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IMPORTANT The following is a slide show presentation, presented by Dr. Richard Wakeford at the CHILDREN with LEUKAEMIA International Scientific Conference in London, September 2004. As such it is strictly the property of Dr. Richard Wakeford and may not be reproduced is any form without his express permission. Page 2 The Epidemiology of The Epidemiology of Leukaemia and other Cancers Leukaemia and other Cancers in Childhood after Exposure in Childhood after Exposure to Ionising Radiation to Ionising Radiation Richard WAKEFORD Richard WAKEFORD BNFL, Daresbury Park, Warrington, Cheshire, UK Page 3 Ionising Radiation and Cancer • It is beyond rational dispute that exposure to moderate and high levels of ionising ...

Leukaemia CARE Society - caring for sufferers of the leukaemias Hodgkin’s and other lymphomas • myelodysplasia • aplastic anaemia • 24hr CARE line 0800 169 6680 • Regional CARE Teams • Support Groups • Information and Booklets • Financial Assistance • Holiday Programme Leukaemia we are here to help When somebody is diagnosed with leukaemia , they feel scared and vulnerable. They need someone to talk to, they have many questions to ask and they need to find out what to do next. At such a distressing time, the Leukaemia CARE Society has members who can help, support and fulfil a vital role. The Leukaemia CARE Society, 2 Shrubbery Avenue, Worcester WR1 1QH. Tel: 01905 330003 Fax: 01905 330090 24-hour CAREline: 0800 169 6680 E-mail: info@leukaemiacare.org.uk Website: www.leukaemiacare.org.uk ...

THE NEW LIGHT OF MYANMAR Wednesday, 8 December, 2004 13 Well trained cat : Russian State Circus animal trainers perform with a cat during a show in Kolkata. —I NTERNET Wang Manli of China skates on the way to win the women's 500-metre of the ISU World Cup speedskating at M-Wave in Nagano, central Japan on 5 Dec, 2004. Wang clocked 38.13 seconds, the same time as Saying Osuga of Japan, to win the race. —I NTERNET Researchers say new leukaemia drugs working better W ASHINGTON , 7 Dec — Next-generation leukaemia pills, designed to help patients not cured by the successful drug Gleevec, work even better than doctors had hoped, researchers said recently. One new drug, made by Bristol-Mvers Squibb, put 80 per cent of patients who tried it into remission — meaning signs of their cancer disappeared, the re- ...

Promyelocytic leukaemia zinc finger protein (PLZF) binds with high affinity to the shaker-1 mutant of myosin VIIa, suggesting a novel function in the inner ear . Richard Hughes 1 , Fabien Guidez 2 , Steve Brown 3 , Jennifer Pinder 1 1. Randall Division for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, London SE1 1UL 2. Department of Medical and Molecular Genetics, Guy’s King’s and St. Thomas’ School of Medicine, 8th Floor Guy’s Tower, London SE1 9RT 3. MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, OX11 ORD, UK Myosin VIIa is found in the inner ear organ of Corti where it is required for stereocilia bundle organization. In mice, mutations in myosin VIIa are responsible for the shaker-1 deafness phenotype and, in humans, they result in Usher syndrome type 1B, a form of combined congenital deafness and blindness. ...

National Healthcare Group Annual Scientific Congress 2004 S4 Annals Academy of Medicine Bone Marrow Transplantation for Leukaemia – Current Status and Strategies for Improvement † FR Appelbaum, 1 MD 1 Fred Hutchinson Cancer Research Center and University of Washington Medical Center, Seattle, Washington, USA Address of Correspondence: Frederick R. Appelbaum, MD, Director, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, N., D5-310 P.O. Box 19024, Seattle, WA 98109-1024, USA Email: fappelba@fhcrc.org † This work was supported, in part, by grants number CA 18029 and CA 15704 from the National Institutes of Health, DHHS Introduction Over the last 35 years, bone marrow transplantation (BMT) has evolved from a highly experimental therapy to a well-established treatment used in the management ...

