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Leukaemia CARE Society - caring for sufferers of the leukaemias Hodgkin’s and other lymphomas • myelodysplasia • aplastic anaemia • 24hr CARE line 0800 169 6680 • Regional CARE Teams • Support Groups • Information and Booklets • Financial Assistance • Holiday Programme Leukaemia we are here to help When somebody is diagnosed with leukaemia , they feel scared and vulnerable. They need someone to talk to, they have many questions to ask and they need to find out what to do next. At such a distressing time, the Leukaemia CARE Society has members who can help, support and fulfil a vital role. The Leukaemia CARE Society, 2 Shrubbery Avenue, Worcester WR1 1QH. Tel: 01905 330003 Fax: 01905 330090 24-hour CAREline: 0800 169 6680 E-mail: info@leukaemiacare.org.uk Website: www.leukaemiacare.org.uk ...

Spatial modelling of leukaemia incidence the Girona Health Region, Spain. The adjustment for environmental and non-environmental confounders, radiofrequency in particular. Aitana Lertxundi-Manterola 1 and Marc Saez 1 1 Research Group on Statistics, Applied Economics and Health, GRECS. University of Girona. Campus de Montilivi, 17071 Girona. Tel: 34-972418736, Fax: 34- 972418032. e-mail: aitaler@yahoo.es Abstract. Leukaemia is a neoplasm of the cells of the haematopoietic system. Acute mielocitic leukaemia is the most frequent in adults, with a higher incidence in developed countries, in urban areas and in men. Several studies have investigated the relationship between radiofrequency (RF) and cancer, in general and between RF and leukaemia , in particular, but the results are not conclusive. Our objective in this paper is to propose ...

www.verdinrete.it/ondakiller British Journal of Cancer (2000) 83 (5), 692-698 Received 23 May 2000 Revised 16 June 2000 Accepted 16 June 2000 Correspondence to: A Ahlbom A pooled analysis of magnetic fields and childhood leukaemia A Ahlbom 1 , N Day 2 , M Feychting 1 , E Roman 3 , J Skinner 2 , J Dockerty 4 , M Linet 5 , M McBride 6 , J Michaelis 7 , JH Olsen 8 , T Tynes 9 and PK VerkasaIo 10,11,12 1 Division of Epidemiology, National Institute of Environmental Medicine, Karolinska Insitute Sweden; 2 Strangeways Research Laboratory University of Cambridge, UK; 3 Leukaemia Research Fund Centre for Clinical Epidemiology, ...

Daycare attendance and risk of childhood acute lymphoblastic leukaemia X Ma 1 , PA Buffler* ,1 , S Selvin 1 , KK Matthay 2 , JK Wiencke 3 , JL Wiemels 3 and P Reynolds 4 1 Division of Public Health Biology and Epidemiology, University of California, Berkeley, California, CA 94720-7360, USA; 2 Department of Pediatrics Oncology, University of California, San Francisco, California, CA 94143, USA; 3 Department of Epidemiology and Biostatistics, University of California, San Francisco, California, CA 94143, USA; 4 Environmental Health Investigations Branch, California Department of Health Services, Oakland, California, CA 94612, USA The relationship between daycare/preschool (‘daycare’) attendance and the risk of acute lymphoblastic leukaemia was evaluated ...

Pesq. Vet. Bras. 19(2):63-67, abr./jun. 1999 63 RESUMO.- [Diagnóstico rápido e sensível da infecção com o vírus da Leucemia Bovina através de Shuttle Nested Polymerase Chain Reaction.] O Vírus da leucemia bovina (BLV) é o agente causal da Leucose Enzoótica Bovina (EBL). Na Ar- gentina, iniciou-se um programa de erradicação da EBL. Nes- te estágio, é prioritário possuir uma ferramenta de diagnós- tico confiável. Embora seja indiscutível a importância do tes- te de agar gel imunodifusão, empregado rotineiramente no diagnóstico serológico da EBL, faz-se necessária uma técnica de diagnóstico adicional capaz de confirmar os resultados duvidosos. Foi possivel detectar ADN proviral aplicando Nested-PCR em novilhos experimentalmente infectados com pequenas doses de sangue total (5ml) obtidas de um bovino BLV soropositivo. Esta técnica, cujo procedimento leva 3 ho- ras, demonstrou ser muito sensível, ...

