AllDocs -> cancers

Abstract. To uncover mechanisms underlying progression of colorectal carcinogenesis and to identify genes associated with liver metastasis, we analyzed expression profiles of 14 primary colorectal cancers (CRCs) with liver metastases, and compared them with profiles of 11 non-metastatic carcinomas and those of 9 adenomas of the colon. A hierarchical cluster analysis using data from a cDNA microarray containing 23,040 genes indicated that the cancers with metastasis had different expression profiles from those without metastasis, although a number of genes were commonly up-regulated in primary cancers of both categories. We documented 54 genes that were frequently up-regulated and 375 that were frequently down-regulated in primary tumors with metastases to liver , but not in tumors without metastasis. Subsequent quantitative PCR experiments confirmed that PRDX4, CKS2, MAGED2 , and an EST (GenBank ...

Abstract. We investigated the efficacy of interferon (IFN)-ß therapy against colon cancer using a novel approach mediated by a lyophilized preparation of High 5 (H5) insect cells transduced with a recombinant baculovirus encoding murine IFN-ß (H5BVIFN-ß). The orthotopic model of CT-26 murine colon cancer in syngeneic BALB/c mice was used in the study, and H5BVIFN-ß was intratumorally delivered. Two injections of H5BVIFN-ß (on days 14 and 21 after tumor cell implantation), but not lyophilized H5 cells (control), significantly reduced the size of cecal tumors and the number of liver metastases. Immunohistochemical analysis revealed that cecal tumors injected with saline or H5 contained many proliferating cells (PCNA + ) and few apoptotic cells (TUNEL + ). In sharp contrast, H5BVIFN-ß-treated tumors contained fewer PCNA + cells and significantly more ...

Journal of Minimal Access Surgery | March 2005 | Volume 1 | Issue 1 37 Two-stage laparoscopic resection of colon cancer and metastatic liver tumour Yukio Iwashita, Atsushi Sasaki, Toshifumi Matsumoto, Kohei Shibata, Masafumi Inomata, Masayuki Ohta, Seigo Kitano Department of Surgery I, Oita University Faculty of Medicine, Oita 879-5593, Japan Address for correspondence: Seigo Kitano, Department of Surgery I, Oita University Faculty of Medicine, 1-1 Hasama-machi, Oita 879- 5593, Japan. E-mail: kitano@med.oita-u.ac.jp Unusual Case Abstract We report herein the case of 70-year-old woman in whom colon cancer and a synchronous metastatic liver tumour were successfully resected laparoscopically. The tumours were treated in two stages. Both postoperative courses were uneventful, and there has been no recurrence during the 8 months since the second procedure. ...

LIVER RESECTION FOR TREATMENT OF CANCER MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA Broadcast February 3, 2005 NARRATOR Welcome to a live webcast from Massachusetts General Hospital in Boston. During this live webcast, surgeons will demonstrate a liver resection to treat cancer . Today’s program is part of Massachusetts General Hospital’s ongoing educational efforts to bring the latest information in health care to patients and physicians. During this program, you may send your questions to the OR surgeons at any time. Just click the MDirectAccess button on the screen. SAM YOON, M.D. Good afternoon and welcome to Massachusetts General Hospital. I’m Dr. Sam Yoon. I’m one of the surgical oncologists at the Mass. General Hospital. I’m sitting outside OR 43. Today we’re going to show you portions of a right liver resection or right hepatectomy. The patient today is a 69-year-old woman who actually ...

NYS NYC 05 Staten Isl 04 Queens 03 Brooklyn 02 Bronx 01 Manhattan 62 Yates * 61 Wyoming * 60 Westchester 59 Wayne * 58 Washington * 57 Warren * 56 Ulster 55 Tompkins * 54 Tioga * 53 Sullivan * 52 Suffolk 51 Steuben * 50 Seneca * 49 Schuyler * 48 Schoharie * 47 Schenectady * 46 Saratoga * 45 St Lawrence * 44 Rockland 43 Rensselaer * 42 Putnam * 41 Otsego * 40 Oswego * 39 Orleans * 38 Orange * 37 Ontario * 36 Onondaga 35 Oneida * 34 Niagara 33 Nassau 32 Montgomery * 31 Monroe 30 Madison * 29 Livingston * 28 Lewis * 27 Jefferson * 26 Herkimer * 25 Hamilton * 24 Greene * 23 Genesee * 22 Fulton * 21 Franklin * 20 Essex * 19 Erie 18 Dutchess * 17 Delaware * 16 Cortland * 15 Columbia * 14 Clinton * 13 ...

This factsheet is for anyone who has been diagnosed with secondary cancer in the liver that has spread from the breast. It describes what secondary liver cancer is, some of the possible symptoms and treatments that may be used. We hope it answers some of your questions and helps you discuss your options further with your specialist team. You may also find it helpful to read our Secondary breast cancer booklet, which looks at the physical and emotional impact of living with secondary breast cancer . What is secondary liver cancer ? Secondary liver cancer occurs when cancer cells spread from the breast through the blood or lymph system and settle in the liver . You may hear this type of spread described as metastases, recurrence of the cancer , secondary tumours or secondaries. The cells that have settled in the liver are breast cancer cells. It is not the same as having cancer that starts ...

