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!"# !$%&'%(!)* #+%,!-./)01%2!34).3#+%5$6.1/ '%7! 6.3!1 Waikato District Health Board Leukaemia Mortality (0-74) Introduction Rationale Methodology Data Coverage Period Method Description Interpretation International Classification of Disease Codes (ICD Version 9 & 10) ICD 9 ICD 10 Findings 1 Ethnicity Volume Trend 2 Age Gender Volume Proportion Profile 3 Age Ethnicity Volume Profile - All years 4 Age Ethnicity Volume Proportion Profile (All Years) 5 Age Standardised Trend - Waikato District Health Board versus NZ rate per 10,000 persons 6 Maori Age Standardised Trend - Waikato District Health Board versus NZ rate per 10,000 persons 7 Paciifc People Age Standardised Trend - Waikato District Health Board versus NZ rate per 10,000 persons 8 Other Ethnicity Age Standardised Trend - Waikato District Health Board versus ...

!"# !$%&'%(!)* #+%,!-./)01%2!34).3#+%5$6.1/ '%7! 6.3!1 Waikato District Health Board Leukaemia Mortality Introduction Rationale Methodology Data Coverage Period Method Description Interpretation International Classification of Disease Codes (ICD Version 9 & 10) ICD 9 ICD 10 Findings 1 Ethnicity Volume Trend 2 Age Gender Volume Proportion Profile 3 Age Ethnicity Volume Profile - All years 4 Age Ethnicity Volume Proportion Profile (All Years) 5 Age Standardised Trend - Waikato District Health Board versus NZ rate per 10,000 persons 6 Maori Age Standardised Trend - Waikato District Health Board versus NZ rate per 10,000 persons 7 Paciifc People Age Standardised Trend - Waikato District Health Board versus NZ rate per 10,000 persons 8 Other Ethnicity Age Standardised Trend - Waikato District Health Board versus NZ rate ...

145 Imagens em Hematologia Rev. bras. hematol. hemoter. 2004; 26 (2):74-75 IMAGENS EM HEMATOLOGIA/IMAGES IN HEMATOLOGY Priscilla M. R. Silva 1 Rosemeire A. V. Bognone 1 Maristela Zocca 1 Katia B. B. Pagnano 1 Carmen S. P. Lima 2 1 Haematology and Hemotherapy Centre 2 Department of Internal Medicine State University of Campinas, Campinas, São Paulo, Brazil 16q22 Changes in acute myeloid leukaemia Alterações citogenéticas 16q22 na leucemia mielóide aguda Correspondence to: Carmen Silvia Passos Lima, MD, PhD Hemocentro – Unicamp – Cidade Universitária “Zeferino Vaz” Caixa Postal 6198, Cep: 13083-970 – Campinas, SP – Brazil Phone: + 55 19 3788-8740 – Fax: + 55 19 3788-8600 – e-mail: carmenl@fcm.unicamp.br The association between structural ...

LEUKAEMIA MEDICAL APPENDIX DEFINITION 1. The leukaemias are a group of diseases affecting the lymphatic and reticulo- endothelial systems, including the bone marrow, resulting in over production of abnormal leucocytes, with or without an increase in these cells in the circulating blood, and infiltration of various structures. Leukaemias are neoplastic diseases and may be regarded as cancers of the haemopoietic organs. They account for 2% of all cancers and of cancer deaths world-wide and 3% of all new malignancies in the UK. NORMAL BLOOD AND BONE MARROW 2. Normal blood contains three main groups of cells: red cells, leucocytes and platelets. The cyclic process of their production, circulation, removal and renewal is not yet fully understood. In health, a balance is maintained and the numbers of these formed elements is remarkably constant. 3. All mature blood cells derive from stem ...

LEUKAEMIA TARGET 44643 ABPI Target Leukaemia 13/5/04 8:46 Page 1 Page 2 The Association of the British Pharmaceutical Industry 12 Whitehall London SW1A 2DY Telephone: 020 7930 3477 Fax: 020 7747 1411 E-mail: abpi@abpi.org.uk Website: www.abpi.org.uk Researched and written by Dr Mike Hall Target Series Editor: Bill Kirkness Acknowledgements The ABPI wishes to thank member companies for the help given in the preparation of this booklet. We are also indebted to Leukaemia Care for their helpful advice and comments on the draft text. In particular, we are grateful to Dr Charles Stiller of the Childhood Cancer Research Group, University of Oxford, for the graphs showing survival in childhood leukaemia , and to the UK Child Cancer Study Group for the figure of overall survival in children. Thanks ...