SHORT REPORT t(7;11)(p15;p15) chronic myeloid leukaemia developed into blastic transformation showing a novel NUP98/HOXA11 fusion A KITAKA S UZUKI , 1 Y OSHIKAZU I TO , 1 G ORO S ASHIDA , 1 S EIKO H ONDA , 1 T OMOKO K ATAGIRI , 1 T AKASHI F UJINO , 2 T AKURO N AKAMURA 2 and K AZUMA O HYASHIKI 1 1 First Department of Internal Medicine, Tokyo Medical University, and 2 Department of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan Received 30 April 2001; accepted for publication ...

1 UK Science, Technology, & Medical News Week of March 11, 2003 Page 2 Leukaemia Virus Discovery May Help Treat HIV Medical - 440 words RESEARCHERS in England and Japan have discovered the mechanism by which human T-lymphotropic virus type one - the virus which causes adult T-cell leukaemia - spreads through the body. Page 3 Probing The Genetics Of Brain Vulnerability Medical - 500 words WHY are people with a specific genetic make-up more likely to develop brain disease and less likely to make a good recovery from head injury? A study by researchers at Edinburgh University, Scotland, has important implications for those with the particular brain protein and who choose to take part in potentially dangerous contact sports such as boxing, ice hockey, football and rugby. Page 5 Investing In Tomorrow’s Technologies Research – 600 words IN THE ...

leukaemia (To be on headed paper) Medical Research Council Acute Lymphoblastic Leukaemia Trial XII (Revised UKALL XII) Patient information sheet You are being invited to take part in a research study. Before you decide it is important for you to understand why the research is being done and what it will involve. Please take time to read the following information carefully and discuss it with others if you wish. Ask us if there is anything that is not clear or if you would like more information. Take time to decide whether or not you wish to take part. Thank you for reading this. What is the purpose of the study? The purpose of this study is to find out more about how best to treat patients with Acute Lymphoblastic Leukaemia (ALL). The more people who take part in these studies, the better the information that we are able to obtain and the more quickly we ...

leukaemia (To be on headed paper) Medical Research Council Acute Lymphoblastic Leukaemia Trial XII (Revised UKALL XII) Parent / Guardian Information Sheet Your child is being invited to take part in a research study. Before you and your child decide it is important for you both to understand why the research is being done and what it will involve. Please take time to read the following information carefully and discuss it with others if you wish. Ask us if there is anything that is not clear or if you would like more information. Take time to decide whether or not you wish your child to take part. Thank you for reading this. What is the purpose of the study? The purpose of this study is to find out more about how best to treat patients with Acute Lymphoblastic Leukaemia (ALL). The more people who take part in these studies, the better the information that we are able to ...

A new experimental leukaemia pill, hailed as the most exciting development in cancer in years, is producing outstanding results. The initial clinical success of the drug, STI571, first became apparent in overseas trials in September 1999 and Australians with chronic myeloid leukaemia began taking part in an international clinical trial using STI571 (now known as Glivec® by mid-2000. The oral capsule, manufactured by Novartis, is the first of a new generation of biological drugs. One of the principal investigators in the drug's early develop- ment, Dr Brian Druker of Oregon, USA, released early clinical information at the end of 1999. Dr Kerry Taylor, president of the Haematology Society of Australia and New Zealand said initial trials with the drug were "quite stunning". "This is the closest thing we've had to a magic bullet and it is quite a thrilling drug to use," he said. STI571 targets ...

Understanding Leukaemia and related bone marrow disorders Page 2 1 PATIENT INFORMATION BOOKLETS This booklet is one of a series published by the Leukaemia Foundation to provide you with information and advice on the various types of leukaemias and associated blood diseases. Each booklet has been carefully written to answer most of the questions you will have about the diagnosis and treatment of a particular disease. However, this does not mean that you should assume the ideal treatment for you is described in these booklets. Your treatment program will be worked out in consultation with you, taking into consideration the many special details that are relevant to your individual case. Physicians associated with the Leukaemia Foundation are aware that the experience of undergoing treatment for cancer can be a difficult time, and that many patients ...

Leukaemia Busters Leukaemia Busters The Children’s Leukaemia Research Charity Telephone: 023 8063 6607 Fax: 023 8063 6609 Donations and correspondence should be sent to: Leukaemia Busters, Southampton General Hospital, Southampton SO16 6YD M M ARA ARA THON THON A A LIVE LIVE ! ! Forty three teams took part in the third 24 hour football marathon at Ashdown Leisure Centre in Poole organised once again by Gary and Jane Meech, aided by friends and relatives. Since the loss of their son Christopher to leukaemia five years ago, Gary and Jane have been committed fundraisers for Leukaemia Busters, raising a total of over £27,500 for the charity. This year’s event was no exception. Between them the teams scored over 327 goals and over £6,000 was raised as a result. ...

