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58 60 62 64 66 68 70 72 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 INCIDENCE: Age-Adjusted Incidence Rates, Invasive Lung Cancer Pennsylvania Residents, 1990-2000 54 55 56 57 58 59 60 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 MORTALITY: Age-Adjusted Mortality Rates, Lung Cancer Pennsylvania Residents, 1991-2001 Lung cancer is one of the most common forms of cancer diagnosed among both men and women in Pennsylvania. In 2000, there were 9,904 cases of invasive lung and bronchus cancer diagnosed. The age-adjusted incidence rate in 2000 was 68.6 per 100,000. In 1990 there were 8,563 cases reported for a rate of 62.9. Total numbers and rates have been on the increase since 1990. The ...

Deaths BF WF BM WM Total NR 21 396 62 881 1,360 Age-adjusted Death Rates by Region, Race and Sex MSA 351 1,811 742 2,966 5,870 Alabama 1998 to 2000 SR 70 267 155 553 1,045 Rate per 100,000 2000 standard million BB 53 65 145 132 395 Total 495 2,539 1,104 4,532 8,670 Lung cancer Race-sex-region-specific age-adjusted death rates; significance tests are at the 95% confidence level Region is not a significant predictor of mortality for black males or black females. South rural and metropolitan white males have a significantly higher rate than north rural white males. White metropolitan females have a significantly higher rate than those in the north rural region. The rate for black males is significantly ...

1 Lung cancer risk from exposure to radon in the home - are policies in the United Kingdom appropriate to the risk? Andrew T. Arthur MPH MCIEH FRSH Abstract: At present, residential exposure to radon gas and its radioactive decay particles is predicted to be a major cause of lung cancer . The degree of risk of lung cancer is predicted from models based largely on data from studies of underground miners. These cohorts of miners were exposed to radon at much higher levels than encountered in the majority of homes and as such, the projected risks may be overstated. This is an area of public health policy over which there has been considerable scientific debate and on which there still remains disagreement and controversy. The controversial issues are examined and discussed and the evidence from residential studies of radon and lung cancer is ...

Agenda: ASCO/FDA Lung Cancer Endpoints Workshop April 15, 2003 Presentations: 1. Opening comments by Dr. Bunn and Dr. Pazdur 2. Regulatory background -Approval standards and approval endpoints (non- lung ) Dr.Williams -Approval endpoints for lung cancer Dr. Cohen -Endpoints used internationally Dr. Canetta 3. Classical lung cancer endpoints Dr. Johnson 4. Nonclassical lung cancer endpoints Dr. Gralla Morning session: discussions on endpoints Topics for discussion: 1. Discuss the pros and cons of each of the endpoints (classical and non-classical) as a primary efficacy endpoint, specifically: a. as a measure of, or a reliable surrogate for, clinical benefit (the efficacy standard for regular drug approval) b. as a surrogate reasonably likely to predict clinical benefit (the efficacy ...

lung cancer NON-TRADITIONAL ENDPOINTS IN LUNG CANCER - Patient Reported Outcomes - Richard J. Gralla, MD New York Lung Cancer Alliance New York, New York ENDPOINTS IN DECISION-MAKING - Clinical Trials and Patient Management - Should become the most used parameter Appropriate if Survival Differences Unlikely QoL The most commonly used parameter Considered to be Unreliable RESPONSE Not relevant for individual patients Appropriate if Survival Difference is likely SURVIVAL MANAGEMENT TRIALS NON-SMALL CELL LUNG CANCER - Quality of Life at Baseline: Influence on Survival - - Prospective Analysis of 673 Patients at 30 Centers - * p = 0.0001, using the LCSS quality of life instrument ...

JNMA, January - February, 2003, 42 POSSIBLE OCCUPATIONAL LUNG CANCER IN NEPAL ORIGINAL ARTICLE Journal of Nepal Medical Association 2003; 42 : 1-5 ABSTRACT The objective of this study was to describe the relationship between occupational exposures and the development of lung cancer among the patients attending Bhaktapur Cancer Care Center, Bhaktapur, Nepal. The study subjects consisted of 85 cases of lung cancer and a reference group of 40 cases of colon cancer . Demographic data and information about work history was obtained by a structured interview. Based on the occupational history, subjects were divided into exposed and non-exposed groups concerning carcinogenic agents. Exposure prone occupations like agriculture, construction of buildings, construction of roads and bridges, manufacturing, and transport were categorised as exposed occupations. Similarly, ...