Asian Pacific Journal of Cancer Prevention, Vol 2, 2001 117 Epidemiology of Liver Cancer in Thailand Asian Pacific J Cancer Prev, 2 , 117-121 MINI-REVIEW Introduction During the last 20 years, the leading cause of death in Thailand has changed from infectious diseases to non- communicable diseases. These comprise diseases of heart (including “heart failure”), malignant neoplasms, and accidents and poisonings. Their rates have gradually increased over the past decade. Cancer registries document cases of cancer within a particular region, providing information on how often cancers occur, and on how many people survive their disease. These data are needed for planning and monitoring cancer control strategies and for identifying priorities in public health. The population – based cancer registry records all new cases in a defined population (most frequently ...

Joseph J Amon et al Asian Pacific Journal of Cancer Prevention, Vol 6, 2005 382 Asian Pacific J Cancer Prev, 6 , 382-386 RESEARCH COMMUNICATION Introduction Worldwide, liver cancer is the fifth most common cancer (Parkin et al., 2001). However, rates of liver cancer and the relative frequency of the two main types (hepatocellular carcinoma and cholangiocarcinoma) vary significantly between countries, as well as in different regions of the same country (Terry, 2003). Hepatocellular carcinoma, which comprises approximately 85% of malignant hepatic tumors worldwide, has a high incidence in Sub-Saharan Africa and China, and an intermediate incidence in other parts of Asia, Latin America and Europe (Bosch et al., 1999). Cholangiocarcinoma is less common worldwide than hepatocellular carcinoma; however, in specific regions of Southeast Asia, most ...

Hideaki Tsukuma et al Asian Pacific Journal of Cancer Prevention, Vol 6, 2005 244 Asian Pacific J Cancer Prev, 6 , 244-250 MINI-REVIEW Introduction Liver cancer is one of the world’s greatest disease burdens, with hepatocellular carcinoma (HCC) above all as one of the leading causes of cancer deaths in Asia and Africa. Chronic infection with hepatitis B and/or hepatitis C viruses is a well-known risk factor and the most influential determinant for HCC. Control of hepatitis virus infections has theoretically been well established through screening of donated blood for hepatitis B virus (HBV) and hepatitis C virus (HCV), use of disposable needles and syringes, and passive/active immunization against HBV with HBIG (HB immunoglobulin) and HB vaccine. In most Asian countries Liver Cancer and its Prevention Hideaki Tsukuma*, Hideo Tanaka, ...

Hepatic resection for primary liver cancer at a private community hospital: retrospective study of 61 patients MH Shiu, DLSSiu, WM Hui, HC Yu, KCLam Objective. To review the outcome after surgical resection for primary liver cancer . Design. Retrospective study. Setting. Private community hospital, Hong Kong. Patients. Sixty-one consecutive patients who underwentliverresection for primarycancer from 1992through 1997. Main outcome measures. Clinicopathological features, type of resection, duration of hospital stay, and actuarial overall and disease-free 5-year survival rates. Results. Cirrhosis was present in 46 (75%) of the patients, and 42 (69%) were positivefor hepatitis B surface antigen. The median tumour diameter was 8 cm (range, 1-16cm). Liver resectionsconsisted ofhemihepatectomy (n=37), trisegmentectomy (n=4), segmentectomy (n= 11),and wedge resection (n=9). Postoperative death and ...

Jun. 2005, Volume 2, No.6 (Serial No.7) Journal of US -China Medical Science, ISSN 1548-6648,USA 16 460 Cases of Radiotherapy for Primary Massive Liver Cancer * Zuoshen Zheng ** , Yuhe Zou , Jian Rao , Huazhu Lv , Yuehai Zheng , Xuezhong Chen Abstract: Objective To summarize the improvement of technological by radiotherapy with moving split fields radiation (MSFR) of the whole liver and diminution field technology and split course and to explore the significance by radiotherapy for primary massive Liver Cancer (PLC). Methods 460 patients with PLC underwent in our hospital between 1987 and 2001 were carried out for retrospective analysis. There were 386 male and 74 female cases of these patients, and the average age was 46.2 years. The tumor size of 245 patients is 1015 cm. The others is 1521 cm. There were three groups defined by the irradiation doses: (1) ...

Table of contents 1 Introduction 1 1.1 Liver cancer 1 1.1.1 Hepatocellular carcinoma 1 1.1.2 Other liver cancers 1 1.1.3 Etiology of HCC 2 1.1.3.1 Hepatitis B virus infection 2 1.1.3.2 Hepatitis C virus infection 2 1.1.3.3 Liver cirrhosis 2 1.1.3.4 Toxins 3 1.1.3.5 Inherited metabolic liver diseases 3 1.1.4 Staging systems for HCC 4 1.2 Treatments of HCC 4 1.2.1 Curative treatments 5 1.2.1.1 Hepatic resection 5 1.2.1.2 Orthotopic liver transplantation 5 1.2.1.3 Percutaneous treatments 6 1.2.1.3.1 Percutaneous ethanol injection and percutaneous acetic acid injection 6 1.2.1.3.2 Radiofrequency ablation 7 1.2.1.3.3 Percutaneous microwave coagulation ...