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MEDIA RELEASE MEDIA LINK - The World's Greatest Shave for a Cure website has a dedicated media page, which can be accessed from the home page at www.worldsgreatestshave.com Here, you can find out more information about WGS and the Leukaemia Foundation, media releases and download WGS images in print-ready format. AUSSIES PUT THEIR HAIR ON THE LINE FOR LEUKAEMIA WORLD’S GREATEST SHAVE FOR A CURE - 12-13 MARCH 2004 Australians are campaigning against leukaemia with more than 10,000 already registered to shave or colour their hair in the Leukaemia Foundation’s World’s Greatest Shave for a Cure ( WGS) on 12-13 March 2004. Sponsored by 92.9, WGS 2004 is the Leukaemia Foundation’s biggest annual fundraising event, and this year more than 2,000 West Australians ...

MEDIA RELEASE MEDIA LINK - The World's Greatest Shave for a Cure website has a dedicated media page, which can be accessed from the home page at www.worldsgreatestshave.com Here, you can find out more information about WGS and the Leukaemia Foundation, media releases and download WGS images in print-ready format. SOUTH AUSTRALIANS ‘CUT IT’ FOR LEUKAEMIA WORLD’S GREATEST SHAVE FOR A CURE - 12-13 MARCH 2004 More South Australians than ever before are getting behind a campaign to fight leukaemia . In SA, more than 1,000 people have already registered to shave or colour their hair in the World’s Greatest Shave for a Cure on 12-13 March 2004. Sponsored by Triple M, World’s Greatest Shave for a Cure is the Leukaemia Foundation’s biggest annual fundraising event, and ...

abc H o d g k i n ’s disease & other lymphomas myeloma • myelodysplasia • aplastic anaemia the myeloproliferative disorders • the leukaemias Page 2 Acknowledgements Leukaemia Research Fund gratefully acknowledges the help and advice of Professor A. V. Hoffbrand in reviewing this series of publications and the assistance of Professor A. Burnett, Professor D. Catovsky, Professor J. Chessells, Professor J. Goldman, Professor E. Gordon-Smith, Professor A. Green, Dr A. Haynes, Professor G. Morgan, Dr S. O’Brien, and Professor J. Sweetenham in the preparation of specific titles. Published by Leukaemia Research Fund , April 2001 43 Great Ormond Street L o n d o n WC1N 3JJ Tel: 020 7405 0101 Email: info@lrf.org . u k Fax: 020 7242 1488 Web: www. l r f . o rg . u k Registered Charity 216032 © All rights reserved. No part of ...

MEDIA RELEASE MEDIA LINK - The World's Greatest Shave for a Cure website has a dedicated media page, which can be accessed from the home page at www.worldsgreatestshave.com Here, you can find out more information about WGS and the Leukaemia Foundation, media releases and download WGS images in print-ready format. LOSING YOUR LOCKS FOR LEUKAEMIA WORLD’S GREATEST SHAVE FOR A CURE - 12-13 MARCH 2004 Queenslanders are laying their locks on the line, pledging to shave or colour for the Leukaemia Foundation’s World’s Greatest Shave for a Cure ( WGS) on 12-13 March 2004. Sponsored by Triple M, WGS 2004, is expected to involve 35,000 people state-wide, who will take up the “hair-razing” challenge to raise $3 million ($10 million nationally) to help in the fight against leukaemia , lymphoma, myeloma and related blood disorders . ...

MEDIA RELEASE MEDIA LINK - The World's Greatest Shave for a Cure website has a dedicated media page, which can be accessed from the home page at www.worldsgreatestshave.com Here, you can find out more information about WGS and the Leukaemia Foundation, media releases and download WGS images in print-ready format. LOSING YOUR LOCKS FOR LEUKAEMIA WORLD’S GREATEST SHAVE FOR A CURE - 12-13 MARCH 2004 South Australians are laying their locks on the line, pledging to shave or colour their hair for the Leukaemia Foundation’s World’s Greatest Shave for a Cure on 12-13 March 2004. Sponsored by Triple M, the event is expected to involve 5,000 people state-wide, who will take up the “hair-razing” challenge to raise $750,000 to help in the fight against leukaemia , lymphoma, myeloma and related blood disorders. Peter Lynch of Leukaemia ...

