AllDocs -> cancers

© 2004, Institute of Oncology Sremska Kamenica,Serbia and Montenegro 71 Case report UDC: 616-006.44:616.831-002 INTRODUCTION araneoplastic neurological syndromes (PNSs) present as remote neurological effects of cancer in which nervous system dysfunction develops without evidence of direct invasion of tumor into neural tissue or of infectious or vascular complica- tions. PNSs occur in about 1% to 6% of all cancer patients. Almost all tumor types may be associates with PNSs, but small cell lung cancer (SCLC), thymoma, ovary and breast cancer are by far the most common. Testicular carcinoma, melanoma, and lymphoma are less likely to trigger the PNSs. Paraneoplastic limbic encephalitis (PLE) is a rare disorder char- acterized by psychiatric symptoms, seizures, and short-term memory loss. Symptoms may precede the tumor diagnosis by some months. At least half of the patients harbor ...

I NTERNATIONAL E XTRANODAL L YMPHOMA S TUDY G ROUP GASTRIC IRRADIATION FOR MALT LYMPHOMA A RETROSPECTIVE STUDY Principal investigators Andrew Wirth Peter MacCallum Cancer Institute Melbourne, Australia John Seymour Peter MacCallum Cancer Centre Melbourne, Australia Mary Gospodarowicz Princess Margaret Hospital Toronto, Canada Joachim Yahalom Memorial Sloan Kettering Cancer Centre New York, USA Emanuele Zucca Oncology Institute of Southern Switzerland Bellinzona, Switzerland Statistician LeAnn Weih Peter MacCallum Cancer Institute Melbourne, Australia Data Manager Juliana Di Iulio Data Manager, Statistical Centre Peter MacCallum Cancer Centre St Andrews Place, East Melbourne, 3002 Institutions ...

Abstract An unusual case of stage D Burkitt’s lymphoma in a 24 year old Nigerian female undergraduate is reported. There was a four month history of left lower lip paraesthesia followed three months later by a slowly progressive ‘pimple-sized’ nodular mandibular swelling arising from the mental foramen region. A full-blown, rapidly developing abdominal mass manifested only three weeks after a biopsy of the mandibular swelling. Aspiration of the latter and a histologic report of the mandibular mass confirmed Burkitt’s lymphoma . The patient responded very well to appropriate chemotherapy. Clinicians should not overlook insidious jaw swellings in any adult residing in the endemic zone of Burkitt’s lymphoma , in view of the fact that successful therapy is dependent on early diagnosis. Mental nerve paraesthesia is very rarely seen in Burkitt’s lymphoma . Key words: ...

PO Box 2345, Beijing 100023, China World J Gastroenterol 2004;10(8):1103-1109 Fax: +86-10-85381893 World Journal of Gastroenterology E-mail: wjg@wjgnet.com www.wjgnet.com Copyright © 2004 by The WJG Press ISSN 1007-9327 • GASTRIC CANCER • Clinicopathologic features of surgically resected primary gastric lymphoma Seong-Ho Kong, Min-A Kim, Do-Joong Park, Hyuk-Joon Lee, Hye-Seung Lee, Chul-Woo Kim, Han-Kwang Yang, Dae-Seog Heo, Kuhn-Uk Lee, Kuk-Jin Choe Seong-Ho Kong, Do-Joong Park, Hyuk-Joon Lee, Han-Kwang Yang, Kuhn-Uk Lee, Kuk-Jin Choe, Department of Surgery, Seoul National University College of Medicine, Seoul, Korea Min-A Kim, Hye-Seung Lee, Chul-Woo Kim, Department of Pathology, Seoul National University College of Medicine, Seoul, Korea Do-Joong Park, Hyuk-Joon Lee, Han-Kwang Yang, Dae-Seog Heo, Cancer Research Institute, Seoul National University ...

