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Appendix Cancer survival by Area Health Services in NSW 1994 – 98 The Cancer Council NSW 64 Leukaemia • The five-year relative survival from leukaemia in NSW between 1994 and 2000 was 36.5% • The adjusted relative risks of excess death after shrinking were lower in Northern Sydney (12%, 38 fewer deaths) and Hunter (13%, 27 fewer deaths) • An additional 249 patients with leukaemia would be expected to survive to five years after diagnosis in NSW if the State average risk was shifted to the 20 th centile of the distribution • There were 3,609 new cases of leukaemia in NSW in 1994 to 1998 (2,094 males and 1,515 females) and 2,183 deaths (1,261 males and 922 females) • There was no area variation in the excess number of new cases in males, and there were no Area Health Services in which the number of new cases in females was different from ...

Page 1 of 4 of Instrument No.15 of 2003 Instrument No.15 of 2003 Revocation and Determination of Statement of Principles concerning CHRONIC MYELOID LEUKAEMIA Veterans’ Entitlements Act 1986 1. The Repatriation Medical Authority under subsection 196B(2) of the Veterans’ Entitlements Act 1986 (the Act): (a) revokes Instrument No.7 of 1997; and (b) determines in its place the following Statement of Principles. Kind of injury, disease or death 2. (a) This Statement of Principles is about chronic myeloid leukaemia and death from chronic myeloid leukaemia . (b) For the purposes of this Statement of Principles, “chronic myeloid leukaemia ” means a haematological neoplasm characterised by the clonal proliferation and accumulation of mature myeloid cells and their progenitors in the peripheral ...

Page 1 of 4 of Instrument No.7 of 1997. Instrument No.7 of 1997 Revocation and Determination of Statement of Principles concerning CHRONIC MYELOID LEUKAEMIA ICD CODES: 205.1, 206.1, 208.1 Veterans’ Entitlements Act 1986 1. The Repatriation Medical Authority under subsection 196B(2) of the Veterans’ Entitlements Act 1986 (the Act): (a) revokes Instrument Nos.99 and 126 of 1995; and (b) determines the following Statement of Principles. Kind of injury, disease or death 2. (a) This Statement of Principles is about chronic myeloid leukaemia and death from chronic myeloid leukaemia . (b) For the purposes of this Statement of Principles, “chronic myeloid leukaemia ” means a haematological neoplasm characterised by the clonal proliferation and accumulation of mature myeloid cells and their progenitors, ...

Page 1 of 3 of Instrument No.77 of 1995 Instrument No.77 of 1995 Statement of Principles concerning ACUTE LYMPHOID LEUKAEMIA ICD CODE: 204.0 Veterans’ Entitlements Act 1986 subsection 196 B (2) 1. Being of the view that there is sound medical-scientific evidence that indicates that acute lymphoid leukaemia and death from acute lymphoid leukaemia can be related to operational service rendered by veterans, peacekeeping service rendered by members of Peacekeeping forces and hazardous service rendered by members of the Forces, the Repatriation Medical Authority determines, under subsection 196B(2) of the Veterans’ Entitlements Act 1986 , that the factors that must as a minimum exist before it can be said that a reasonable hypothesis has been raised connecting acute lymphoid leukaemia or death from acute lymphoid ...

Page 1 of 2 of Instrument No.148 of 1996 Instrument No.148 of 1996 REVOKED Amendment of Statement of Principles concerning CHRONIC MYELOID LEUKAEMIA ICD CODE: 205.1 Veterans’ Entitlements Act 1986 subsection 196B(3) The Repatriation Medical Authority amends, under subsection 196B(3) of the Veterans’ Entitlements Act 1986 (the Act), Instrument No.100 of 1995, (Statement of Principles concerning chronic myeloid leukaemia ) by: 1. omitting paragraph 1(d), and replacing it with the following: “(a) smoking 35 pack years of cigarettes before the clinical onset of chronic myeloid leukaemia and, where smoking has ceased, the clinical onset of chronic myeloid leukaemia has occurred within five years of cessation; (b) inability to obtain appropriate clinical management for chronic myeloid leukaemia .”; 2. omitting paragraph ...