26 www.tcd.ie/tsmj TSMJ May 2000 Volume 1 Symptoms Signs fever 61% lymphadenopathy 63% bruising 48% hepatomegaly 61% anaemia 45% splenomegaly 57% bone pain 23% mediastinal mass 5-10% Table 1: Frequency of presenting features of ALL Acute Lymphoblastic Leukaemia : A Review Robert Reichmann, 6th Year Medicine Acute Lymphoblastic Leukaemia , ALL, is a malignant transformation of lymphoblasts and represents the single commonest type of cancer in the paediatric population. In the United States there are 7000 new cases of paediatric cancer each year and 2100 (30%) of these are ALL. 1 The overall incidence of ALL is 4 per 100,000, the male to female ratio is 1.3:1, and the peak age at presentation is 4 years. 1 The exact aetiology of ALL is still being ...

leukaemia Leukaemia & lymphoma cytogenetics Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne Thursday February 6th 2003 11.00-16.30 Lyndal Kearney Team Leader, LRF Molecular Cytogenetics, London Molecular basis of leukaemia cytogenetics Graham Jackson Consultant Haematologist, Newcastle upon Tyne Genetics, prognosis & management in adult acute leukaemia Rod Skinner Consultant Paediatric Oncologist, Newcastle upon Tyne Genetics, prognosis & management in childhood leukaemia Steve O?Brien Consultant Haematologist, Newcastle upon Tyne Imatinib (STI571) therapy for CML ...

AGE CLASSES Men Women 15-44 12 3 45-54 8 6 55-64 23 16 65-74 22 23 75+ 24 31 ALL 89 79 obs rel obs rel obs rel 1 year 85 89 77 80 82 84 3 years 71 79 62 68 67 74 5 years 54 66 52 62 53 64 95% CI (44-64) (53-78) (41-63) (49-74) (45-60) (55-73) AGE CLASSES Men Women 15-44 8 5 45-54 8 7 55-64 31 16 65-74 30 26 75+ 35 21 ALL 112 75 obs rel obs rel obs rel 1 year 81 84 71 73 77 ...

Study on Leukaemia and Malignant Lymphoma in Northern Germany (NLL) Summary Wolfgang Hoffmann Claudia Terschüren Walter Schill Hermann Pohlabeln Eberhard Greiser Funded by the Ministry of Environment, Nature Conservation and Agriculture, Schleswig-Holstein, and the Ministry of Social Affairs, Women, Family, and Health, Lower Saxony Bremen Institute for Prevention Research and Social Medicine (BIPS) Bremen, March 2003 Page 2 Contents 1 INTRODUCTION 3 1.1 B ACKGROUND OF THE N ORTH G ERMAN S TUDY ON L EUKAEMIA AND M ALIGNANT L YMPHOMA (NLL).. 3 2 MATERIAL AND METHODS: STUDY DESIGN.. 5 2.1 S TUDY P ERIOD .. ...

LISA: Leukaemia Intervention Scheduling and Advice LISA: Leukaemia Intervention Scheduling and Advice Collaboration between Cancer Research UK’s: Collaboration between Cancer Research UK’s: Information Systems Team Information Systems Team Advanced Computation Laboratory Advanced Computation Laboratory Children’s Cancer Group Children’s Cancer Group – – RLH RLH Aim: Aim: Provide system to support shared care of paediatric leukaemia Provide system to support shared care of paediatric leukaemia Page 2 ALL Treatment 1 ALL Treatment 1 95% of children with ALL are enrolled into MRC clinical trial (c 95% of children with ALL are enrolled into MRC clinical trial (c ompares 2 steroids, 2 ompares 2 steroids, 2 thiopurines thiopurines ) and treatment follows ...

abc H o d g k i n ’s disease & other lymphomas myeloma • myelodysplasia • aplastic anaemia the myeloproliferative disorders • the leukaemias Page 2 Acknowledgements The Leukaemia Research Fund gratefully acknowledges the help and advice of Professor A. V. Hoffbrand in reviewing this series of publications and the assistance of Professor A. Burnett, Professor D. C a t o v s k y, Professor J. Chessells, Professor J. Goldman, Professor E. Gordon-Smith, Professor A. Green, Dr A. Haynes, Professor G. Morg a n , Dr S. O'Brien, Professor J. Sweetenham and Professor J. A. L. Yin in the preparation of specific titles. Published by Leukaemia Research Fund , April 2001 43 Great Ormond Street L o n d o n WC1N 3JJ Tel: 020 7405 0101 Email: info@lrf.org . u k Fax: 020 7242 1488 Web: www. l r f . o rg . u k Registered Charity 216032 ...

