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Research Triumphs OHRI discoveries in the fight against: Stroke Lung cancer Heart disease Retinal degeneration Multiple sclerosis Summer / Fall 2006 Page 2 Research Triumphs About the cover: Dr. Dennis Bulman and research student Andrew Seto (see page 6 for full story). About this publication: Research Triumphs is published biannually by the Ottawa Health Research Institute, an affiliated research institute of the University of Ottawa and the research arm of The Ottawa Hospital. This magazine is also available electronically at www.ohri.ca/corporate/ohripub- lications.asp. Please send comments to info@ohri.ca. The ertlotinib graphic on page 3 was pro- duced using information from Sliwkowski et. al. published in J. Biol. Chem. v277, p.46265. About our supporters: All of our research is supported by The Ottawa Hospital Foundation. ...

CONTACT : Emily Oehler (703) 460-5572 Emily@SIRweb.org EMBARGOED FOR RELEASE: July 17, 2006 Non-Surgical Treatment Gives Patients with Inoperable Lung Cancer Three Years or More Interventional Radiologists’ Outpatient Procedure Uses Heat to Destroy Lung Tumors Fairfax, Virginia – Fifty-seven percent of lung cancer patients who were treated with thermal ablation survived to three years, two years beyond average life expectancy, according to research in the July issue of the Journal of Vascular and Interventional Radiology (JVIR). The patients had early-stage, I-II, non- small cell lung cancer (NSCLC). During thermal ablation, an interventional radiologist uses imaging to guide a small needle through the skin into the tumor. Energy is then transmitted to the tip of the needle to “cook” and kill the tumor with heat or “freeze” it with cold. “Only one-third of patients diagnosed ...

MSNBC.com Women smokers face twice the lung cancer risk But females are less likely to die from the disease, study finds Reuters Updated: 4:56 p.m. PT July 11, 2006 CHICAGO - Cigarette-smoking women run twice the risk of lung cancer as men who smoke but are far less likely to die from the disease than males, according to a study published Tuesday. Why women are more susceptible to the cancer -causing agents in cigarette smoke is not clear, the report said, but the findings indicate that women who smoke should be screened sooner and targeted with anti-smoking messages earlier. The conclusions, from researchers at New York-Presbyterian Hospital/Weill Cornell Medical Center in New York City, were based on 7,498 women and 9,427 men, at least 40 years of age and with a history of cigarette smoking, who were checked for lung cancer between 1993 and 2005. When ...

For the past 2 years, scientists from the Genetic Epidemiology of Lung Cancer Consortium (official name of the Family Lung Cancer Study!) have been hunting for the actual gene or genes that increase a person’s chances of developing lung cancer . We found that part of chromosome 6 is linked to lung cancer susceptibility and we are now trying to find the lung cancer gene(s) on this chromosome. We have discovered some very inter- esting findings but we have more work to do! We are still working to recruit new families into the Family Lung Cancer Study. Adding more families gives us more information and a better chance of finding the gene(s) that may cause lung cancer . We also keep in touch with families who have already partici- pated in our study. These families sometimes find out more information about the history of cancer ...

Lung Cancer Lung cancer is the deadliest cancer and is by far the leading cause of cancer deaths for both men and women. An estimated 162,460 people are expected to die of lung canc 2006. Tobacco use is the most common cause of lung cancer . Smoking is also respon for most cancers of the lar er in sible ynx, oral cavity and pharynx, esophagus, and bladder. In ddition, it is a cause of kidney, pancreatic, cervical and stomach cancers, as well as emia. PR E bacco, quit. unity. AT IS nces such as arsenic, radon and asbestos • oke SY In t e ms. Later these signs may appear: ugh • ECTION The i ose the dise • • o n to t ve risks and benefits of lung cancer screening for them. If they have not a acute myeloid leuk EV NTION • Don’t use tobacco ...

Investigation of Lung Cancer to Human Activities in Sri Lanka M. A. K. K. P. Perera K. R. R. Mahanama Department of Chemistry University of Colombo Page 2 Effects of Air Pollution to our Health • Respiratory system diseases: Acute lower respiratory infections Upper respiratory infections • Chronic Pulmonary Diseases: Chronic obstructive pulmonary diseases • Asthma • Cancer : Lung cancer Bladder cancer Page 3 Indoor Air Pollution • Indoor air pollution can be traced to prehistoric time when human first moved to temperate climate and it become necessary to construct shelter and use fire inside them for cooking, warmth and light • Approximately, half of the world's population and 90% of rural households in developing ...