July 1998, Vol. 27 No. 4 491 Infections in Acute Lymphoblastic Leukaemia —C Y Chong et al Infections in Acute Lymphoblastic Leukaemia C Y Chong,* MBBS, MRCP (UK) , A M Tan,** FAMS, MBBS, M Med (Paed) , J Lou,** FAMS, M Med (Paed), FRCAP (Aust) Abstract We did a retrospective study of all acute lymphoblastic leukaemia (ALL) patients on United Kingdom ALL protocol who were admitted for febrile neutropenia. The aim of the study was to document the types of infections and aetiological agents associated with febrile neutropenia and to document the factors affecting mortality. Over the 8 1 / 2 -year period from 1986 to June 1995, there were 77 episodes in 32 children with a mean of 2.4 episodes. Morbidity due to infection was 61%; unknown causes of fever contributed 39%. Of the ...

July 2001, Vol. 30 No.4 401 ATRA and Chemotherapy for APL—L P Koh et al Treatment of Acute Promyelocytic Leukaemia Using a Combination of All-trans Retinoic Acid and Chemotherapy L P Koh,* MBBS, MRCP(UK) , Y T Goh,** FAMS, MBBS, M Med (Int Med) , G Teoh,*** MBBS, M Med (Int Med), Cert Rad Safety (Harvard University) , P Tan,** FAMS, MBBS, M Med (Int Med) Abstract Introduction: The combination of all-trans retinoic acid (ATRA) with chemotherapy has improved the outcome of acute promyelocytic leukaemia (APL). Effective induction as well as maintenance therapy for APL can be achieved using this combination of anti-leukaemic agents. Materials and Methods: Twenty-four consecutive patients with newly-diagnosed APL were treated with ATRA daily together with either daunorubicin or idarubicin. Therapy with ATRA ...

November 1999, Vol. 28 No. 6 867 A Case Report of ATLL—W Y K Hwang et al A Case Report of Adult T-Cell Leukaemia /Lymphoma (ATLL) W Y K Hwang,* MBBS, MRCP (UK), M Med (Int Med) , S L Tien,** FAMS, M Med (Int Med), FRCPA , P H C Tan,*** FAMS, MBBS, M Med (Int Med) Abstract Adult T-cell leukaemia /lymphoma (ATLL) is a unique disease with distinct manifestations, a characteristic phenotype and a likely retroviral aetiology. It is unusual in Southeast Asia, though more commonly seen in some countries like Japan. We report a case of this disease in a 71-year-old man in Singapore who presented with papular erythematous eruptions for 6 years and subsequently developed generalised lymphadenopathy. He was diagnosed to have ATLL and, despite an initial response, became resistant to combination chemotherapy. We discuss the aetiology, characteristics ...

HK J Paediatr (new series) 2003; 8 :170-183 Current Status of Acute Lymphoblastic Leukaemia in Children GCF C HAN , CH P UI Children's Centre of Cancer and Blood Diseases, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Hong Kong, China GCF C HAN ( ? ) MD St. Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, Tennessee, USA CH P UI ( ? ) MD Correspondence to: Dr GCF C HAN Received October 2, 2002 Supported in part by grant CA-21765 from the National Institute of Health, by a Center of Excellence grant from the State of Tennessee, and by the American Lebanese Syrian Associated Charities (ALSAC). CH Pui is an American ...

Section 4 – Your Child’s Diagnosis – Acute Myeloid Leukaemia Page 1 of 4 Acute Myeloid Leukaemia What is Acute Myeloid Leukaemia ? Leukaemia is a disease of the white blood cells (WBC). All blood cells are produced in the bone marrow and originate from stem cells. The following is a simple diagram showing how stem cells develop into the two forms of white cells: the myeloid line and lymphoid line. Stem Cell Myeloid Line Lymphoid Line Neutrophils T lymphocyte B lymphocyte There are two main types of WBC, lymphocytes and Neutrophils. Neutrophils develop from immature cells of the myeloid line. If the myeloid cells become cancerous the type of leukaemia is called Myeloid Leukaemia . In leukaemia the bone marrow produces large numbers of these abnormal white blood cells. These abnormal, immature white ...

