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EGAM 2004 EORTC LUNG CANCER GROUP PROGRAM 22.4.04 14.00 Welcome Minutes New treasurer (van Meerbeeck) Election for chair of chemotherapy subgroup (van Meerbeeck) New members, membership status, report of Quality Assurance Subcommittee (Ardizzoni) Calendar , publications/abstracts (Price) Finances (Biesma/van Meerbeeck) 1415 Closed trials 08941 Surgery vs RT in chemoresponsive patients with pN2 NSCLC ( van Meerbeeck- van Schil) 08971b Phase III study of adjuvant vaccination in LD SCLC (Giaccone) 08972 Sequential vs concomitant CT-RT in NSCLC (Belderbos) 08983 Phase III study of Chemotherapy in mesothelioma (van Meerbeeck) 1430 Open trials 22993/08993 PCI in ED SCLC (Slotman) 22003/08004 PCI in LD SCLC (Senan) 08012 Neoadjuvant CT in operable NSCLC (van Meerbeeck) 08013 Neoadjuvant ...

lung cancer 1 Classification of High-Dimensional Lung Cancer Microarray Data Tsvika Klein Tufts University (Joint work with Frederick Crimins, Robert Dimitri, Nathan Palmer and Lenore J. Cowen) 2 Lung Carcinomas A leading cause of cancer death Claims ~150,000 lives every year in the US A better understanding can help: Design effective drugs Predict patients survival Understand lung cancer pathology 3 U95 Probe Microarray The Human Genome U95 consist of five GeneChip® arrays (Affymetrix) A powerful tool to analyze human cells and tissues Expression level of ~ 60,000 genes ~12,000 genes in the first array 4 Microarray Data 5 The Dataset 186 patient ...

Nat Med 1996 Sep;2(9):1033-5 Microsatellite alterations in plasma DNA of small cell lung cancer patients. Chen XQ, Stroun M, Magnenat JL, Nicod LP, Kurt AM, Lyautey J, Lederrey C, Anker P Laboratory of Plant Biochemistry and Physiology, Faculty of Science, Geneva, Switzerland . Microsatellite instability is an important characteristic of many tumor types especially those associated with hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome. Microsatellite alterations in 50% of primary small cell lung carcinoma (SCLC) have been found. These alterations were also found in the sputum. Because neoplastic characteristics such as decreased strand stability9 and ras mutations have been found in the plasma DNA of cancer patients, we looked for microsatellite alterations in the plasma of SCLC patients. A microsatellite alteration was present in 16 out of 21 (76%) SCLC tumors and in 15 ...

providing research and information services to the Scottish Parliament 1 Research Note 00/95 13 November 2000 LUNG CANCER AND ASBESTOS (MESOTHELIOMA) This note provides background information on S1M-1273, for debate on 16 November 2000, on compensation for mesothelioma sufferers. THE ISSUE S1M-1273 reads: 'that the Parliament notes the plight of shipyard workers and their families who were exposed to asbestos, became ill and have now contracted mesothelioma; expresses concern over the length of time their compensation cases are taking to reach conclusion and the use of so-called "blanket denials" by the defenders, and notes that this practice victimises and denies justice to these cancer sufferers.' 1 Sufferers have in mind to persuade the Parliament to precipitate a change in the law that will allow compensation claims to proceed more quickly ...

T he word “spore” comes from the Greek term for sowing or seed, so it’s a perfect acronym for the Specialized Program of Research Excellence sponsored by the National Cancer Institute. The NCI recently honored UCLA’s Jonsson Comprehensive Cancer Center with a $13.9 million, five-year SPORE grant, one of only six SPOREs awarded nationwide for lung cancer research, and the first on the west coast. “The SPORE is an honor for the cancer center. It means UCLA has been judged to be among the leaders in lung cancer research in the country. It is an honor that recognizes not only the excellence of our scientists, but also the teamwork among them that is making this collective effort a success,” says Dr. Steven Dubinett, the pro- gram’s lead investigator at the Jonsson Cancer Center. Dubinett works closely with Dr. Robert Figlin, a professor ...

