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Pesq. Vet. Bras. 19(2):63-67, abr./jun. 1999 63 RESUMO.- [Diagnóstico rápido e sensível da infecção com o vírus da Leucemia Bovina através de Shuttle Nested Polymerase Chain Reaction.] O Vírus da leucemia bovina (BLV) é o agente causal da Leucose Enzoótica Bovina (EBL). Na Ar- gentina, iniciou-se um programa de erradicação da EBL. Nes- te estágio, é prioritário possuir uma ferramenta de diagnós- tico confiável. Embora seja indiscutível a importância do tes- te de agar gel imunodifusão, empregado rotineiramente no diagnóstico serológico da EBL, faz-se necessária uma técnica de diagnóstico adicional capaz de confirmar os resultados duvidosos. Foi possivel detectar ADN proviral aplicando Nested-PCR em novilhos experimentalmente infectados com pequenas doses de sangue total (5ml) obtidas de um bovino BLV soropositivo. Esta técnica, cujo procedimento leva 3 ho- ras, demonstrou ser muito sensível, ...

Daycare attendance and risk of childhood acute lymphoblastic leukaemia X Ma 1 , PA Buffler* ,1 , S Selvin 1 , KK Matthay 2 , JK Wiencke 3 , JL Wiemels 3 and P Reynolds 4 1 Division of Public Health Biology and Epidemiology, University of California, Berkeley, California, CA 94720-7360, USA; 2 Department of Pediatrics Oncology, University of California, San Francisco, California, CA 94143, USA; 3 Department of Epidemiology and Biostatistics, University of California, San Francisco, California, CA 94143, USA; 4 Environmental Health Investigations Branch, California Department of Health Services, Oakland, California, CA 94612, USA The relationship between daycare/preschool (‘daycare’) attendance and the risk of acute lymphoblastic leukaemia was evaluated ...

- 347 - Leukaemia Inhibitory Factor and Other Cytokines as Factors Influencing Regeneration of Skeletal Muscle John B. Kurek, John J. Bower (1) , Jason D. White (1) , Catriona M. Muldoon (1) and Lawrence Austin (1) Amrad Pharmaceutical Research and Development, Richmond, Victoria, and (1) Melbourne Neuromuscular Research Centre, St. Vincent’s Hospital, Fitzroy, Victoria, Australia Abstract When skeletal muscle is injured, mononuclear muscle precursors, the satellite cells, are activated and begin to proliferate and then fuse with each other to form new multinucleated myotubes, which eventually become the mature muscle fibres. The process of muscle regeneration is regulated by locally produced growth factors that control cellular proliferation and differentiation. Several polypeptide growth factors have been implicated ...

a report by Professor Martin J S Dyer Professor of Haemato-Oncology and Honorary Consultant Physician, Medical Research Council (MRC) Toxicology Unit, University of Leicester Risk Stratification in the Treatment of Chronic Lymphocytic Leukaemia B U S I N E S S B R I E F I N G : E U R O P E A N P H A R M A C O T H E R A P Y 2 0 0 5 1 Reference Section Martin J S Dyer is Professor of Haemato-Oncology and Honorary Consultant Physician in the Medical Research Council (MRC) Toxicology Unit at the University of Leicester. His research interests are the antibody therapy and molecular genetics of B-cell malignancy. He worked for 11 years at the Royal Marsden Hospital with Professor Daniel Catovsky, following his training in medicine at Oxford and Cambridge Universities in the UK. Introduction One of the greatest medical ...

26 www.tcd.ie/tsmj TSMJ May 2000 Volume 1 Symptoms Signs fever 61% lymphadenopathy 63% bruising 48% hepatomegaly 61% anaemia 45% splenomegaly 57% bone pain 23% mediastinal mass 5-10% Table 1: Frequency of presenting features of ALL Acute Lymphoblastic Leukaemia : A Review Robert Reichmann, 6th Year Medicine Acute Lymphoblastic Leukaemia , ALL, is a malignant transformation of lymphoblasts and represents the single commonest type of cancer in the paediatric population. In the United States there are 7000 new cases of paediatric cancer each year and 2100 (30%) of these are ALL. 1 The overall incidence of ALL is 4 per 100,000, the male to female ratio is 1.3:1, and the peak age at presentation is 4 years. 1 The exact aetiology of ALL is still being ...

