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Lymphoma Simplified Our body is made of countless cells of many types. Cells have specialized jobs and names, such as skin, nerve, heart, lung, blood, immune cells, and so on. For the human body to function normally, each organ must have a certain number of cells. By design, the cells in most organs have a short lifespan. Therefore, to continue functioning the body needs to replace these lost cells by the process of cell division. Cell division and cell death are controlled by genes that are located in the cell nucleus. Genes function like an instruction manual telling the cell what proteins to make. These proteins in turn control the behavior of the cell. Some proteins direct the cell to divide; others how long it will live; and others begin cell death - a normal process by which the body rids itself of old, unneeded, or damaged cells. Under ...

173 Chapter 16 Non-Hodgkin’s lymphoma Ray Cartwright, Helen Wood, Mike Quinn Summary • In the UK and Ireland in the 1990s, non-Hodgkin’s lymphoma accounted for 1 in 30 cases of cancer and 1 in 40 deaths from cancer. • There was the suggestion of a north-south divide in incidence across England, with higher than average rates in London and the south, and lower incidence in the midlands and north. Incidence was also higher than average in Northern Ireland and Scotland. • The observed pattern in mortality was similar to, but less clear-cut than that for incidence. • There appears to be a weak (negative) link between incidence and deprivation, with slightly higher rates in more affluent areas, although there is no known causative factor for which affluence could be a marker. • It is unlikely that any of the known risk factors for developing NHL ...

Center for Environmental Health Studies (617) 482-9485 44 Farnsworth Street, Boston, MA 02210 http://www.jsi.com Non-Hodgkin’s Lymphoma (NHL) and Exposure to Ionizing Radiation 1 Non-Hodgkin’s Lymphoma (NHL) and (Lymphosarcoma and reticulum cell sarcoma) Exposure to Ionizing Radiation Summary : Some evidence has been recorded of a possible connection between non-Hodgkin's lymphoma and exposure to ionizing radiation. There is possible evidence from studies conducted at Los Alamos National Laboratory. Studies of nuclear workers at other sites who have been exposed to ionizing radiation and persons exposed to the atomic bomb show an increase risk of developing non-Hodgkin's lymphoma . The National Research Council’s BEIR V committee did not address the issue of radiation- induced non-Hodgkin’s lymphoma . Non-Hodgkin's lymphoma is designated as a “specified” cancer ...

A fact sheet from the Greater Bay Area Cancer Registry B-cell lymphoma in the Greater Bay Area 1988-2002 Spring 2005 B-cell lymphoma comprises about 85% of all non-Hodgkin’s lymphomas, the fifth most com- mon cancer in non-Hispanic white males. It is more commonly diagnosed in men and among the elderly. In 2002, over 900 cases of b-cell lymphoma were diagnosed in the Greater Bay Area. Figure 1. Age-adjusted incidence rates forb-cell lympoma by sex and yearof diagno- sis, Greater Bay Area, 1988-2002 Figure 2. Age-adjusted incidence rates for b-cell lym- phoma by sex and race/ethnicity, Greater Bay Area, 1988-2002 0 5 10 15 20 25 1988-1990 1991-1993 1994-1996 1997-1999 2000-2002 Year of diagnosis R a t e pe r 100,000 Males Females 21.7 ...

North American Educational Forum on Lymphoma November 2004, San Francisco, CA Antisense Therapy - Barbara Pro, M.D. This is a transcript of an audio recording from the North American Educational Forum on Lymphoma , provided as a free service to the public. A professional medical transcription service produced the transcript. LRF and the speakers have not edited the content for accuracy or omissions of information. Patients are encouraged to talk to their physicians for complete information on how their disease should be diagnosed, treated, and followed. LRF’s educational materials are not intended to take the place of medical care or advice from your doctor. Webcasts (audio and slides) are archived at lymphoma .org. Pro: Barbara Pro F: Female speaker M: Male speaker Pro: Thank you very much for the initiation. It is a pleasure to be here and to be able to share ...

North American Educational Forum on Lymphoma November 2004, San Francisco, CA Vaccine For NHL: Update Julie M. Vose, MD This is a transcript of an audio recording from the North American Educational Forum on Lymphoma , provided as a free service to the public. A professional medical transcription service produced the transcript. LRF and the speakers have not edited the content for accuracy or omissions of information. Patients are encouraged to talk to their physicians for complete information on how their disease should be diagnosed, treated, and followed. LRF’s educational materials are not intended to take the place of medical care or advice from your doctor. Webcasts (audio and slides) are archived at lymphoma .org. Vose: Julie M. Vose, MD, University of Nebraska Medical Center F: Female speaker M: Male speaker M: Our next speaker’s going to be Dr. Julie ...