Abstract —We present the development and performance characteristics of a free-space fluorescence tomography system. The imaging system can capture complete angle projections of photons propagating through tissue in transillumination using a CCD camera. Experimental data on imaging lung cancer are presented. Overall, this imaging approach can offer unprecedented imaging performance in Fluorescence Molecular Tomography of small animals. I. I NTRODUCTION LUORESCENCE MOLECULAR TOMOGRAPHY (FMT) has a great potential to serve as investigational tool for small animal research and drug discovery. FMT comes to improve on several shortcomings of planar epi-illumination methods that use CCD cameras to image fluorescence back-emitted from tissues after wide-field illumination. The method is based on tomographic principles, coupled ...

FOR IMMEDIATE RELEASE Contact: Michelle Pollak The Wellness Community (202) 659-9709 michelle@thewellnesscommunity.org NEW INFORMATION ABOUT SMALL CELL LUNG CANCER WASHINGTON, D.C. – April 13, 2005 – A new resource about small cell lung cancer (SCLC) is now available free of charge from The Wellness Community® (TWC), an international, non-profit dedicated to providing free support and education to people affected by any type of cancer . A booklet entitled, Frankly Speaking About Lung Cancer : A Special Focus on Small Cell Lung Cancer offers key steps for a better understanding of SCLC so that people may maximize treatment options and make educated decisions about therapy. It also provides information on proactively managing side effects, including the emotional impact of cancer . The booklet incorporates the philosophy of The Wellness Community’s Patient ...

Artificial Ingelligence in Medicine, 2002, vol.24, no.1, pp.25-36. @Elsevier Lung Cancer Cell Identification Based on Artificial Neural Network Ensembles Zhi-Hua Zhou*, Yuan Jiang, Yu-Bin Yang, Shi-Fu Chen National Laboratory for Novel Software Technology, Nanjing University, Nanjing 210093, P.R.China Abstract An artificial neural network ensemble is a learning paradigm where several artificial neural networks are jointly used to solve a problem. In this paper, an automatic pathological diagnosis procedure named Neural Ensemble based Detection (NED) is proposed, which utilizes an artificial neural network ensemble to identify lung cancer cells in the images of the specimens of needle biopsies obtained from the bodies of the subjects to be diagnosed. The ensemble is built on a two-level ensemble architecture. The first-level ensemble is used to judge whether a cell is normal with high confidence ...

Contact: Regina Vidaver 608-233-7905 NATIONAL LUNG CANCER PARTNERSHIP ANNOUNCES 2006 GRANTS Two Grants for up to $100,000 Each Available for Lung Cancer Research MADISON, Wis. – June 2, 2006 – National Lung Cancer Partnership (formerly Women Against Lung Cancer ) will award two grants in 2006 to further its mission to decrease deaths due to lung cancer and help patients live longer and better through research, awareness and advocacy. “We founded National Lung Cancer Partnership to be able to support and promote lung cancer research, and to encourage professionals to enter into and achieve success in lung cancer research, treatment and care,” said Joan Schiller, MD, president of National Lung Cancer Partnership. “By putting the spotlight on lung cancer research, and especially the important issue of sex differences in the disease, we hope to drive more funding, more interest, ...

44 2 0 0 5 ¦ H o p k i n s W h i t e P a p e r s . c o m arguing that these levels of radon do not pose a significant risk and that attention should be focused on finding the homes with the highest levels. Recently, researchers estimated that reducing radon levels in all homes with readings higher than 4 pCi/L would result in 2% to 4% fewer lung cancer deaths. To determine whether radon levels are high in your area, call your local EPA office. Taking a radon measurement in an individ- ual house is the only way to definitively know the radon level, and several inexpensive kits are available in most hardware stores. Etched-track or electret detectors are good choices; the best of these kits take measurements over at least a three-month period. / Lung cancer is the most dangerous type of cancer , killing 85% of people within five years of diagnosis. ...

Contact: Regina Vidaver 608-233-7905 WOMEN AGAINST LUNG CANCER CHANGES NAME TO NATIONAL LUNG CANCER PARTNERSHIP MADISON, Wis. – June 2, 2006 – Women Against Lung Cancer announced today at its annual meeting in Atlanta that the organization has changed its name to National Lung Cancer Partnership. National Lung Cancer Partnership is the only national lung cancer organization founded by physicians and researchers and focused on understanding how the disease affects women and men differently. The organization also unveiled a new logo and website. National Lung Cancer Partnership’s annual meeting takes place in conjunction with the American Society of Clinical Oncology (ASCO) 2006 Annual Meeting in Atlanta from June 2 - 6. “We are changing our name to better reflect the partnership we have forged with physicians, researchers, patients, families, advocacy organizations and the media ...

