; Maurer, G. 3 ; Assangani, I. 2 ; Leupold, J. 2 ; Lengyel, E. 4 ; Post, S. 5 ; Allgayer, H. 2 1 Dr. von Haunersches Kinderspital, Ludwig-Maximilians-Universität, München; 2 Abteilung für experimentelle Chirurgie und Molekulare Onkologie, Universitätsklinikum, Mannheim; 3 Chirurgische Klinik Grosshadern, Ludwig-Maximilians-Universität, München; 4 Department of Obstetrics and Gynecology, University ...

07. Gastrointestinal Cancer including Liver OP168 EGFR REACTIVATES TELOMERASE IN IMMORTALIZED SQUAMOUS EPITHELIAL CELLS THROUGH PI3K/AKT-MEDIATED PHOSPHORYLATION AND TRANSCRIPTIONAL REGULATION VIA HIF-1ALPHA Heeg, S. 1 ; Heeg, S. 1 ; von Werder, A. 1 ; Doebele , M. 1 ; Quante, M. 1 ; Scheffer, E. 1 ; Goessel, G. 1 ; Fulda, C. 1 ; Kunert , H. 1 ; Nakagawa, H. 2 ; Beijersbergen, R. 3 ; Blum, H.E. 1 1 Medizinische Klinik, Universität, Freiburg; 2 Gastroenterology Division, University of Pennsylvania, Philadelphia, PA, USA; 3 Netherlands Cancer Center, Amsterdam, Netherlands Introduction: In our cellular model ...

07. Gastrointestinal Cancer including Liver OP172 DEVELOPMENT OF THE NOVEL DOUBLE ENRICHED NESTED PCR (DEN-PCR) ASSAY FOR DETECTION OF K-RAS CODON 12 MUTATIONS IN COLORECTAL CARCINOMA PATIENTS Kraus, M.C. 1 ; Berger, M.R. 1 1 Deutsches Krebsforschungszentrum (DKFZ), Heidelberg Detection of disseminated tumour cells (DTC) in histopathologically inconspicuous tissues is presumably of high importance but often flawed with the difficulty to discover one mutated cell in a surplus of wild-type cells. The aim of this study was to develop a rapid and sensitive assay for detecting K-ras codon 12 mutations indicating DTC in tissue samples from colorectal carcinoma patients. Methods: The double enriched nested (DEN-) PCR makes use of the thermostable restriction enzyme BstNI during the first PCR and locked nucleic acid (LNA) clamping oligonucleotides during the second ...

Centre for Clinical Research in Cancer Victorian Cooperative Oncology Group Key Published Articles Listing — Gastrointestinal Cancer (2004) Title & Abstract Author Journal Colonoscopy screening for colorectal cancer : The outcomes of two recruitment methods Objectives: To determine the response to colorectal cancer (CRC) screening by colonoscopy, through direct invitation or through invitation by general practitioners. Design and Setting: Two- way comparison of randomised population sampling versus cluster sampling of a representative general practice population in the Australian Capital Territory, May 2002 to January 2004. Intervention: Invitation to screen, assessment for eligibility, interview, and colonoscopy. Subjects: 881 subjects aged 55–74 years were invited to screen: 520 from the electoral roll (ER) sample and 361 from the general practice (GP) cluster sample. ...

Centre for Clinical Research in Cancer Victorian Cooperative Oncology Group Key Published Articles Listing — Gastrointestinal Cancer (2005) Title & Abstract Author Journal First Amsterdam, then Bethesda, now Melbourne? [Editorial] Lenz HJ. Journal of Clinical Oncology Sep 2005; 23(27): 6445–6449. Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer Purpose: The relationships between mismatch repair (MMR) protein expression, microsatellite instability (MSI), family history, and germline MMR gene mutation status have not been studied on a population basis. Methods: We studied 131 unselected patients with colorectal cancer diagnosed younger than age 45 years. For the 105 available tumors, MLH1, MSH2, MSH6, and PMS2 protein expression using immuno-histochemistry (IHC) and MSI were measured. Germline ...