Onconurse.com Fact Sheet 1 Symptoms of Lung Cancer behind a diagnostic test or exam that may seem odd on its face, and to give you an idea of the range of symp- toms that lung cancers may cause. As you can see, symptoms vary tremendously. Discuss any symptoms with your doctor. Pulmonary symptoms The symptoms of lung cancer that are clearly and direct- ly related to lung function are: • Coughing, the most common symptom, experi- enced by 74 percent of patients • Bloody sputum (phlegm; 57 percent) • Shortness of breath (37 percent) • Chest pain (25 percent) • Hoarseness (18 percent) • Paralysis of the diaphragm, either symptomless or perceived as shortness of breath • Wheezing or vibrating breathing noises (stridor) • Recurrent pneumonia or bronchitis • Difficulty swallowing (dysphagia) Symptoms in other organs ...

July/August 2001, Vol. 8, No.4 326 Cancer Control Treatment of Advanced Non–Small-Cell Lung Cancer : A Review of Current Randomized Clinical Trials and an Examination of Emerging Therapies Eric B. Haura, MD Background: Lung cancer continues to be the leading cause of cancer -related deaths for Americans. As most patients present with nonsurgically curable disease, major efforts have been made in the treatment of advanced non–small-cell lung cancer (NSCLC) with chemotherapy. Several new agents and new combinations of chemotherapy are available. Methods: The author reviews randomized clinical trials investigating chemotherapy for advanced NSCLC in chemotherapy-naive patients, in patients who present with relapsed or progressive disease, and in elderly patients. Therapies that incorporate new biological agents to target specific aberrations in ...

Proceedings of the Second International Workshop on EGS, 8.-12. August 2000, Tsukuba, Japan KEK Proceedings 200-20, pp.100-106 Dose Distribution of Stereotactic Irradiation for Thorax R. Sakai 1 , H. Saitoh 2 , T. Fujisaki 3 , S. Abe 3 , K. Fukuda 2 , M. Fukushi 2 and E. Kunieda 4 1 Medical Front 2 Tokyo Metropolitan University of Health Sciences 7-2-10, Higashi-Ogu, Arakawa-ku, Tokyo 116-8551 Japan 3 Ibaraki Prefectural University of Health Sciences 4 Keio University Abstract Stereotactic irradiation has been adopted in many hospitals recently. For this treatment, ac- curate dosimetry is ...

Mayo Clin Proc, September 2003, Vol 78 CT Screening for Lung Cancer 1187 Mayo Clin Proc . 2003;78:1187-1188 1187 © 2003 Mayo Foundation for Medical Education and Research Commentary Computed Tomographic Screening for Lung Cancer : Home Run or Foul Ball? S TEPHEN J. S WENSEN , MD; J AMES R. J ETT , MD; D AVID E. M IDTHUN , MD; AND T HOMAS E. H ARTMAN , MD From the Department of Radiology (S.J.S., T.E.H.) and Division of Pulmonary and Critical Care Medicine and Internal Medicine (J.R.J., D.E.M.), Mayo Clinic, Rochester, Minn. This commentary was funded in part by the National Cancer Institute (RO1 CA 79935-03). Individual reprints of this article are not available. ...

Mortality from Lung cancer in FINLAND, 1952-95 (annual rates per 100 000) Year Male 35-54 Female 35-54 Male 55-74 Female 55-74 1952-3 41.2 3.8 251.8 23.4 1954-5 38.5 4.3 265.6 21.2 1956-7 43.3 3.1 278.7 18.6 1958-9 44.4 3.3 337.8 21.7 1960-1 47.9 3 331.6 16.6 1962-3 45.5 3.9 361.1 19.6 1964-5 46.2 3.2 366.3 18.9 1966-7 41.2 3.9 371.6 20.5 1968-9 44.9 3.6 403.8 19.1 1970-1 41.6 3.8 419.6 18.3 1972-3 38 3.4 398.1 21.7 1974-5 33.7 3.4 392.4 20.8 1976-7 37.3 4.5 410.2 26.4 1978-9 34.7 5 402.2 26.6 1980-1 32.8 4.1 383.5 31.5 1982-3 23.6 3.7 368.5 30.3 ...