Section 4 – Your Child’s Diagnosis – Acute Lymphoblastic Leukaemia Page 1 of 3 Acute Lymphoblastic Leukaemia What is Acute Lymphoblastic Leukaemia (ALL)? Leukaemia is a cancer of the white blood cells. About 85% of children with leukaemia have A cute L ymphoblastic L eukaemia . This is a cancer of immature lymphocytes (a type of white cell) called lymphoblasts or blast cells. The blast cells accumulate in the blood and crowd out the other blood cells such as the red blood cells, other white blood cells and platelets. The number of these good cells in the circulating blood becomes greatly reduced. This means the remaining red blood cells cannot transport enough oxygen to the body’s tissues and organs. The other white blood cells cannot fight infections and the platelets cannot ‘plug’ all the leaks in the blood vessels. What are the symptoms? A ...

1 Book chapter Cospeciation and horizontal transmission in the murine leukaemia -related retroviruses Joanne Martin, Peter Kabat $ and Michael Tristem* Department of Biology, Imperial College, Silwood Park, Ascot, Berkshire, SL5 7PY. U. K. (Tel 01344 294 373) (Fax 01344 294 339) $ Present address: Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 84246 Bratislava, Slovak Republic * Correspondent footnote. Mailing address: Department of Biology, Imperial College, Silwood Park, Ascot, Berkshire, SL5 7PY, UK. Telephone (01344) 294 373 Fax (01344) 294 339 e-mail: m.tristem@ic.ac.uk Page 2 2 Box1-retroviruses Retroviruses are enveloped viruses which encode a (+) sense non-segmented RNA genome. The best known retrovirus is undoubtably HIV, ...

leukaemia Instrument No.78 of 1995 Statement of Principles concerning ACUTE LYMPHOID LEUKAEMIA ICD CODE: 204.0 Veterans’ Entitlements Act 1986 subsection 196B(3) 1. Being of the view that, on the sound medical-scientific evidence available to the Repatriation Medical Authority, it is more probable than not that acute lymphoid leukaemia and death from acute lymphoid leukaemia can be related to eligible war service (other than operational service) rendered by veterans and defence service (other than hazardous service) rendered by members of the Forces, the Repatriation Medical Authority determines, under subsection 196B(3) of the Veterans’ Entitlements Act 1986, that the factors that must exist before it can be said that, on the balance of probabilities, acute lymphoid leukaemia or death from acute lymphoid leukaemia is connected with the circumstances of that service, are: ...

leukaemia Instrument No.77 of 1995 Statement of Principles concerning ACUTE LYMPHOID LEUKAEMIA ICD CODE: 204.0 Veterans’ Entitlements Act 1986 subsection 196 B (2) 1. Being of the view that there is sound medical-scientific evidence that indicates that acute lymphoid leukaemia and death from acute lymphoid leukaemia can be related to operational service rendered by veterans, peacekeeping service rendered by members of Peacekeeping forces and hazardous service rendered by members of the Forces, the Repatriation Medical Authority determines, under subsection 196B(2) of the Veterans’ Entitlements Act 1986, that the factors that must as a minimum exist before it can be said that a reasonable hypothesis has been raised connecting acute lymphoid leukaemia or death from acute lymphoid leukaemia with the circumstances of that service, are: (a) being present within ...

leukaemia Instrument No.80 of 1995 Statement of Principles concerning CHRONIC LYMPHOID LEUKAEMIA ICD CODE: 204.1 Veterans’ Entitlements Act 1986 subsection 196B(3) 1. Being of the view that, on the sound medical-scientific evidence available to the Repatriation Medical Authority, it is more probable than not that chronic lymphoid leukaemia and death from chronic lymphoid leukaemia can be related to eligible war service (other than operational service) rendered by veterans and defence service (other than hazardous service) rendered by members of the Forces, the Repatriation Medical Authority determines, under subsection 196B(3) of the Veterans’ Entitlements Act 1986, that the factors that must exist before it can be said that, on the balance of probabilities, chronic lymphoid leukaemia or death from chronic lymphoid leukaemia is connected with the circumstances of that service, ...

