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1 Supplementary Information for DIFFUSE LARGE B-CELL LYMPHOMA OUTCOME PREDICTION BY GENE EXPRESSION PROFILING AND SUPERVISED MACHINE LEARNING Margaret A. Shipp, Ken N. Ross, Pablo Tamayo, Andrew P. Weng, Jeffery L. Kutok, Ricardo C. T. Aguiar, Michelle Gaasenbeek, Michael Angelo, Michael Reich, Geraldine S. Pinkus, Tane S. Ray, Margaret A. Koval, Kim W. Last, Andrew Norton, T. Andrew Lister, Jill Mesirov, Donna S. Neuberg, Eric S. Lander, Jon C. Aster, and Todd R. Golub December 6, 2001 Contents: Section I: Expanded Methods __ 3 Primary Lymphoma Specimens and Clinical Information _3 Microarray Hybridization_3 Preprocessing and Re-scaling _4 Supervised Learning4 Gene Marker Selection_5 Permutation Test and Neighborhood Analysis for Marker Genes _5 Algorithms__9 Weighted Voting 9 k-Nearest Neighbors (KNN) 9 Support Vector ...

53. 9. Hartung HP, Stoll G, Toyka KV. Immune reactions in the peripheral nervous system. Peripheral Neuropathy. Philadelphia: Saunders, 1993: 418–454: 10. Jann S, Santilli IM, Scarpini E, Gatti A, Bramerio MA. Peripheral nervous system involvement after orthotopic liver transplantation [Abstract]. Neurology 1999; 52(2): A83. 11. Ropper AH. The Guillain-Barre Syndrome. The N Engl J Med 1992; 326: 1130–1136. 12. Haymaker W, Kernohan JW. The Landry-Guillain-Barre syndrome: clin- icopathologic report of fifty fatal cases and a critique of the literature. Medicine 1949; 28: 59–141. 13. Honaver M, Tharakan JKJ, Hughes RAC, Leibowitz S, Winer JB. A clinicopathological study of the Guillain-Barre syndrome: nine cases and literature review. Brain 1991; 114: 1245–1269. 14. Kaldor J, Speed BR. Gillain-Barre syndrome and Campylobacter jejuni, a serological study. Br Med J 1984; 288: 1867–1870. 15. Koski ...

Primary Central Nervous System Lymphoma A Patient Education Monograph prepared for the American Uveitis Society January 2003 by Justine R. Smith, MBBS, PhD Assistant Professor Casey Eye Institute Oregon Health & Sciences University NOTE: The opinions expressed in this monograph are those of the author(s) and not necessarily those of the membership of the American Uveitis Society, its leadership, or the Editorial Board of UveitisSociety.org. All medical decisions should be made in consultation with one’s personal physician. Introduction Primary central nervous system (CNS) lymphoma is a rare cancer that involves the central nervous system (brain, spinal cord, one or both eyes, and/or the coverings of the brain and optic nerve, also known as the meninges). The designation as a " lymphoma " reflects the fact that the cancerous cells are lymphocytes, a type of white blood ...

Page 2 Current Status of Management of Adult Non-Hodgkin’s Lymphoma in Egypt By Dr. Hussein M. Khaled Professor of Medical Oncology Dean , National Cancer Institute Cairo University Page 3 Page 4 Adapted from Greenlee RT, et al. CA Cancer J Clin. 2000;51:18, 15-36. stimated deaths stimated deaths Estimated incidence E Estimated incidence E Melanoma of skin Oral cavity & pharynx Lung & bronchus Pancreas Kidney Colon & rectum Prostate Urinary bladder Leukemia Non-Hodgkin’s lymphoma All others 5% 3% 14% 2% 3% 10% 31% 6% 3% 5% 18% Esophagus Lung & bronchus Pancreas Liver Kidney ...

lymphoma Cutaneous T-Cell Lymphoma Shachar Peles M.D. Hematology & Oncology Grand Rounds September 26, 2003 Case Presentation 52 year old Left forearm rash for 4 years Intermittent erythematous patches Left forearm rash flared up – nodular, rapidly progressing Case Presentation PMH: Polio – age 4 Cyst removal near parotid 30 yrs ago Meds: Centrum Silver, Gingko All: NKDA SH: 1ppd x 25 years. Social Etoh. FH: F – died age 92 – CHF M – Alzheimer’s &...

Brochure More information from http://www.researchandmarkets.com/reports/328860/ Lymphoma Drug Pipeline Update 2006 Description: Lymphoma is a broad term encompassing a variety of cancers of the lymphatic system. NHL can be divided into two forms: aggressive and low-grade. The world prevalence is around 550,000 cases, of which 250,000 are low grade and 300,000 are aggressive. The prevalence is currently increasing, mainly because of population ageing and an increase in HIV-related lymphomas. More than 100 companies are active in the process of developing and improving lymphoma therapies. Many of the biotechnology approaches, such as antibodies, tumor specific treatments, stem cell transplantations etc, seem to suit this diffuse form of cancer well. There are today no less than 117 emerging therapeutics targeting lymphoma , from early preclinical to marketed drugs. Lymphoma Drug Pipeline ...

