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6 8 E. DIAMANTI-KANDARAKIS, ET AL HORMONES 2004, 3(1):68-73 Case Report Primary Adrenal lymphoma presented with adrenal insufficiency Evanthia Diamanti-Kandarakis 1 , Pantelis Chatzismalis 1 , Frangiskos Economou 1 , Stefanos Lazarides 1 , Athena Androulaki 2 , Grigorios Kouraklis 3 1 Endocrine Section, First Department of Medicine, Athens University Medical School, 2 Department of Pathology, Laiko General Hospital, 3 2 nd Department of Surgery Athens University Medical School, Athens, Greece ABSTRACT We report a 71-year old man who presented with symptoms of adrenal insufficiency and large bilateral adrenal masses. Computed tomography guided FNA biopsy was not diagnostic. However, because of the rapid growth of the masses, ...

Primary Central Nervous System Lymphoma A Patient Education Monograph prepared for the American Uveitis Society January 2003 by Justine R. Smith, MBBS, PhD Assistant Professor Casey Eye Institute Oregon Health & Sciences University NOTE: The opinions expressed in this monograph are those of the author(s) and not necessarily those of the membership of the American Uveitis Society, its leadership, or the Editorial Board of UveitisSociety.org. All medical decisions should be made in consultation with one’s personal physician. Introduction Primary central nervous system (CNS) lymphoma is a rare cancer that involves the central nervous system (brain, spinal cord, one or both eyes, and/or the coverings of the brain and optic nerve, also known as the meninges). The designation as a " lymphoma " reflects the fact that the cancerous cells are lymphocytes, a type of white ...

COMPUTATIONAL MOLECULAR BIOLOGY HOMEWORK 2 SHUBHRA GUPTA ASU ID 993755974 Follicular non-Hodgkin’s lymphoma (NHL) is an indolent B cell malignancy with an annual incidence exceeding 10,000 cases in the United States. Rituximab, a chimeric IgG1 monoclonal antibody directed at the B cell antigen. Column and row represent: Each row represents a particular cDNA and each column is an individual follicular lymphoma (FL) or normal lymphoid tissue sample. CLID : Clone id FL1_CR_LC: follicular lymphoma (patient number)_complete response_lymphochip microarrays FL1_NR_LC: follicular lymphoma (patient number)_no response_lymphochip microarrays FL1_PR_LC: follicular lymphoma (patient number)_partial response_lymphochip microarrays GWEIGHT (gene weight) and EWEIGHT (experiment weight) Name: clone identifier IMAGE and LCP: clone name or ...

Identification of Apoptosis-associated Proteins in a Human Burkitt Lymphoma Cell Line CLEAVAGE OF HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 BY CASPASE 3* (Received for publication, June 2, 1998, and in revised form, July 30, 1998) Ekkehard Brockstedt‡§, Anke Rickers§ ¶ , Susanne Kostka‡, Andreas Laubersheimer ¶ , Bernd Do ¨ rken ¶ , Brigitte Wittmann-Liebold‡**, Kurt Bommert ¶ , and Albrecht Otto‡ From ‡ Proteinchemie and ¶ Medizinische Onkologie und Tumorimmunologie, Max-Delbru ¨ ck-Centrum fu ¨ r Molekulare Medizin, Robert-Ro¨ssle-Straße 10 and Charite´, Humboldt University of Berlin, Robert Ro¨ssle Klinik, D-13125 Berlin, Germany Apoptosis or programmed cell death is essential in the process of controlling lymphocyte growth and selection. We identified ...

D ATA S HEET Rev 021803B ALK (Anaplastic Lymphoma Kinase) p80 Epitope Specific Rabbit Antibody Cat. #RB-9001-P0, -P1, or -P (0.1ml, 0.5ml, or 1.0ml at 200µg/ml) (Purified Ab with BSA and Azide) Cat. #RB-9001-R7 (7.0ml) (Ready-to-Use for Immunohistochemical Staining) Cat. #RB-9001-PCS (5 Slides) (Positive Control for Histology) #&&( ÃXrvtu?rÃ9? ÃA?r?Ã86ÃÃ(#$"(ÃVT6Ã Ury)Ã ' Ã'!' %!'ÃÃAh?)Ã $ Ã(( !'!%Ã @?hvy)Ãyhi?v?v?5yhi?v?v? pÃÃXri?v?r)Ã yhi?v?v? p Description: Recognizes a human p80 protein, identified as a hybrid of the anaplastic lymphoma kinase (ALK) gene and the nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in a third of large cell lymphomas. This rebbit polyclonal antibody can be used to detect p80 in these lymphomas and may also be used ...