Prevalence of antibody to human T cell leukaemia / lymphoma virus in women attending antenatal clinic in southeast London: retrospective study Matthew Donati, Habib Seyedzadeh, Teresa Leung, Maggie Blott, Mark Zuckerman Infection with human T cell leukaemia /lymphoma virus (HTLV) type I occurs mainly in Japan, central and west Africa, and the Caribbean basin. Infection confers a lifetime risk of 2-4% for adult T cell leukaemia or lymphoma and 0.2-5% for tropical spastic paraparesis. However, the incubation period for these conditions after naturally acquired infection may be several decades. 1 The virus is transmitted via infected lymphocytes, and in areas of high prevalence breast feeding is an important route of transmission, particularly if continued for over six months. 2 We determined the prevalence of HTLV antibody in women who had attended ...

129 Radiation Protection Dosimetry Vol. 77, No. 1/2, pp. 129–131 (1998) Nuclear Technology Publishing LEUKAEMIA AND THYROID TUMOUR IN AN EAST-SLOVAKIAN DISTRICT AFTER CHERNOBYL J. Icso´ and M. Szo¨llo¨sova´ Department of Internal Medicine and Policlinical Department of Clinical Oncology Sv. Barbora Hospital, 048 01 Roznava, Slovakia Abstract — The incidence of leukaemia and thyroid gland tumour in the 10 year period after the Chernobyl accident has been investigated in Roznava-district with 86,000 inhabitants (east Slovakia, 1600 km SW of Chernobyl), and compared with a control period before the accident. A 2.1 times higher cumulative incidence of acute lymphatic leukaemia (median age: 11 y) and 1.3 times higher of thyroid gland tumour (median age: 47 y) was found compared with the same period before the accident. There was no increase in acute myeloid leukaemia , nor ...

U U K K A A L L L L X X I I I I Medical Research Council Trial for Adult Patients with Acute Lymphoblastic Leukaemia Under 56 years of Age: UKALL XII Principal Investigator : Dr. R Marcus & Dr. J Keidan Study Objectives: To investigate the role of bone marrow transplants in adults aged 15- 55 years with acute lymphoblastic leukaemia (ALL). The outcome of treatment with allogenic transplantation will be compared with either myeloablative chemoradiotherapy or intensive consolidation and maintenance chemotherapy. Patients in whom the Philadelphia chromosome is detected either cytogenetically or by molecular biological methods will in addition be eligible to receive an allogenic bone marrow transplant for a matched unrelated donor (MUD) and to receive alpha-interferon drug maintenance. Study Treatment: NO COMPATIBLE ...

ADULT LEUKAEMIA WORKING PARTY SERIOUS ADVERSE EVENT REPORT Patient Identification: Name: . Trial No: . Centre: . Consultant: . Associated Drug: Trial: PT1: Anagrelide AML: ATRA Fludarabine PSC-833 HD AraC (A400) Other: . Adverse Event: Definition:- A severe adverse event is any unexpected event, which may be related to the drug, which is (a) life threatening, or (b) requires admission to hospital, or (c) results in significant disability, or (d) results in cancer. SAE: . Details:

College of Medicine and Health Sciences The Fourth Annual U.A.E. University Research Conference MHS - 32 Protein Phosphorylation in Leukaemia Cells: Expression Profiles and Cell Dynamics Kate Hammond, Department of Biochemistry, E-mail: katehmnd@uaeu.ac.ae M M Qureshi, Department of Biochemistry , U.A.E. University, Al-Ain, P.O. Box: 17555, U.A.E. S Madjarevic, Department of Molecular Medicine and Haematology, University of the Witwatersrand, South Africa 1. INTRODUCTION The presence of phosphate in protein molecules was known a century ago, but only in recent years was its vital functional importance recognized, and now more and more phosphate- containing proteins, protein kinases and phosphoprotein phosphatases continue to be identified at an ever-increasing rate. Initially it was thought that the only possible targets for phosphorylation ...