North American Educational Forum on Lymphoma November 2004, San Francisco, CA Bridging the Gap Between Nutrition and Lymphoma Valerie Kogut, MA, RD, LDN This is a transcript of an audio recording from the North American Educational Forum on Lymphoma , provided as a free service to the public. A professional medical transcription service produced the transcript. LRF and the speakers have not edited the content for accuracy or omissions of information. Patients are encouraged to talk to their physicians for complete information on how their disease should be diagnosed, treated, and followed. LRF’s educational materials are not intended to take the place of medical care or advice from your doctor. Webcasts (audio and slides) are archived at lymphoma .org. Kogut: Valerie Kogut, MA, RD, LDN, University of Pittsburgh Medical Center F: Female speaker M: Male speaker Kogut: ...

North American Educational Forum on Lymphoma November 2004, San Francisco, CA Cancer Clinical Trials: An Overview Patty Delaney, U.S. Food and Drug Administration This is a transcript of an audio recording from the North American Educational Forum on Lymphoma , provided as a free service to the public. A professional medical transcription service produced the transcript. LRF and the speakers have not edited the content for accuracy or omissions of information. Patients are encouraged to talk to their physicians for complete information on how their disease should be diagnosed, treated, and followed. LRF’s educational materials are not intended to take the place of medical care or advice from your doctor. Webcasts (audio and slides) are archived at lymphoma .org. Delaney: Patty Delaney, Food and Drug Administration F: Female speaker M: Male speaker M: [UNRELATED ...

FOLLICULAR LYMPHOMA Histology: This section of the treatment guidelines covers Follicular lymphoma grades I and II only. Follicular lymphoma grade III is treated like Large Cell Diffuse lymphoma (see corresponding section). Staging procedure: - Pathology review - CBC, differential - Bone Marrow biopsy ( unilateral ) - Electrolytes, BUN, Creatinine, Uric acid , LDH - Serum protein electrophoresis - CXR - C.T. scan of chest, abdomen and pelvis - ENT assessment for high neck node involvement or gastrointestinal involvement. - Lumbar puncture in patients with CNS, bona marrow, testicular involvement, or with elevated LDH and extranodal involvement, or unexplained neurological symptoms. Staging: Based on the Ann-Arbor system . [as in LCDL]. B- symptoms (should be recorded.) [as in LCDL] International Prognostic Index (IPI) ...

Aggressive Histology Non-Hodgkin’s Lymphoma Diffuse Large B Cell Lymphoma Diagnosis There are 6000 new cases of non-Hodgkin’s lymphoma diagnosed annually in Canada, of which 30% are diffuse large B cell histology. Fine needle aspiration is not generally accepted as adequate for diagnosis. Core needle or excisional biopsy is required because of the need to establish the diagnosis unequivocally and to determine the histologic subtype. Staging Procedure • Pathology review • Bloodwork including CBC and differential , AST, ALT, albumin, ALP, bilirubin, Cr, LDH, uric acid • Hepatitis serology (HBsAg, HBcAb) • Consider HIV testing in high risk patients • Consider unilateral bone marrow aspiration and biopsy • CXR PA and Lateral • CT scan thorax, abdomen, pelvis • EF assessment (echo, MUGA) if >60 years of age or cardiac risk factors • Consider ENT examination ...

DRAFT 1 Lymphoma site group: draft treatment policy document for ‘other lymphomas’, paraproteinemias, etc in adults B-CELL NEOPLASMS PRECURSOR B-CELL NEOPLASM Precursor B lymphoblastic Leukemia (precursor B-ALL)/ lymphoma 1. Essential Diagnostic Investigations • Bone marrow with immunophenotype and cytogenetics 2. Staging and other necessary investigations • CBC, creatinine, electrolytes, phosphate 3. Chemotherapy • Good performance status and age < 65 years i. Standard adult ALL regimen (e.g. CALGB 8811) or ii. NCIC clinical trial for standard therapy in adult ALL • 65 years and over: Vincristine and Prednisone induction plus other treatment as appropriate. In general do not use aggressive induction, consolidation or CNS therapy 4. Radiation Therapy • CNS prophylaxis in selected patients 5. Supportive Care ...