Acute Myeloid Leukaemia (AML) What is leukaemia ? Leukaemia is a cancer of cells in the bone marrow (the cells which develop into blood cells). Cancer is a disease of the cells in the body. There are many types of cancer which arise from different types of cell. What all cancers have in common is that the cancer cells are abnormal and do not respond to normal control mechanisms. Large numbers of cancer cells build up because they multiply 'out of control', or because they live much longer than normal cells, or both. With leukaemia , the cancerous cells in the bone marrow spill out into the bloodstream. There are several types of leukaemia . Most types arise from cells which normally develop into white blood cells. (The word leukaemia comes from a greek work which means 'white blood'.) If you develop leukaemia it is important to know exactly what type it is. This is because the outlook (prognosis) ...

A genome scan of 18 families with chronic lymphocytic leukaemia Lynn R. Goldin, 1 Naoko Ishibe, 1 Maria Sgambati, 1 Gerald E. Marti, 2 Laura Fontaine, 1 Maxwell P. Lee, 3 Jenny M. Kelley, 3 Titia Scherpbier, 3 Kenneth H. Buetow 3 and Neil E. Caporaso 1 1 Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 2 Flow and Image Cytometry Section, Division of Cell and Gene Therapies, Center for Biologics Research and Evaluation, Food and Drug Administration, and 3 Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA Received 25 November 2002; accepted for publication 14 January 2003 Summary. Chronic ...

Detecting small area similarities in the epidemiology of childhood acute lymphoblastic leukaemia and type 1 diabetes: a Bayesian approach Richard G Feltbower 1* , Samuel OM Manda 2 , Mark S Gilthorpe 2 , Roger C Parslow 1 and Patricia A McKinney 1 . 1 Paediatric Epidemiology Group and 2 Biostatistics Unit, Unit of Epidemiology and Health Services Research, University of Leeds, 30 Hyde Terrace, Leeds, LS2 9LN, UK. * Tel +44(0)113 343 4841, fax +44(0)113 343 4877, Email r.g.feltbower@leeds.ac.uk. Summary Childhood acute lymphoblastic leukemia (ALL) and type 1 diabetes have common epidemiological and etiological features including correlated international incidence and associations with infections. We tested whether their similar large-scale distributions are reflected ...

Non-occupational exposure to pesticides and childhood acute leukaemia Florence Menegaux and Jacqueline Clavel INSERM U170-IFR69, 16 av. Paul Vaillant Couturier, 94800 Villejuif, France Tel: 33 1 45 59 51 53 – Fax: 33 1 45 59 51 51 – E-mail: menegaux@vjf.inserm.fr Summary The present study, which included 280 cases of acute leukaemia and 288 controls, investigated the relationship between childhood acute leukaemia (AL) and non-occupational exposure to pesticide during pregnancy and childhood. Acute leukaemia was associated to home insecticide use during pregnancy and during childhood (OR=1.8 [1.2-2.8], OR=1.7 [1.1-2.4], respectively) and garden insecticide use during childhood (OR=2.1 [1.1-4.0]). The association was more pronounced when garden insecticide was used during both pregnancy and childhood (OR=2.9 [1.1-7.3]). Lice infestation of the index child was also associated with ...

Time trends in childhood leukaemia incidence Michel P Coleman Anjali Shah Non-Communicable Disease Epidemiology Unit London School of Hygiene and Tropical Medicine Keppel Street London WC1E 7HT Page 2 Time trends in childhood leukaemia incidence Leukaemia is the most common malignancy in children under the age of 15 years, representing about a third of all new cases 1 . Some 480-500 children under 15 are diagnosed in Britain each year, and about 100 die of it. Four out of five cases of leukaemia in children are of acute lymphoblastic (or lymphoid) leukaemia (ALL), and the remainder are almost all acute myeloid leukaemia (AM) 2 . Leukaemia is about 10% more common in boys than girls. It is useful to examine of trends over time in the occurrence of new cases (incidence) and deaths (mortality), and how these measures ...