Abstract. Vincristine (VCR), a microtubule interfering anti- cancer agent, plays a key role in the treatment of childhood acute lymphoblastic leukaemia (ALL). The route of VCR induced apoptosis in ALL cells is not well defined. In this study we demonstrated caspase-9 and -3 activation in vivo in bone marrow leukaemic cells of a child with newly diagnosed ALL, after treatment with a single dose of VCR. We hypothe- sized that VCR induced apoptosis in ALL cells proceeds by a mitochondrial controlled pathway. We further studied the route of VCR induced apoptosis in Jurkat acute lymphoblastic leukaemia cells. First we showed that VCR induces activation of caspase-9 and -3 in Jurkat cells. With the caspase-9 inhibitor Z-LEHD-FMK we proved that caspase-9 was activated prior to caspase-3. Loss of mitochondrial transmembrane potential was independent of caspase-9 activation. To confirm the mitochondrial ...

8. Hehlmann R, et al. Randomized comparision of Inter- feron-Alpha with Busulfan and Hydroxyurea in chronic myelogenous leukemia (CML). Blood 1994; 84: 382a 9. Fujita T, Kimura Y, Miyamoto M, et al. Induction of endogenous IFN-a and IFN-ß genes by a regulatory trans- cription factor, IRF-1. Nature 1989; 337: 270-272. 10. Fujita T, Reis LF, Watanabe N, et al. Induction of the transcription factor IRF-1 and interferon mRNAs by cyto- kines and activators of second-messenger pathways. Proc Natl Acad Sci USA 1989; 86: 729-739. 11. Carella AM, Podesta M, Frassoni F, et al. Collection of "normal" blood repopulating cells during early hema- topoietic recovery after intensive conventional chemo- therapy in chronic myelogenous leukemia. Bone Marrow Transplantation 1993; 12: 267-271. 12. McGlave PB, De Fabritis P, Deisseroth A, et al. Auto- logous transplants for chronic myelogenous leukaemia : results ...

LISA: Leukaemia Intervention Scheduling and Advice LISA: Leukaemia Intervention Scheduling and Advice Collaboration between Cancer Research UK’s: Collaboration between Cancer Research UK’s: Information Systems Team Information Systems Team Advanced Computation Laboratory Advanced Computation Laboratory Children’s Cancer Group Children’s Cancer Group – – RLH RLH Aim: Aim: Provide system to support shared care of paediatric leukaemia Provide system to support shared care of paediatric leukaemia Page 2 ALL Treatment 1 ALL Treatment 1 95% of children with ALL are enrolled into MRC clinical trial (c 95% of children with ALL are enrolled into MRC clinical trial (c ompares 2 steroids, 2 ompares 2 steroids, 2 thiopurines thiopurines ) and treatment follows the trial ...

ACUTE LYMPHOBLASTIC LEUKAEMIA NAME: STUDY NUMBER: DATE OF BIRTH: NHS NUMBER: SEX: HOSPITAL NUMBER: ADDRESS: CONSULTANT: HOSPITAL: MARROW NUMBER: POST CODE: DATE OF DIAGNOSIS: Initial Count: Hb FAB Classification: MCV: Platelets: WBC: <20,000 >20,000 Cytogenetics: (please attach copy if possible) Clinical Details (eg previous chemotherapy, splenomegaly, CNS involvement): Immunophenotyping: Treatment: NEAL ? (standard) NEAL (poor) UKALL: Specify: B-ALL: V&P: None: Other (specify) Treatment started: Initial Remission: Transplant: Allo: Auto: Date: Relapse: Date: Site: Subsequent Remission: Date of Death: Duration of Survival: Comments: (eg Family ...