Neurological Signs due to Spinal Lymphoma in a Ferret Jennifer M. Mateleska, DVM and Joerg Mayer, Dr. Med.vet., MSc. Lymphoma is one of the most common neoplasias seen in ferrets and can affect ferrets of all ages. The disease can involve numerous tissues, most often including peripheral and visceral lymph nodes, liver, spleen, bone marrow, kidney, lung, mediastinum, and intestine. Less often, the nervous system, stomach, pancreas, adrenal glands, and skin are involved. Clinical signs of lymphoma in ferrets are often vague and can mimic those seen in other diseases. Viral involvement has been suggested, but there is no significant evidence of this to date. Presentation A six-year-old castrated male ferret named Fred presented to the Exotics Service at Tufts University School of Veterinary Medicine with a three-day history of lethargy and hind limb paresis. There was no known history of trauma ...

Lymphoma Foundation of America SOLVENTS AND LYMPHOMA A Report Published by Lymphoma Foundation of America 814 N. Garfield Street Arlington, VA 22201 (703) 875-9800 Contact Lymphoma Foundation of America at (703) 875-9800 for information on this report or for information on pesticides and other environmental causes of lymphoma . Founded by lymphoma patients and their families in 1986, Lymphoma Foundation of America is a non-profit charity serving lymphoma survivors and their families with counseling, referrals, support, and information on ways to prevent recurrences of lymphoma . © 2005 All rights reserved. Page 2 Lymphoma Foundation of America INTRODUCTION: SOLVENTS AND LYMPHOMA Everyone wants to be as healthy as possible. Whether you are a lymphoma survivor who wants to stay in remission, ...

Summary Usefulness of Gallium-67 Scintigraphy in Diagnosing Pyothorax-associated Lymphoma Hiroshi S HIROYAMA , Mitsuru K OIZUMI and Takashi Y AMASHITA Department of Nuclear Medicine, Cancer Institute Hospital Two cases of pyothorax-associated malignant lym- phoma were reported. The presence of chronic tuber- culous pyothorax after thoracoplasty and the develop- ment of non-Hodgkin’s lymphoma on the chest wall are closely related. Both patients had suffered from tuberculous pyothorax for more than thirty years, and developed new painful chest wall tumors. CT and MRI delineated both malignant lymphoma and pyothorax. Gallium-67 accumulated strongly in ma- lignant lymphoma , however did not in pyothorax. Gallium-67 scintigraphy was useful for detection of malignant lymphoma in both cases; therefore it could be a useful test for diagnosing ...

research for a cure laboratory without walls National Foundation for Cancer Research Cancer FAQs about lymphoma Frequently Asked Questions about common cancers. Page 2 About Lymphoma Hodgkin’s Disease and Non-Hodgkin’s Lymphoma Lymphoma is a general term for cancers of the lymphatic system. The lymphatic system is part of the immune system. It consists of a network of vessels and nodes. The vessels carry a watery fluid called lymph, which contains infection-fighting white blood cells, to all parts of the body. Scattered throughout the network of vessels are lymph nodes, where white blood cells are made and stored. Clusters of lymph nodes are found in the underarms, groin, neck, chest and abdomen. The spleen, bone marrow, thymus and tonsils are also parts of the lymphatic system. Lymphoma develops when white blood cells ...

178 J La State Med Soc VOL 154 July/August 2002 Journal of the Louisiana State Medical Society C LINICAL C ASE OF THE M ONTH T ARGET A UDIENCE The July/August Clinical Case of the Month is intended for all physicians, especially family physicians, inter- nists, general practitioners, pediatricians, emergency medicine physicians, dermatologists, hematologists- oncologists, clinical pharmacologists, and neurologists, and is also intended for clinical pharmacists. E DUCATIONAL O BJECTIVES After reading this article, physicians be able to better identify and understand the epidemiology, clinical pre- sentation, pathogenesis, and treatment of the anticon- vulsant hypersensitivity syndrome. C REDIT The LSMS Educational and Research ...

This real life story highlights the life-saving power of Best Doctors ® 1 – connecting people to the best medical care. Case Study – Lymphoma Page 2 This real life story highlights the life-saving power of Best Doctors – connecting people to the best medical care. Ellen * , Age 55 Canada Initial Diagnosis Ellen was experiencing severe abdominal pain. Despite seeing several doctors and receiving a variety of treatments, including antibiotics, pain killers, anti-inflammatory and immunosuppressive therapies, nothing seemed to help. Ultimately, several imaging studies showed a thickening of the abdominal fat (mesenterium). Ellen’s doctors recommended and performed surgery to remove the abdominal fat, as well as her appendix. After surgery, the pathologist diagnosed Ellen with a mesenteric panniculitis, ...