Childhood leukaemia and electromagnetic radiation – a review of epidemiological studies Anders Ahlbom, Ph D Professor of epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm , Sweden E-mail: anders.ahlbom@imm.ki.se Risk factors for childhood leukaemia are largely unknown. The only established external risk factor is ionizing radiation. For quite a number of other environmental factors it has been hypothesized that they might play a role in the origin or development of the disease and a substantial number of such hypotheses have been tested epidemiologically. While increased disease risks have been seen for several of these exposures, the results have not been consistent enough for firm conclusions about causality to be drawn. The exposures that have been looked at have concerned exposure to the child itself, exposure in utero, and also maternal and even paternal ...

March 2004 151 139 228 72 PB 359 155 580 74 PB 36 8 65 4 BM + PB 565 236 1635 381 BM 3 3 1 1 BM + PB 1142 145 2644 82 PB HLA identical Sibling ALLO AUTO Family Mismatch Unrelated Donor 119 326 112 131 Unrelated CB * 30 19 26 6 BM + PB 100 117 120 38 BM 909 990 988 253 BM 1534 1187 2706 584 BM 95 12 397 24 BM + PB 1165 320 3378 216 PB ADULTS CHILDREN ADULTS CHILDREN ...

Biochem. J. (2004) 383 , 27–35 (Printed in Great Britain) 27 Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia Ngai CHEUNG*, Chi Wai SO†, Judy W. P. YAM*, C. K. C. SO*, Randy Y. C. POON‡, Dong-Yan JIN§ and Li Chong CHAN* 1 *Department of Pathology, University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China, †Department of Pathology, Stanford University, Palo Alto, CA, U.S.A., ‡Department of Biochemistry, University of Science and Technology, Hong Kong, People’s Republic of China, and §Department of Biochemistry, University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China EEN (extra eleven nineteen), also known as EA2 (endophilin A2), a fusion partner of the MLL (mixed-lineage leukaemia ) gene in human acute leukaemia , is a member of the endophilin A family, involved in the formation of endocytic vesicles. We present evid- ...

Project Timescale Stakeholders Involved Brief Summary Community Brainstorm regarding alleged Leukaemia Clusters in South Newbury 1997 Concerned local people, media and local government representatives from South Newbury For a number of years prior to this work, there had been significant public concern in South Newbury about an alleged cluster of leukemia cases in the area. Local people played a fundamental part in identifying the occurrence of a cluster and, after notifying the local health authority about their concerns, an investigation led to the discovery of a statistically significant cluster. The Head of Environmental Health in Newbury District Council at the time recognized that a facilitated meeting would offer the best opportunity and most effective way of hearing local concerns regarding the possible causes for the cluster. LINK: http://www.the-environment-coun...

Section 4 – Your Child’s Diagnosis – Acute Myeloid Leukaemia Page 1 of 4 Acute Myeloid Leukaemia What is Acute Myeloid Leukaemia ? Leukaemia is a disease of the white blood cells (WBC). All blood cells are produced in the bone marrow and originate from stem cells. The following is a simple diagram showing how stem cells develop into the two forms of white cells: the myeloid line and lymphoid line. Stem Cell Myeloid Line Lymphoid Line Neutrophils T lymphocyte B lymphocyte There are two main types of WBC, lymphocytes and Neutrophils. Neutrophils develop from immature cells of the myeloid line. If the myeloid cells become cancerous the type of leukaemia is called Myeloid Leukaemia . In leukaemia the bone marrow produces large numbers of these abnormal white blood cells. These abnormal, immature white blood cells are called blasts. They ...

Section 4 – Your Child’s Diagnosis – Acute Lymphoblastic Leukaemia Page 1 of 3 Acute Lymphoblastic Leukaemia What is Acute Lymphoblastic Leukaemia (ALL)? Leukaemia is a cancer of the white blood cells. About 85% of children with leukaemia have A cute L ymphoblastic L eukaemia . This is a cancer of immature lymphocytes (a type of white cell) called lymphoblasts or blast cells. The blast cells accumulate in the blood and crowd out the other blood cells such as the red blood cells, other white blood cells and platelets. The number of these good cells in the circulating blood becomes greatly reduced. This means the remaining red blood cells cannot transport enough oxygen to the body’s tissues and organs. The other white blood cells cannot fight infections and the platelets cannot ‘plug’ all the leaks in the blood vessels. What are the symptoms? A patient with leukaemia ...

