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North American Educational Forum on Lymphoma November 2004, San Francisco, CA Cancer Clinical Trials: An Overview Patty Delaney, U.S. Food and Drug Administration This is a transcript of an audio recording from the North American Educational Forum on Lymphoma , provided as a free service to the public. A professional medical transcription service produced the transcript. LRF and the speakers have not edited the content for accuracy or omissions of information. Patients are encouraged to talk to their physicians for complete information on how their disease should be diagnosed, treated, and followed. LRF’s educational materials are not intended to take the place of medical care or advice from your doctor. Webcasts (audio and slides) are archived at lymphoma .org. Delaney: Patty Delaney, Food and Drug Administration F: Female speaker M: Male speaker M: [UNRELATED ...

, , - - - - @ . Non-Hodgkin’s lymphoma reprinted from national cancer institute, www.cancer.gov, united states Introduction The diagnosis of cancer brings with it many questions and a need for clear, understandable answers. This National Cancer Institute (NCI) booklet is intended to help people with non- Hodgkin’s lymphoma and their families and friends better understand this type of cancer. We hope others will read it as well to learn more about this disease. This booklet discusses symptoms, diagnosis, and treatment. It also has information about resources and sources of support for people with non-Hodgkin’s lymphoma . Medical research has led to real progress against non-Hodgkin’s lymphoma —increased survival rates and improved quality of life. Through research, our knowledge about non- Hodgkin’s lymphoma ...

Lymphoplasmacytoid Lymphoma Presenting as Severe Osteoporosis W. Atoyebi, 1 * M. Brown, 2 J. Wass, 2 T.J. Littlewood, 1 and C. Hatton 1 1 Department of Hematology, John Radcliffe Hospital, Oxford, United Kingdom 2 Department of Endocrinology and Metabolism, Nuf®eld Orthopedic Centre, Oxford, United Kingdom We report four cases presenting with severe osteoporosis which on further investigation were found to have an underlying lymphoplasmacytoid lymphoma (LPL). Common sec- ondary causes of osteoporosis were excluded in each case. Three of the cases re- sponded to treatment with a biphosphonate. As these lymphomas share some common pathological and clinical features with multiple myeloma (MM) an association with os- teoporosis is likely to represent more than a coincidental ®nding. ...

NH LYMPHOMA BOTH SEXES TABLE 1A. -- Characteristics of persons reported to the Connecticut Tumor Registry with an initial non-Hodgkin's lymphoma , 1935-82+ _ Category Male Female Total _ No. with first primary cancer* 3,539 3,195 6,734 No. who developed a second primary cancer 196 123 319 Average age at diagnosis of first cancer, yr 56 60 58 Average yr of diagnosis of first cancer 1966 1967 1967 Person-yr of follow-up 14,378 12,854 27,231 Average follow-up, yr 4.1 4.0 4.0 Percent given radiotherapy for first cancer 52.0 50.5 51.3 _ + ICD-O morphology codes = 9590-9642,9690-9701,9750. * Number excludes all persons who survived less than 2 mo after the diagnosis of their first primary cancer or who developed a simultaneous cancer during this period. First primary cancers diagnosed only at autopsy or by death certificate are also excluded as are in situ cancers. TABLE 1B. -- Microscopic ...

131 Colon and Rectum Summary Male Female Utah 1996-2000 US 1996-99 Utah 1996-2000 US 1996-99 Average annual age-adjusted incidence rates* 2.8 3.1 2.0 2.6 Rank among cancer incidence rates <20 <20 20 19 Average annual number of new cases 28 4,050 21 3,590 Percent of all new cancer cases 0.9 % 0.7 % 0.7 % 0.6 % * Rates per 100,000 and standardized to the 2000 U.S. population Lifetime risk of this cancer (00-79 years) 1 in 414 1 in 385 1 in 658 1 in 478 Average annual age-adjusted mortality rates* 0.6 0.6 0.3 0.4 Rank among cancer mortality rates <20 <20 <20 <20 Average annual number of deaths 4 769 2 622 Percent of all cancer deaths ...

137 Colon and Rectum Summary Male Female Utah 1996-2000 US 1996-99 Utah 1996-2000 US 1996-99 Average annual age-adjusted incidence rates* 23.4 23.5 14.3 15.9 Rank among cancer incidence rates 6 5 7 6 Average annual number of new cases 163 27,580 117 23,690 Percent of all new cancer cases 5.0 % 4.3 % 4.1 % 3.8 % * Rates per 100,000 and standardized to the 2000 U.S. population Lifetime risk this of cancer (00-79 years) 1 in 44 1 in 44 1 in 68 1 in 62 Average annual age-adjusted mortality rates* 10.5 10.8 7.1 7.2 Rank among cancer mortality rates 4 5 5 6 Average annual number of deaths 68 12,047 58 11,115 Percent of all cancer deaths 5.7 % 4.3 % ...