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Epidem iology EUROPEAN PROGRAMME FOR INTERVENTION EPIDEMIOLOGY TRAINING Veyrier-du-Lac, 28 September – 18 October 2003 Tobacco and lung cancer Exercise Source : Centers for Disease Control Atlanta, GA, USA Page 2 Tobacco and lung cancer , Page 2 of 11 Objectives This exercise uses the classic studies by Doll and Hill which demonstrated a relationship between smoking and lung cancer . After completing this exercise, the participant should be able to: 1. Discuss the elements of design and the advantages and disadvantages of case-control versus prospective cohort studies; 2. Discuss some of the biases which might have affected these studies; 3. Calculate and interpret a relative risk, rate difference, odds ratio, and attributable risk among the exposed; 4. Appreciate how the measures do or ...

Nature 182 (1958 July 12), 108. 275 LUNG CANCER AND CIGARETTES T HE ASSOCIATION observable between the practice of cigarette-smoking an the incid- ence of cancer of the lung , to which attention has been actively, or even vehemently, directed by the Medical Research Council Statistical Unit, has been interpreted, by that Unit, almost as though it demonstrated a casuals connection between these variables. The suggestion 1 , among others that might be made on the present evidence, that without any direct causation being involved, both characteristics might be largely in- fluenced by a common cause, in this case the individual genotype, was indeed rejected by one writer 2 , although I believe that no one doubts the importance of the genotype in predisposing to cancers of all types. It seemed to me that although the importance of this factor had ...

Purpose Resection planning for lung cancer treatment not only requires exact knowledge of the tumor’s localization and extent but also a sufficiently accurate prognosis of postope- rative lung function. Featuring precise CT-based segmentation of the lungs, the lung lobes, the bronchial tree and the tumor itself as well as a good approximation of the pulmonary segments, the proposed method is able to cover both aspects. Based on the segmentation results, a prognosis for postoperative lung function is given along with qualitative and quantitative information about the nodule’s localization with respect to other anatomical structures such as lobar boundaries. Moreover, the entry points of vessels and airways into the lobe(s) or lung to be resected can be displayed in 3d. The acquired information assists the surgeon in assessing risks and benefits of different resection strategies preoperatively and in planning ...

Agenda: ASCO/FDA Lung Cancer Endpoints Workshop April 15, 2003 Presentations: 1. Opening comments by Dr. Bunn and Dr. Pazdur 2. Regulatory background -Approval standards and approval endpoints (non- lung ) Dr.Williams -Approval endpoints for lung cancer Dr. Cohen -Endpoints used internationally Dr. Canetta 3. Classical lung cancer endpoints Dr. Johnson 4. Nonclassical lung cancer endpoints Dr. Gralla Morning session: discussions on endpoints Topics for discussion: 1. Discuss the pros and cons of each of the endpoints (classical and non-classical) as a primary efficacy endpoint, specifically: a. as a measure of, or a reliable surrogate for, clinical benefit (the efficacy standard for regular drug approval) b. as a surrogate reasonably likely to predict clinical benefit (the efficacy standard ...

Workshop Summary on Endpoints for Approval of Cancer Drugs for Lung Cancer Workshop participants: Paul Bunn, MD Richard Pazdur, MD Laurie Burke, PhD, MPH Renzo Canetta, MD Martin H. Cohen, MD Janet Dancey, MD Thomas R. Fleming, PhD Richard J. Gralla, MD David Johnson, MD Richard Kaplan, MD Patricia Keegan, MD Gerard T. Kennealey, MD Ellen Stovall Steve Piantadosi, MD, PhD Sheila Ross Scott Saxman, MD Deborah Y. Kamin, PhD Mark Somerfield, PhD Mary Lopez Wilson (This document summarizes discussions among the workshop participants and does not necessarily represent the views of the FDA.CDER) Abstract: The United States Food and Drug Administration (FDA) is embarking upon a process to evaluate endpoints used as the basis for approval of cancer drugs. In a series of public workshops, FDA will seek input ...

Summary of Recommendation The U.S. Preventive Services Task Force (USPSTF) concludes that the evidence is insufficient to recommend for or against screening asymptomatic persons for lung cancer with either low dose computerized tomography (LDCT), chest x-ray (CXR), sputum cytology, or a combination of these tests. I recommendation. The USPSTF found fair evidence that screening with LDCT, CXR, or sputum cytology can detect lung cancer at an earlier stage than lung cancer would be detected in an unscreened population; however, the USPSTF found poor evidence that any screening strategy for lung cancer decreases mortality. Because of the invasive nature of diagnostic testing and the possibility of a high number of false-positive tests in certain populations, there is potential for significant harms from screening. Therefore, the USPSTF could ...