ELIMINATION OF LEUKAEMIA FUND TRAVEL AND TRAINING FELLOWSHIP APPLICATION FORM Please read the notes overleaf Personal Details (The address should be the organisation you are affiliated to, see over .) Title First Name _ Initial Surname _ Address _ Town County _ Post code __ Telephone __ Fax __ Email __ Grant Application Type of grant: Travel £ Training £ Title, location, date and brief details of conference, meeting or course and funding required. Date of event __ Depart __ Return _ Conference/Training fee Travel costs Subsistence Total £ __ £ __ £ __ £ Please give costs in £ sterling Background Information Experience in field to which this application is relevant Brief details of benefit to you and to your department Have you applied elsewhere for support for this work? No £ Yes £ If YES give details Support of Head of ...

leukaemia CHRONIC MYELOID LEUKAEMIA . CLINICAL FEATURES. Rare below the age of 20 years, but occurs in all decades, with a median age of onset of 40-50 years. The incidence is slightly higher in males than in females. In most cases there are no predisposing factors but the incidence was increased in survivors of the atom bomb exposures in Japan. Clinical features. The clinical features include: Symptoms related to hypermetabolism e.g weight loss, lassitude, anorexia or night sweat. Splenomegaly is nearly always present and is frequently massive – can be associated with considerable discomfort, pain or indigestion. Features of anaemia – pallor, dyspnoea and tachycardia. Bruising, epistaxis, menorrhagia or haemorrhage from other sites because of abnormal ...

Abstract The development of osteolytic bone lesions in patients with chronic lymphocytic leukaemia (CLL) is extremely rare and has not been reported to involve the mandible. A case of bilateral pathologic fracture of the mandible extensively involved with multiple bony deposits of CLL is reported. Key words: Chronic lymphocytic leukaemia , pathological fracture, case report. (Received for publication September 1995. Accepted February 1996.) Introduction The causes of mandibular fractures are diverse. A review of the literature reveals that world wide, 77 per cent of mandibular fractures are the result of assaults or vehicular trauma, seven per cent are work related, seven per cent are as the result of falls, four per cent occur as a result of sporting accidents and the remainder (five per cent) are due to miscell- aneous causes including path o l o gical fracture. ...

102 23 Leukaemia Summary Relative survival after diagnosis of leukaemia is poor when compared with relative survival of other cancer sites. Relative survival one year after diagnosis of leukaemia was 65.7% for males and 62.9% for females. Five-year relative survival was 41.2% for males and 43.2% for females (Table 23.1). Survival ten years after diagnosis was 34.1% for males and 35.9% for females in 1987–1991, the most recent period for which ten-year relative survival data are available (Figure 23.2; Tables 23.2 and 23.3). There was no significant difference in relative survival for males between 1982–1986 and 1992–1997. For females, there was an increase in five-, six- and seven-year relative survival, with relative survival five years after diagnosis increasing by 3.8 percentage points (Figure 23.2; Tables 23.2 and 23.3). Leukaemia affects a larger proportion of children than older age ...

RESIDENTIAL MAGNETIC FIELDS AS A RISK FACTOR FOR CHILDHOOD ACUTE LEUKAEMIA : RESULTS FROM A GERMAN POPULATION-BASED CASE-CONTROL STUDY Joachim S CHUZ 1, *, Jan-Peter G RIGAT 2 , Karl B RINKMANN 2 and Jörg M ICHAELIS 1 1 Institute for Medical Statistics and Documentation, University of Mainz, Mainz, Germany 2 Forschungsuerbund: EMV biologischer Systeme (Electromagnetic Compatibility of Biological Systems), Technical University of Braunschweig, Braunschweig, Germany Our objective was to investigate whether exposure to res- idential power-frequency (50 Hz) magnetic fields above 0.2 T increases a child’s risk of leukaemia and to confirm or reject a finding froma previous German study on this topic, which reported increased leukaemia risk with exposure to stronger magnetic ...

All-Ireland cancer statistics 1994-96 97 Leukaemia 23. LEUKAEMIA ICD-O.2 morphologies M9800/3-9827/3, M9840/3-M9941/3 ICD-10 C91-C95 ICD-9 204-208 Leukaemias involve the production and release of neoplastic white blood cells by blood-forming tissues (principally bone marrow). Included here are lymphoid (ICD-10 code C91), myeloid (C92), monocytic (C93), other specified (C94) and unspecified leukaemias (C95), but not plasma cell leukaemia (C90.1). Key facts • Average of 445 new cases per year, 1994-96: 183 per year in females, 262 in males. • Average of 285 deaths per year: 123 in females, 162 in males. • Age-standardised incidence and mortality rates about 70% higher in males than females. • Incidence rates higher in the Republic of Ireland (RoI) than in Northern Ireland (NI), by about 24% for females and about 21% for males, although part ...