MEDIA RELEASE MEDIA LINK - The World's Greatest Shave for a Cure website has a dedicated media page, which can be accessed from the home page at www.worldsgreatestshave.com Here, you can find out more information about WGS and the Leukaemia Foundation, media releases and download WGS images in print-ready format. LOSING YOUR LOCKS FOR LEUKAEMIA WORLD’S GREATEST SHAVE FOR A CURE - 12-13 MARCH 2004 New South Welshmen are laying their locks on the line, pledging to shave or colour for the Leukaemia Foundation’s World’s Greatest Shave for a Cure ( WGS) on 12-13 March 2004. Sponsored by Triple M, WGS 2004, is expected to involve 20 000 people state-wide, who will take up the ‘hair-razing’ challenge to raise $3.5 million ($10 million nationally) to help in the fight against leukaemia , lymphoma, myeloma and related blood disorders ...

MEDIA RELEASE MEDIA LINK - The World's Greatest Shave for a Cure website has a dedicated media page, which can be accessed from the home page at www.worldsgreatestshave.com Here, you can find out more information about WGS and the Leukaemia Foundation, media releases and download WGS images in print-ready format. LOSING YOUR LOCKS FOR LEUKAEMIA WORLD’S GREATEST SHAVE FOR A CURE, 12-13 MARCH 2004 West Australians are laying their locks on the line, pledging to shave or colour for the Leukaemia Foundation’s World’s Greatest Shave for a Cure ( WGS) on 12-13 March 2004. Sponsored by 92.9, WGS 2004, is expected to involve 2,000 people state-wide, who will take up the “hair-razing” challenge to raise $1 million ($10 million nationally) to help in the fight against leukaemia , lymphoma, myeloma and related blood disorders . ...

Impact of molecular techniques in diagnosis and management of leukaemia 5 June 2003 Abstracts and references Principles of RT-PCR methodologies Professor Nick Cross Wessex Regional Genetics Laboratory, Salisbury The ability to rapidly and specifically amplify DNA sequences by the polymerase chain reaction (PCR) has revolutionised molecular diagnostics over the past 10–15 years. Genomic DNA targets can be amplified directly, whereas expressed genes can be detected following reverse transcription of cellular RNA to cDNA followed by PCR amplification (RT-PCR). The presence or absence of specific sequences may give information about a particular pathogenetic state, for example minimal residual disease (MRD) after treatment for malignancy, specific infectious agents or alterations in gene expression. The aim of MRD analysis is to enable a better assessment of the response ...

abc H o d g k i n ’s disease & other lymphomas myeloma • myelodysplasia • aplastic anaemia the myeloproliferative disorders • the leukaemias Page 2 Acknowledgements Leukaemia Research Fund gratefully acknowledges the help and advice of Professor A. V. Hoffbrand in reviewing this series of publications and the assistance of Professor A. Burnett, Professor D. Catovsky, Professor J. Chessells, Professor J. Goldman, Dr A. Haynes, Professor G. Morg a n , Dr S. O’Brien, and Professor J. Sweetenham in the preparation of specific titles. Published by Leukaemia Research Fund , April 2001 43 Great Ormond Street L o n d o n WC1N 3JJ Tel: 020 7405 0101 Email: info@lrf.org . u k Fax: 020 7242 1488 Web: www. l r f . o rg . u k Registered Charity 216032 © All rights reserved. No part of this publication may be reproduced or ...

Aetiology of Childhood Leukaemia Tracy Lightfoot Epidemiology & Genetics Unit Page 2 Childhood Cancer 0.0% 5.0% 10.0% 15.0% 20.0% 25.0% 30.0% 35.0% leukaemia brain lymphoma soft tissue sarcoma neuroblastoma kidney bone germ cell retinoblastoma epithelial liver other Page 3 What is Leukaemia ? • Leukaemia is a clonal disease originating in a single cell • It evolves by the accrual of mutations within a clone resulting in genetic diversification • Dominant mutant subclones are then naturally selected • The nature of the clone and how far it has evolved determines the clinical outcome • Delay in diagnosing increases the likelihood that the clone will have ...