lung cancer PET scanning for staging of Non- Small Cell Lung Cancer Giancarlo Pillot 12 Sep 2003 Talk Overview Background Statistics Staging Overview Traditional Staging methods Clinical Exam and history CXR CT Chest Surgical Staging Talk Overview PET scanning Physics Staging Trials "Preoperative Staging of Non- Small Cell Lung Cancer with PET" Co- registered images trial “Staging of Non-Small Cell Lung Cancer with Integrated Positron- Emission Tomography and Computed Topography” Future directions Background Lung cancer (of all types) is the second most common malignancy and the leading cause of cancer death Lung cancer mortality rate ...

lung cancer Lung Cancer Epidemiology, diagnosis and treatment Estimated new cases (incidence) and deaths (mortality) worldwide for the 15 most common cancers, 2000 Thousands Lung Breast Colon/rectum Stomach Liver Prostate Cervix uteri Oesophagus Bladder Non-Hodgkin’s lymphoma Oral cavity Leukaemia Pancreas Ovary Kidney Males Females 1200 1000 800 600 400 200 Parkin et al 2001 Age-adjusted lung cancer death rates, USA (1930-1998) and the influence of smoking 80 60 40 20 0 1930 1940 1950 ...

Experimental Oncology 25, 143-145, 2003 (June) 143 Many patients with advanced locoregional non- small cell lung cancer (NSCLC), presenting recurrent primary tumors in the chest or metastatic disease, will at some point require palliative treatment for one or more symptoms in association with their disease process. This type of therapy includes radiotherapy, brachythe- rapy, chemotherapy and cryotherapy with the intention to reduce the severity of the symptoms, as well as to improve the quality of life in patients suffering from en- dobronchial lung tumors. The efficacy of irradiation in relieving symptoms such as hemoptysis, cough, dyspnea and chest pain by us- Received: May 07, 2003. *Correspondence: Fax: +3-26510-97850; E-mail: kcharala@cc.uoi.gr Abbreviation used : NSCLC ? non-small cell lung cancer . PALLIATIVE CARE AND QUALITY OF LIFE IN ...

-more- LUNG CANCER 101: DISEASE OVERVIEW The Condition Lung cancer is the uncontrolled growth of abnormal cells in one or both of the lungs. While normal lung tissue cells reproduce and develop into healthy lungs, these abnormal cells reproduce rapidly and never grow into normal lungs. Lumps of cancer cells (tumors) then form and disrupt the lung , making it difficult for the lung to function properly. More than 87 percent of lung cancers are smoking related. However, not all smokers develop lung cancer . Smoking cessation reduces an individual’s risk significantly, although former smokers remain at greater risk for lung cancer compared to people who never smoked. Exposure to other carcinogens such as asbestos and radon gas also increase an individual’s risk, especially when combined with cigarette or cigar smoking. Types The two main ...

Illinois Department of Public Health q 535 West Jefferson Street q Springfield, Illinois 62761 q 217.782.3300 www.idph.state.il.us q TTY800.547.0466 LUNG CANCER FA C T S E v e ry Breath Counts 3 FACTS Lung cancer is the leading cause of cancer death. In Illinois, between 1973 and 1992, the death rate from lung cancer rose more than the rate for all other cancers combined, including breast, prostate and colorectal cancers. In Illinois, pro- jections for 2001 indicate that there will be more than 8,540 new cases of invasive lung cancer and more than 7,000 people will die. Experts predict that in the next four years, twice as many women will die from lung cancer as from breast cancer . The lungs are large and cancer can grow in them for a ...

R A D I A T I O N T H E R A P Y f o r LUNG CANCER Facts to Help Patients Understand Their Treatment ABOUT ASTRO The American Society for Therapeutic Radiology and Oncology is the largest radiation oncology society in the world. ASTRO's mission is to advance radiation oncology by promoting excellence in patient care, supporting research and distributing research results. LEARNING ABOUT CLINICAL TRIALS The radiation oncology team is always looking for new ways to treat and cure cancer through studies called clinical trials. Today's lung cancer radiation therapy treatments are the result of clinical trials completed in the past proving that radiation therapy kills cancer cells and is safe long term. For more information on clinical trials, please visit the following Web sites: National Cancer Institute ...