Neoplasms of the sacrum are relatively uncommon, representing 1 to 2% of all musculoskeletal tumors. 2 They can be classified as primary or metastatic lesions, the for- mer being either benign or malignant. The most common malignancy of the sacrum is metastatic disease, whereas the most common primary sacral tumor is chordoma. Other sacral malignant lesions include Ewing sarcoma, myeloma, osteosarcoma, neurofibrosarcoma, angiosarco- ma, chondrosarcoma, and rarely lymphoma . Referred pain in the leg or buttock is the typical presenting symptom of sacral tumors. Neurological signs are rarely seen, and their manifestation is often late. We describe two rare cases in which diffuse large B-cell lymphomas presented as pri- mary malignant sacral tumors. CASE REPORTS Case 1 History. This 52-year-old man presented with a 3-week history of increasing back pain radiating down ...

Letters to the Editor haematologica 2004; 89(3):March 2004 368 Correspondence: dr. Gisele Colleoni, Rua Botucatu, 740, 3º andar, Hematologia, CEP 043900-000, Vila Clementino, São Paulo, SP, Brazil. Fax: international +55.11.55718806. E-mail: gcolleoni@hemato.epm.br References 1. Hopwood P, Crawford DH. The role of EBV in posttransplant malig- nancies: a review. J Clin Pathol 2000;53:248-54. 2. Muti G, Cantoni S, Oreste P, Klersy C, Gini G, Rossi V, et al. Post- transplant lymphoproliferative disorders: improved outcome after clinico-pathologically tailored treatment. Cooperative Study Group on PTLDs. Haematologica 2002;87:67-77. 3. Stevens SJC, Verchuuren EAM, Pronk I, van der Bij W, Harmsen MC, Hauw The T, et al. Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative ...

elderly patients with AML less is more . Many patients, surprisingly including the group with the most favor- able prognosis, did not profit from standard induction therapy and had a comparable outcome with palliative therapy. However, in some patients, such as those with a high white cell count, standard induction therapy may be superior to palliative therapy. Clearly, further studies to evaluate risk factors, molecular biology and detailed quality of life aspects of the elderly patients with AML are needed. If we learn more about the diversity of AML in the elderly, we will be able to cre- ate differential treatment strategies with better risk- benefit ratios for the individual patient and responsi- ble use of existing resources. This could result in a gen- eral improvement of the unfavorable outcome of eld- erly AML patients, which has remained almost un- changed sinche the 1980s. ...

Introduction Primary lymphoma of the testis is a rather rare disease. It accounts for around 1% of all NHL’s, 2% of extranodal lymphoma and less than 10% of all testicular neoplasms. However, in men over 60, it is the most com- mon malignancy of the testis. The prognosis of testicular lymphoma is relatively poor com- Radiol Oncol 2003; 37(3): 175-81. Radiotherapy for stage IAE non-Hodgkin’s lymphoma of the testicle - a case report Antonio Juretic 1* , Mirko Živkovic 1 , Marija Gamulin 1* , Tonko Herceg 1 , Davorin Bagovic 1 , Damir Kucan 2 , Žarko Zeljko 2** , Radmila Ajdukovic 3 1 Department of Radiotherapy, University Hospital for Tumors; 2 Department of Urology, Clinical Hospital ...

46 nursing standard january 21/vol18/no19/2004 By reading this article and writing a practice profile, you can gain a certificate of learning. You have up to a year to send in your practice profile. Guidelines on how to write and submit a profile are featured at the end of this article. Hodgkin’s lymphoma NS225 Cole S, Dunne K (2004) Hodgkin’s lymphoma . Nursing Standard . 18, 19, 46-52. Date of acceptance: October 6 2003. For related articles visit our online archive at: www.nursing-standard.co.uk and search using the key words above. Online archive C O N T I N U I N G P R O F E S S I O N A L D E V E L O P M E N T Author Sylvia Cole RGN, RM, BSc(Hons), is Haematology Nurse Specialist, Altnagelvin Hospital, and Kathleen Dunne RGN, RM, RCNT, RNT, BEd(Hons), PG Dip, MSc, DNSc, is Nurse Lecturer, North ...