ELIMINATION OF LEUKAEMIA FUND TRAVEL AND TRAINING FELLOWSHIP APPLICATION FORM Please read the notes overleaf Personal Details (The address should be the organisation you are affiliated to, see over .) Title First Name _ Initial Surname _ Address _ Town County _ Post code __ Telephone __ Fax __ Email __ Grant Application Type of grant: Travel £ Training £ Title, location, date and brief details of conference, meeting or course and funding required. Date of event __ Depart __ Return _ Conference/Training fee Travel costs Subsistence Total £ __ £ __ £ __ £ Please give costs in £ sterling Background Information Experience in field to which this application is relevant Brief details of benefit to you and to your department Have you applied elsewhere for support for this work? No £ Yes £ If YES give details Support of Head of Department Signature ...

Role of maintenance therapy in Acute Myeloid Leukaemia Page 2 2 Study 1 Yves Perel, Anne Auvrignon, Thierry Leblanc, Jean-Pierre Vannier, Gerard Michel, Brigitte Nelken, Virginie Gandemer, Claudine Schmitt, Jean-Pierre Lamagnere, Lionel De Lumley, Brigitte Bader-Meunier, Gerard Couillaud, Gerard Schaison, Judith Landman-Parker, Isabelle Thuret, Jean-Hugues Dalle, Andre Baruchel, Guy Leverger for the Group LAME of the French Society of Paediatric Haematology and Immunology Impact of Addition of Maintenance Therapy to Intensive Induction and Consolidation Chemotherapy for Childhood Acute Myeloblastic Leukemia: Results of a Prospective Randomized Trial, LAME 89/91 J Clin Oncol 2002; 20: 2774-2782 Study design This was a prospective randomised multi-centre study that extended from December 1988 to June 1996 Randomisation methodology was not ...

Modification of continuing chemotherapy in acute lymphoblastic leukaemia Schedule of therapy Page 2 2 Study 4 Kjeld Schmiegelow, Olle Björk, Anders Glomstein, Göran Gustafsson, Niels Keiding, Jon Kristinsson, Anne Mäkipernaa, Susanne Rosthøj, Carol Szumlanski, Tine M Sørensen, and Richard Weinshilboum Intensification of Mercaptopurine/Methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia J Clin Oncol 2003; 21: 1332-1339 The Nordic Society of Paediatric Haematology and Oncology [NOPHO] ALL-92 was a multi-centre prospective randomised trial that ran from January 1992 till December 1996. Objectives The study aimed to explore whether dose adjustment of 6-mercaptopurine [6MP] and methotrexate [MTX] by erythrocyte [E] levels of thioguanine nucleotides [TGN] and MTX ...

Cancer The building blocks of the body are cells, which normally repair and reproduce in a controlled process. With cancer, this process goes wrong and cells divide and grow in an uncontrolled way. The body is made up of many different types of cells, such as skin, nerve, muscle and blood cells. With leukaemia , it is white blood cells that are affected. About leukaemia White blood cells are produced by the bone marrow, the soft spongy centre of bones. They then pass from the bone marrow into the blood stream and lymph system. White blood cells are involved in various functions of the immune system (the body’s defence system), which protects the body from infections. In leukaemia , some blood cells do not grow properly, but remain within the bone marrow and continue to reproduce in an uncontrolled way. These cells fill up the bone marrow ...

Is indoor radon linked to leukaemia in children and adults? - A review of the evidence Denis L Henshaw and Janet E Allen H H Wills Physics Laboratory, University of Bristol, Tyndall Avenue, Bristol, BS8 1TL, UK, Tel: +44 (0) 117 9260353; Fax: + 44 (0) 117 9251723; e-mail: d.l.henshaw@bris.ac.uk Abstract The evidence linking indoor radon exposure to childhood and adult leukaemia is reviewed. At the UK average indoor exposure of 20 Bq m -3 , it is estimated that the radon derived equivalent dose accrued to the fetus is 106 µSv. The equivalent dose rate to adult bone marrow ~130 µSv y -1 . Standard radiation risk factors suggest that 5% of childhood and 4% of adult leukaemia is linked to radon at 20 Bq m -3 exposure. Geographical studies generally support such a link at about this magnitude. A number of case-control studies have been carried ...