Periodic chronic myelogenous leukaemia : spectral analysis of blood cell counts and aetiological implications P ASCAL F ORTIN AND M ICHAEL C. M ACKEY * Departments of Physiology and Physics and * Departments of Physiology, Physics and Mathematics, Centre for Nonlinear Dynamics, McGill University, Montreal, Canada Received 23 June 1998; accepted for publication 23 October 1998 Summary. Of 24 published clinical reports of periodic chronic myelogenous leukaemia (PCML), 21 had sufficient data to analyse for periodicity, and 12 showed significant periodicity ( p 0·05) using the Lomb periodogram. Leuco- cyte oscillations had periods T ranging from 37 to 83 d. When data were also reported for platelets and reticulocytes there was no significant difference between their periods and those of the leucocytes. These data and ...

a report by Professor Martin J S Dyer Professor of Haemato-Oncology and Honorary Consultant Physician, Medical Research Council (MRC) Toxicology Unit, University of Leicester Risk Stratification in the Treatment of Chronic Lymphocytic Leukaemia B U S I N E S S B R I E F I N G : E U R O P E A N P H A R M A C O T H E R A P Y 2 0 0 5 1 Reference Section Martin J S Dyer is Professor of Haemato-Oncology and Honorary Consultant Physician in the Medical Research Council (MRC) Toxicology Unit at the University of Leicester. His research interests are the antibody therapy and molecular genetics of B-cell malignancy. He worked for 11 years at the Royal Marsden Hospital with Professor Daniel Catovsky, following his training in medicine at Oxford and Cambridge Universities in the UK. Introduction One of the greatest medical ...

The Ulster Medical Journal, Volume 71, No. 1, pp. 72-75, May 2002. Case Report Acute B Cell Lymphoblastic Leukaemia and Human Immunodeficiency Virus Infection (HIV) J Hamilton, M McBride, P Kettle Accepted 24 April 2002 Highly active anti-retroviral therapy (HAART) and prophylactic therapy for opportunistic infection have significantly improved the survival and quality of life for patients infected with the Human Immunodeficiency Virus (HIV). 12 Lymphoproliferative disease complicates the clinical course of HIV infection in approximately 10% of patients and the incidence of Non Hodgkins Lymphoma is 60-200 times more common than the general population. 34 Diffuse large B cell lymphoma, Burkitt's Lymphoma, Burkitt like Lymphoma and Primary Cerebral Lymphoma are the most common subtypes with Hodgkins Disease, Plasmacytoma and Body ...

IJTCVS Karthik et al 93 2004; 20: 93–94 AML after oesophagectomy Chest radiograph revealed diffuse bilateral fluffy shadows. He also developed atrial fibrillation which responded to cardioversion and amiodarone. Despite various interventions his condition continued to deteriorate over the next two days. He developed renal failure and required haemofiltration. He developed pyrexia with a steep rise in the white blood count. From a pre-operative level of 11.0x10 6 /ml, the white cell count rose to 27.5 on the first post- operative day and from thereon in a dramatic fashion to 69, 99, 149.7 and finally to over 250x10 6 /ml. Initially, this was considered as a response to sepsis. However, as the rise continued, the possibility of leukaemoid reaction or acute leukaemia were considered. His peripheral smears were reviewed. The preoperative smears ...

Australian Dental Journal 2003;48:3. 195 Acute leukaemia presenting as oral ulceration to a dental emergency service AK Dean,* JW Ferguson,† ES Marvan‡ Abstract Leukaemia is a neoplastic disease characterized by an excessive proliferation of immature white blood cells and their precursors. Oral lesions may be the presenting feature of acute leukaemias, which can be rapidly fatal if left untreated. This report describes the case of a 22-year-old female who presented to a dental emergency department with oral manifestations of acute leukaemia . It outlines the role of oral lesions in the diagnosis of acute leukaemias and emphasizes the importance of immediate referral by general dental practitioners. Key words: Acute leukaemia , oral ulceration, oral manifestations. (Accepted for publication 9 November 2001.) The leukaemias ...