SUPPORTING THE NEEDS OF THE UNDERINSURED Patient Access Network Foundation PO Box 221858 Charlotte, NC 28222-1858 1.866.316.PANF (7263) www.patientaccessnetwork.org NON-HODGKIN’S LYMPHOMA Non-Hodgkin’s lymphoma (NHL) is a malignant growth of B or T cells in the lymph system. In the US, childhood Non-Hodgkin's lymphomas make up about 5 percent of the cases of NHL diagnosed each year. There are approximately 29 adult non-Hodgkin's lymphomas. There are several treatments for NHL. Usually chemotherapy is used. If the lymphoma is localized, radiation therapy might be used possibly in conjunction with chemotherapy. In some types of advanced NHL (but not all) bone marrow or peripheral blood stem cell transplants can be used (often for serious/ unresponsive cases). Private insurance and Medicare are the most common types of health coverage ...

INDIAN JOURNAL OF MEDICAL & PAEDIATRIC ONCOLOGY Vol. 25 No.4, 2004 32 size and appeared to be totally replaced by an extensive lobulated homogenous solidly enhancing soft tissue mass. The size of the mass was approximately 11x8x13 cms in maximum axial and vertical dimensions causing marked elevation of urinary bladder and detrusor ischiorectal from chronic outlet obstruction. The mass exhibited a lobulated outline, loss of fat planes with the rectum posteriorly and the levator ani muscles laterally,extending into the ischiorectal fossa bilaterally. The lesion exhibited more or less homogenously solid enhancement and attenuation characteristics. Multiple solidly enhancing lymph nodes were also appreciated in the bilateral inguinal regions, bilateral internal and external iliac regions with the largest nodes measuring approximately 2.5 cms in maximum transverse dimensions ...

GeneExpression in Adult T Cell Leukemia/ Lymphoma : Up-Regulation of Matrix Metalloproteinase2in Skin Lesions KennosukeKarube ,Koichi Ohshima ,Makoto Hamasaki , Takeshi Tsuchiya ,Takahiro Yamaguchi ,Hiroaki Suefuji , Junji Suzumiya ,Kazuki Nabeshima ,AtaeUtsunomiya , MineHarada and Masahiro Kikuchi The neoplastic cells of adult T-cell leukemia/ lymphoma (ATLL) invade various body organs, typicallythe lymph nodes (LN)and skin. Thepresent studywas designed to clarifythemechanism of invasion, by using a DNA array that allowed comparison of gene expression among ATLL cells in different sites,namelyperipheralblood (PB),LN,andskin. Theexpressionofmatrix metalloproteinase 2(MMP-2)mRNA wassignificantlyup-regulated in skin relativeto PB. Immunohistochemistryshowed higher MMP-2expression in ATLL cells found in theskin than in LN. Expression ofmembrane-type1- MMP (MT1-MMP),an activator ofpro-MMP-2,was detected in ...

1 Hillard M. Lazarus, MD, FACP Case reviews for Elidel and lymphoma January 11, 2005 I. Case 1: A 61 year old woman who apparently developed histiocytic lymphoma after only a few weeks of exposure to Elidel treatment. 1. Additional info: Evaluating the tissue would be useful (true histiocytic lymphoma is quite rare). Obtaining serology to document HIV and HCV status would have been useful. What was the patient’s history for tobacco use and what was the duration of the patient’s exposure to hair dye? 2. Causal association: in my opinion, it is extremely unlikely that this patient developed lymphoma on the basis of Elidel therapy. 3. Explanation: The interval between duration and development of lymphoma is so short it is more likely that the patient already had contracted lymphoma at the time the Elidel was initiated. In fact, there is an association between eczema and the subsequent ...

Jonathan W. Friedberg: Lymphoma Case Review Novartis Pharmaceutical Corporation General comment: clinicopathologic features of NHL as a consequence of immunosuppression Assessment of EBV in malignant cells is critical in determining whether or not a biopsy represents a lymphoma secondary to immunosuppression. At most academic centers, EBER staining is the standard (RNA probe bound to peroxidase, resulting in “brown stain”), with high sensitivity and specifity. Other ways of assessing EBV include EBNA-2 staining, and in situ assessment of EBV. In the appropriate clinical setting, NHL containing EBV is almost certainly representative of an “immunodeficiency- related” NHL, either from HIV, iatrogenic immunosuppression, or idiopathic causes. Hodgkin’s disease is somewhat different, as up to 30-40% of HD is EBV positive in several series, without clear relationship to otherwise immunosuppressed state. ...