Keypoint blood. 20.12.01 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------- DSMIG(UK) 2001. www.dsmig.org.uk 14.01.02 DOWN’S SYNDROME: BLOOD DISORDERS / LEUKAEMIA Key Points (based on conference paper by Professor Judith Chessells at RSM conference. April 2001) • Over 60% of neonates polycythaemic – unrelated to congenital heart disease • MCV increased at all ages • Almost unique risk of transient abnormal myelopoesis (TAM) in newborns (approx 10%) • Morphologically indistinguishable from megakaryocytic leukaemia • Usually asymptomatic • Usually resolves spontaneousely without treatment • Around 25% with TAM may develop acute myeloid leukaemia (AML) later ...

abc H o d g k i n ’s disease & other lymphomas myeloma • myelodysplasia • aplastic anaemia the myeloproliferative disorders • the leukaemias Page 2 Acknowledgements The Leukaemia Research Fund gratefully acknowledges the help and advice of Professor A. V. Hoffbrand in reviewing this series of publications and the assistance of Professor A. Burnett, Professor D. C a t o v s k y, Professor J. Chessells, Professor J. Goldman, Professor E. Gordon-Smith, Professor A. Green, Dr A. Haynes, Professor G. Morg a n , Dr S. O'Brien, Professor J. Sweetenham and Professor J.L. Yin in the preparation of specific titles. Published by Leukaemia Research Fund , April 2001 43 Great Ormond Street L o n d o n WC1N 3JJ Tel: 020 7405 0101 Email: info@lrf.org . u k Fax: 020 7242 1488 Web: www. l r f . o rg . u k Registered Charity 216032 ...

Leukaemia risk higher for air crews Flight crews are more at risk of leukaemia because they are exposed to greater radiation, scientists have found. A team from Denmark studied chromosomes of seven air-crew members with leukaemia and found that four had the same kind of damage as those with the disease who had been given radiotherapy. The finding, reported in The Lancet, strengthens the link between flight crew members and leukaemia , which has been shown in epidemiological studies. The reason is that flight crews spend a lot of time in the air with less to shield them against radiation. Direct evidence that this is the cause has been lacking. Dr Maryanne Gundestrup of the University Hopsital in Copenhagen and her colleagues compared the chromosomes of seven air crew with leukaemia with 19 people with the disease after radiotherapy and other leukaemia patients with no known cause. ...

102 23 Leukaemia Summary Relative survival after diagnosis of leukaemia is poor when compared with relative survival of other cancer sites. Relative survival one year after diagnosis of leukaemia was 65.7% for males and 62.9% for females. Five-year relative survival was 41.2% for males and 43.2% for females (Table 23.1). Survival ten years after diagnosis was 34.1% for males and 35.9% for females in 1987–1991, the most recent period for which ten-year relative survival data are available (Figure 23.2; Tables 23.2 and 23.3). There was no significant difference in relative survival for males between 1982–1986 and 1992–1997. For females, there was an increase in five-, six- and seven-year relative survival, with relative survival five years after diagnosis increasing by 3.8 percentage points (Figure 23.2; Tables 23.2 and 23.3). Leukaemia affects a larger proportion of children than ...

HTLV-I ASSOCIATED ADULT T-CELL LEUKAEMIA /LYMPHOMA (ATLL) PHASE II MULTICENTRE OPEN LABEL STUDY OF COMBINATION THERAPY WITH ZIDOVUDINE/LAMIVUDINE (COMBIVIR*) AND INTERFERON ALPHA UK THERAPY SUBCOMMITTEE OF THE HTLV EUROPEAN RESEARCH NETWORK (HERN) Page 2 2 CONTENTS 1. Trial Personnel 2. Ethical considerations 3. Trial background 4. Trial objectives 5. Selection of patients 5.1. Patient numbers 5.2. Eligibility criteria 5.3. Exclusion criteria 6 . Diagnostic and staging investigations 6.1. Registration data 6.2. Risk factors 6.3. Clinical features 6.4. Laboratory features (Routine and diagnostic/research samples) 6.5. Follow-up investigations 7. Treatment design 7.1. Drug schedule ...