164.476 Lung cancer research fund -- Consortium between Universities of Kentucky and Louisville to be known as the Governance Board of the Lung Cancer Research Project -- Annual audit. (1) The " Lung Cancer Research Fund" is created and shall receive funds each year from the Kentucky health care improvement fund in the amount specified in KRS 304.17B-003(5)(b). The lung cancer research fund shall be used to finance the Lung Cancer Research Project described in subsection (5) of this section. No revenues from the lung cancer research fund shall be allocated until the board has adopted the strategic plan described in subsections (5) and (6) of this section. (2) A research consortium between the University of Kentucky and the University of Louisville is created and shall be known as the Governance Board of the Lung Cancer Research Project. The consortium shall be ...

5 Chemoprevention of lung cancer : from concept to reality Roczniki Akademii Medycznej w Bialymstoku · Vol. 48, 2003 · Annales Academiae Medicae Bialostocensis ADDRESS FOR CORRESPONDENCE: Department of Thoracic Oncology Netherlands Cancer Institute Plesmanlaan 121 1066 CX Amsterdam, The Netherlands e-mail: n.v.zandwijk@nki.nl tel.: 3120 5122958 fax: 31 20 5122752 Received 3.07.2003 Accepted 10.07.2003 Abstract Among all cancer , lung cancer is the leading cause of cancer death in the western world. The poor lung cancer survival figures argue powerfully for new approaches to control this disease such as chemoprevention, that has been defined as the use of agents that reverse, suppress or pre- vent lung carcinogenesis. Over 80% of lung cancers are attributed to tobacco and carcinogens from cigarette smoke ...

Philadelphia, PA www.fccc.edu ? FACULTY ? Melvyn Goldberg, MD Vice Chairman, Surgical Oncology Chief, Thoracic Surgical Oncology ? Fox Chase Cancer Center Corey J. Langer, MD, FACP Medical Director, Thoracic Medical Oncology ? Fox Chase Cancer Center Benjamin Movsas, MD Vice Chairman, Radiation Oncology ? Fox Chase Cancer Center Michael Unger, MD, FACP, FCCP Director, Pulmonary Cancer Detection and Prevention Program Director, Pulmonary Endoscopy and High-Risk Lung Cancer Program ? Fox Chase Cancer Center STATEMENT OF THE FOX CHASE CANCER CENTER DISCLOSURE POLICY It is the policy of Fox Chase Cancer Center to insure that all sponsored continuing medical education activities are independently designed and produced, relative ...

Research Updates January 2004 Alliance for Lung Cancer Advocacy, Support, and Education 500 W. 8 th Street, Suite 240, Vancouver, WA 98660 Lung Cancer Hotline: 800-298-2436 (US only) www.alcase.org 1 Trastuzumab (Herceptin ® ) Adds Little to Effects of Standard Chemotherapy for Advanced NSCLC Researchers from Germany have announced results from a phase II clinical trial that studied the effects of trastuzumab (Herceptin ® ) in combination with standard chemotherapy for the treatment of advanced NSCLC. The study of 100 people found the addition of trastuzumab led to no significant improvements over chemotherapy alone. 1 While the results were disappointing, researchers stated there may still be a role for trastuzumab (a monoclonal antibody) among people whose lung cancer ...

Plutonium might be deadlier than thought - Lung cancer danger occurs even at 'safe' levels, study says Rocky Mountain News April 18, 2003 http://www.rockymountainnews.com/drmn/local/article/0,1299,DRMN_15_1898112,00.html People who inhale plutonium have a higher risk of lung cancer than previously believed, according to a study of Rocky Flats workers. The link between plutonium and lung cancer occurs even at levels currently considered safe, the study concluded. People who inhaled plutonium were more than twice as likely to get lung cancer as those who had not. That risk level is equivalent to smoking a pack of cigarettes a day for between 12 and 20 years, said Dr. James Ruttenber of the University of Colorado Health Sciences Center, who led the study. "Those results suggest a risk from plutonium higher than seen before," Ruttenber said. He, along with colleagues ...

lung cancer Understanding Lung Cancer & New Directions in Research and Treatment Options David P. Carbone, M.D., Ph.D. We = re going to have several physicians speak today. I = m going to start out talking about lung cancer in general and some of the things we = re doing. This is not really about the lung cancer SPORE grant but rather about lung cancer and how it affects patients. The SPORE grant is just a mechanism to use to try to help lung cancer patients. Dr. Choy is going to talk to us a little bit about the radiation aspects of lung cancer and some other issues. This afternoon Dr. Sandler is going to talk to you about clinical trials that we = re doing. So I = m not going to focus on specific clinical trials, I = m just going to give you brief summaries. This is my message for my talk and I = m going to start out ...