- more - Contact: Regina Vidaver 608-233-7905 LUNG CANCER IN THE UNITED STATES FACTS • Approximately 175,000 people are diagnosed with lung cancer in the U.S. each year. 1 • Lung cancer kills more than 160,000 people annually – more people than breast, colon and prostate cancers combined . 1 • Lung cancer is responsible for more than a quarter of all cancer -related deaths every year. 1 • Smoking is the primary cause of lung cancer . Approximately 90 percent of lung cancer cases occur in people who are currently smoking or have previously smoked. 2 • Although the risk of developing lung cancer goes down with smoking cessation, a significant risk remains for 20 years or longer after quitting. 2, 3 • Approximately fifty percent of all lung cancers occur in people who have already quit smoking. 4 ...

National Lung Cancer Partnership/LUNGevity Foundation Career Development Award Request for Applications Purpose of Award The award provides funding for clinical and basic science junior faculty to advance their careers in lung cancer etiology, prevention, early detection, treatment, and symptom management. The Career Development Award is intended to provide "protected time" for newly independent investigators to develop their careers for two years of their initial lung cancer research projects. The award will be provided for up to $50,000 per year ($100,000 maximum over 2 years). The award is designed to be used primarily for salary support, but can also be used for the support of research, including technical assistance, supplies or reagents. The award cannot be used to purchase major equipment for general use. It is the policy of National Lung Cancer Partnership and the LUNGevity ...

Lung Cancer Support Community LCSC "Making a difference one member at a time" LCSC is the largest and most complete Lung Cancer Support Communities on the web. Come and join our family completely for FREE and take part in the message board which currently has over 140,000 posts and over 2000 members. We receive over 4 million visits a month! As the leading lung cancer support organization online, LCSC offers those with lung cancer & their family members HOPE . There ARE survivors of this disease. Regardless of the statistics, at LCSC you will connect with other people who are defying the odds, learn about their treatments, their successes and their disappointments. You will find the support and understanding you deserve. * LEARN ABOUT YOUR LC * LEARN ABOUT TREATMENT * READ SURVIVOR STORIES * ASK THE ...

Lung Cancer You’ve been diagnosed. You’re NOT alone. There ARE options! Becoming pro-active in your care may increase your chances of SURVIVAL! YOU’VE BEEN DIAGNOSED, NOW WHAT? SOME THINGS TO ASK YOUR DOCTOR What type of lung cancer do I have? What stage is my cancer ? Has my cancer spread to other parts of my body? What are my treatment options? Am I a candidate for radiation or surgery? Is this facility trained and familiar with my type of lung cancer ? RESEARCH: Find out everything you can about your lung cancer . There are excellent resources online about L/C, hospitals, specialists, new treatments options, chemotherapy, radiation, RFA, Gamma Knife, PCI and the latest in clinical trials across the country. DO NOT let the statistics scare you. Put them on a shelf in the back of your mind and know that the survival rate is NOT “0” and that there ARE survivors! ...

August 12, 2005 Health Styles Provided Courtesy of Central Michigan Community Hospital Various facts about lung cancer Lung cancer is the number one cancer killer in men and women, and the third leading cause of death in the United States. The disease claims over 150,000 lives yearly. Even more tragic than this statistic is the fact many of these deaths might have been prevented, as smoking is the number one cause of lung cancer . According to the American Lung Association, the more time and quantity you smoke, the greater your risk of lung cancer . But if you stop smoking, the risk of lung cancer decreases each year as normal cells replace abnormal cells. After ten years, the risk drops to a level that is one- third to one-half of the risk for people who continue to smoke. In addition, quitting smoking greatly reduces the risk of developing other smoking-related diseases, ...

FOR IMMEDIATE RELEASE CONTACT : Amanda Fliger March 31, 2006 Public Relations Counsel (850) 224-0174 amandaf@moore-pr.com CONGRESS TO DECLARE LUNG CANCER A PUBLIC HEALTH PRIORITY TALLAHASSEE, FLA ---The American Lung Association of Florida applauds the efforts of Congress for recognizing the importance of increased funding to fight lung cancer , the deadliest form of cancer . Florida Congressman Clay Shaw (R-FL) proposed Congressional legislation that would commit to a 50 percent reduction of lung cancer mortality within nine years and declare the disease a major national public health priority. “This legislation unites many different organizations and federal agencies in their focus on lung cancer and its treatment,” says Steve Scott volunteer and president of the American Lung Association of Florida. “This is a milestone for an under-funded and under-researched ...