474 Annals Academy of Medicine Orbital Lymphoma Treated with Radiotherapy—H Y Lau et al Orbital Lymphoma : Results of Radiation Therapy H Y Lau,* MD, FRCP (Canada) , E T Chua,** FAMS, MBBS, FRCR , T L Yang,*** FAMS, MBBS, FRCR , E J Chua,**** FAMS, MD, DMRT Abstract Orbital lymphoma is a rare presentation of non-Hodgkin’s lymphoma . Treatment with radiotherapy is well-established. Twenty cases of orbital lymphoma treated at the Singapore General Hospital with radiation therapy were reviewed. All patients had improvement of their initial presenting symptoms and complete remission after radiation. Long-term local control was achieved in 17 of 20 (85%) of the treated orbits. Ann Acad Med Singapore 1998; 27:474-7 Key words: Eye, Non-Hodgkin’s lymphoma , Orbit, Radiotherapy * Senior ...

Daniel J. Medina, PhD Lymphoma Vaccine Development [We will modify cells from patients with non-Hodgkin’s lymphoma or chronic lymphocytic leukemia so that they will be recognized by their immune system and rejected.] Many patients with non-Hodgkin’s lymphoma or chronic lymphocytic leukemia can not be cured with chemotherapy. Treatment for those patients must incorporate novel therapies. This proposal describes pre-clinical studies designed to develop therapeutic vaccine for these patients. The approach will be to entice the malignant cell to change its surface so that it will be recognized by the immune system and rejected. We will obtain malignant cells from patients and manipulate the cells in the laboratory. We will study a variety of manipulations and select those anticipated to make the malignant cell most recognizable by the immune system. We will then test the capacity of these ...

Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Asyia Ahmad, M.D., Yogesh Govil, M.D., MRCP (UK), and Barbara B. Frank, M.D. Division of Gastroenterology and Hepatology, Drexel University, and Graduate Hospital, Philadelphia, Pennsylvania ABSTRACT The connection between Helicobacter pylori and gastric mucosa-associated lymphoid tissue (MALT) lymphoma is well established. H. pylori infection causes an immunolog- ical response, leading to chronic gastritis with formation of lymphoid follicles within the stomach. These lymphoid fol- licles resemble nodal tissues found throughout the body and are composed of reactive T cells and activated plasmal cells and B cells. The B cells are responsible for initiating a clonal expansion of centrocyte-like cells that form the basic his- tology of MALT lymphoma . Early diagnosis of MALT lymphoma is difficult but essential for adequate ...

1 MEET THE EXPERT ON NON-HODGKIN LYMPHOMA : N E W I N S I G H T S A N D T R E AT M E N T S MS. BANACKY: My name is Illona Banacky. I was diagnosed with non-Hodgkin lymphoma on November 13, 2003. At the time, my doctor explained that there were a few options available. These included chemotherapy through pills or intravenous therapy, and the most aggressive would be stem cell transplant. When I first diagnosed, I think I went into treatment too quickly. I think before you even opt to go into immediate treatment, do the research first and make sure that you’re comfortable with the doctor and the facility where you are being treated. I think it was important that the doctor and everyone around me — family, friends — understood what I was going through, not just emotionally, but also the treatment options, and helped me decide which road ...

Acquired Immunodeficiency Syndrome Presenting as Childhood Non-Hodgkin’s Lymphoma W S Lee, T L Chan, M T Koh, W A Ariffin, H P Lin Department of Paediatrics University of Malaya Medical Centre 59100 Kuala Lumpur Malaysia W S Lee, MRCP (UK) Associate Professor T L Chan, MBBS (Malaya) Lecturer M T Koh, FRCP (Edin) Associate Professor W A Ariffin, FRCP (Edin) Professor H P Lin, FRACP Professor Correspondence to: Dr Lee Way Seah Tel: (603) 7950 2065 Fax: (603) 7955 6114 Email: leews@ ummc.edu.my Singapore Med J 2001 Vol 42(11) : 530-533 C a s e R e p o r t ABSTRACT Two children with non-Hodgkin’s lymphoma (NHL) as the presenting illness of acquired immunodeficiency syndrome (AIDS) are described. There was a delay in diagnosing the underlying AIDS in both ...