leukaemia THE EXPOSURE OF T-LYMPHOBLASTOID LEUKAEMIA CCRF-CEM CELLS TO 900 MHZ ELECTROMAGNETIC FIELD MODULATES GENE EXPRESSION AFFECTING CELL PROLIFERATION, APOPTOSIS AND CELL-CYCLE CONTROL. MARINELLI F., LA SALA D., CATTINI L. §, TOMASSETTI G.*, CICCIOTTI G. AND CINTI C. Inst. of Cytomorphology N. P. CNR- c/o I.O.R. Via di Barbiano 1/10 40136 Bologna Italy. § Inst. of Immunology and genetics IOR-Bologna Italy. Inst. of Radioastronomy CNR-Bologna Italy. Abstract It is becoming increasingly evident that electromagnetic radiation (NIR) is able to produce effects on biological systems and cells at biochemical and molecular level with effects independent from thermal phenomena (Barnes 1996, Astumian et al.1995, Litovitz et al. 1993). Recent studies have shown that NIR can affects cell metabolism and proliferation, inducing potentially damaging effects in all cellular compartments, ...

Hodgkin’s lymphoma & other lymphomas myeloma • myelodysplasia • aplastic anaemia the myeloproliferative disorders • the leukaemias Revised Sep 2003 Page 2 Acknowledgements The Leukaemia Research Fund gratefully acknowledges the help and advice of many clinicians who have generously given their time to aid in preparation of our patient information publications. A list can be found at www.lrf.org.uk/advisors/ Published by Leukaemia Research Fund , April 2001 43 Great Ormond Street London WC1N 3JJ Tel: 020 7405 0101 Email: info@lrf.org.uk Fax: 020 7242 1488 Web: www.lrf.org.uk Registered Charity 216032 Revised and Reprinted September 2003 © All rights reserved. No part of this publication may be reproduced or transmitted without permission in writing from Leukaemia Research Fund. Series Author: ...

1 Childhood leukaemia - communicating with a worried public Burls, Amanda J.E. Department of Public Health and Epidemiology University of Birmingham Edgbaston Birmingham B15 2TT United Kingdom A.J.Burls@bham.ac.uk 1. Introduction This presentation is a case-history of an attempt by a local health authority in the U.K. to deal with high levels of public anxiety about a cluster of childhood leukaemia in Northampton by a risk communication strategy. Usually, in similar circumstances of intense public demand and extensive adverse publicity, health authority’s have responded by setting up, predictably inconclusive, epidemiological studies. Despite intense public, political, media and management pressure to do just this, we chose rather to educate the public about disease clusters and the limitations of epidemiological methods. This involved working with ...

MEDIA RELEASE 6 October 2003 Corporates take up the challenge for leukaemia patients MELBOURNE -- Hundreds of corporates and celebrities will step up to the challenge tomorrow and put their best foot forward to compete in the BMDI LapforLeukaemia , a corporate treadmill challenge powered up by Crazy John’s. The 4-day fundraising race to out-tread corporate competitors will make its home in the forecourt of the AXA building on Collins Street where participants who have sought out sponsors will do their “Lap for Leukaemia .” One lap is 400m on a treadmill and every lap brings teams closer to winning the challenge and if the event is anything like last year, it will be a heated competition. The focus of the BMDI LapforLeukaemia is the collective effort of teams to inspire, motivate and walk together to win the race against leukaemia and other cancers. Among those joining participants ...

121 Leukaemia 18 18.1. INTRODUCTION AND SUMMARY Table 18.1. Summary of incidence and mortality statistics: leukaemia INCIDENT CASES DEATHS males females both sexes males females both sexes All cancers (ICD-O 2 C42.1, M-9800 to M-9941 and ICD-10 C91 to C95) 1997 cases 195 144 339 124 90 214 % of all cancers 1.8% 1.3% 1.6% 3.1% 2.5% 2.8% Incidence and mortality rates (per 100,000 persons per year) crude rate 10.8 7.8 9.3 6.9 4.9 5.9 World age-standardised rate 8.9 6.2 5.4 3.2 European age-standardised rate 12.0 7.5 7.8 4.3 cumulative risk (0-74) 0.8% 0.5% 0.5% 0.3% mortality/incidence ratio 0.636 0.625 0.631 Time trends (all cancers) 1994 cases 180 ...