Communication Multidrug resistance-associated protein — reduction of expres- sion in human leukaemia cells by antisense phosphorothioate olignucleotides *. Wojciech Niewiarowski 1 , Edyta Gendaszewska 1 , Grzegorz Rêbowski 1 ½ , Marzena Wójcik 1 , Barbara Miko³ajczyk 1 , Wies³awa Goss 1 , Miros³aw Soszyñski 2 and Grzegorz Bartosz 2 1 Polish Academy of Sciences, Centre of Molecular and Macromolecular Studies, Department of Bioorganic Chemistry, £ódŸ, Poland, and 2 University of £ódŸ, Department of Molecular Biophysics, £ódŸ, Poland Received: 20 April, 2000; revised: 14 June, 2000; accepted: 20 September, 2000 Key words: antisense oligonucleotides, multidrug resistance, MRP Multidrug resistance-associated protein ...

BCR-ABL Positive Essential Thrombocythaemia:AVariant of Chronic Myelogerous Leukaemia orA Distinct Clinical Entity:A Special Case Report SAW Fadilah, S K Cheong Division of Haematology Department of Medicine Faculty of Medicine Universiti Kebangsaan Malaysia (UKM) Jalan Tenteram Bandar Tun Razak 56000 Cheras Kuala Lumpur Malaysia S A W Fadilah, MMed (MAL) Lecturer and clinical specialist Department of Pathology S K Cheong, FRCP (Glasg, FRCP (Edin), FRCPA (Aust) Correspondence to: Dr Fadilah S-Adul Wahid Tel: (03) 973 7829 Fax:(03) 970 2394 ABSTRACT A 37-year-old Malay man presented initially with the clinical picture of essential thrombocythaemia (ET) without the extreme leukocytosis, marked splenomegaly and low neutrophil alkaline phosphatase ...

1 Feline Leukaemia Virus (FeLV) What is FeLV? Feline Leukaemia Virus is a retrovirus. This is a family of viruses to which the HIV (human AIDS virus) and FIV (Feline Immunodeficiency Virus) belong. However, FeLV belongs to a different subfamily. FeLV is one of the most important virus diseases of the domestic cat and produces a wide variety of diseases which are rarely curable and ultimately result in death. Can People Catch FeLV? NO – there is no evidence to suggest that man can be infected by FeLV. Can Other Animals Catch FeLV? NO – FeLV has not been found to infect any animal other than the cat. How is FeLV Spread from Cat to Cat? FeLV is shed in the saliva, urine, faeces, milk and nasal secretions of infected cats. Transmission can occur from cat to cat (horizontal) or kittens can become infected whilst in the uterus (vertical). The saliva from infected cats seems to be the major ...

HKMJ Vol 6 No 1 March 2000 37 Bone marrow transplantation Introduction In the past 30 years, the treatment of acute myeloid leukaemia (AML) has evolved and improved con- siderably. The general trend in the therapeutic strategy has been to administer aggressive treatment Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong YK Mak, MRCP, FHKAM (Medicine) CH Chan, FRCP (Edin, Glas), FHKAM (Medicine) YC Chu, FRCP (Edin), FHKAM (Medicine) YT Chen, MRCP, FHKAM (Medicine) CK Lau, MB, BS, MRCP JSM Lau, MB, BS, MRCP Correspondence to: Dr YK Mak Autologous bone marrow transplantation for patients with acute myeloid leukaemia : prospective follow-up study YK Mak, CH Chan, YC Chu, YT Chen, CK Lau, JSM Lau Objective. To study the use of autologous bone marrow transplantation to treat acute myeloid leukaemia when ...

Biochem. J. (1998) 335 , 691–696 (Printed in Great Britain) 691 Demonstration of a RNA-dependent nuclear interaction between the promyelocytic leukaemia protein and glyceraldehyde-3-phosphate dehydrogenase Graeme W. CARLILE*†, William G. TATTON*† and Katherine L. B. BORDEN†‡§ 1 *Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada, †Department of Neurology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Annenberg Building, New York, NY 10029-6574, U.S.A., ‡Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada, and §Department of Physiology and Biophysics, Mount Sinai School of Medicine, One Gustave L. Levy Place, Annenberg Building, New York, NY 10029-6574, U.S.A. The promyelocytic leukaemia (protein) (PML) localizes to multi- protein complexes known as PML nuclear bodies. We found that glyceraldehyde-3-phosphate ...