Page 1 of 4 of Instrument No. 9 of 2005 Instrument No. 9 of 2005 Revocation and Determination of Statement of Principles concerning CHRONIC LYMPHOID LEUKAEMIA for the purposes of the Veterans’ Entitlements Act 1986 and Military Rehabilitation and Compensation Act 2004 1. The Repatriation Medical Authority under subsection 196B(2) and (8) of the Veterans’ Entitlements Act 1986 (the VEA): (a) revokes Instrument No. 67 of 2001, as amended by No. 59 of 2003; and (b) determines in their place the following Statement of Principles. Kind of injury, disease or death 2. (a) This Statement of Principles is about chronic lymphoid leukaemia and death from chronic lymphoid leukaemia . (b) For the purposes of this Statement of Principles, “chronic lymphoid leukaemia ...

Page 1 of 4 of Instrument No. 10 of 2005 Instrument No. 10 of 2005 Revocation and Determination of Statement of Principles concerning CHRONIC LYMPHOID LEUKAEMIA for the purposes of the Veterans’ Entitlements Act 1986 and Military Rehabilitation and Compensation Act 2004 1. The Repatriation Medical Authority under subsection 196B(3) and (8) of the Veterans’ Entitlements Act 1986 (the VEA): (a) revokes Instrument No. 68 of 2001; and (b) determines in its place the following Statement of Principles. Kind of injury, disease or death 2. (a) This Statement of Principles is about chronic lymphoid leukaemia and death from chronic lymphoid leukaemia . (b) For the purposes of this Statement of Principles, “chronic lymphoid leukaemia ” means an indolent malignant neoplasm ...

leukaemia 1146 Consultative Exercise on Radiation Risks of Internal Emitters (CERRIE) 8th Meeting, February 27, 2003 Paper 8/12 Conference Room 8 DEFRA, Ashdown House 123 Victoria Street London SW1E 6DE Review of the Study of Leukaemia Incidence near Estuaries by Lloyd et al. (2002) 1. The Committee will recall that at the December meeting, Dr Wakeford stated he wished to submit comments on the recent Lloyd et al paper on leukaemia incidence near estuaries. 2. Attached is a copy of Dr Wakeford’s paper. IF Feb 13 CERRIE February 2003 A Review of the Study of Leukaemia Incidence near Estuaries by Lloyd et al. (2002) by Richard Wakeford ...

Martin J S Dyer is Professor of Haemato-Oncology and Honorary Consultant Physician in the Medical Research Council (MRC) Toxicology Unit at the University of Leicester. His research interests are the antibody therapy and molecular genetics of B-cell malignancy. He worked for 11 years at the Royal Marsden Hospital with Professor Daniel Catovsky, following his training in medicine at Oxford and Cambridge Universities in the UK. a report by Professor Martin J S Dyer Professor of Haemato-Oncology and Honorary Consultant Physician, Medical Research Council (MRC) Toxicology Unit, University of Leicester Introduction One of the greatest medical advances of the last century was the curing of childhood acute lymphoblastic leukaemia (ALL) with combination chemotherapy. From being a disease that was invariably and rapidly fatal, over 70% ...

J. Meletis et al 324 A. Tragiannidis et al Musculoskeletal manifestations at diagnosis in children with acute lymphoblastic leukaemia Athanassios Tragiannidis 1 , Fani Athanassiadou 1 , Theodotis Papageorgiou 1 , Vassiliki Sidi 2 , Israel Rousso 1 , Dimitrios Koliouskas 2 , Christos Papastergiou 3 1 Hematology-Oncology Unit, 2 nd Department of Paediatrics, AHEPA Hospital, 2 Pediatric Oncology Department, Hippokration Hospital, 3 Radiology Department, Papageorgiou Hospital, Thessaloniki, Greece * Correspondence: Fani Athanassiadou, MD, Metropoleos 55 str., 546 23 Thessaloniki, Greece, Tel.:+3902310.994804, e-mail: atragian@hotmail.com Copyright © Hellenic Society of Haematology HAEMA (Áßìá) ÉSSN: 1108-2682 ...

