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Use the magnifying glass on the tool bar to enlarge the charts. LIVER CANCER CASES AND DEATHS IN FLORIDA AVERAGE AVERAGE RACE ANNUAL ANNUAL AND CASES DEATHS GENDER 95-97 95-97 NON-WHITE MALE 47 52 WHITE MALE 300 367 NON-WHITE FEMALE 22 33 WHITE FEMALE 130 183 498 635 Note: Deaths exceed cases mainly because some of the deaths are not primary liver cancer while the cases are primary liver cancers only. FLORIDA AGE ADJUSTED LIVER CANCER RATES 0 1 2 3 4 5 6 7 8 83-85 86-88 89-91 92-94 95-97 YEARS RATE PER 100,000 Non-White Male White Male Non-White Female White Female Graph done by: FL Dept of Health Bureau of Epidemiology Source of data: Florida Cancer Data System ...

P2 CANCER . BASIC ASPECTS 78 Obstructive Jaundice Results in Increased Liver Expression of Uncoupling Protein 2 and Intact Skeletal Muscle Glucose Metabolism in the Rat Bengt Isaksson 1 , Catarina Rippe 2 , Rusana Simonoska 1 , Jan-Erik Holm 1 , Ralf Segersvärd 1 , Jörgen Larsson 1 , Charlotte Erlanson-Albertsson 2 , Johan Permert 1 Arvid Wretlind Laboratory for Metabolic and Nutritional Research 1 , Department of Surgery, Karolinska Institute at Huddinge University Hospital, S-141 86 Stockholm, Sweden, Department of Medical Chemistry 2 , Lunds University Hospital, Lund, Sweden Background and Aims : A majority of patients with pancreatic cancer have obstructive jaundice and diabetes with skeletal muscle insulin ...

A BASIC INFORMATION DESCRIPTION Uncontrolled growth of malignant cells in the liver . Liver cancer may be primarily resulting from abnormal liver or bile-duct cells, or it may result from spread of cancer from another site (metastases). The most com- mon sources are cancers of the rectum, colon, lung, breast, pancreas, esophagus or skin (malignant melanoma). Liver cancer can affect all ages, but is most common in men over 60. FREQUENT SIGNS AND SYMPTOMS • Loss of appetite and weight loss. • Tender mass in the right upper abdomen. • Pain in the upper abdomen. • Low fever, usually less than 101° F (38.3° C). • Yellow eyes and skin (sometimes). • Swollen abdomen from fluid retention (sometimes). • Lethargy. CAUSES Unknown. It occurs most often in population groups with a high incidence of viral hepatitis and other chronic liver ...

When cells in the liver become abnormal, grow out of control and form a cancerous tumor, the disease is called primary liver cancer , also known as malignant hepatoma or hepatocellular carcinoma. (“Hepato” means “ liver .”) Primary liver cancer is not the same disease as cancer that spreads (metastasizes) to the liver from another part of the body (secondary liver cancer ). The liver is often the site of secondary tumors that result from the spread of cancer from another organ, such as the colon or breast. The cancer cells in the secondary tumor are like those of the original cancer , the primary cancer , which is named for the part of the body in which it began. Thus, cancer that begins in the colon or breast and spreads to the liver is called metastatic colon cancer or metastatic breast cancer . What are ...

Liver Cancer Jonathan M Hemli Thomas J Hugh Royal North Shore Hospital General Surgical Training Program (NSW), 3rd March 2004 Overview A large number of malignant lesions have been described in the liver , both of primary hepatic origin, and metastatic in nature (Table 1). The most common primary hepatic malignancy is hepatocellular carcinoma, accounting for over 85% of primary cancers of the liver , while intrahepatic cholangiocarcinoma is the next most common disease, constituting up to 10% of reported cases. Metastatic disease to the liver is considerably more common than primary hepatic malignancy. Hepatocellular Carcinoma Table 1. Malignant lesions of the liver Background Hepatocellular carcinoma (HCC) is one of the most commonly occurring solid tumours worldwide, with an estimated one million new ...