Cigarette smoking and risk of non-Hodgkin lymphoma subtypes among women LM Morton 1 , TR Holford 1 , B Leaderer 1 , P Boyle 2 , SH Zahm 3 , Y Zhang 1 , S Flynn 4 , G Tallini 4 , B Zhang 5 , PH Owens 1 and T Zheng* ,1 1 Department of Epidemiology and Public Health, Yale University School of Medicine, 129 Church Street, Suite 700, New Haven, CT 06510, USA; 2 Department of Epidemiology and Biostatistics, European Institute of Oncology, Milan 20141, Italy; 3 Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA; 4 Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA; 5 Department of Epidemiology ...

Abstract. Malignant lymphoma may be very difficult to diagnose with routine histopathological methods because they may recapitulate benign architecture or contain benign infiltrates. The best method of diagnosis is to establish the clonal profile of the lymphocyte population, since a mono- clonal proliferation is highly suggestive of neoplasia. By means of a PCR (polymerase chain reaction) method it is possible to detect the immunoglobulin heavy chain (IgH) gene rearrangement and therefore establish the lymphocyte clonality. PCR with primers complementary to relatively conserved regions called frameworks (FR1-FR3) laying among hyper variable regions (CDR1-CDR3) of IgH gene unable us to detect monoclonal versus polyclonal B-cell population. The length of the PCR product with these primers is unique if we deal with a monoclonal population. On the contrary, a polyclonal population gives PCR products ...

Center for Environmental Health Studies (617) 482-9485 44 Farnsworth Street, Boston, MA 02210 http://www.jsi.com * Findings were statistically significant (strong evidence) + Evidence of a dose-response relationship (strongest evidence) Page 71 Non-Hodgkin’s Lymphoma (NHL) and (Lymphosarcoma and reticulum cell sarcoma) Exposure to Ionizing Radiation Summary : Some evidence has been recorded of a possible connection between non- Hodgkin's lymphoma and exposure to ionizing radiation. There is possible evidence from studies conducted at Los Alamos National Laboratory. Studies of nuclear workers at other sites who have been exposed to ionizing radiation and persons exposed to the atomic bomb show an increase risk of developing non-Hodgkin's lymphoma . The Nationa l Research Council’s BEIR V committee did not address ...

Abstract. Undifferentiated carcinoma of the nasopharyngeal type (UCNT) that histologically mimics Hodgkin's lymphoma (HL) (‘Hodgkin's lymphoma -like UCNT’ - HL-like UCNT) is known as a diagnostic pitfall. Using immunohistochemistry, Western blot and cDNA array technology, we wanted to document its phenotypical and molecular characteristics. We report herein 5 cases of UCNT that morphologically mimic HL and 3 classical UCNT cases. We compared the expression profiles of a thousand selected genes in HL-like UCNT and in classical UCNT cases. No difference in the profile of EBV infection was noted between the HL-like UCNT and control cases. Significant differences were detected in the expression of genes involved in the matrix modelling, angiogenesis, apoptosis and regulation of the Th-2 interleukins. The eosinophil chemoattractant eotaxin was expressed in the stroma of HL-like UCNT, but not ...

The Studies of Pesticides and Lymphoma Alavanja, M.C. , Rush, G.A., Stewart, P., Blair, A. Proportionate mortality study of workers in the grain industry. Journal of the National Cancer Institute 78(2): 247–252 (Feb., 1987). Grain workers’ mortality rates from particular causes of death were studied using union insur- ance records. Information concerning pesticide use was also gathered. The authors found that pesticides used in the grain industry include aluminum phosphide (phosphine), carbon disul - fide, carbon tetrachloride, ethylene dibromide, ethylene dichloride, Malathion, and methyl bro- mide. In this study of the deaths of 1,114 white males, findings indicated increased risk of lym- phoma among grain mill workers (prompting a later study — see below). Mortality rates for several other types of cancer were also elevated. National Cancer Institute. ...