Centre for Clinical Research in Cancer Victorian Cooperative Oncology Group Key Published Articles Listing — Gastrointestinal Cancer (2000–2003) Title & Abstract Author Journal Is home screening for bowel cancer a good idea? (Editorial) Adelstein B, Trevena L, Barratt A & Salkeld G. Australian & New Zealand Journal of Public Health 2003; 27(3): 265–6. Multiple colorectal adenomas – Is their number up? (Editorial) Marra G & Jiricny J. The New England Journal of Medicine 27 Feb 2003; 348(9): 845–7. Multiple colorectal adenomas, classic adenomatous polyposis, and germ- line mutations in MYH Background: Germ-line mutations in the base-excision-repair gene MYH have been associated with recessive inheritance of multiple colorectal adenomas. Tumors from affected persons displayed excess somatic transversions of a guanine-cytosine ...

Summer 2005 Issue 1 Gastrointestinal Cancer Rapid Medical Donation Program Newsletter Inside: Meet The Lab 2 Participant Family Corner 3 Contact Information 4 Related Programs - NFPTR 6 Related Programs - Breast Cancer Medical Donation 6 The Johns Hopkins University School of MedicineKnowledge, For The World I write to you today with two goals-to introduce both myself and my laboratory to you, and to provide an update of the tremendous impact your loved one has made by participating in the Johns Hopkins Gastrointestinal Cancer Rapid Medical Donation Program (GICRMDP). Who am I? Born and raised in Bayshore, New York, I learned at the early age of 10 how devastating a cancer diagnosis can be when my father passed away of advanced colorectal cancer . When he was diagnosed, the cancer had already ...

Cancer Therapy Vol 3, page 525 525 Cancer Therapy Vol 3, 525-530, 2005 Incidence of gastrointestinal toxicity during estramustine phosphate therapy for prostate cancer is associated with the single-nucleotide polymorphisms in the cytochrome P450 1A1 (CYP1A1) gene Research Article Mohammed Rafiqul Islam Mamun 1 , Motofumi Suzuki 1 , Satoru Takahashi 1 , Kazuo Hara 2 , Takeshi Ozeki 3 , Yasuhiko Yamada 3 , Takashi Kadowaki 4 , Yoshitsugu Yanagihara 5 , Shuji Kameyama 6 , Yoichi Minagawa Ito 7 , Takumi Takeuchi 1 and Tadaichi Kitamura 1, * 1 Department of Urology, Graduate School of Medicine, The University ...

FRIDAY Joint Symposium: MOGA / ANTIGER Neuroendocrine Tumours – Recent Advances in DIAGNOSIS AND Management 18 Neuroendocrine GEP-tumors: Advances in Diagnosis and Treatment By Kjell Öberg, M.D., Ph.D. Professor Endocrine Oncology Dept. of Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden Neuroendocrine tumors of the gastrointestinal tract and pancreas constitute about 2 % of all malignant tumors. They include a number of different tumors, derived from cells of the diffuse neuroendocrine cell-system. The largest group of neuroendocrine tumors are the so called carcinoids with an incidence of about 2.5/100 000 per year. The old classification of neuroendocrine GEP-tumors is based on the embryonic origin, but there is a new WHO- classification taking into the consideration the tumor biology of different subtypes of neuroendocrine tumors. The tumors exhibit substantial differences in ...

Dog AKC Number __ Please check all applicable boxes Cancer Hemangiosarcoma Affected Littermate Affected Produced affected offspring Lymphoma Affected Littermate Affected Produced affected offspring Mast cell Affected Littermate Affected Produced affected offspring Osteosarcoma Affected Littermate Affected Produced affected offspring Other _ Affected Littermate Affected Produced affected offspring Cardiac disorders Subaortic stenosis Affected Littermate Affected Produced affected offspring Dermatological disorders Atopic dermatitis Affected Littermate Affected Produced affected offspring Gastrointestinal disorders Bloat Affected Littermate Affected Produced affected offspring Megaesophagus Affected ...

