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National Cancer Institute SEER Program 68 LIVER AND INTRAHEPATIC BILE DUCT P rimary cancers of the liver and intrahepatic bile ducts are far more common in regions of Africa and Asia than in the United States, where they only account for about 1.5% of all cancer cases. Five-year survival rates are very low in the United States, usually less than 10%. Reported statistics for these cancers often include mortality rates that equal or exceed the incidence rates. This discrepancy (more deaths than cases) occurs when the cause of death is misclassified as “ liver cancer ” for some patients whose cancer originated as a primary cancer in another organ and spread (metastasized) to become a “secondary” cancer in the liver . Non-Hispanic white men and women have the lowest age-adjusted incidence rates ...

A714-Test slide, Liver cancer tissues with corresponding normal tissues (formalin fixed) For research use only Specifications: • No. of cases: 6 • Tissue type: Test slide, Liver cancer tissues with corresponding normal tissues • No. of spots: 6 spots from each cancer case (6 spots) 6 non-neoplastic spots (6 spots) •Total spots: 12 • Corresponding normal tissues with cancers: Yes • Diameter: 1. 0 mm Documents : • Product specification: layout, summary of tissue spots • H&E stained images • Detailed pathological information Layout: Page 2 A714-Test slide, Liver cancer tissues with corresponding normal tissues (formalin fixed) For research use only Summary of tissue spots No Sex Age Key word 1 A 1 m 67 ...

A204: Liver cancer tissues - Hepatocellular carcinoma (formalin fixed) For research use only Specifications: •No. of cases: 35 •Tissue type: Liver cancer tissues – Hepatocellular carcinoma •No. of spots: 2 spots from each cancer case (70 spots) 4 non-neoplastic spots (4 spots) •Total spots: 74 •Corresponding normal tissues with cancers: Yes •Diameter: 1.0 mm Documents: •Product specification: layout, summary of tissue spots •H&E stained images •Detailed pathological information Layout: Page 2 Summary of tissue spots A204 : Liver cancer tissues - Hepatocellular carcinoma (formalin fixed) For research use only No. Sex Age KeyWord E-S grade* TNM Stage 1 1, 2 f 48 hepatocellular carcinoma I T2NxM0 ...

A205 : Liver cancer tissues - Cholangiocarcinoma (formalin fixed) For research use only Specifications: •No. of cases: 46 •Tissue type: Liver cancer tissues – Chalangicarcinoma •No. of spots: 2 spots from each cancer case (92 spots) 4 non-neoplastic spots (4 spots) •Total spots: 96 •Corresponding normal tissues with cancers: No •Diameter: 1.0 mm Documents: •Product specification: layout, summary of tissue spots •H&E stained images •Detailed pathological information Layout: Page 2 Summary of tissue spot A205 : Liver cancer tissues - Cholangiocarcinoma (formalin fixed) For research use only No Sex Age KeyWord Grade TNM Stage 1 1, 2 f 73 Cholangio ca. G1 T1N0M0 (I) 2 3, 4 ...

Mefenamic acid-induced apoptosis in human liver cancer cell-lines through caspase-3 pathway Dong Ho Woo a , In-Seob Han b , Guhung Jung a, * a School of Biological Sciences, Seoul National University, Seoul 151-742, South Korea b Department of Biological Science, University of Ulsan, Ulsan 690-749, South Korea Received 8 October 2003; accepted 15 April 2004 Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) have anti-proliferative effects and induce apoptosis in colon and other cancers. In the present study, we report that mefenamic acid (MEF), a member of NSAIDs, has an inhibitory effect on a proliferation of liver cancer cells. We used Chang and Huh-7 cells as human liver cancer cells. MEF-treated Huh-7 and Chang cells displayed apoptotic morphological changes and the portion of cells in sub G1 was ...

LIVER CANCER Cancer Contr ol Cancer Control Bulletin Issue 30 • January/February 2003 Information for GPs LIVER CANCER SOUTH EAST HEALTH Hepatocellular carcinoma (HCC) and colorectal liver metastases are the most common types of tumours in the liver treated in South Eastern Sydney. Hepatocellular carcinoma In Australia, HCC is a relatively rare cancer , accounting for 1.4% of cancer deaths. Males are 3 times more likely to be diagnosed with primary liver cancer as females and 3.6 times as likely to die from the disease. The incidence of HCC has trebled in the last 20 years, mainly due to the spread of hepatitis B and C virus (HBV and HCV). Five-year survival has improved only marginally in that time and is currently 8% for males and 11% for females. HCC is endemic in developing countries, where three-quarters ...