1 Lymphology 29 (1996) 166-169 PRIMARY NON-HODGKIN LYMPHOMA PRESENTING AS ILEOCOLIC INTUSSUSCEPTION P.H. Gerst, M. Niazi, V. Narasimha, R. Saraiya, E. Albu Departments of Surgery (PHG,VN,RS,EA) and Pathology (MN), Bronx-Lebanon Hospital Center, Bronx, New York USA ABSTRACT We report the case of an HIV-seropositive patient with non-Hodgkin lymphoma of the small intestine who presented with an ileocolic intussusception. This lesion fulfilled the diagnostic criteria for primary gastrointestinal lymphoma . Such a neoplasm in an immunocompromised patient is usually more aggressive and less responsive to treatment than in an HIV-seronegative patient.

© 2003, Institute of Oncology Sremska Kamenica,Serbia and Montenegro 21 Case report UDC: 616-006.44:616.8-009.86 INTRODUCTION ntravascular lymphoma (IVL) is a very rare form of non- Hodgkin's lymphoma , characterized by widespread intravascular proliferation of malignant lymphoid cells often pre- senting with nonspecific clinical features and extremely poor prognosis. The terminology used to describe this entity is variable and suggests endothelial origin of neoplastic cells. The most used term is neoplastic (malignant) angioendotheliomatosis or angioendotheliosis. However, there is conclusive evidence that this tumor represents a special form of malignant lymphoma (1- 4) and therefore intravascular lymphoma is the most appropriate name for this disease. Although not specifically recognized by the Revised European-American Classification of Lymphoid neo- plasms, ...

Version 5, December 99 Page 1 of 2 RANDOMISED STUDY OF RITUXIMAB IN PATIENTS WITH RELAPSED FOLLICULAR LYMPHOMA PATIENT INFORMATION SHEET (Version 5, December 99) Your relapsed low grade follicular non-Hodgkin’s lymphoma has responded particularly well to chemotherapy, and your doctor has recommended more intensive treatment with high dose therapy (HDT). The advantages and disadvantages of high dose therapy and the collection of blood stem cells before your high dose therapy has been fully explained to you by your doctors and you have already agreed to have this treatment. We are inviting you to take part in a research study investigating whether an antibody treatment given before and after high dose therapy is better at delaying or even preventing recurrence of the lymphoma . This study is being conducted by the European Bone Marrow Transplant Group (EBMT) in major hospitals throughout ...

Lymphoma Induced Cell Death Lymphoma Induced Cell Death 0 5 10 15 20 25 30 35 5 2.5 1 0.5 0.25 #Cellx10^5 CP Mx 10^3 Alone Thymic Protein A •This study demonstrates that mouse lymphoma cells undergo apoptosis (“cell suicide”) in the presence of Thymic Protein A. Page 2 National Institutes of Health (NIH) National Institutes of Health (NIH) - - Human Human Reduction of Viral infected Cells 0 10 20 30 40 50 60 0 1.5 3 6 12 25 50 TISF (ng) % p24 inhibition Thymic Protein A • Contrary to the expectation of enhanced HIV expression as is observed with other immune modulators, Thymic Protein A actually suppressed HIV production as measured ...

NYS NYC 05 Staten Isl 04 Queens 03 Brooklyn 02 Bronx 01 Manhattan 62 Yates * 61 Wyoming 60 Westchester 59 Wayne 58 Washington 57 Warren 56 Ulster 55 Tompkins 54 Tioga 53 Sullivan 52 Suffolk 51 Steuben 50 Seneca * 49 Schuyler * 48 Schoharie * 47 Schenectady 46 Saratoga 45 St Lawrence 44 Rockland 43 Rensselaer 42 Putnam 41 Otsego 40 Oswego 39 Orleans 38 Orange 37 Ontario 36 Onondaga 35 Oneida 34 Niagara 33 Nassau 32 Montgomery 31 Monroe 30 Madison 29 Livingston 28 Lewis * 27 Jefferson 26 Herkimer 25 Hamilton * 24 Greene 23 Genesee 22 Fulton 21 Franklin 20 Essex * 19 Erie 18 Dutchess 17 Delaware 16 Cortland * 15 Columbia 14 Clinton 13 Chenango 12 Chemung 11 Chautauqua 10 Cayuga ...