Cancer Dataset Cancer Data Manual – Lung Cancer Appendix Appendix for Lung Cancer Table of contents Cancer Care Spell2 Lung Cancer Specific Codes and definitions.3 Additional data items for Lung Cancer ..9 Version 4.0 Page 1 of 10 Issue Date: 11.08.03 Page 2 Cancer Dataset Cancer Data Manual – Lung Cancer Appendix Cancer Care Spell A new Cancer Care Spell for • Any tumour with a different histology, irrespective of ICD-10 code or laterality • A tumour with a different three-character ICD-10 code, except in cases where this is considered to be recurrence of the original primary tumour • A tumour with different laterality except in cases where this is considered to be recurrence of the original primary tumour However, a single lesion of one histologic type is considered ...

Industrial Health 2003, 41 , 231–235 *To whom correspondence should be addressed. Original Article Mortality due to Silico-Tuberculosis and Lung Cancer Among 200 Whetstone Cutters Suteo OGAWA, Hiroto IMAI and Masayuki IKEDA* Kyoto Industrial Health Association, 67 Nishinokyo-Kitatsuboicho, Nakagyo-ku, Kyoto 604-8472, Japan Received January 10, 2003 and accepted March 5, 2003 Abstract: The objective of the present study was to examine if the mortality due to tuberculosis and cancer in the lungs was elevated in a cohort of 200 male whetstone cutters. 1955–1995 death certificate- based mortality data on the cohort were available, and the data were reviewed in the present study for mortality due to the two diseases to calculate standardized mortality ratios (SMR) in reference to the health statistics of Kyoto prefecture, where the cohort lived. Among the 200 cohort members, ...

MJA Vol 179 4 August 2003 125 Helical computed tomography for lung cancer screening Given the controversy over this strategy, Australia should be involved in its evaluation L UNG CANCER IS the leading cause of cancer death in Australia and has a dismal prognosis, with 7800 new cases and 6800 deaths each year, and a 5-year post-diagnosis survival of only 12%. New cases increasingly occur in ex- smokers. 1 Helical computed tomography (CT) is a fast and sensitive screening technique that can detect ...

Illinois Department of Public Health q 535 West Jefferson Street q Springfield, Illinois 62761 q 217.782.3300 www.idph.state.il.us q TTY800.547.0466 LUNG CANCER FA C T S E v e ry Breath Counts 3 FACTS Lung cancer is the leading cause of cancer death. In Illinois, between 1973 and 1992, the death rate from lung cancer rose more than the rate for all other cancers combined, including breast, prostate and colorectal cancers. In Illinois, pro- jections for 2001 indicate that there will be more than 8,540 new cases of invasive lung cancer and more than 7,000 people will die. Experts predict that in the next four years, twice as many women will die from lung cancer as from breast cancer . The lungs are large and cancer can grow in them for a long time, often for as long ...

F R E Q U E N T LY A S K E D Q U E S T I O N S WomensHealth.gov 1-800-994-9662 TDD: 1-888-220-5446 Q: Why should I be concerned about lung cancer ? Lung Cancer A: Did you know that lung cancer kills more women every year than breast cancer ? Researchers continue to study Q: What is lung cancer ? the causes of lung cancer and to search A: Cancer is a disease in which certain body cells don’t function right, divide very fast, and produce too much tissue that forms a tumor. The lungs, a pair of sponge-like, cone-shaped organs, are part of the body’s respiratory system. When we breathe in, the lungs take in oxygen, which our cells need to live and carry out their normal functions. When we breathe out, the lungs get rid ...

Progress in Lung Cancer Chemoprevention Victor Cohen, MD, and Fadlo R.Khuri, MD Background: Lung cancer is one of the major causes of cancer -related deaths. Lung cancer mortality figures argue powerfully for new approaches to control this disease. The term chemoprevention can be defined as the use of specific natural or synthetic chemical agents to reverse, suppress, or prevent premalignancy from progressing to invasive cancer . Methods: Issues related to lung cancer chemoprevention are reviewed, including risk factors and identification of high-risk cohorts, endpoint biomarkers, and current and new chemopreventive agents. Also, important findings from chemoprevention randomized, controlled trials are summarized. Results: Trials in lung cancer chemoprevention have so far produced either neutral or harmful primary endpoint results, whether in the primary, secondary, or ...