J. Meletis et al 262 E. Papageorgiou et al Haema 2005; 8(2): 262-268 Original article Treatment of high risk myelodysplastic syndromes and acute myeloid leukaemia following MDS with idarubicin and cytocine arabinoside supported by granulocyte-macrophage colony stimulating factor: a single center experience Efstathios Papageorgiou, Theofanis Economopoulos, Sotirios Papageorgiou, Vassiliki Pappa, Nikolaos Xiros, Panagiotis Tsirigotis, Panteleimon Kountourakis, John Dervenoulas, Sotirios Raptis Second Department of Internal Medicine Propaedeutic, University of Athens, Attikon Hospital, Haidari, Greece Abstract. Between April 1990 and December 1999 patients with high risk myelodysplastic syn- drome (MDS), namely RAEB (BM blasts >10%) or RAEB-t and patients progressed to acute mye- loid leukaemia (AML) from MDS, were treated with moderately intensive chemotherapy ...

255 FISH DETECTION OF SPECIFIC CHROMOSOMAL ABERRATIONS AND CLONALITY IN ADULT ACUTE LEUKAEMIA Haema 2005; 8(2): 255-261 Original article FISH detection of specific chromosomal aberrations and clonality in adult acute leukaemia Milena Velizarova 1 , Dora Popova 2 , Evgenii Hadjiev 3 , Kamelia Aleksandrova 3 , Ivanka Dimova 4 , Boriana Zaharieva 4 , Lachezara Schemelecova 3 , Stavri Toshkov 5 , Janin Stojanova 5 , Marin Penev 1 , Draga Toncheva 4 1 Chair of Clinical laboratory and Clinical Immunology, Department of Laboratory Haematology, Medical Univer- sity, 2 Laboratory of Clinical Immunology, Department of Allergiology and Clinical Immunology, 3 Clinic of Haema- ...

Leukaemia What is leukaemia ? Leukaemia is a cancer of cells in the bone marrow (the cells which develop into blood cells). Cancer is a disease of the cells in the body. There are many types of cancer which arise from different types of cell. What all cancers have in common is that the cancer cells are abnormal and do not respond to normal control mechanisms. Large numbers of cancer cells build up because they multiply 'out of control', or because they live much longer than normal cells, or both. With leukaemia , the cancerous cells in the bone marrow spill out into the bloodstream. There are several types of leukaemia . Most types arise from cells which normally develop into white blood cells. (The word leukaemia comes from a greek work which means 'white blood'.) If you develop leukaemia it is important to know exactly what type it is. This is because the outlook (prognosis) and treatments ...

Chronic Lymphocytic Leukaemia (CLL) What is leukaemia ? Leukaemia is a cancer of cells in the bone marrow (the cells which develop into blood cells). Cancer is a disease of the cells in the body. There are many types of cancer which arise from different types of cell. What all cancers have in common is that the cancer cells are abnormal and do not respond to normal control mechanisms. Large numbers of cancer cells build up because they multiply 'out of control', or because they live much longer than normal cells, or both. With leukaemia , the cancerous cells made in the bone marrow spill out into the bloodstream. There are several types of leukaemia . Most types arise from cells which normally develop into white blood cells. (The word leukaemia comes from a greek work which means 'white blood'.) If you develop leukaemia it is important to know exactly what type it is. This is because the outlook ...

Acute Myeloid Leukaemia (AML) What is leukaemia ? Leukaemia is a cancer of cells in the bone marrow (the cells which develop into blood cells). Cancer is a disease of the cells in the body. There are many types of cancer which arise from different types of cell. What all cancers have in common is that the cancer cells are abnormal and do not respond to normal control mechanisms. Large numbers of cancer cells build up because they multiply 'out of control', or because they live much longer than normal cells, or both. With leukaemia , the cancerous cells in the bone marrow spill out into the bloodstream. There are several types of leukaemia . Most types arise from cells which normally develop into white blood cells. (The word leukaemia comes from a greek work which means 'white blood'.) If you develop leukaemia it is important to know exactly what type it is. This is because the outlook (prognosis) ...