Center for Environmental Health Studies (617) 482-9485 44 Farnsworth Street, Boston, MA 02210 http://www.jsi.com Liver Cancer and Exposure to Ionizing Radiation 1 Liver Cancer and (including intra-hepatic bile duct) Exposure to Ionizing Radiation Summary: Moderately strong evidence has been recorded of a possible connection between liver cancer deaths and exposure to ionizing radiation. This evidence is based upon studies conducted at Los Alamos National Laboratory, studies of nuclear workers at other sites, and others exposed to ionizing radiation. These findings are consistent with the National Research Council’s determination that the liver is sensitive to ionizing radiation. Liver cancer is designated as a “specified” cancer under the Energy Employees Occupational Illness Compensation Program Act. Historically, incidence of ...

The 1996-2000 average annual age-adjusted incidence rate for invasive cancers of the liver and intrahepatic bile duct was almost three times higher in males than in females (6.8 compared to 2.4 per 100,000), and blacks of both sexes had higher rates compared to whites. There were 708 cases of liver /intrahepatic bile duct cancers diagnosed and reported among residents of Pennsylvania for 2000 – the highest annual figure recorded between 1991 and 2000. The annual age-adjusted incidence rates by sex and race for ten years (1991 through 2000) showed increasing rates among males, especially black males, and females of both races. The 1996-2000 average annual age-specific incidence rates show that black males have had the highest risks. During the period of 1996-2000, over 62 percent of the cases were diagnosed among residents 65 years of age or older. In 2000, over 57 percent of the staged liver /intrahepatic bile duct cancers were ...

Illustrations and/or unpublished data in these reports should not be used without permission of the author. HEPATITIS VIRUSES AND LIVER CANCER WILLIAM S. MASON, Ph.D., Senior Member; Research Associate Professor of Microbiology, University of Pennsylvania GLORIA MORALEDA, a Ph.D., Postdoctoral Associate (until May 1997) YUAO ZHU, Ph.D., Postdoctoral Fellow (from December 1997) MENG-CHE YEH, b MD., Graduate Student, University of Pennsylvania (until June 1997) TIANLUN ZHOU, MD., Graduate Student, University of Pennsylvania YING QIAN, Bristol-Myers Squibb Fellow, Yale University, New Haven, CT (June–August 1997) CAROL E. ALDRICH, Scientific Assistant JEFFRY SAPUTELLI, Scientific Technician Hepatitis ...

Last revised: 4/21/05 UM Cancer Center Patient Education Document #0032 Apr05 Ed. Online version: http://www. cancer .med.umich.edu/learn/percpathways.htm University of Michigan Comprehensive Cancer Center Patient Education Resource Center (PERC) INFORMATION GUIDE Liver Cancer The purpose of this information guide is to help patients newly diagnosed with Liver Cancer and their families to find sources of information and support. This list is not meant to be comprehensive, but rather to provide starting points for information seeking. The materials can be found at the Patient Education Resource Center at the University of Michigan Comprehensive Cancer Center in room B1-361. Brochure Available free at the Patient Education Resource Center on Level B-1 National Cancer Institute. What You Need To Know About: ...

Last Revised: 3/18/2005 UM Comprehensive Cancer Center Patient Education Document # 0015 Mar05 Ed. Online version: http://www. cancer .med.umich.edu/learn/percpathways.htm University of Michigan Comprehensive Cancer Center Patient Education Resource Center (PERC) INFORMATION GUIDE Childhood Cancer : Liver Cancers The purpose of this information guide is to help parents of children newly diagnosed with liver tumors find sources of information and support. This list is not meant to be comprehensive, but rather to provide starting points for information seeking. The materials can be found at the Patient Education Resource Center at the University of Michigan Comprehensive Cancer Center in room B1-361. Book Chapters Available for loan in the Patient Education Resource Center on level B1 room 361 Janes-Hodder, Honna ...

A BASIC INFORMATION DESCRIPTION Uncontrolled growth of malignant cells in the liver . Liver cancer may be primarily resulting from abnormal liver or bile-duct cells, or it may result from spread of cancer from another site (metastases). The most com- mon sources are cancers of the rectum, colon, lung, breast, pancreas, esophagus or skin (malignant melanoma). Liver cancer can affect all ages, but is most common in men over 60. FREQUENT SIGNS AND SYMPTOMS • Loss of appetite and weight loss. • Tender mass in the right upper abdomen. • Pain in the upper abdomen. • Low fever, usually less than 101°F (38.3°C). • Yellow eyes and skin (sometimes). • Swollen abdomen from fluid retention (sometimes). • Lethargy. CAUSES Unknown. It occurs most often in population groups with a high incidence of viral hepatitis and other chronic liver ...