Abstract. Whether a common and a single clone present, or not, among follicles of follicular lymphoma (FL) was examined in 12 cases with FL. Histologic grade was I in 6 cases, II in 3, and III in 3. DNA was selectively extracted from the neoplastic follicles of paraffin-embedded samples with use of laser capture microdissection method, and used for PCR-based analysis of rearrangement of immunoglobulin heavy chain variable region gene. Three different follicles in each case of FL were microdissected. Semi-nested PCR was performed using two sets of primers (Fr2A and Fr3A). In PCR with Fr2A primers, nine of 12 cases showed a common band among neoplastic follicles. The remaining three cases showed no PCR products. With Fr3A primers, eight of 12 cases showed a common band among follicles of the same case. The other four cases showed oligoclonal bands, among them presence of a common band was difficult ...

Algorithm GRANK – Case study: Diffuse Large B-Cell Lymphoma Ref.: A.A. Alizadeh, a.o., Nature 403 (2000) 503-511. Database: http://llmpp.nih.gov/ lymphoma Number of gene clones: 4026 Number of DLCL samples: 50 Number of clusters found: 17 Vector space covered: 100% Significance level: 5% per gene Each gene clone in the database has an identifier. For some clones, this identifier refers to a known human gene. For other clones, the identifier may reflect sequence homology, but not identity, to a gene as judged by BLAST analysis (labeled “Similar to ”). The remainder of the clones are listed as “Unknown”. If these “Unknown” clones have been assigned to a Unigene cluster, as defined by NCBI, the identifier includes “UG Hs.” Followed by the Unigene identification number. The identifier is prefaced by an asterisk if the sequence assignment of the clone has been verified; otherwise ...

Lymphoma A form of cancer divided into two types: Hodgkins, and Non Hodgkins. Same rules as cancers. Stage I & II have a better prognosis. Still need the APS with pathology report to offer. People with this disease tend to be better informed about the disease than most other cancers. See the Cancer section for more details

Abstract. The aim of the study was to investigate the incidence of thyroid abnormalities in neck irradiated lymphoma patients. Of the 298 patients who had irradiation to the neck for lymphoma between 1966-1988, 174 were found to be alive and free of disease. These patients were invited to participate in the study. From the 174, 93 were able to participate (group 1). Two control groups were recruited; both were sex and aged matched. One group (group 2) consisted of lymphoma patients who were treated with chemotherapy (n=39) or irradiation to areas other than the neck (n=16). The other group (group 3) consisting of healthy volunteers (n=35) recruited from hospital staff and minor surgery attendees, had never had lymphoma or radiotherapy. All participants were required to complete a past medical history and thyroid symptom questionnaire, had blood taken for assays of thyroid stimulating ...

Abstract. High-grade B-cell non-Hodgkin's lymphoma (NHL), a diagnostic disease for the acquired immunodeficiency syndrome (AIDS), is a late manifestation of HIV infection and is generally related to severe lymphopenia. We reviewed the main clinico-pathological features of this disease and analysed its pathogenetic mechanisms with potential therapeutic implications. Contents 1. Introduction 2. Pathogenetic mechanisms 3. Molecular and histopathological characteristics 4. Clinical aspects 5. Diagnosis and staging evaluation 6. Prognosis 7. Therapy 8. Conclusion 1. Introduction High-grade B-cell NHL is, together with Kaposi's sarcoma (KS) and invasive cervix cancer, an AIDS-defining disease (1). It occurs late in the natural history of HIV infection and is generally associated with severe lymphocytopenia. Though representing the cause of death in 12-16% of HIV ...