Session: Occupational Epidemiology, Sept. 13, 11:20 No clear increase in liver cancer risk in women exposed to potential occupational hazards H EINEMANN K, W ILLICH S, H EINEMANN LAJ, G ARBE E Institut für Arbeits-,Sozialmedizin und Epidemiologie, Universitätsklinikum Charité, Humboldt Universität Berlin Session: Occupational Epidemiology, Sept. 13, 11:20 Introduction The epidemiological evidence for an association between certain occupational exposures and hepatocellular cancer (HCC) is weak. Moreover, very little research is done in women. To measure relative risk estimates for liver cancer in women concerning potential work-related hazards. Methods and Results This report describes the risk associated with occupation and specific agents among 317 cases of HCC in women under age 65, ...

A205 : Liver cancer tissues - Cholangiocarcinoma For research use only (formalin fixed) Specifications: •No. of cases: 46 •Tissue type: Liver cancer tissues – Chalangicarcinoma •No. of spots: 2 spots from each cancer case (92 spots) 4 non-neoplastic spots (4 spots) •Total spots: 96 •Corresponding normal tissues with cancers: No •Diameter: 1.0 mm Documents: •Product specification: layout, summary of tissue spots •H&E stained images •Detailed pathological information Layout: Page 2 A205 : Liver cancer tissues - Cholangiocarcinoma For research use only (formalin fixed) Summary of tissue spot No Sex Age Key Word Grade TNM Stage 1 1, 2 f 73 Cholangio ca. G1 T1N0M0 (I) 2 3, 4 ...

447 March Road Kanata, Ontario Canada K2K 1X8 Tel: 613 592-2790 NEWS RELEASE March 21, 2000 Inoperable Primary Liver Cancer Treatment Receives Humanitarian Device Exemption TheraSphere’s Microscopic Glass Beads Offer Alternative to Chemotherapy in Inoperable Cases Kanata, Ontario, Canada - MDS Nordion, a global leader in radioisotope technology, received authorization from the US Food and Drug Administration to market TheraSphere , a non-surgical outpatient therapy that uses microscopic glass beads to deliver radiation therapy to treat inoperable hepatocellular carcinoma (HCC), a liver cancer . This form of liver cancer is one of the most common tumours in the world, affecting up to 10 percent of the population in sub-Saharan Africa and Southeast Asia. 1 At present, the incidence of HCC in the US is low, but is expected ...

PO Box 2345, Beijing 100023, China World J Gastroenterol 2004;10(10):1402-1408 Fax: +86-10-85381893 World Journal of Gastroenterology E-mail: wjg@wjgnet.com www.wjgnet.com Copyright © 2004 by The WJG Press ISSN 1007-9327 • LIVER CANCER • Construction of human liver cancer vascular endothelium cDNA expression library and screening of the endothelium-associated antigen genes Xing Zhong, Yu-Liang Ran, Jin-Ning Lou, Dong Hu, Long Yu, Yu-Shan Zhang, Zhuan Zhou, Zhi-Hua Yang Xing Zhong, Yu-Liang Ran, Dong Hu, Long Yu, Yu-Shan Zhang, Zhuan Zhou, Zhi-Hua Yang , Department of Cell and Molecular Biology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing ,100021, China Jin-Ning Lou, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China Supported by the ...