[CANCER RESEARCH 55, 294-297, January 15, 1995] Antiepileptic Treatment and Risk for Hepatobiliary Cancer and Malignant Lymphoma Jørgen H. Olsen, 1 Gabi Schulgen, John D. Boice, Jr., John Whysner, Lois B. Travis, Gary M. Williams, Frank B. Johnson, and James 0'D. McGee Division for Cancer Epidemiology, Danish Cancer Society, DK-2100 Copenhagen Ø, Denmark [J. H. O.]; Institut für Medizinische Biometric and Informatik der Albert Ludwigs Universität Freiburg, D-79104 Freiburg, Germany [G. S.]: Radiation Epidemiology Branch National Cancer Institute, Bethesda, Maryland 20892 [J. D. B., L B. T.]; Division of Pathology and Toxicology, American Health Foundation, Valhalla, New York 10595 [J. W., G, M. W.]; Department of Cheemical Pathology, Armed Forces Institute of Pathology, Washington, DC [F. B. J.]: and Nuffield Department of Pathology and Bacteriology, John Radcliff Hospital ...

Summary A Case of Orbital MALT Lymphoma in which 67 Ga Scintigraphy was Useful for Evaluating the Radiation Therapy Response Toru T AKESHITA *, Tatsuro K AMINAGA *, Shigeru F URUI *, Takeo S UGIYAMA *, Tokuzou Y OKOKAWA *, Yuji N EMOTO ** and Fumihiko T ANAKA *** * Department of Radiology, ** Department of Ophthalmology, *** Department of Surgical Pathology, Teikyo University School of Medicine A 67-year-old man was hospitalized at our institu- tion complaining with epiphora and exophthalmos on the left side. Magnetic resonance imaging (MRI) showed an ill demarcated retrobulbar mass in the left orbit. 67 Ga scintigraphy revealed avid uptake in the left orbital region. The patient was treated with radia- tion therapy. ...

100 CME Gastroenterology 2001; 4(3):100-101 Rila Publications Ltd. Crohn’s Disease associated lymphoma after treatment with infliximab Case Report Abstract Infliximab (antibody to tumour necrosis factor) has a growing place in the management of refractory and fistulating Crohn’s disease. Lymphoma has been associated with the use of other immunomodulatory drugs but far from unequivocally so when they are used in Crohn’s disease. A case is described in which use of infliximab was followed by the early presentation of an Epstein-Barr virus-associated anaplastic lymphoma . The possible links between these phenomena are discussed. Keywords Case report, Crohn’s disease, lymphoma , infliximab, tumor necrosis factor. Case report A 25 year old female patient had developed Crohn’s disease at the age of ...

lymphoma The Leukemia & Lymphoma Society?s 2004 Man & Woman of the Year Campaign The Man & Woman of the Year Awards are part of a national campaign to raise money for the fight against blood cancers such as leukemia, lymphoma and myeloma. Hundreds of men and women in cities across America vie for the title each year. The Leukemia & Lymphoma Society's National Capital Area Chapter will launch its 2004 Man & Woman of the Year campaign the week of April 5, 2004. The campaign will run for approximately 10 weeks, ending with a Grand Finale Gala on Friday, June 11, 2004, at the Four Seasons Hotel in Georgetown. All candidates vying for the title of Man & Woman of the Year agree to utilize their leadership abilities to conduct their own fundraising campaigns for the Society. Every dollar counts as one vote. The top male and female candidates with the most votes are named ...

Induction and Prevention of Virus-associated Malignant Lymphoma by Serial Transmission of EBV-related Virus from Cynomolgus by Blood Transfusion in Rabbits Tirtha Raj Koirala , Kazuhiko Hayashi , Zaishun Jin , Sachiyo Onoda , Takehiro Tanaka , Wakako Oda , Koichi Ichimura , Nobuya Ohara , Takashi Oka , Masao Yamada , and Tadashi Yoshino Department of Pathology, Department of Virology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan, and Division of Molecular Pathology, Department of Microbiology and Pathology, Tottori University Faculty of Medicine, Yonago 683-8503, Japan Epstein-Barr virus (EBV)-related herpesvirus (Si-IIA-EBV)was serially transmitted for 3 passages from rabbit to rabbit of the opposite sex by blood transfusion, which subsequently induced virus- associated rabbit lymphomas. The virus could be transmitted by transfusion with 15-20 ml of whole blood ...