Mortality from Lung cancer in NORWAY, 1952-95 (annual rates per 100 000) Year Male 35-54 Female 35-54Male 55-74 Female 55-74 1952-3 9.5 1.6 37.3 15.1 1954-5 11.3 1.6 40.1 13.8 1956-7 8.5 2.1 48.6 13.2 1958-9 9.3 1.8 61.9 14.7 1960-1 11.2 2 72.3 14.3 1962-3 10.1 2.7 76.5 12.8 1964-5 13.2 2.6 82.3 11.7 1966-7 13.1 2.9 90.2 15.1 1968-9 14.3 4.2 108 18.4 1970-1 14.4 4.3 118 17.3 1972-3 14.1 5.4 119.4 19.4 1974-5 15.7 4.9 129 20.3 1976-7 17.5 5.2 139.3 25.5 1978-9 16.6 5.8 145.7 23.5 1980-1 17.3 6.6 162.7 29.6 1982-3 19.5 7.8 160.7 33.2 1984-5 ...

Recent changes in lung cancer incidence for south Asians Lucy K Smith, Michael D Peake, Johannes L Botha In England, the incidence of lung cancer among south Asians (Indian, Pakistani, and Bangladeshi) is much lower than in the rest of the population. 1 In the UK, south Asian population, however, it is the commonest cancer for men and the second commonest for women. 2 We explored trends in lung cancer incidence from 1990 to 1999 in Leicester (22% of residents classified as south Asian in 1991 census). Participants, methods, and results We identified cases of lung cancer diagnosed in Leicester residents between 1 January 1990 and 31 December 1999 from the Trent Cancer Registry. Ethnicity data were not available for all patients, so we used software assessing forename and surname to classify patients as ...

Gemma Schaepman, Senior Account Manager C.I.P. – Conference Information Publishing, P.O. Box 993, 1000 AZ Amsterdam, The Netherlands Tel: (+31) 20 485 2930 Fax: (+31) 20 485 2940 E-mail: g.schaepman@elsevier.com www.cip-elsevier.com LUNG CANCER Journal of the International Association For the Study of Lung Cancer (IASLC) EDITOR-IN CHIEF: H.H. Hansen Department of Oncology, The Finsen Institute Righospitalet, Copenhagen, Denmark ABSTRACTED/INDEXED IN: Current Contents/Clinical Medicine; Excerpta Medica (EMBASE); Index Medicus (MEDLINE); Oncology Information Service; SciSearch; Current Awareness in Biological Services (CABS) IMPACT FACTOR/RANKING: 2.451 43/114 Oncology 9/32 Respiratory Systems SCOPE : Lung Cancer aims to provide all members of the International Association for the Study of Lung ...

B e t t e r H e a l t h f o r W o m e n : A G l o b a l H e a l t h P r o g r a m B r i s t o l - M y e r s S q u i b b F o u n d a t i o n , I n c . L U N G C A N C E R I N W O M E N z2370 6/4/02 3:22 PM Page 1 Page 2 I n 1998, more than 70,000 women died of lung cancer in the U.S. That’s more than the number of women who died as a result of breast and ovarian cancers combined. The sad fact is that the disease – the number one cancer killer in the U.S. – is on the rise in women: according to the American Cancer Society, in the 20-year span between 1974 and 1994, lung cancer deaths among women increased by 147 percent; by contrast, the number of deaths among men increased 20 percent over that same time period. In 1998 alone, more than 80,000 new cases of female lung cancer were diagnosed. And the prognosis ...