Pilot Projects Program Grant Application Gastrointestinal Cancer Pilot Project Grant Application Instructions Deadline: November 21, 2005 Page 2 Pilot Projects Program Grant Application Abramson Cancer Center of the University of Pennsylvania and the University of Pennsylvania’s NIH Center for Molecular Studies in Gastrointestinal and Liver Diseases Deadline: November 21, 2005 Submission & Budget Guidelines The Abramson Cancer Center of the University of Pennsylvania and the UPenn NIH Center for Gastrointestinal and Liver Diseases announces the availability of Pilot Project Grants for faculty to conduct cancer -related research projects. Investigator Eligibility • Full-time University faculty who have not held extramural support (R29, RO1, PO1) are eligible to apply for the Gastrointestinal Cancer Pilot ...

The Twelfth International Conference on Gastrointestinal Cancer : Announcement and Call for Abstracts Pancreas, Biliary Tract, Hepatoma, and Hepatic Metastasis The Twelfth International Conference on Gastrointestinal Cancer : Announcement and Call for Abstracts Pancreas, Biliary Tract, Hepatoma, and Hepatic Metastasis October 20-22, 2005 University of Virginia – Charlottesville,Virginia October 20-22, 2005 University of Virginia – Charlottesville,Virginia Presented by: The University of Virginia Health System • The George Washington University Medical Center Université Victor Ségalen • Institut Bergonié Sponsored by: The Office of Continuing Medical Education,University of Virginia School of Medicine Page 2 Who Should Attend? This international conference is ...

1 7 th WORLD CONGRESS ON GASTROINTESTINAL CANCER 15-18 June, 2005, Barcelona (some selected aspects discussed on the pancreas) This annual meeting was once again held in Barcelona, and after the change of meeting place to CCIB convention center near the Forum 2004, the frame of the meeting was even better than before. For those who had the possibility to stay a day before or after the congress, Barcelona is one of the most interesting European towns today – a long history of culture, the most thrilling architecture in the world, and vibrant music, art, football and good food today. There is something for everybody, and always more to see and experience than what is possible to find time for. Moreover, the tourist attractions are well organised, and the Spaniards really try to get the tourists to feel at ease. The congress i growing for each year – both concerning number of ...

1 7 th WORLD CONGRESS ON GASTROINTESTINAL CANCER Barcelona, June 15-18, 2005 (Discussions related to selected aspects of the pancreas) This annual meeting was once again held in Barcelona. The congress is growing every year with regard to the attendance, number of posters, number of industrial exhibitors and the scientific field covered. Moreover, the pharmaceutical exhibition gets increasingly sophisticated and gives rise to numerous satellite symposia. However, as only the largest companies are present, the news shown during the exhibition are influenced by commercial considerations. As last year, the focus of the meeting was on the medical treatment of gastrointestinal cancers, especially on colorectal cancer . To this focus are added diagnostic and surgical aspects, but the meeting was still not covering the whole field of cancer management and research. Whether ...

• BRIEF REPORTS • Raman spectra of single cell from gastrointestinal cancer patients Xun-Ling Yan, Rui-Xin Dong, Lei Zhang, Xue-Jun Zhang, Zong-Wang Zhang ELSEVIER PO Box 2345, Beijing 100023, China World J Gastroenterol 2005;11(21):3290-3292 www.wjgnet.com World Journal of Gastroenterology ISSN 1007-9327 wjg@wjgnet.com © 2005 The WJG Press and Elsevier Inc. All rights reserved. Xun-Ling Yan, Rui-Xin Dong, School of Physics Science and Information Engineering, Liaocheng University, Liaocheng 252059, Shandong Province, China Lei Zhang, Xue-Jun Zhang, Zong-Wang Zhang,Surgery of Liaocheng People’s Hospital, Liaocheng 250059, Shandong Province, China Supported by the National Natural Science Foundation of China, No. 60471049 and the Natural Science Foundation of Shandong Province of China, No. Y2004G09 Correspondence to: Xun-Ling Yan, School ...