Editorial C a n c e r C o n t r o l July/August 2003, Vol.10, No.4 Cancer Control 275 Lung cancer continues to be a disease of epidemic proportion. In this year alone, it is estimated that 171,900 persons in the United States will be newly diagnosed with lung cancer and 157,200 will die of it. Thus, more people will die of lung cancer than of breast cancer , col- orectal cancer , and prostate cancer combined. The magnitude of the problem is similar in Europe. Because of an increasing prevalence of cigarette smoking in most parts of the world,it is anticipated that annu- al deaths from lung cancer may exceed 10,000,000 by 2030. In the United States, approximately one third of all deaths in people between 35 and 69 years of age are attribut- able to cigarette smoking,and ...

July/August 2003, Vol.10, No.4 306 Cancer Control A Systematic Review and Lessons Learned From Early Lung Cancer Detection Trials Using Low-Dose Computed Tomography of the Chest Gerold Bepler, MD, PhD, Dawn Goodridge Carney, MSPH, Benjamin Djulbegovic, MD, PhD, Robert A.Clark, MD, MBA, and Melvyn Tockman, MD, PhD Background : Computed tomography (CT) screening of the chest has shown promise for early detection of lung cancer , but evidence for a reduction in lung cancer mortality by CT screening is not available. Methods: We reviewed 208 articles to synthesize available evidence for efficacy of CT screening in detecting potentially curative stages of lung cancer and for evidence in reducing lung cancer mortality. Other outcomes of interest included detection rate of cancer and of suspicious lesions, histology and stage of cancer at detection, screening-related ...

Abstract: A pilot study was undertaken to investigate the differences in oxidative DNA damage and 2-h DNA repair in peripheral lymphocytes between lung cancer patients and healthy subjects. Twenty-four lung cancer patients and 23 normal controls were recruited from the Queen Mary Hospital, Hong Kong SAR, China. Single cell gel electrophoresis (comet assay) was performed to measure the oxidative damage, repair and baseline of peripheral lymphocytes in the subjects. There were no significant differences in baseline DNA damage and oxidative stress damage and DNA repair at 2 h among the two groups of lung cancer patients who had blood taken before and those who had blood taken after chemotherapy, and normal subjects. There were no differences in basal DNA, oxidative DNA damage or DNA repair between those with and without vitamin supplements in normal subject diets. ...

1 Of Mice Men and ( Lung ) Cancer Aravind Subramanian, Alejandro Sweet-Cordero, and Sayan Mukherjee The Problem: Validating a mouse model of lung cancer at the molecular level. Given DNA expres- sion data from a mouse model of lung adenocarcinoma, among a variety of human cancer expression data state the one most similar to the mouse model of adenocarcinoma. In addition, examine whether mutational effects in the human data might be related to the mouse model. Motivation: Animal models of human disease serve are basic to our understanding and attempts at treatment of disease. Mouse models have been used extensively to study cancer . However, there has never been a genomic or molecular validation of the various mouse models developed. We performed the first molecular validation of a mouse model. The mouse model we focussed on is a mouse model of adenocarcinoma. Previous Work: The mouse model ...

CIK 8852 CENTER FOR CONTINUING EDUCA TION 986800 Nebraska Medical Center Omaha, NE 68198-6800 NONPROFIT ORG. U.S. POST AGE P A I D OMAHA, NE PERMIT NO. 454 FALL MIDWEST LUNG CANCER CONFERENCE FALL MIDWEST LUNG CANCER CONFERENCE September 15-16, 2006 Omaha Marriott Hotel 10220 Regency Circle Omaha, Nebraska FRIDAY, September 15, 2006 7:30 a.m. R EGISTRATION AND C ONTINENTAL B REAKFAST 8:00 a.m. W ELCOME /I NTRODUCTIONS Rudy P. Lackner, MD 8:10 a.m. P ATHOLOGY OF L UNG C ANCER William W. West, MD 8:50 a.m. L UNG C ANCER S CREENING ...

Industrial Health 2001, 39 , 65–74 *To whom correspondence should be addressed. Review Article Asbestos-Related Lung Cancer and Mesothelioma in Japan Kenji MORINAGA 1 *, Takumi KISHIMOTO 2 , Mitsunori SAKATANI 3 , Masanori AKIRA 3 , Kunihiko YOKOYAMA 3 and Yoshizumi SERA 3 1 Osaka Medical Center for Cancer and Cardiovascular Diseases, 1–3–3 Nakamichi, Higashinari-ku, Osaka 537- 8511, Japan 2 Okayama Rousai Hospital, 1–10–25 Chikko-midorimachi, Okayama 702-8055, Japan 3 National Kinki-Chuo Hospital for Chest Disease, 556 Nagasone-cho, Sakai 537-8888, Osaka, Japan Received January 15, 2001 and accepted February 28, 2001 Abstract: In Japan, crocidolite had been used for asbestos cement pipe and spraying, and amosite had been ...