PO Box 2345, Beijing 100023, China World J Gastroenterol 2004;10(5):654-659 Fax: +86-10-85381893 World Journal of Gastroenterology E-mail: wjg@wjgnet.com www.wjgnet.com Copyright © 2004 by The WJG Press ISSN 1007-9327 • LIVER CANCER • Anti- liver cancer activity of TNF-related apoptosis-inducing ligand gene and its bystander effects Chao He, Wei-Feng Lao, Xiao-Tong Hu, Xiang-Ming Xu, Jing Xu, Bing-Liang Fang Chao He, Wei-Feng Lao, Xiao-Tong Hu, Jing Xu, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China Xiang-Ming Xu, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China Bing-Liang Fang, Department of Thoracic and Cardiovascular Surgery, M.D. Anderson Cancer Center, Huston, 77030, USA Supported by the National Natural Science ...

that they are useful (a) in identifying the organism in women with symptoms but a negative potassium hydroxide test, particularly if empirical treatment aimed at uncomplicated vulvovaginal candidiasis has already failed, and (b) before embarking on long term suppressive antifungal treatment. 10 Jeanne Marrazzo medical director Harborview Medical Center, Seattle, WA 98104 US (jm2@washington.edu) Competing interests: JM has received research funding and honoraria for speaking from Pfizer Inc, who make Diflucan. 1 Consumer Health Care Products Association.www.chpa-info.org/ (accessed 25 Mar 2003). 2 Ferris DG, Dekle C, Litaker MS. Women’s use of over-the-counter antifungal medications for gynecologic symptoms. J Fam Pract 1996;42:595-600. 3 De Leon EM, Jacober SJ, Sobel JD, Foxman B. Prevalence and risk factors for vaginal Candida ...

INTRODUCTION Ginseng has been used as a medicinal plant for more than 2000 yr in Asian countries. In fact, various pharmacological activities have been found in ginseng extract or its consti- tuents. Among them, anti-carcinogenic effect seems to be especially important, since development of effective method for cancer prevention is urgent problem not only in Asian countries but also in all over the world. Inhibitory effect of red ginseng extracts on pulmonary carcinogenesis has already been well documented (1). And tendency of suppression on liver carcinogensis has also reported (1). Thus, at first, we have extended the study on inhibitory effect of red ginseng extracts in liver carcinogensis using other experimental mod- els. Furthermore, anti-carcinogenic activity of white gin- seng extracts, besides red ginseng extracts, was also investi- gated. MATERIALS AND METHODS ...

Fox Chase Cancer Center 2003 Scientific Report 1 Clearance of Infected Hepatocytes During the Resolution of a Transient Hepadnavirus Infection. Mason, Aldrich, Saputelli, in collaboration with Summers, a Jilbert b Hepadnavirus infections in adults normally clear after a few months. Prior to clearance, every hepatocyte may be infected. Infection of every hepatocyte may also characterize chronic infections but, in this case, the immune response causes a persistent disease without clearing the virus. A goal of our research is therefore to characterize how virus is elimi- nated during resolution of transient infections and, in the long term, whether this same pro- cess can be induced, to cure chronic infections. To study the fate of infected hepatocytes during a transient infection, we infected woodchucks with woodchuck hepatitis ...

PO Box 2345, Beijing 100023, China World J Gastroenterol 2004;10(13):1867-1871 Fax: +86-10-85381893 World Journal of Gastroenterology E-mail: wjg@wjgnet.com www.wjgnet.com Copyright © 2004 by The WJG Press ISSN 1007-9327 • LIVER CANCER • Endostatin gene therapy for liver cancer by a recombinant adenovirus delivery Li Li, Jia-Ling Huang, Qi-Cai Liu, Pei-Hong Wu, Ran-Yi Liu, Yi-Xin Zeng, Wen-Lin Huang Li Li, Jia-Ling Huang, Ran-Yi Liu, Pei-Hong Wu, Yi-Xin Zeng, Wen-Lin Huang, Cancer Center, Sun Yat-sen University, 651 Dongfeng Road East, Guangzhou 510060, Guangdong Province, China Qi-Cai Liu, Experimental Medical Research Center, Guangzhou Medical College, 195 Dongfeng Road West, Guangzhou 510182, Guangdong Province, China Supported by the National High Technology Research and Development Program of China (863 Program), No. 2003AA216061 ...

This factsheet is for anyone who has been diagnosed with secondary cancer in the liver that has spread from the breast. It describes what secondary liver cancer is, some of the possible symptoms and treatments that may be used. We hope it answers some of your questions and helps you discuss your options further with your specialist team. You may also find it helpful to read our more general booklet on Secondary breast cancer . What is secondary liver cancer ? Secondary liver cancer occurs when cancer cells spread from the breast through the bloodstream and settle in the liver . You may hear this type of spread described as metastases, recurrence of the cancer , secondary tumours or secondaries. The cells that have settled in the liver are breast cancer cells. It is not the same as having cancer that starts in the liver . What does the liver ...

Secondary liver cancer This factsheet is for anyone who has been diagnosed with secondary cancer in the liver that has spread from the breast. It describes what secondary liver cancer is, some of the possible symptoms and treatments that may be used. We hope it answers some of your questions and helps you discuss your options further with your specialist team. You may also find it helpful to read our more general booklet on Secondary breast cancer . What is secondary liver cancer ? Secondary liver cancer occurs when cancer cells spread from the breast through the bloodstream and settle in the liver . You may hear this type of spread described as metastases, recurrence of the cancer , secondary tumours or secondaries. The cells that have settled in the liver are breast cancer cells. It is not the same as having cancer that starts ...

June 15, 2004 Contact: Patty Keiler 312.926.5900 pkeiler@nmh.org TINY BEADS OFFER BIG HOPE TO LIVER CANCER PATIENTS Northwestern Memorial Hospital First in Illinois to Offer New Minimally-Invasive Endovascular Radiation Treatment CHICAGO – Northwestern Memorial Hospital is the first in Illinois, and one of about 15 hospitals across the country, to offer a new radiation treatment for inoperable liver tumors. The technique uses tiny radioactive glass beads – or microspheres – carrying high doses of radiation (yttrium-90) to kill cancerous tumors within the liver . “This technique represents a novel way of delivering radiation therapy to liver tumors, which may prolong and improve the quality of life for the growing number people who are diagnosed with liver cancer ,” said Riad Salem, M.D., M.B.A, and Director of Interventional Oncology at Northwestern ...

Asian Pacific Journal of Cancer Prevention, Vol 2, 2001 117 Epidemiology of Liver Cancer in Thailand Asian Pacific J Cancer Prev, 2 , 117-121 MINI-REVIEW Introduction During the last 20 years, the leading cause of death in Thailand has changed from infectious diseases to non- communicable diseases. These comprise diseases of heart (including “heart failure”), malignant neoplasms, and accidents and poisonings. Their rates have gradually increased over the past decade. Cancer registries document cases of cancer within a particular region, providing information on how often cancers occur, and on how many people survive their disease. These data are needed for planning and monitoring cancer control strategies and for identifying priorities in public health. The population – based cancer registry records all new cases in ...

Dose Response Relationships Between Furan Induced Cytotoxicity and Liver Cancer . T. L. Goldsworthy, R. Goodwin, M. Burnett, P. King, H. El-Sourady, G. Moser, J. Foley, and R. R. Maronpot. Integrated Laboratory Systems, Inc., Research Triangle Park, NC, and NIEHS, Research Triangle Park, NC. Furan is hepatocarcinogenic and hepatotoxic, and thus is considered a model agent for studying the dose response characteristics and mechanisms of action of cytotoxic carcinogens. In mice, furan, at does levels >4.0 mg/kg, has been shown to increase cell replication. The current study tested the hypothesis that furan-induced hepatic cancer only occurs at doses that produce cytotoxicity and compensatory cell growth. Furan was administered in corn oil to female B6C3F1 mice (n=50-100/group) 5 days per week for 2 years at doses of 0, 0.5, 1.0, 2.0, 4.0, or 8.0 mg/kg. Survival was somewhat decreased in the 8.0 mg/kg furan-exposed ...