Acute Lymphoblastic Leukaemia (ALL) What is leukaemia ? Leukaemia is a cancer of cells in the bone marrow (the cells which develop into blood cells). Cancer is a disease of the cells in the body. There are many types of cancer which arise from different types of cell. What all cancers have in common is that the cancer cells are abnormal and do not respond to normal control mechanisms. Large numbers of cancer cells build up because they multiply 'out of control', or because they live much longer than normal cells, or both. With leukaemia , the cancerous cells in the bone marrow spill out into the bloodstream. There are several types of leukaemia . Most types arise from cells which normally develop into white blood cells. (The word leukaemia comes from a greek work which means 'white blood'.) If you develop leukaemia it is important to know exactly what type it is. This is because the outlook (prognosis) ...

ELIMINATION OF LEUKAEMIA FUND TRAVEL AND TRAINING FELLOWSHIP APPLICATION FORM Please read the notes overleaf Personal Details (The address should be the organisation you are affiliated to, see over .) Title First Name _ Initial Surname _ Address _ Town County _ Post code __ Telephone __ Fax __ Email __ Grant Application Type of grant: Travel £ Training £ Title, location, date and brief details of conference, meeting or course and funding required. Date of event __ Depart __ Return _ Conference/Training fee Travel costs Subsistence Total £ __ £ __ £ __ £ Please give costs in £ sterling Background Information Experience in field to which this application is relevant Brief details of benefit to you and to your department Have you applied elsewhere for support for this work? No £ Yes £ If YES give details Support of Head of ...

Chronic Myeloid Leukaemia (CML) What is leukaemia ? Leukaemia is a cancer of cells in the bone marrow (the cells which develop into blood cells). Cancer is a disease of the cells in the body. There are many types of cancer which arise from different types of cell. What all cancers have in common is that the cancer cells are abnormal and do not respond to normal control mechanisms. Large numbers of cancer cells build up because they multiply 'out of control', or because they live much longer than normal cells, or both. With leukaemia , the cancerous cells made in the bone marrow spill out into the bloodstream. There are several types of leukaemia . Most types arise from cells which normal develop into white blood cells. (The word leukaemia comes from a greek work which means 'white blood'.) If you develop leukaemia it is important to know exactly what type it is. This is because the outlook ...

Mortality from Leukaemia (SMR) 2001-2003, All Ages Notes Mortality from leukaemia (ICD10 C91-C95) Indirectly standardised ratios (SMR) All ages 2001-03 (Pooled) England 2001-03 = 100 (Standard rates are England annual age-specific rates 2001-03) Data are based on the original underlying cause of death. Data are based on ONS population estimates (February 2005 release). Highlights At PCT level there was no significant difference in Leukaemia mortality from England. St Albans & Harpenden had the lowest ratio of Leukaemia mortality in Bedfordshire and Hertfordshire SHA, while Watford & Three Rivers PCT had the highest ratio of Leukaemia mortality in Bedfordshire and Hertfordshire SHA. For More Information Please Contact David Edwards, Public Health Intelligence Epidemiologist (david.edwards@phi-bedsherts.nhs.uk) Page 2 Source: National Statistics, ...

Adult Leukaemia Unit PERIPHERAL BLOOD STEM CELL (PBSC) HARVEST This information is written for anyone having a PBSC collection. We hope this leaflet and discussion with the Transplant Co-ordinators will help you to understand what the procedure involves. WHAT ARE PERIPHERAL BLOOD STEM CELLS? Stem cells are immature parent cells which live in the bone marrow. From these stem cells all of your red cells, white cells and platelets will develop. Stem Cells can be collected from the peripheral blood (PBCS Collection) and/or from the bone marrow (Bone Marrow Harvest). HOW ARE STEM CELLS ENCOURAGED INTO THE BLOOD STREAM? Only a few stem cells are found in the peripheral blood. So they need to be artificially mobilized or moved into your blood stream for them to be harvested. We use a combination of chemotherapy and/or growth factors (GCSF) to achieve this. Once collected, stem cells can be ...