Our research programme funds more than 120 projects at universities and hospitals across the UK, and we need £20 million a year to keep making progress in the fight against these deadly diseases. Our research is innovative and exciting, involving DNA, molecular biology, gene therapy, cutting-edge technology and more. Our goal is to ensure that everyone with leukaemia and the other blood cancers makes a full recovery. LEUKAEMIA R E S E A R C H Animal experiments, medical advances and Leukaemia Research Leukaemia Research Fund 43 Great Ormond Street London WC1N 3JJ Registered Charity 216032 020 7405 0101 www.lrf.org.uk The aim of our research is to conquer life-threatening diseases and alleviate suffering. What is leukaemia ? Leukaemia is often referred to as blood cancer. It occurs when massive numbers of rogue white blood ...

DANIS H ME DI CA L BUL L E T I N VO L . 51 NO . 27/ M A Y 2004 223 ABSTRACT OF PhD DISSERTATION Aspects of the natural history of childhood leukaemia Lisa Lyngsie Hjalgrim This PhD dissertation was accepted by the Faculty of Health Sciences of the University of Copenhagen, and defended on March 19, 2004. Official opponents: Mikael Rørth, Jørgen H. Olsen, and Steen Rosthøj. Supervisors: Kjeld Schmiegelow and Mads Melbye. Correspondence: Lisa Lyngsie Hjalgrim, Søvangs Alle 12, DK-3500 Værløse. E-mail: lih@ssi.dk Dan Med Bull 2004;51:223. ABSTRACT The studies included in this PhD dissertation were carried out at the Department of Epidemiology Research, Statens Serum Institut, and focus on characterising the occurrence of childhood leukaemia , tim- ing of critical genetic events involved in childhood leukaemia devel- ...

DANIS H ME DI CA L BUL L E T I N VO L . 51 NO . 2/ M A Y 2004 225 ABSTRACT OF PhD DISSERTATION Molecular changes in acute myeloid leukaemia Towards a framework for prognostication Lene Hyldahl Olesen This PhD dissertation was accepted by the Faculty of Health Sciences of the University of Aarhus, and defended on Marts 19, 2004. Official opponents: Torben Palshof, Ove Juul Nielsen and David Grimwade, United Kingdom. Tutor: Peter Hokland, Jan Maxwell Nørgaard and MSc Per Guldberg. Correspondence: Lene Hyldahl Olesen, Department of Haematology, Aarhus Sygehus, DK-8000 Aarhus C. E-mail: lene.hyldahl.olesen@aas.auh.dk Dan Med Bull 2004;51:225. ABSTRACT The present PhD dissertation was carried out at the Department of Haematology, University of Aarhus, Aarhus, Denmark, and is based on three publications and an ...

Haema 2004; 7(3): 363-365 Case report Extramedullary involvement in a case of acute myelomonocytic leukaemia Sotirios Papageorgiou 1 , Theofanis Economopoulos 1 , Panteleimon Kountourakis 1 , Dimitra Rontogianni 2 , Efstathios Papageorgiou 1 and Sotirios Raptis 1 1 Second Department of Internal Medicine, Propaedeutic, Athens University, Áttikon Hospital, 2 Pathology Department, Evangelismos Hospital, Athens, Greece Abstract. Granulocytic sarcomas (chloromas) are tumor masses of immature myeloid cells occurring in an extramedullary site. Organ involvement by granulocytic sarcomas has been documented to be extremely variable. We describe an unusual case of acute myeloid leukaemia in a 58-year-old male presenting with a painless mass in the left neck and leukocytosis. Further ...