11/02/2005 1/4 EORTC LYMPHOMA GROUP MEETING S HERATON B RUSSELS , H OTEL & T OWERS H OLBEIN M EETING R OOM 3 P LACE R OGIER , 1210 B RUSSELS , B ELGIUM F RIDAY M ARCH 18, 2005 09.00 – 12.30 09.00 – 09.25 First session: information, NHL session 09.00 Welcome H. Eghbali 09.05 Minutes of Meeting in Leiden All 09.15 Election of new chairman H. Eghbali 09.25 – 10.30 Discussion about ongoing studies (NHL) Ongoing trials NHL 09.25 - 20971 Follicular st.I: IFRT +/- low dose TBI J. Meerwaldt, C. Rozewicz 09.40 - 20981 Follicular relapse CHOP+/-Mabthera ...

Page 2 Contents 2 Lymphoma 3 Lymphatic System 4 Tests 8 Diagnosis 10 Radiotherapy 13 Chemotherapy 21 Digestion Problems 24 Eating Well 25 Fertility and Sex 27 Hospital 32 Going Home 36 Treatment Options and Trials 38 Getting More Help 40 My Notes Page 3 1 This book is for you If you are a young person who has lymphoma . It gives information about lymphoma and how it is treated. It also covers ways you can look after yourself, and how you may feel. It is divided into sections You don’t need to read them in order. Besides information, a section ...

abc H o d g k i n ’s disease & other lymphomas myeloma • myelodysplasia • aplastic anaemia the myeloproliferative disorders • the leukaemias Page 2 A c k n o w l e d g e m e n t s Leukaemia Research Fund gratefully acknowledges the help and advice of Professor A. V. Hoffbrand in reviewing this series of publications and the assistance of Professor A. Burnett, Professor D. Catovsky, Professor J. Chessells, Professor J. Goldman, Dr A. Haynes, Professor G. Morg a n , Dr S. O’Brien, and Professor J. Sweetenham in the preparation of specific titles. Published by Leukaemia Research Fund , April 2001 43 Great Ormond Street L o n d o n WC1N 3JJ Tel: 020 7405 0101 Email: info@lrf.org . u k Fax: 020 7242 1488 Web: www. l r f . o rg . u k Registered Charity 216032 © All rights reserved. No part of this publication may be reproduced ...

Primary thyroid lymphomas constitute up to 5% of all thyroid malignancies and can be divided into non- Hodgkin’s lymphomas (NHL) of the B and T cell types and Hodgkin’s lymphomas. Mucosa-associated lymphoid tissue (MALT) lymphomas are a subset of B cell NHL, and they are listed as marginal zone B cell lymphomas of the MALT type according to the revised European-American lymphoma classification (1) and the more recently proposed World Health Organization classification of hematopoietic and lymphoid tissue neoplasms (2). MALT lymphomas’ most common location is the mucosa of the gastrointestinal tract. However, they may also occur in the lungs, salivary glands, skin, subcutaneous tissue and other sites including the thyroid (3-6). It is thought that lymphomas originating in this wide variety of primary sites represent a malignant transformation of acquired lymphocytic tissue during the course ...

In a case-control study based on 859 consecutive non- Hodgkin’s lymphoma (NHL) cases identified through a tumor registry between 1990 and 1998, the authors col- lected demographic, occupational, exposure, and edu- cation information. Exposures were identified through self-report, reported occupational history, and the use of a job-exposure matrix. Conditional logistic regression analyses of the 859 cases and 1,310 controls showed increased risks in workers exposed to gasoline (odds ratio [OR] 1.46; 95% confidence interval [CI] 1.04, 2.05), aliphatic or alicyclic hydrocarbons (OR 1.75; CI 1.03, 2.99), aromatic hydrocarbons (OR 1.45; CI 1.13, 1.86), and solvents for more than five years (OR 1.59; CI 1.11, 2.28), as well as automobile mechanics (OR 1.82; CI 1.18, 2.81) and painters (OR 1.77; CI 1.13, 2.76). Exposures to pesticides and farming were not associated with increased risk. Prior radiotherapy ...

302 The co-authors dedicate this report to Alessandro Ricchi, Antonio Carta and Gian Marco Pinna who, flying in the sky of Sardinia to save a life, passed away on February 24, 2004. They will not be forgotten. Introduction Cardiac non-Hodgkin lymphomas (NHLs) may be distinguished in primary NHLs which are confined to the heart and/or pericardium 1 , and in cardiac NHLs secondary to a systemic NHL. The former are extremely rare especially in immuno- competent patients 2 ; the latter occur in about 20% of patients with intrathoracic lymphoma 3 . In general, primary cardiac NHLs are fast-growing intracavitary and/or intramy- ocardial nodular masses while secondary NHLs most commonly infiltrate the cardiac tissue. By any definition, cardiac NHLs usually manifest through arrhythmias, re- fractory ...

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