The Impact of PET on the Management of Lung Cancer : The Referring Physician’s Perspective Marc A. Seltzer, MD 1 ; Cecelia S. Yap, BS 1 ; Daniel H. Silverman, MD, PhD 1 ; Joubin Meta, BS 1 ; Christiaan Schiepers, MD, PhD 1 ; Michael E. Phelps, PhD 1 ; Sanjiv S. Gambhir, MD, PhD 1 ; Jyotsna Rao, MD 2 ; Peter E. Valk, MD 2 ; and Johannes Czernin, MD 1 1 Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic/Nuclear Medicine, UCLA School of Medicine, Los Angeles, California; and 2 Northern California PET Imaging Center, Sacramento, California 18 F-FDG PET is a molecular whole-body imaging modality that is increasingly being used for diagnosing, staging, and restaging cancer ...

Residential radon and lung cancer NEZAHAT HUNTER • NATIONAL RADIOLOGICAL PROTECTION BOARD • CHILTON In most of the world, the major risk factor for lung cancer is tobacco consumption. Occupational radon and asbestos exposure are other important factors but affect specific groups only. While studies of underground miners have shown that lung cancer is induced in humans by exposure to radon and its decay products, the evidence of health effects from studies of indoor radon exposure is less certain. To address this problem, a European pooled study is being performed to resolve the lung cancer risk from indoor radon to the public. his article summarises a workshop held in Oxford, during April 2000, by a European collaborative group that is examining the lung cancer risk associated with residential radon exposure. The workshop also served as the contractors meeting ...

RNA-BINDING PROTEINS IN LUNG CANCER Luis M. Montuenga, Ph.D. University of Navarra, Spain Modeling Human Lung Cancer in mice 4th International Mouse Lung Tumorigenesis symposium Bar Harbor, October 23-26 2003 Page 2 Pre mRNA mRNA Protein Splicing and maturation genes mRNA transport and stability genes Translation control genes Posttranslational modification and protein degradation genes Changes in Gene Expression Modified from: Cell, 100, 57–70, 2000 The Hallmarks of Cancer Douglas Hanahan and Robert A. Weinberg Page 3 Dreyfuss et al. Nature Reviews Mol Cell 3: 195; 2002 hnRNPs EJC: Exon-Exon Junction Complex Poly A binding complex PABP Etc. RNA-BINDING PROTEINS ...

7 Lung Cancer Cancer of the lung and bronchus is the second most common cancer among both men and women and is the leading cause of cancer death in both sexes. There were an estimated 164,100 new cases of lung cancer and an estimated 156,900 deaths from lung cancer in the United States in 2000. Among all cancer deaths in the State and the County, it has been the leading causes of death for many years. In 2001, it caused 119 deaths out of 1681 deaths in Lancaster County. Smoking is the single most well established attributable risk factor for lung cancer . Other risk factors include exposure to secondhand tobacco smoke, occupational exposure, and indoor and outdoor air pollution. The higher the number of cigarettes smoked per day the higher the risk of dying from lung cancer . However, cessation of smoking decreases the risk of having lung ...

lung cancer BRITISH THORACIC SOCIETY LUNG CANCER WORKING PARTY CONSENSUS STATEMENT ON SPECIALISED DIAGNOSTIC & THERAPEUTIC BRONCHOSCOPY Introduction: Specialised bronchoscopic techniques are available for diagnosis and for treatment of endobronchial disease. Principal treatment modalities are de-bulking techniques (electrocautery; forceps removal; laser; cryotherapy), photodynamic therapy, stenting, and brachytherapy. These modalities can be used alone or in combination to attempt cure or for symptom palliation, and can be combined with external beam radiotherapy for cancer , or prior to definitive surgery. Fluorescence Bronchoscopy (FB): Examples of the systems in use are laser imaging fluorescence endoscopy (LIFE); the Stortz D-light system; and the PENTAX SAFE 1000 system. Endobronchial ...