Liver cancer Liver cancer can be a primary cancer (starts in the liver ) or a secondary cancer (starts in another part of the body and spreads to the liver ). Primary liver cancer is one of the less common cancers in Victoria. Secondary liver cancers are the most common liver cancers. Liver cancer usually has no symptoms in the early stages. Functions of the liver The liver is the largest organ inside the body. It is located on the right hand side of the abdomen and is protected by the ribcage. The liver will function normally with only a small portion of it in working order. Its functions include: • Destroying harmful substances, such as alcohol, and getting rid of waste products. • Converting food containing fats and sugars to be used by the body for energy. • Producing bile to help ...

When cells in the liver become abnormal, grow out of control and form a cancerous tumor, the disease is called primary liver cancer , also known as malignant hepatoma or hepatocellular carcinoma. (“Hepato” means “ liver .”) Primary liver cancer is not the same disease as cancer that spreads (metastasizes) to the liver from another part of the body (secondary liver cancer ). The liver is often the site of secondary tumors that result from the spread of cancer from another organ, such as the colon or breast. The cancer cells in the secondary tumor are like those of the original cancer , the primary cancer , which is named for the part of the body in which it began. Thus, cancer that begins in the colon or breast and spreads to the liver is called metastatic colon cancer or metastatic breast cancer . What are ...

Any State 30 Year Fixed Rate Boston.com home News wires Northeast Nation Washington World Sports Business Technology Education Health Regional news All Northeast Massachusetts New Hampshire Rhode Island Maine Vermont Connecticut New York [ Send this story to a friend | Easy-print version ] Stanford Researcher Identifies Genes Pointing to Liver Cancer ; Advocates Screening for Asian Populations By Ascribe, 6/4/2002 14:37 STANFORD, Calif., June 4 (AScribe Newswire) -- Cancerous liver cells rely on a different set of genes than normal liver cells in order to function. Now researchers at Stanford University Medical Center have identified genes needed by cancerous liver cells but ignored or used at different ...

Fox Chase Cancer Center 2003 Scientific Report 1 Clearance of Infected Hepatocytes During the Resolution of a Transient Hepadnavirus Infection. Mason, Aldrich, Saputelli, in collaboration with Summers, a Jilbert b Hepadnavirus infections in adults normally clear after a few months. Prior to clearance, every hepatocyte may be infected. Infection of every hepatocyte may also characterize chronic infections but, in this case, the immune response causes a persistent disease without clearing the virus. A goal of our research is therefore to characterize how virus is elimi- nated during resolution of transient infections and, in the long term, whether this same pro- cess can be induced, to cure chronic infections. To study the fate of infected hepatocytes during a transient infection, we infected woodchucks with woodchuck hepatitis virus ...

Fox Chase Cancer Center 2004 Scientific Report 1 Clonal Expansion of Hepatocytes During Chronic Infection with Woodchuck Hepatitis Virus. Mason, in collaboration with Jilbert, a Summers b Hepadnaviruses can cause chronic life-long infections of the liver . Within the liver , the viral target is the hepatocyte. Hepatocytes comprise a self-renewing cell population with a very low rate of turnover. Infection of hepatocytes is associated with persistent viral replication and shedding of virus into the blood stream. How- ever, infection is not cytopathic. Persistent liver injury leading to cirrhosis and hepatocellular carcinoma results instead from chronic hepati- tis caused by the immune response to viral antigens, with an elevated rate of death and compensatory proliferation within the hepato- cyte population. In this ...

Fox Chase Cancer Center 2001 Scientific Report EPIDEMIOLOGY, PATHOGENESIS, AND PREVENTION OF HEPATITIS B VIRUS INFECTION AND LIVER CANCER W. Thomas London, M.D., Senior Member; Adjunct Professor of Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine Anna P. O’Connell, A.B., Staff Scientist Manette Fine, D.O., Research Physician Malick Diene,* M.D., Visiting Scientist, Army Health Service, Dakar, Senegal Mouhamadou Mbengue, M.D., Visiting Scientist, Army Health Service, Dakar, Senegal Gang Chen, M.D., Ph.D., Research Associate Joyce Atleson, R.N., B.F.A., Nurse Coordinator Gail Duncan, B.S., Scientific Assistant Lora Pasternak, B.S., Research Specialist Kathleen Gillespie, Data Technician Diane Faison, Scientific Technician Kimberly Newman-McCown, Scientific Technician ...