Adult Leukaemia Unit TOTAL BODY IRRADIATION (TBI) What is Radiotherapy? This is a form of treatment which uses controlled x-rays to cause maximum damage to cancer cells. Radiotherapy is usually given in a number of small divisions or treatments called fractions over several days. The number of fractions used does not relate only to the seriousness of your disease, but depends on other factors, such as your age, general health and the specific cancer. For this reason the treatment is planned individually, and even with the same type of cancer, two people may not have identical treatment. You cannot see or feel radiotherapy and the treatment is painless. Radiotherapy does not make you radioactive and it is perfectly safe for you to be with other people, including children, throughout your treatment. What is Total Body Irradiation? Total body irradiation (TBI) is a form ...

Acta Dermatoven APA Vol 13, 2004, No 4 125 The multifunctional role of leukaemia inhibitory factor in cutaneous biology J. C. Szepietowski, A. Reich and R.C McKenzie Leukaemia Inhibitory Factor (LIF) is a polyfunctional cytokine, that belongs to the family of haemopoietic growth factors. LIF plays a role in growth-promotion and differentiation, regulates calcium and bone metabolism, induces acute phase proteins and causes cachexia in organisms with neoplastic disor- ders. LIF is also to be found in normal skin, where it may be involved in the differentiation process of keratinocytes. In addition, recent data in medical literature indicates that LIF is engaged in the patho- genesis of some skin disorders as well. It has been clearly demonstrated that LIF may act as a proinflammatory cytokine. In allergic contact dermatitis, the expression of LIF mRNA is augmented to a significant degree, ...

Guidelines on the diagnosis and management of chronic lymphocytic leukaemia Methods The purpose of this guideline is to provide a rational approach to the diagnosis and management of patients with chronic lymphocytic leukaemia (CLL). This guideline has been compiled by the Guidelines Working Group of the UK CLL Forum on behalf of the British Committee for Standards in Haematology (BCSH). Recommendations are based on a review of the literature using Medline/Pubmed searches under the heading, CLL, up to October 2003 and data presented at the American Society of Hematology in 2003 and at the 10th International Workshop on CLL in 2003. The results of meta-analyses and phase 3 studies that have been published or presented in abstract form are included. Treatment recommendations were influenced by current and proposed clinical trials in the UK and by guidance from The National Institute ...

Clinical Endocrinology (2004) 61 , 683–691 doi: 10.1111/j.1365-2265.2004.02149.x © 2004 Blackwell Publishing Ltd 683 Blackwell Publishing, Ltd. Survivors of childhood acute lymphoblastic leukaemia , with radiation-induced GH deficiency, exhibit hyperleptinaemia and impaired insulin sensitivity, unaffected by 12 months of GH treatment Birgitta Bülow, Katarina Link, Bo Ahrén, Ann-Sofie Nilsson and Eva Marie Erfurth Department of Medicine, Lund University, Lund, Sweden (Received 18 May 2004; returned for revision 28 June 2004; finally revised 13 August 2004; accepted 1 September 2004) Summary OBJECTIVE Adult survivors of childhood acute lym- phoblastic leukaemia (ALL) often exhibit GH deficiency (GHD), due to prophylactic cranial radiotherapy (CRT). It is not known whether the observed risk for adiposity in ...

49 AsPac J. Mol. Biol. Biotechnol., Vol. 12 (1&2), 2004 Detection of AML1/ETO transcript in AML Asia Pacific Journal of Molecular Biology and Biotechnology, 2004 Vol. 12 (1&2) : 49-52 *Author for Correspondence. Mailing address: Department of Haematology, School of Medical Sci- ences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan. Tel:609-7664139. Fax: 609-7653370. E.mail: roslin@kb.usm.my The Detection of AML1/ETO Fusion Transcript in Acute Myeloid Leukaemia in Universiti Sains Malaysia Hospital H. Rosline 1* , M. Y. Narazah 2 , I. Illunihayati 4 , M. N. Isa 2 , A. A. Baba 3 1 Departments of Haematology, 2 Human Genome Center, 3 Department of Medicine, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang ...