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Liver Cancer survival, incidence and mortality in NSW 1994–2000 26 The Cancer Council NSW Liver cancer • The five-year relative survival from liver cancer in NSW between 1994 and 2000 was 12.6% • The adjusted relative risks of excess death after shrinking were higher in Mid North Coast (33%, seven excess deaths), and lower in South Eastern Sydney (21%, 34 fewer deaths) • If the State average risk of excess death was shifted to the 20 th centile of the distribution, an additional 119 people with liver cancer in NSW would be expected to survive to five years after diagnosis • There were 1,016 new cases of liver cancer in NSW in 1994 to 1998 (749 males and 267 females) and 774 deaths (567 males and 207 females) • There were more new cases of liver cancer than expected in Central Sydney (38 in males), Western Sydney (18 in males), South Western Sydney ...

Liver cancer -results Liver cancer -results John Buscombe John Buscombe Page 2 Methods of treatment Methods of treatment Directed to HCC Directed to HCC Vascular tumours Vascular tumours Supplied by Hep artery Supplied by Hep artery (normal liver also Portal vein) (normal liver also Portal vein) Ability to deliver radioactivity by catheter Ability to deliver radioactivity by catheter 2 main methods 2 main methods Y-90 labelled Y-90 labelled microspheres microspheres Labelled Labelled Lipiodol/Chitosan Lipiodol/Chitosan Page 3 SIR spheres SIR spheres They are tiny glass beads They are tiny glass beads 35 micron in size 35 micron in size Y-90 within ...

Center for Environmental Health Studies (617) 482-9485 44 Farnsworth Street, Boston, MA 02210 http://www.jsi.com * Findings were statistically significant (strong evidence) + Evidence of a dose-response relationship (strongest evidence) Page 57 Liver Cancer and (including intra-hepatic bile duct) Exposure to Ionizing Radiation Summary: Moderately strong evidence has been recorded of a possible connection between liver cancer deaths and exposure to ionizing radiation. This evidence is based upon studies conducted at Los Alamos National Laboratory, studies of nuclear workers at other sites, and others exposed to ionizing radiation. These findings are consistent with the National Research Council’s determination that the liver is sensitive to ionizing radiation. Liver cancer is designated as a “specified” cancer ...

P.O.Box 2345, Beijing 100023,China World J Gastroenterol 2003;9(6):1212-1215 Fax: +86-10-85381893 World Journal of Gastroenterology E-mail: wjg@wjgnet.com www.wjgnet.com Copyright © 2003 by The WJG Press ISSN 1007-9327 • LIVER CANCER • Changes in survival patterns in urban Chinese patients with liver cancer Xi-Shan Hao, Ke-Xin Chen, Peizhong Peter Wang, Tom Rohan Xi-Shan Hao, Ke-Xin Chen, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China Peizhong Peter Wang, Department of Public Health Sciences, University of Toronto, Toronto, Canada Tom Rohan, Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, U.S.A Correspondence to: Dr. P. Peter Wang, ACREU, Toronto Western Hospital Research Institute, University Health Network, MP 10- 327, 399 Bathurst Street, ...

Overview Numerous surgical advances and the involvement of surgeons early in the evalua- tion of liver lesions have resulted in the ability to resect more liver malignancies with lower rates of operative mortality. At California Pacific, a medical-surgical team including an oncologist, hepatologist, radiologist and surgeon work together on all hepatocellular carcinoma (HCC) cases, evaluating patients’ability to tolerate a liver resection or other treatment regimens. Because time is critical after the diagnosis of HCC, patients who are not candidates for resection should be referred immediately for possible ablative therapy, chemotherapy and/or liver transplantation if indicated. Tumor Detection Initially, liver cancer is hard to detect. Patients typically don’t feel any differently as most tumors are asymptomatic. For this reason, physicians ...

Last revised: 4/10/03 UM Cancer Center Patient Education Document #0032 Apr03 Ed. Online version: http://www.cancer.med.umich.edu/learn/percpathways.htm University of Michigan Comprehensive Cancer Center Patient Education Resource Center (PERC) INFORMATION GUIDE Liver Cancer The purpose of this information guide is to help patients newly diagnosed with Liver Cancer and their families to find sources of information and support. This list is not meant to be comprehensive, but rather to provide starting points for information seeking. The materials can be found at the Patient Education Resource Center at the University of Michigan Comprehensive Cancer Center in room B1-361. Brochure Available free at the Patient Education Resource Center on Level B-1 National Cancer Institute. What You Need To Know About: Liver Cancer. Full-text available ...

www.wjgnet.com P.O.Box 2345, Beijing 100023,China World J Gastroenterol 2003;9(1): 192 Fax: +86-10-85381893 World Journal of Gastroenterology E-mail: wcjd@public.bta.net.cn www.wjgnet.com Copyright © 2003 by The WJG Press ISSN 1007-9327 • CORRESPONDENCE • Radiofrequency ablation: A good regional therapy for liver cancer I read the article “Clinical short-term results of radiofrequency ablation in liver cancers”. World J Gastroenterol 2002 August 15, 8(4): 624-630 by Liu et al with interest. Radiofrequency ablation is now most common technique to ablate unresectable liver tumours. We have been using transarterial chemoembolisation for irresectable HCC bigger than 5 cm in size before RFA. Have authors have any experience of combining RFA with trans arterial chemoembolisation? Recent literature suggests that targeted chemotherapy may ...

Abstract. Des- Á -carboxy prothrombin (DCP), also known as protein induced by vitamin K absence or antagonist II absence (PIVKA-II), has been considered as a useful serum tumor marker for hepatocellular carcinoma (HCC). However, the underlying mechanism causing the elevation of serum DCP levels in HCC patients remains unclear. This study was under- taken to identify the relationship between serum DCP levels and the expression of DCP in cancer and surrounding non- cancer liver tissues of HCC patients. Serum and tissue samples prepared from 92 patients with a single HCC nodule were subjected to clinicopathological study by measuring serum DCP levels and performing immunohistochemical staining for tissue DCP. Serum DCP levels correlated significantly with clinicopathological factors such as hepatitis markers, tumor differentiation, vascular invasion, intrahepatic metastasis, TNM ...

Abstract. Pancreatic cancer is a malignant tumor with an extremely poor prognosis. The mechanisms of the aggressive growth and metastasis are not yet extensively understood. Over-expression of epidermal growth factor receptor (EGFR) was suggested to be associated with malignant transformation of pancreatic cancer . We examined EGFR expression in 77 cases of invasive ductal adenocarcinoma of the pancreas, and analyzed the relation between the EGFR expression pattern and clinicopathological factors. EGFR immunoreactivity was detected in 41.6% (32/77) of human pancreatic cancers; i.e. diffuse expression in 32.5% (25/77) and focal expression in 9.1% (7/77). The EGFR expression was associated with gender (p<0.05), histological differentiation (p<0.05) and metastatic status of TNM classification (p<0.01). The observations suggested that EGFR expression plays important roles in metastasis, especially ...

STATE UNIVERSITY OF NEW YORK UNIVERSITY HOSPITAL AND MEDICAL CENTER STONY BROOK, NEW YORK 11794 LIVER (INCLUDING INTRAPHEPATIC BILE DUCTS) CANCER STAGE FORM Type of specimen __ Histopathologic Type Tumor Size _ TU2C036 (10/02) Patient Name _ Date of Birth __ MR# __ Enc# __ Sex Race __ Pt Type: § In § Out § E.D Clin Path [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] Clin Path [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] [ ] DEFINITIONS Primary Tumor (T) TX Primary tumor cannot be assessed T0 No evidence of primary tumor T1 ...

Contents 2 Imaging Techniques Help Diagnose Previously Undetected Hepatic Tumors 2 New Physicians Join Liver Disease & Transplant Team 3 Liver Biopsy Offers Significant Insight for Managing Hepatitis C 4 Research Uncovers New Therapies for Treating Liver Cancer In cases of fibrolamellar hepatocellular carcinoma, AFP levels are notoriously normal. To increase the sensitivity of AFP to 85%, the des-gamma- carboxyprothrombin (DCP) tumor marker is used in some institutions, particularly in Japan. Periodic ultrasound examination offers the best HCC surveillance tool because it has more sensitivity and specificity than AFP. However, recommendations from recent conferences advocate: • Older patients with cirrhosis or with certain congenital metabolic conditions known to be at risk ...

Fox Chase Cancer Center 2001 Scientific Report EPIDEMIOLOGY, PATHOGENESIS, AND PREVENTION OF HEPATITIS B VIRUS INFECTION AND LIVER CANCER W. Thomas London, M.D., Senior Member; Adjunct Professor of Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine Anna P. O’Connell, A.B., Staff Scientist Manette Fine, D.O., Research Physician Malick Diene,* M.D., Visiting Scientist, Army Health Service, Dakar, Senegal Mouhamadou Mbengue, M.D., Visiting Scientist, Army Health Service, Dakar, Senegal Gang Chen, M.D., Ph.D., Research Associate Joyce Atleson, R.N., B.F.A., Nurse Coordinator Gail Duncan, B.S., Scientific Assistant Lora Pasternak, B.S., Research Specialist Kathleen Gillespie, Data Technician Diane Faison, Scientific Technician Kimberly Newman-McCown, Scientific Technician Catherine ...

Fox Chase Cancer Center 2001 Scientific Report Depletion of WHV Replication Intermediates Via a By-stander Effect in a Transgenic Mouse. Song, Zhou, d Mason, in collaboration with Jilbert, e Seeger, § Sigal, § Rall § Previous studies from us and others have revealed that clearance of transient hepatitis B virus (hepadnavirus) infections must initiate with a shut down of virus replication within infected cells. Moreover, experiments with HBV transgenic mice have shown that cytok- ines elaborated by the immune system can induce a rapid degradation of intermediates in hepadnavirus replication, effectively shutting down virus production, without producing any damage to the infected cell. For example, INF ? and TFN a , produced in response to infection of only a few percent ...

Clinical: Pancreatic Cancer 250 Pancreatic Cancer -Associated Diabetes is Correlated with Increased Liver Nitric Oxide (NO) D. Basso, P. Fogar 1 , C. Bassi 3 , A. Valerio 2 , M. Abu-Hilal 3 , S. Mazza, F. Navaglia, C.-F. Zambon, E. Greco, M. Falconi 3 , S. Pedrazzoli 1 , M. Plebani Dept. of Laboratory Medicine, 1 Dept. of Medical and Surgical Sciences, 2 Clin. and Experimental Medicine, Padova; 3 Dept of Surgery and Gastroenterology, Pancreatic Unit, Verona, Italy Background: In pancreatic cancer -associated diabetes mellitus (PC-DM) an altered liver and muscle glucose metabolism occurs. NO modifies glucose release by isolated hepatocytes. Our aims were to verify whether PC-DM determines in the liver ...

EXPERIMENTAL and MOLECULAR MEDICINE, Vol. 33, No. 4, 179-190, December 2001 Chronic liver injury, TGF- ß , and cancer D. Montgomery Bissell 1,2 1 University of California, San Francisco 2 Corresponding author: Fax, +1-415-476-0659; E-mail, dmbiss@itsa.ucsf.edu Accepted 19 November 2001 Abbreviations: ECM, extracellular metrix; HSC, hepatic stellate cell; HCC, hepatocellular carcinoma Abstract Cells termed myofibroblasts are prominent in the injury response of all epithelial tissues. They exhibit proliferation, migration, production of collagen and other extracellular matrix (ECM) molecules, and con- traction, all for containing the injury and closing the wound. When the injury is limited in time, the final stage of the repair involves a dismantling of the cel- lular apparatus and restoration of normal tissue ...

P2 CANCER . BASIC ASPECTS 78 Obstructive Jaundice Results in Increased Liver Expression of Uncoupling Protein 2 and Intact Skeletal Muscle Glucose Metabolism in the Rat Bengt Isaksson 1 , Catarina Rippe 2 , Rusana Simonoska 1 , Jan-Erik Holm 1 , Ralf Segersvärd 1 , Jörgen Larsson 1 , Charlotte Erlanson-Albertsson 2 , Johan Permert 1 Arvid Wretlind Laboratory for Metabolic and Nutritional Research 1 , Department of Surgery, Karolinska Institute at Huddinge University Hospital, S-141 86 Stockholm, Sweden, Department of Medical Chemistry 2 , Lunds University Hospital, Lund, Sweden Background and Aims : A majority of patients with pancreatic cancer have obstructive jaundice and diabetes with skeletal muscle insulin ...

All-Ireland cancer statistics 1994-96 50 Liver and intrahepatic bile ducts 8. MALIGNANT CANCER OF THE LIVER AND INTRAHEPATIC BILE DUCTS (summary) ICD-O.2 C22 ICD-10 C22 ICD-9 155 Key facts • Average of 113 new cases per year, 1994-96: 43 cases in females, 70 in males. • Average of 192 deaths per year: 80 in females, 112 in males. • Age-standardised incidence and mortality rates about twice as high in males as in females. • 11th most common cause of cancer deaths in males, 12th in males. • Incidence rates in Northern Ireland (NI) about 130% higher for females, 50% for males, than the Republic (RoI). • Incidence rates well below EU 1995 averages. Summary statistics Table 8.1 Incidence 1994-96 Primary, malignant cancer of the liver and intrahepatic bile ducts is uncommon. On average each ...

332 Population Science Division Gender and Risk of Hepatocellular Carcinoma in the Haimen City Cohort. Chen, London, in collaboration with Evans,§ Ross, § Balshem, § Shen, b Lin, c Fan, d Haimen City Cooperating Group Haimen City is located on the north bank of the Yangtze River, about 50 miles west of Shanghai, P.R. China. It is primarily an agricul- tural area, but does have small factories widely distributed among all the villages and town- ships. About 75% of the one million inhabitants are farmers. HCC has long been known to be a major medical and public health problem in this community. In order to identify the specific environmental, viral and genetic factors that may affect risk of HCC and the interaction of such factors, a prospective study was initiated in Haimen City between ...

Basic Science Division 105 The Role of Hepatocyte Regeneration in the Clearance of Hepadnavirus Infections from the Liver . Zhu, Yamamoto, Saputelli, Aldrich, Mason, in collaboration with Cullen, b Litwin, § Furman, c Jilbert d Hepatitis B viruses cause chronic and pro- ductive infections of hepatocytes. New viral DNA is produced by reverse transcription, which occurs in the cytoplasm, but viral RNA is transcribed from a covalently closed circular form of viral DNA (cccDNA) that is only found in the nucleus. The goal of antiviral therapy is to eliminate not just the viral DNAs in the cyto- plasm, but also the cccDNA in the nucleus. Inhibitors of the hepatitis B virus DNA poly- merase block new viral DNA synthesis, so that these DNAs are quickly cleared from the cyto- plasm of the infected cell. However, cccDNA ...

1 54684: Mechanisms Involved in Trichloroethylene-Induced Liver Cancer : Importance to Environmental Cleanup (First Year of Funding: 1996) DOE report Number: 3/1/00 Principal Investigator Richard J. Bull, Ph.D. Pacific Northwest National Laboratory P.O. Box 999, MSIN P7-56 Richland, WA 99352 (509) 373-6218 (phone) Dick.bull@pnl.gov Co-Principal Investigator Brian D. Thrall Pacific Northwest National Laboratory P.O. Box 999, MSIN P7-56 Richland, WA 99352 (509) 376-3809 (phone) Brian.thrall@pnl.gov Contributors Lyle B. Sasser (Lyle.sasser@pnl.gov) John H. Miller (John.h.miller@pnl.gov) Irvin R. Schultz (Irvin.schultz@pnl.gov) Graduate Students Anja J. Stauber Alberto Gonzalez-Leon Junko Kato-Weinstein James Merdink Melissa K. Linghor Page 2 ...

Bradfield; Mechanisms of Liver Carcinogenesis 18 UNIT V: Models of Liver Cancer , Non Genotoxic Carcinogens Assigned Reading: Pitot et al. (1996). Quantitation of multistage carcinogenesis in rat liver . Toxicologic Pathology. 24:119. 1) Not all carcinogens are genotoxic, (i.e., directly alkylate DNA and cause mutations). 2) Chemicals that enhance carcinogenic responses to genotoxic carcinogens are known as promoters. 3) Modeling HCC in rodents can be performed by monitoring the evolution of carcinogen induced enzyme altered foci. Non Genotoxic Carcinogens: Until now, we have been talking about carcinogens that act via direct/covalent modification of DNA (“alkylation”). We have talked about the early proposal that all carcinogens are mutagens. From the initial DNA alkylation studies and mutagenicity studies came the classification of mutagenic/alkylating carcinogens ...

Bradfield; Mechanisms of Liver Carcinogenesis 1 Chris Bradfield, 262-2024 213 McArdle , Bradfield@oncology.wisc.edu Assignments: Each lecture summary sheet will have questions within the text that are bold and in italics. Please be prepared to answer these questions in class. In addition written short answers to these same questions will be due four times throughout the next few weeks. I will assign the exact dates in class depending on how fast we move through the material. Assigned Reading for unit I: These readings are meant to provide background. 1) Briefly review liver physiology before the first session (any physiology text will do). 2) Venook, AP (1994). Hepatocellular carcinoma: Too many options? J. Clin. Oncology. 12:1323. UNIT I: Liver Biology, Pathology and Cancer It is important to understand liver biology, pathology and cancer because: ...

Population Science Division 329 EPIDEMIOLOGY, PATHOGENESIS, AND PREVENTION OF HEPATITIS B VIRUS INFECTION AND LIVER CANCER W. Thomas London, M.D., Senior Member; Adjunct Professor of Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine Anna P. O’Connell, A.B., Staff Scientist Manette Fine, D.O., Research Physician Malick Diene, M.D., Visiting Scientist, Army Health Service, Dakar, Senegal Gang Chen, M.D., Ph.D., Postdoctoral Associate Long-Long Gao, M.D., Graduate Student, University of Pennsylvania School of Medicine Marla Snyder, B.A., Research Data Coordinator Joyce Atleson, R.N., B.F.A., Nurse Coordinator Gail Duncan, B.S., Technical Specialist Lora Pasternak, B.S., Research Specialist Kathleen Gillespie, Data Technician Diane Faison, Scientific Technician Jeffry Saputelli, ...

Hepatitis B shots reduce liver cancer In July 1984, Taiwan instituted a free, nationwide vaccination campaign against the hepati- tis B virus. The program started with infants, but by the end of the 1980s, preschool and school-age children were also getting the shots. Predictably, hepatitis B cases in Taiwanese children declined by more than 90 percent between 1984 and 1994. Now, a review of Taiwan’s national cancer registry shows that the incidence of liver cancer in Taiwanese children has dropped dramatically as well. Researchers had suspected the same virus often underlies both diseases. To gauge the cancer decline, Taiwanese researchers documented all 294 cases of hepatocel- lular carcinoma, the most common liver cancer , between 1981 and 1994 in children age 6 to 14. The number of cases fell from 26 in 1982 to 8 in 1993, Mei-Hwei Chang’s team at the National Taiwan University in Taipei reports in ...

Project ID: 54684 Project Title: Mechanism Involved in Trichloroethylene-Induced Liver Cancer : Importance to Environmental Cleanup Lead Principal Investigator : Dr. Richard J. Bull Pacific Northwest National Laboratory MSIN P7-56 P. O. Box 999 Richland, Washington 99352 Telephone: 509-373-6218 e-mail: Dick.bull@pnl.gov Co Principal Investigators: Brian D. Thrall Pacific Northwest National Laboratory P.O. Box 999 MSIN P7-56 Richland Washington 99352 Telephone: (509) 376-3809 e-mail: Brian.thrall@pnl.gov Page 2 5.2 Mechanisms Involved in Trichloroethylene-Induced Liver Cancer : Importance to Environmental Cleanup (First Year of Funding: 1996) Principal Investigator Richard J. Bull, Ph.D. Pacific Northwest National Laboratory P.O. Box 999, MSIN P7-56 Richland, WA 99352 ...

A BASIC INFORMATION DESCRIPTION Uncontrolled growth of malignant cells in the liver . Liver cancer may be primarily resulting from abnormal liver or bile-duct cells, or it may result from spread of cancer from another site (metastases). The most com- mon sources are cancers of the rectum, colon, lung, breast, pancreas, esophagus or skin (malignant melanoma). Liver cancer can affect all ages, but is most common in men over 60. FREQUENT SIGNS AND SYMPTOMS • Loss of appetite and weight loss. • Tender mass in the right upper abdomen. • Pain in the upper abdomen. • Low fever, usually less than 101°F (38.3°C). • Yellow eyes and skin (sometimes). • Swollen abdomen from fluid retention (sometimes). • Lethargy. CAUSES Unknown. It occurs most often in population groups with a high incidence of viral hepatitis and other chronic liver diseases. ...

research for a cure laboratory without walls National Foundation for Cancer Research Cancer FAQs about liver cancer Frequently Asked Questions about common cancers. Page 2 Cancer FAQs What are the different types of liver cancer ? There are many kinds of tumors than can originate in the liver . Of the four main types that are cancerous (angiosarcomas, cholangiocarcinomas, hepatoblastomas, and hepatocellular carcinomas), hepatocellular carcinoma (also called hepatoma or HCC), is by far the most common, accounting for about 84 percent of all liver cancer cases. HCC starts growing in the hepatocytes, the main type of cell found in the liver . What are the risk factors for liver cancer ? A risk factor is anything that increases a person’s chance of getting a disease. There are several known risk factors ...