Cancer and Industrial Pollution The Findings of the Workers Inquiry into the Wollongong Leukaemia and Cancer Crisis September 9, 1997 Page 2 © September 1997 Socialist Equality Party All rights reserved PO Box 367 Bankstown NSW 2200 Page 3 The Workers Inquiry into the Wollongong leukaemia and cancer crisis was held at Port Kembla on the weekend of July 19-20, 1997. The six inquiry commissioners have found that: 1 The staggering number of leukaemia and lymphoma deaths among former Warrawong High School students since 1989 is not a mysterious coincidence but part of a wider pattern of cancers and ill-health, particularly among young peo- ple, throughout the Wollongong area. 2 BHP, the owners of the Port Kembla copper smelter and other major compa- ...

Biochem. J. (1997) 328 , 879–888 (Printed in Great Britain) 879 Structure of the mouse leukaemia inhibitory factor receptor gene: regulated expression of mRNA encoding a soluble receptor isoform from an alternative 5 h untranslated region Ian CHAMBERS* 1 , Alison COZENS*, Joanne BROADBENT* 2 , Morag ROBERTSON*, Muriel LEE†, Meng LI* and Austin SMITH* *Centre for Genome Research, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh EH9 3JQ, Scotland, U.K., and †The MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, U.K. The low-affinity leukaemia inhibitory factor receptor (LIF-R) is a component of cell-surface receptor complexes for the multi- functional cytokines leukaemia inhibitory factor, ciliary neuro- trophic factor, oncostatin M and cardiotrophin-1. Both soluble and transmembrane forms ...

Biochem. J. (1997) 325 , 693–700 (Printed in Great Britain) 693 Evidence for the formation of a heterotrimeric complex of leukaemia inhibitory factor with its receptor subunits in solution Jian-Guo ZHANG*, Catherine M. OWCZAREK*§, Larry D. WARD†, Geoffrey J. HOWLETT‡, Louis J. FABRI†, Bronwyn A. ROBERTS* and Nicos A. NICOLA*R *The Walter and Eliza Hall Institute of Medical Research and The Cooperative Research Centre for Cellular Growth Factors, P.O. Royal Melbourne Hospital, Victoria 3050, Australia, †AMRAD Operations Pty. Ltd., Richmond, Victoria 3121, Australia, and ‡Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3052, Australia Leukaemia inhibitory factor (LIF) is a polyfunctional cytokine that is known to require at least two distinct receptor components (LIF receptor a-chain and gp130) in order to form a high- affinity, functional, ...

Biochem. J. (1997) 323 , 321–328 (Printed in Great Britain) 321 Rat basophilic leukaemia (RBL) cells overexpressing Rab3a have a reversible block in antigen-stimulated exocytosis Janet SMITH*, Nicola THOMPSON*, Jeff THOMPSON*, John ARMSTRONG*, Brian HAYES*, Andy CROFTS*, Jane SQUIRE*, Carmel TEAHAN*, Louise UPTON† and Roberto SOLARI*‡ *Cell Biology Unit, GlaxoWellcome Research and Development Ltd., Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts. SG1 2NY, and †Department of Physiology, University College London, University Street, London, U.K. The rat basophilic leukaemia (RBL) cell line has been widely used as a convenient model system to study regulated secretion in mast cells. Activation of these cells through the high-affinity receptor for IgE (Fce-RI) results in degranulation and the extracellular release of mediators. There is good evidence of a role for GTPases ...

MOLECULAR P A THOLOG Y – HAEMA T O-ONCOLOG Y 32 Understanding chronic lymphocytic leukaemia Advancing its diagnosis, prognosis and treatment Daniel Catovsky DSc(Med) FRCPath FRCP FMedSci Professor of Haematology A disease of variable guises C hronic lymphocytic leukaemia (CLL) is the most common form of leukaemia in Western countries. Indeed, in the United Kingdom alone, there are about 2,700 new cases of CLL a year, and most occurrences are in adults, particularly those over the age of 60. CLL is a heterogeneous disease, having variable symptoms and a widely varying clinical course – thus making it difficult for clinicians to determine how it will evolve (ie its prognosis) and how best to treat. For instance, it is not unknown for some patients to be diagnosed, ...