Industrial Health 2001, 39 , 194–197 *To whom correspondence should be addressed. Case Report An Operated Case of Lung Cancer with Pleural Plaques: Its Asbestos Bodies, FiberAnalysis and Asbestos Exposure Takesuke HIRAOKA 1 *, Akira WATANABE 1 , Yasuhiro USUMA 1 , Takashi MORI 1 , Norihiko KOHYAMA 2 , Ayako TAKATA 2 1 National Miyazaki Hospital Kawaminami 19403–4, Koyu-gun 889-1301, Miyazaki, Japan 2 National Institute of Industrial Health, Ministry of Labour, Nagao 6–21–1, Tama-ku, Kawasaki 214-8585, Japan Received January 5, 2001 and accepted March 2, 2001 Abstract: This case was a 79-year-old man with pleural plaques, which had been pointed out in the left lung field on chest X-ray six years ago. A new shadow in the right chest appeared ...

Industrial Health 2003, 41 , 94–100 *To whom correspondence should be addressed. Original Article Clinical Study of Asbestos-Related Lung Cancer Takumi KISHIMOTO 1 *, Kazuo OHNISHI 2 and Yoshiaki SAITO 3 1 Department of Occupational Pulmonary Disease, Okayama Industrial Injury Hospital, 1-10-25 Chikkomidorimachi, Okayama 702-8055, Japan 2 Kobe Industrial Injury Hospital, Kobe, Japan 3 Keihai Industrial Injury Hospital, Fujiwara, Japan Received May 30, 2002 and accepted February 6, 2003 Abstract: We analyzed the characteristics of 120 patients of primary lung cancer supposed to be induced by exposure to asbestos. Most of 120 patients were male and the age ranged from 47 to 87 years with a median of 70 years. No particular tendency was observed in the histological types of the lung ...

LUNG Josephine Fleming set a world record as the first lung cancer patient to survive five years after starting gene therapy. A life-long resident of Denton, Texas, Fleming enjoys her eight grandchildren, going places with friends, and making tamales, pralines and peanut brittle. Just the Facts Lung Cancer Smoking is responsible for 87 percent of all lung cancer cases in the United States. Eliminating tobacco use is the key to reducing the impact of this disease. Symptoms Symptoms of lung cancer vary from person to person and may include: • a cough that will not go away and gets worse over time • constant chest pain, or arm and shoulder pain • coughing up blood • shortness of breath, wheezing or hoarseness • repeated episodes of pneumonia or bronchitis • swelling of the neck and face • loss of appetite and/or weight loss ...

Artificial Ingelligence in Medicine, 2002, vol.24, no.1, pp.25-36. @Elsevier Lung Cancer Cell Identification Based on Artificial Neural Network Ensembles Zhi-Hua Zhou*, Yuan Jiang, Yu-Bin Yang, Shi-Fu Chen National Laboratory for Novel Software Technology, Nanjing University, Nanjing 210093, P.R.China Abstract An artificial neural network ensemble is a learning paradigm where several artificial neural networks are jointly used to solve a problem. In this paper, an automatic pathological diagnosis procedure named Neural Ensemble based Detection (NED) is proposed, which utilizes an artificial neural network ensemble to identify lung cancer cells in the images of the specimens of needle biopsies obtained from the bodies of the subjects to be diagnosed. The ensemble is built on a two-level ensemble architecture. The first-level ensemble is used to judge whether a cell is normal with high confidence ...

548 American Journal of Epidemiology Copyright © 2002 by the Johns Hopkins Bloomberg School of Public Health All rights reserved Vol. 156, No. 6 Printed in U.S.A. DOI: 10.1093/aje/kwf070 Exposure to Residential Radon and Lung Cancer in Spain: A Population-based Case-Control Study Juan Miguel Barros-Dios 1,2 , María Amparo Barreiro 1 , Alberto Ruano-Ravina 1 , and Adolfo Figueiras 1 1 Department of Preventive Medicine and Public Health, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. 2 Preventive Medicine Unit, Santiago de Compostela University Teaching Hospital, Santiago de Compostela, Spain. Received for publication July 26, 2001; accepted for publication May 8, 2002. Although high radon concentrations have been linked to increased ...