Recent changes in lung cancer incidence for south Asians Lucy K Smith, Michael D Peake, Johannes L Botha In England, the incidence of lung cancer among south Asians (Indian, Pakistani, and Bangladeshi) is much lower than in the rest of the population. 1 In the UK, south Asian population, however, it is the commonest cancer for men and the second commonest for women. 2 We explored trends in lung cancer incidence from 1990 to 1999 in Leicester (22% of residents classified as south Asian in 1991 census). Participants, methods, and results We identified cases of lung cancer diagnosed in Leicester residents between 1 January 1990 and 31 December 1999 from the Trent Cancer Registry. Ethnicity data were not available for all patients, so we used software assessing forename and surname to classify patients as ...

October 9, 2002 news release New procedures available for lung cancer patients Lung cancer patients are benefiting from new interventional bronchoscopy procedures in the Calgary Health Region. Dr. Alain Tremblay, a respirologist at Foothills Hospital and one of few physicians in Canada who performs these procedures, offers lung cancer patients an opportunity to have tumors removed by guiding a catheter and camera through the trachea in a minimally invasive procedure. Prior to these procedures, the only available treatment for lung cancer patients was radiation therapy. "These procedures improve the quality of life, and in some cases can extend length of life," says Tremblay. "We are able to remove blockages in the lungs caused by inflammatory disease, tumors or scarring with procedures that reduce hospitalization stays from two weeks to as soon as the next day." The procedures ...

B.C. Cancer Agency Protocol Summary LUNAVP Page 1 of 1 TREATMENT FOR ADVANCED NON-SMALL CELL LUNG CANCER (NSCLC) WITH CISPLATIN AND VINORELBINE (INTERIM VERSION) Protocol Code: LUNAVP Tumour Group: Lung Contact Physician: Dr. Christopher Lee ELIGIBILITY: Advanced non-small cell lung cancer ECOG performance status of 0, 1 or 2 EXCLUSIONS: More than one previous chemotherapy regimen TESTS: Baseline: CBC & differential, platelets, creatinine, liver function tests, bilirubin Before each treatment: CBC and differential, platelets If clinically indicated: creatinine, bilirubin prior to each cycle PREMEDICATIONS: Antiemetic protocol for High Moderate emetogenic chemotherapy protocols as long as cisplatin dose is not = 50 mg. If cisplatin is = 50 mg use antiemetic protocol for Highly emetogenic ...

PATIENT HOSPITAL # SURGICAL PATHOLOGY # DATE: Procedure Lymph Nodes Bronchoscopy Mediastinoscopy Wedge Resection Segmentectomy N2 NODES Total Positive Lobectomy Bi-lobectomy 1. Highest mediastinal Pneumonectomy 2. Upper paratracheal Site right Right lung Left lung left RU lobe LU lobe 3. Pre and retrotracheal RM lobe LL lobe 4. Lower paratracheal RL lobe right Maximum tumor diameter cm left Bronchial involvement 5. Aortopulmonary Main 6. Anterior mediastinal Lobar 7. Subcarinal Segmental 8. Paraesophageal Subsegmental 9. Pulmonary ligament None N1 NODES Total Positive Histological type: 10. Hilar Differentiation right Well Other left ...

Lung Cancer Survey 2001 Page 2 Figure 1. Smoking History - 131 newly diagnosed lung cancer patients at Stony Brook Hospital in 2001 Current 54% Former 37% Never 6% Unknown 3% Current Former Never Unknown Page 3 Figure 2. Gender distribution for lung cancer patients at Stony Brook Hospital in 2001 compared to National Cancer Data Base 1994-1998 benchmark report. 0% 10% 20% 30% 40% 50% 60% 70% Males Females Stony Brook NCDB Page 4 Figure 3. Age at diagnosis of lung cancer at Stony Brook Hospital in 2001 compared to National Cancer Database 1994-1998 benchmark report. 0 10 20 30 ...

RISK FACTOR INFORMATION FOR SELECTED CANCER TYPES Source: Community Assessment Unit, Bureau of Environmental Health Assessment, Massachusetts Department of Public Health July, 2001 Lung Cancer Lung cancer generally arises in the epithelial tissue of the lung . Several different histologic or cell types of lung cancer have been observed. The various types of lung cancer occur in different regions of the lung and each type is associated with slightly different risk factors (Blot and Fraumeni 1996). The most common type of lung cancer in the United States today is adenocarcinoma which accounts for about 40% of all lung cancers (ACS, 2000). The greatest established risk factor for all types of lung cancer is cigarette smoking, followed by occupational and environmental exposures. The incidence of lung cancer increases sharply with age peaking ...