Abstract. Reduced apoptosis is associated to cancer development. Agents able to restore the programmed cell death responsiveness of cancer cells are foreseen as potential effective cancer therapies. In this study, we report that a glutathione-S-derivative, S-acetyl-glutathione (Sag), induces significant apoptosis in three human lymphoma cell lines, including Daudi, Raji and Jurkat cells while it had no or little effect on either Hut-78 lymphoma cells or the normal BT lymphocytes. We used Annexin-V FACS analysis and DNA laddering to demonstrate that Sag activated apoptosis in the three sensitive cell lines in a dose- and time-dependent- fashion. Using mercury orange staining and FACS analysis, we showed that Sag generated an intracellular GSH depletion in Daudi, Raji and Jurkat cells but not in Hut-78 or the normal BT cells. These data provide direct evidence that Sag specifically activates ...

NEOPLASIA 5-Hydroxytryptamine drives apoptosis in biopsylike Burkitt lymphoma cells: reversal by selective serotonin reuptake inhibitors Adamantios Serafeim, Gillian Grafton, Anita Chamba, Christopher D. Gregory, Randy D. Blakely, Norman G. Bowery, Nicholas M. Barnes, and John Gordon Serotonin (5-HT), a well-known neuro- transmitter of the central nervous sys- tem, has been implicated in diverse as- pects of immune regulation. Here we show that 5-HT can efficiently drive pro- grammed cell death in established Burkitt lymphoma (BL) lines that remain faithful to the original biopsy phenotype (group 1). Group 1 BL cells cultured in the pres- ence of 5-HT exhibited marked suppres- sion of DNA synthesis that was accompa- nied by extensive apoptosis—serotonin- driven apoptosis was complete within 24 hours, was preceded by early caspase activation, ...

eprosy is an ancient disease, and although the treatment for leprosy has been available for several decades, the number of cases of lep- rosy worldwide was recently estimated to be approximately 5.5 million. 1 Most cases of leprosy occur in tropical countries. In the United States, indigenous transmission has been recorded in Hawaii, Pacific island territories, and sporadically along the Gulf Coast. 2 Generally, patients with leprosy do not experience increased morbidity as a result of viral, fungal, or pro- tozoal infections, for which cellular immunity is an important defense mechanism. Mycobacterium leprae infection has not been shown to predispose patients to an increased risk for neoplasia, 2 and Hodgkin’s lymphoma has rarely been reported in a patient with leprosy. 3 In contrast, several cases of leprosy have been ...

Acta Nephrologica Primary renal lymphoma 147 INTRODUCTION Systemic non-Hodgkin lymphoma with renal in- volvement is not an uncommon clinical presentation 1 . In contrast, primary renal lymphoma is an extremely rare tumor. To our knowledge, only about 39 cases have been reported since 1926 2-5 . Therefore, We thought it is worthwhile to report our experience with a pa- tient who suffered from bilateral renal lymphoma and who had no other identifiable primary site. Clinical- ly, he presented with intermittent abdominal pain ini- tially, then renal insufficiency and uremia in rapid progression. CASE PRESENTATION A previously healthy 4-year-old boy presented with intermittent abdominal pain for two weeks and was treated as functional gastroenteral disturbance by a local medical practitioner since April, 1996. The in- termittent abdominal ...

A MERICAN F ERRET R EPORT , VOLUME 9, NUMBER 4, 1998 21 M EDICAL N EWS Diagnosis and Treatment by Dr. Leanne Ksiazek November 3, 1996 A one-year-old intact hob, Emmett, is brought in with increased respiratory rate and effort. He has been showing symptoms for 2 days. Weight is 3 pounds, he has been eating well, is active, bright and alert. Mucous mem- branes are pink and moist. Capillary refill time is approximate- ly 2 sec. Heart is within normal limits, lungs bilaterally dull. Abdominal exam reveals splenomegaly. X-ray shows a large mediastinal mass with elevation of the trachea with signifi- cant amount of pleural effusion. Ferret is admitted and sedat- ed with atropine and ketamine IM. His chest is tapped, and 5ml of fluid are extracted. An IV catheter is inserted, ...