PRACTICE GUIDELINE – page 1 Evidence-based Series #7-3 (Version 2.2005): Section 1 Management of Unresected Stage Ill Non-Small Cell Lung Cancer : A Clinical Practice Guideline G. Okawara. J.A. Mackay, W.K. Evans, Y.C. Ung, and the Lung Cancer Disease Site Group A Quality Initiative of the Program in Evidence-based Care (PEBC), Cancer Care Ontario (CCO) Original Report Date: June 2005 Current Report Date: January 2006 This Evidence-based Series report replaces an earlier version of the report that was completed in 1997. Guideline Questions 1. What is the role of different schedules or doses of radiotherapy as a treatment in patients with unresected stage Ill non-small cell lung cancer ? 2. Does chemotherapy combined with radiotherapy improve survival compared with radiotherapy alone in patients with unresected stage III non-small cell lung ...

• Lung cancer is a tumor of the lungs where abnormal cells multiply quickly and destroy healthy lung tissue. • Symptoms of lung cancer include: chronic cough, constant chest pain, coughing up blood, shortness of breath, loss of weight or appetite, and frequent lung infections. • Smoking causes about 87% of lung cancer cases. • Nonsmokers can get lung cancer from breathing in secondhand smoke. • By the time symptoms are noticeable, the cancer is often in advanced stages, which is why prevention is a key factor. • The best way to prevent lung cancer is to quit or never start smoking. • Lung cancer can be treated. F A C T S A B O U T F A C T S A B O U T F A C T S A B O U T L U N G C A N C E R L U N G C A N C E R L U N G C A N C E R Phone: ...

Incidence and Mortality Rate Trends Lung cancer is the second most common cancer and the most common cause of cancer -related death in both men and women in the United States. The overall mortality rate for lung and bronchus cancer rose steadily through the 1980s and peaked around 1990. While incidence and mortality rates for men have dropped in the last decade, this trend has not been observed for women. Mortality rates are highest among African American males, followed by White males. It is estimated that approximately $9.6 billion* is spent in the United States each year on treatment of lung cancer . *In 2004 dollars, as reported in Brown ML, Riley GF, Schussler N, and Etzioni RD. Estimating health care costs related to cancer treatment from SEER-Medicare data. Medical Care 2002 Aug; 40 (8 Suppl): IV-104-17. Source for incidence ...

About Lung Cancer • Lung cancer is one of the most common cancers in Australia. • In 2001, it was the third most commonly occurring cancer in men (5,384 new cases) and the fourth most common in women (2,891 new cases). 1 • Between 1991 and 2001, the incidence of lung cancer among males fell by an average of 2.1% per year. In contrast, incidence among females increased by 1.2% per annum. 1 • In Western Australia in 2003, there were 503 new cases of lung cancer in men and 301 in women. 2 • Lung cancer is a leading cause of cancer death in Australia. • In 2002, it was the most common cause of cancer death in men (4,760 deaths) and the second most common in women, after breast cancer (2,543 and 2,698 deaths respectively). 3 • In Australia between 1998 and 2002, the male ...

Lung CAD Offers Promise in Better Cancer Detection April 1, 2006 By Cheryl Hall Harris, RN With early diagnosis the only way to beat lung cancer , lung CAD is focused on finding tumors of 2 to 8 millimeters or more imaged via chest CT or analog or digital x-ray. While it’s too early to say if lung CAD will be successful in bringing better outcomes for lung cancer patients — it is beginning to m a k e i t s m a r k . The challenges of detecting lung cancer at a very early stage are formidable, but the urgency propels the development of tools for early detection. The prognosis for surviving beyond five years is abysmal — 9 to 12 percent — for patients who are diagnosed with more advanced stages of this disease. The National Cancer Institute released a report in August 2005 ...