Fox Chase Cancer Center 2002 Scientific Report Clearance of Infected Hepatocytes During the Resolution of a Transient Hepadnavirus Infection. Mason, Aldrich, Saputelli, Zhu, a in collaboration with Litwin, § Jilbert, b Summers c Hepadnavirus infections in adults normally clear after a few months. Prior to clearance, every hepatocyte may be infected. Infection of every hepatocyte may also characterize chronic infections but, in this case, the immune response allows a persistent disease without clearing the virus. A goal of our research is therefore to characterize how virus is elimi- nated during resolution of transient infections and, in the long term, whether this same pro- cess can be induced, to cure chronic infections. To study the fate of infected hepatocytes during a transient infection, we infected wood- ...

Fox Chase Cancer Center 2001 Scientific Report Depletion of WHV Replication Intermediates Via a By-stander Effect in a Transgenic Mouse. Song, Zhou, d Mason, in collaboration with Jilbert, e Seeger, § Sigal, § Rall § Previous studies from us and others have revealed that clearance of transient hepatitis B virus (hepadnavirus) infections must initiate with a shut down of virus replication within infected cells. Moreover, experiments with HBV transgenic mice have shown that cytok- ines elaborated by the immune system can induce a rapid degradation of intermediates in hepadnavirus replication, effectively shutting down virus production, without producing any damage to the infected cell. For example, INF ? and TFN a , produced in response to infection of only a few percent ...

332 Population Science Division Gender and Risk of Hepatocellular Carcinoma in the Haimen City Cohort. Chen, London, in collaboration with Evans,§ Ross, § Balshem, § Shen, b Lin, c Fan, d Haimen City Cooperating Group Haimen City is located on the north bank of the Yangtze River, about 50 miles west of Shanghai, P.R. China. It is primarily an agricul- tural area, but does have small factories widely distributed among all the villages and town- ships. About 75% of the one million inhabitants are farmers. HCC has long been known to be a major medical and public health problem in this community. In order to identify the specific environmental, viral and genetic factors that may affect risk of HCC and the interaction of such factors, a prospective study was initiated in Haimen City between ...

Population Science Division 329 EPIDEMIOLOGY, PATHOGENESIS, AND PREVENTION OF HEPATITIS B VIRUS INFECTION AND LIVER CANCER W. Thomas London, M.D., Senior Member; Adjunct Professor of Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine Anna P. O’Connell, A.B., Staff Scientist Manette Fine, D.O., Research Physician Malick Diene, M.D., Visiting Scientist, Army Health Service, Dakar, Senegal Gang Chen, M.D., Ph.D., Postdoctoral Associate Long-Long Gao, M.D., Graduate Student, University of Pennsylvania School of Medicine Marla Snyder, B.A., Research Data Coordinator Joyce Atleson, R.N., B.F.A., Nurse Coordinator Gail Duncan, B.S., Technical Specialist Lora Pasternak, B.S., Research Specialist Kathleen Gillespie, Data Technician Diane Faison, Scientific Technician Jeffry ...

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research for a cure laboratory without walls National Foundation for Cancer Research Cancer FAQs about liver cancer Frequently Asked Questions about common cancers. Page 2 Cancer FAQs What are the different types of liver cancer ? There are many kinds of tumors than can originate in the liver . Of the four main types that are cancerous (angiosarcomas, cholangiocarcinomas, hepatoblastomas, and hepatocellular carcinomas), hepatocellular carcinoma (also called hepatoma or HCC), is by far the most common, accounting for about 84 percent of all liver cancer cases. HCC starts growing in the hepatocytes, the main type of cell found in the liver . What are the risk factors for liver cancer ? A risk factor is anything that increases a person’s chance of getting a disease. There are ...

PROFILE JANUARY 2005 22 SCHOLARLY ACTIVITIES SCHOLARLY ACTIVITIES New drug against liver cancer L iver cancer , also known as Hepatocellular Carcinoma or HCC is one of the five most common human cancers in the world and the second leading cause of cancer death in Hong Kong. A joint research team formed among our Department of Applied Biology and Chemical Technology, HKU’s Centre for the Study of Liver Disease and a commercial partner, has broken new ground in developing a drug to fight against liver cancer . The new drug is developed based on the mechanism of arginine depletion which is believed to be effective in inhibiting tumor growth in HCC without affecting the normal cells. Earlier, PolyU researchers have successfully produced a human recombinant arginase that has a prolonged half-life in the circulation to allow ...