Guidelines on the diagnosis and management of chronic lymphocytic leukaemia Methods The purpose of this guideline is to provide a rational approach to the diagnosis and management of patients with chronic lymphocytic leukaemia (CLL). This guideline has been compiled by the Guidelines Working Group of the UK CLL Forum on behalf of the British Committee for Standards in Haematology (BCSH). Recommendations are based on a review of the literature using Medline/Pubmed searches under the heading, CLL, up to October 2003 and data presented at the American Society of Hematology in 2003 and at the 10th International Workshop on CLL in 2003. The results of meta-analyses and phase 3 studies that have been published or presented in abstract form are included. Treatment recommendations were influenced by current and proposed clinical trials in the UK and by guidance from The National Institute ...

© JAPI • VOL. 52 • MAY 2004 www.japi.org 423 Case Report Myelodysplasia and Acute Myeloid Leukaemia in a Case of Rheumatoid Arthritis with Secondary Amyloidosis Treated with Chlorambucil C Balakrishnan*, E Pathan*, S Khodaiji**, A Dasgupta**, G Mangat*, VR Joshi* Abstract Immunosuppressive therapy related secondary haematologic malignancy is well reported. A 52 years lady with established rheumatoid arthritis developed reactive amyloidosis. This was initially treated with colchicine and cyclophosphamide and later with chlorambucil. Ten months after stopping chlorambucil she developed pancytopenia and vitamin B12 deficient megaloblastic anaemia. The pancytopenia was refractory to vitamin B12 supplements and a repeat bone marrow confirmed myelodysplasia (FAB1 RAEB-T). Within three weeks of this diagnosis she evolved into acute myeloid leukaemia and expired due to refractory thrombocytopenia ...

College of Medicine and Health Sciences The Fourth Annual U.A.E. University Research Conference MHS - 32 Protein Phosphorylation in Leukaemia Cells: Expression Profiles and Cell Dynamics Kate Hammond, Department of Biochemistry, E-mail: katehmnd@uaeu.ac.ae M M Qureshi, Department of Biochemistry , U.A.E. University, Al-Ain, P.O. Box: 17555, U.A.E. S Madjarevic, Department of Molecular Medicine and Haematology, University of the Witwatersrand, South Africa 1. INTRODUCTION The presence of phosphate in protein molecules was known a century ago, but only in recent years was its vital functional importance recognized, and now more and more phosphate- containing proteins, protein kinases and phosphoprotein phosphatases continue to be identified at an ever-increasing rate. Initially it was thought that the only possible targets for phosphorylation ...

Proceedings of the TTT2005 Academic Conference - 14 - The Effect of Arsenic Trioxide (ATO) on Human Leukaemia Cells Annie Hung-Hsin Liu Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan; Genomics Research Centre, School of Health Sciences and School of Biomolecular and Biomedical Sciences, Griffith Uiversity, Australia ABSTRACT Studies into the effects of toxins on cancer cells provide clues on how to induce apoptosis of malignant cells. Arsenic Trioxide (ATO) may be effective in inducing apoptosis in rapidly dividing cells. Arsenic compounds have been used in traditional Chinese medicine for thousands of years. Commonly known as a poison, it is also used to treat a variety of ailments from syphilis to cancer. The Food and Drug Administration (FDA) approved ATO for treatment against acute promyelocytic leukaemia (APL) in 2000 (Food and Drug Administration ...

This booklet is for you if you or someone close to you has Acute Lymphoblastic Leukaemia (ALL). The information in this booklet represents an agreed view on ALL, its diagnosis and management, and the key aspects of living with it. It has been prepared and checked by doctors, other relevant specialists, nurses and patients. The booklet had been designed so it can be used by many hospitals but each hospital may have its own guidelines or restrictions that are not mentioned here. Please ask your own doctor or nurse if you have any questions. If you are a patient, your doctor or nurse may wish to go through this booklet with you and mark sections that are particularly important for you. You can make a note below of the contact names and information that you may need quickly. Acute Lymphoblastic Leukaemia Understanding Specialist nurse/contact names Hospital Phone Treatments ...