Lung CanCer © Copyright 2006 American Lung Association of Metropolitan Chicago. All rights reserved. Signs and Symptoms While symptoms in the earliest stages of lung cancer are hard to detect, as the disease progresses symptoms can include: • Chronic cough • Hoarseness • Coughing up blood • Weight loss or loss of appetite • Shortness of breath • Unexplained fever • Wheezing • Recurring bronchitis or pneumonia • Chest or shoulder pain If you have any symptoms, or you believe you may be at risk, talk to your doctor, who can help take the necessary steps to protect your health. An Overview for You and Your Family Resources American Lung Association of Metropolitan Chicago (312) 243-2000 www.lungchicago.org CancerCare, Inc. (800) 813 HOPE (4673) www.cancercare.org Cancer Support Center (708) 798-9171 ...

Lung Cancer Initiative Advisory Council Susan Abbinanti Alexian Brothers Medical Center Joel Africk American Lung Association of Metropolitan Chicago Jenny Abrams, MSW Loyola University Medical Center Kathy Albain, MD Loyola University Medical Center Lissa Anderson Cancer Wellness Center Renate Anderson American Lung Association of Metropolitan Chicago David Asplund Lung Cancer Survivor and Advocate Philip Bonomi, MD Rush University Medical Center Kathleen Boss Gilda’s Club Chicago Deborah Bullwinkle Lung Cancer Advocate Jeannie Cella Wellness House Prem Chawla Lung Cancer Alliance Illinois Advocate Cindy Collins LUNGevity Foundation Margaret Davis Healthcare Consortium of Illinois Willard Fry, MD Board of Directors, ALAMC Thomas Hensing, MD Evanston Northwestern ...

Lung Cancer Resources American Lung Association of Metropolitan Chicago 1440 West Washington Blvd., Chicago, IL 60607 (312) 243-2000 www.lungchicago.org American Society for Clinical Oncology www.asco.org CancerCare, Inc. 120 East Avenue; New York, NY 10001 (800) 813 HOPE (4673) www.cancercare.org Jennifer S. Fallick Cancer Support Center 2028 Elm Road; Homewood, IL 60430 (708) 798-9171 www.cancersupportcenter.org Cancer Survivors against Radon www.cansar.org Cancer Wellness Center 215 Revere Drive; Northbrook, IL 60062 (847) 509-9595 www.cancerwellness.org Gilda’s Club Chicago 537 N. Wells St.; Chicago, IL 60610 (312) 464-9900 www.gildasclubchicago.org Joan’s Legacy: The Joan Scarangello Foundation to Conquer Lung Cancer ...

Lung Cancer Survey 2001 Page 2 Figure 1. Smoking History - 131 newly diagnosed lung cancer patients at Stony Brook Hospital in 2001 Current 54% Former 37% Never 6% Unknown 3% Current Former Never Unknown Page 3 Figure 2. Gender distribution for lung cancer patients at Stony Brook Hospital in 2001 compared to National Cancer Data Base 1994-1998 benchmark report. 0% 10% 20% 30% 40% 50% 60% 70% Males Females Stony Brook NCDB Page 4 Figure 3. Age at diagnosis of lung cancer at Stony Brook Hospital in 2001 compared to National Cancer Database 1994-1998 benchmark report. 0 10 20 30 40 ...

Contact: Michelle Slattery Spectrum Science Public Relations 1020 19th Street NW Suite 800 Washington, DC 20036 (202) 955-6222 mts@spectrumscience.com Copyright 2001 Burrelle's Information Services ABC News SHOW: Women and Cigarettes: A Fatal Attraction (10:00 PM ET) - ABC July 5, 2001 Thursday TYPE: Special Program/Profile LENGTH: 7322 words HEADLINE: Smoking poses greater health risks for women ANCHORS: Dr. NANCY SNYDERMAN BODY: Announcer: This is an ABC News Special. Dr. NANCY SNYDERMAN, host: (VO) You won't believe how many women are doing it--teen-agers, hot young stars, maybe even you. Young women lighting up cigarettes more and more. And did you know smoking hurts women more than men? (OC) When you see pictures of yourself with a cigarette in your hand, do you cringe? Ms. CHRISTY TURLINGTON: Oh, my God. It's awful. ...

(formalin fixed) A716: Test slide - Lung cancer tissues with corresponding normal tissues For research use only Specifications: • No. of cases: 6 • Tissue type: Test slide, lung cancer tissues with corresponding normal tissues • No. of spots: 1 spot from each cancer case (6 spots) 6 non-neoplastic spots (6 spots) • Total spots: 12 • Corresponding normal tissues with cancers: Yes • Diameter: 1. 0 mm Documents : • Product specification: layout, summary of tissue spots • H&E stained images • Detailed pathological information Layout: Page 2 (formalin fixed) A716: Test slide - Lung cancer tissues with corresponding normal tissues For research use only Summary of tissue spots No. Coordinate Sex Age Organ KeyWord 1 ...