Understanding Chronic Leukaemia A guide for people with leukaemia , their families and friends. Page 2 Understanding Chronic Leukaemia A guide for people with leukaemia , their families and friends. First published June 1997 This edition August 2003 © The Cancer Council New South Wales 2003 ISBN 186507 080 7 Acknowledgements We thank Professor David Ma, at the Department of Haematology and Stem Cell Transplantation, St Vincent’s Hospital, Sydney and Faculty of Medicine, University of New South Wales; and Ann Attwood, clinical nurse consultant, Nepean Cancer Care Centre, for reviewing the booklet. Thanks also to John Stubbs, of Cancer Voices NSW, and Jean Baigent, Cancer Council volunteer, for their valuable input on this booklet. Series editor: Marge Overs Editor: Jenny Mothoneos Cartoonist: Greg Smith The Cancer ...

Introduction Haematological neoplasms are usually primarily sensitive to chemotherapy, but the relapse rate is still high, except for Hodgkin’s lymphoma and childhood acute lymphoblastic leukaemia (ALL). Drug resistance is therefore a major cause of chemotherapeutic failure and patient death in haemato-oncology. A mathematical model for the development of drug resistance in tumours was proposed in 1979 by Goldie and Coldman (1). This model was based on the postulate that cancer cells have a high spontaneous mutation rate, leading over time to the emergence of cells resistant to chemotherapeutic drugs. In accordance with this hypothesis, it was suggested that a reduction in the rate of emergence of resistant cells could be achieved by the simultaneous administration of multiple drugs with different targets. However, despite combination chemotherapies, treatment failures were observed in ...

45 No. D evelopment and E valuation C Report ommittee Pentostatin and cladribine for hairy cell leukaemia December 1995 This report has been prepared as part of the Development and Evaluation Service funded by the Research and Development Directorate South and West. It is intended to provide rapid, accurate and usable information on health technology effectiveness to purchasers, clinicians, managers and researchers in the South and West. Further copies of the report may be obtained from: R&D Directorate, South and West Regional Health Authority Canynge Hall, Whiteladies Road, Bristol BS8 2PR Tel: 0117 9287224 Fax: 0117 9287204 Page 2 The Development and Evaluation Service The Development and Evaluation Service is funded by the Research ...

52 No. D evelopment and E valuation C Report ommittee Alpha interferon in the treatment of chronic myeloid leukaemia March 1996 This report has been prepared as part of the Development and Evaluation Service funded by the Research and Development Directorate South and West. It is intended to provide rapid, accurate and usable information on health technology effectiveness to purchasers, clinicians, managers and researchers in the South and West. Further copies of the report may be obtained from: R&D Directorate, NHS Executive South and West, Whiteladies Road, Bristol BS8 2PR Tel: 0117 9287224 Fax: 0117 9287204 W ESSEX MEDICINE INSTITUTE OF PUBLIC HEALTH Page 2 The Development and Evaluation Service ...

SHORT REPORT t(7;11)(p15;p15) chronic myeloid leukaemia developed into blastic transformation showing a novel NUP98/HOXA11 fusion A KITAKA S UZUKI , 1 Y OSHIKAZU I TO , 1 G ORO S ASHIDA , 1 S EIKO H ONDA , 1 T OMOKO K ATAGIRI , 1 T AKASHI F UJINO , 2 T AKURO N AKAMURA 2 and K AZUMA O HYASHIKI 1 1 First Department of Internal Medicine, Tokyo Medical University, and 2 Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan Received 30 April 2001; accepted for publication ...

leukaemia NATIONAL CANCER REGISTRY (NCR) Leukaemia - 2002 Dr. Visalachy Purushothaman Consultant Haematologist Hospital Kuala Lumpur NCR – LEUKAEMIA 2002 Co-chairman : Datin Prof. Dr. G. Duraisamy Consultant Haematologist UPM Members : Dr. Rosline Hassan Consultant Haematologist USM Dr. Goh Ai Sim Consultant Haematologist Hospital Penang ...

A genome scan of 18 families with chronic lymphocytic leukaemia L y n n R . G o l d i n , 1 N a o k o I s h i b e , 1 M a r i a S g a m b a t i , 1 G e r a l d E . M a r t i , 2 L a u r a F o n t a i n e , 1 M a x w e l l P . L e e , 3 J e n n y M . K e l l e y , 3 T i t i a S c h e r p b i e r , 3 K e n n e t h H . B u e t o w 3 a n d N e i l E . C a p o r a s o 1 1 Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 2 Flow and Image Cytometry Section, Division of Cell and Gene Therapies, Center for Biologics Research and Evaluation, Food and Drug Administration, and 3 Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, ...