All-Ireland cancer statistics 1994-96 97 Leukaemia 23. LEUKAEMIA ICD-O.2 morphologies M9800/3-9827/3, M9840/3-M9941/3 ICD-10 C91-C95 ICD-9 204-208 Leukaemias involve the production and release of neoplastic white blood cells by blood-forming tissues (principally bone marrow). Included here are lymphoid (ICD-10 code C91), myeloid (C92), monocytic (C93), other specified (C94) and unspecified leukaemias (C95), but not plasma cell leukaemia (C90.1). Key facts • Average of 445 new cases per year, 1994-96: 183 per year in females, 262 in males. • Average of 285 deaths per year: 123 in females, 162 in males. • Age-standardised incidence and mortality rates about 70% higher in males than females. • Incidence rates higher in the Republic of Ireland (RoI) than in Northern Ireland (NI), by about 24% for females and about 21% for males, although ...

P-2a-48 1 Leukaemia and low dose radiation:- Is there an association between leukaemia and cumulative external dose amongst the British Nuclear Fuel plc. (BNFL) workers? D. M c Geoghegan and K. Binks Westlakes Scientific Consulting, Moor Row, Cumbria, CA24 3LN Abstract. A detailed examination of the BNFL leukaemia data is presented, for the period 1946-1995, using the recently assembled company wide BNFL epidemiological database and the BNFL leukaemia case-control data set. The association of this occupationally exposed cohort is examined with respect to both leukaemia mortality and leukaemia morbidity. The excess relative risk for total leukaemia excluding chronic lymphatic leukaemia amongst the BNFL radiation workers was found to be 3.64 Sv -1 (90% CI –0.13-11.22); for Sellafield and Springfields this figure was 7.99 Sv ...

1 Feline Leukaemia Virus (FeLV) What is FeLV? Feline Leukaemia Virus is a retrovirus. This is a family of viruses to which the HIV (human AIDS virus) and FIV (Feline Immunodeficiency Virus) belong. However, FeLV belongs to a different subfamily. FeLV is one of the most important virus diseases of the domestic cat and produces a wide variety of diseases which are rarely curable and ultimately result in death. Can People Catch FeLV? NO – there is no evidence to suggest that man can be infected by FeLV. Can Other Animals Catch FeLV? NO – FeLV has not been found to infect any animal other than the cat. How is FeLV Spread from Cat to Cat? FeLV is shed in the saliva, urine, faeces, milk and nasal secretions of infected cats. Transmission can occur from cat to cat (horizontal) or kittens can become infected whilst in the uterus (vertical). The saliva from infected cats seems to be the ...

HKMJ Vol 6 No 1 March 2000 37 Bone marrow transplantation Introduction In the past 30 years, the treatment of acute myeloid leukaemia (AML) has evolved and improved con- siderably. The general trend in the therapeutic strategy has been to administer aggressive treatment Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong YK Mak, MRCP, FHKAM (Medicine) CH Chan, FRCP (Edin, Glas), FHKAM (Medicine) YC Chu, FRCP (Edin), FHKAM (Medicine) YT Chen, MRCP, FHKAM (Medicine) CK Lau, MB, BS, MRCP JSM Lau, MB, BS, MRCP Correspondence to: Dr YK Mak Autologous bone marrow transplantation for patients with acute myeloid leukaemia : prospective follow-up study YK Mak, CH Chan, YC Chu, YT Chen, CK Lau, JSM Lau Objective. To study the use of autologous bone marrow transplantation to treat acute myeloid leukaemia ...

470 The Faculty of Science, PhD Several of the retroviral elements involved in replication have not been fully described. My project was devoted to construction and utilisation of new retroviral transduction systems suitable for analysis of many of these incom- pletely described elements. Two replication-competent systems, designated the mini-virus system and the maxi-virus system, and a specialised single-round transduction system, designated the integrase-deficient system, were devel- oped. The three transduction systems have a wide range of applications and they may contribute to further research into several basic aspects of retroviruses and gene transfer features. Replication-competent vectors may be used with advantage in evolutionary studies, as these vectors are capable of performing multiple rounds of infec- tion. The mini-virus system consists of a bi-cistronic vector expressing Env- proteins ...

Cancer and Industrial Pollution The Findings of the Workers Inquiry into the Wollongong Leukaemia and Cancer Crisis September 9, 1997 Page 2 © September 1997 Socialist Equality Party All rights reserved PO Box 367 Bankstown NSW 2200 Page 3 The Workers Inquiry into the Wollongong leukaemia and cancer crisis was held at Port Kembla on the weekend of July 19-20, 1997. The six inquiry commissioners have found that: 1 The staggering number of leukaemia and lymphoma deaths among former Warrawong High School students since 1989 is not a mysterious coincidence but part of a wider pattern of cancers and ill-health, particularly among young peo- ple, throughout the Wollongong area. 2 BHP, the owners of the Port Kembla copper smelter and other major compa- nies are ...