Case-control study of the correlation between lung cancer and pneumoconiosis in ex-miners in the Nord-pas-de Calais coalfield Cat. Number Language Price CE-V/4-98-005-EN-C EN FREE Summary: A case-referent study was designed in order to explore the possible relationship between coal-workers pneumoconiosis (CWP) and lung cancer among retired coalminers of Nord-pas-de-Calais (NPC). A registry of thoracic cancers, including lung and pleural cancers was set on a regional basis with the help of pneumologists and pathologists. A study of standardised incidence was conducted from the 1364 cases of lung cancer diagnosed in men in 1992 : 151 cases were observed compared with 121 expected. A significant excess of risk was shown for retired coalminers in general (SIR = 125, 95% CI : 106-146) and, among them, for those compensated for CWP (SIR = 145, 95% CI :116-178). ...

1 Lung Cancer in the Elderly Anand B. Karnad, MD Professor of Medicine Interim Division Chief, Medical Oncology, UTHSCSA, Chief, Medical Oncology Audie L Murphy Memorial V A Hospital, San Antonio Page 2 2 Page 3 3 American 132 76.8 USA 18 Mediterran ean 109 78 Greece 10 Nordic 108 79 Sweden 4 Asian 106 79.9 Japan 2 East-West 97 81.2 Okinawa 1 Eating Pattern Age- adjusted Ca Death Rates Life Expectancy Location Rank MORTALITY RATES IN LONG-LIVED POPULATIONS (WHO 1996; OKINAWA CENTENARIAN STUDY) Lung Cancer in the Elderly (SEER Data; NCI) • Median age at diagnosis is 69 years • 50% of Stg-IV diagnosed > 65 years • ...

The incidence of lung cancer in men is high but has decreased by 21% since 1989-91, and in women increased up to 1989-91 and has been stable since. Mortality from lung cancer followed similar trends reducing by 17% in men since 1980-82 and increasing by 46% in women between 1980-82 and 1989-91 and remaining stable since. Lung Cancer is the leading cause of cancer mortality amongst men and the second highest cause of cancer mortality amongst women in South Australia. Background notes Lung Cancer Page 2 Male Lung Cancer - Incidence and Mortality* 1977-2000 All Ages Source - SA Cancer Registry Data 0 10 20 30 40 50 60 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 Year Age Standardised for World ...

T h e U n i v e r s i t y o f T e x a s H e a l t h S c i e n c e C e n t e r a t S a n A n t o n i o C o n t i n u i n g M e d i c a l E d u c a t i o n - M S C 7 9 8 0 7 7 0 3 F l o y d C u r l D r i v e S a n A n t o n i o , T e x a s 7 8 2 2 9 - 3 9 0 0 U p d a t e s i n L u n ...

Lung Cancer Biomarkers Methods for Diagnosis of Lung Cancer Intellectual Property ID Number 147 Contact Robert F. Williams, Ph.D., M.B.A. Director, Office of Technology Transfer (757) 446-5099 WilliaRF@evms.edu Inventors O.J.. Semmes, Ph.D. L. Cazares Field Oncology Technology Protein biomarkers for lung cancer diagnostics Key Features • Diagnostic biomarkers with potential for early detection of lung cancer • Detection formats ranging from immunoassay to mass spectrometry possible Stage of Development Clinical data from two different studies: 1) 74 patients with 61 normal and 13 cancer ; and, 2) 51 patients with 30 normal and 21 cancer (the 30 normal were comprised ...

Lung cancer is the #1 cause of cancer death among women in the United States. Lung cancer used to be thought of as a man's disease, but women now account for almost half (46%) of the more than 172,000 people who will be newly diag- nosed with lung cancer this year, and for 45% of the more than 163,000 lung cancer deaths this year. Of all the types of lung cancer , women are more likely to develop small-cell lung cancer , which is more aggressive and harder to treat than other types. Risk Factors Everyone knows that smoking is the leading cause of lung cancer , but 30% of women with lung can- cer never smoked. That is about twice as high as the percentage of men's lung cancers that are not attributed to smoking. In addition, exposures to radon, arsenic, asbestos, radiation, air pollution, some organic chemicals such as benzene, ...

Quarterly Health Newsletter Vol. 16, No. 1, Spring 2006 http://hospitals.unm.edu/ L ung cancer is currently the num- ber one cause of cancer death in both men and women in the United States. More people die each year of lung cancer than colon cancer , breast cancer , and prostate cancer combined. It is estimated that 184,000 new cases of lung cancer will be diagnosed this year and that 168,000 patients will die of this type of cancer . Despite these statistics, early-stage lung cancer can be effectively treated with surgical resection, achieving good 5-year survival rates of 70% for stage I lung cancer (in which the cancer has not yet begun to spread) and 50% for stage II lung cancer (in which there is limited spread of the cancer within the lung itself). In ...