Patient Information File: CF281 Page 1 of 7 Consent for: Procedures for lymphoma treatment (child) Cambridge University Hospitals NHS Foundation Trust Parent agreement to investigation or treatment For parents of a child who has lymphoma – Routine procedures under general anaesthetic for the whole course of lymphoma treatment • • • Lumbar puncture (to obtain samples of cerebrospinal fluid - CSF) Intrathecal chemotherapy (part of leukaemia treatment) Bone marrow aspirate and trephine (to sample the bone marrow using a smaller or larger needle) Authors: Paediatric Oncology Unit • These procedures are usually carried out as day-case procedures in the Paediatric Day Unit at Addenbrooke’s Hospital • Please ask about anything you do not fully understand or wish to have explained in more detail. • If you would like ...

178 J La State Med Soc VOL 154 July/August 2002 Journal of the Louisiana State Medical Society C LINICAL C ASE OF THE M ONTH T ARGET A UDIENCE The July/August Clinical Case of the Month is intended for all physicians, especially family physicians, inter- nists, general practitioners, pediatricians, emergency medicine physicians, dermatologists, hematologists- oncologists, clinical pharmacologists, and neurologists, and is also intended for clinical pharmacists. E DUCATIONAL O BJECTIVES After reading this article, physicians be able to better identify and understand the epidemiology, clinical pre- sentation, pathogenesis, and treatment of the anticon- vulsant hypersensitivity syndrome. C REDIT The LSMS Educational and Research ...

RIMARY epidural lymphomas comprise only 7% of all intracranial lymphomas and must be distin- guished from meningeal infiltration by the presence of a systemic lymphoproliferative disorder. Found pre- dominately in elderly men, primary epidural lymphomas are often classified as low- or intermediate-grade lesions, and they are largely composed of centrocytic and centro- blastic cells. Diagnosis is based on the absence of other primary or systemic lymphomas, and differential diag- noses include meningioma and meningeal infiltration by other primary or metastatic tumors. We report a case of primary epidural lymphoma in a 70- year-old man. The immunohistochemical and molecular features of the tumor indicated centrofollicular differenti- ation. Case Report Presentation. This 70-year-old man reported increasing difficulty walking. Symptoms had begun 1 month earlier with paresthesias ...

TYPE OF CANCER: Diffuse Large B-Cell Lymphoma TYPE OF TRIAL: Phase II TRIAL SPONSOR: Cell Therapeutics PRINCIPAL INVESTIGATOR: Nam Dang M.D. CONTACT PERSON: Carol Varela (702) 822-5449 STUDY SUMMARY A Phase II, Randomized, Multi-Center, Comparative Trail with Cyclophosphamide, Doxorubicin, Vincristine, Prednisone plus Rituximab (CHOP-R) and Cyclophophamide, Pixantrone, Vincristine, Prednisone plus Rituximab (CPOP-R) in Elderly Patients with Diffuse Large B-Cell Lymophoma TREATMENT OVERVIEW • Each cycle is 21 days • There is a total of 8 cycles • Patient should be seen by the physician at least every 2-3 weeks. PRE-TREATMENT ASSESSMENTS • Lymph Node Biopsy and/or CT Guided Biopsy • Bone Marrow aspirate and biopsy • Lumbar puncture • MUGA • ECG • Serum cardiac Troponin T • CT/MRI of Chest/Abdomen/Pelvis ...

ANSWERS ICD-O-3 Coding Exercise Lymphoma and Leukemia Histology Coding Diagnostic Statement Histology/Behavior Grade* 1. ANLL (acute non-lymphocytic leukemia) 9861/3 9 2. B-cell lymphoma 9591/3 6 3. AML t(8;21)(q22;q22) 9896/3 9 4. M2 acute myelocytic leukemia 9874/3 9 5. Mucosal associated lymphoid tissue (MALT) lymphoma 9699/3 9 6. Anaplastic large B-cell lymphoma 9680/3 6 7. Intravascular B-cell lymphoma 9680/3 6 8. Diffuse histiocytic lymphoma 9680/3 9 9. T-cell rich large B-cell lymphoma 9680/3 6 10. Centroblastic lymphoma 9680/3 9 11. Nodular lymphocyte predominant Hodgkin’s disease 9659/3 9 12. Diffuse lymphocyte predominance Hodgkin’s disease ...

lymphoma 1581 Customized Cancer Medicine All Treatments are Customized at the point of delivery All Treatments Are Designed to Take advantage of Differences between Cancer Cells and Normal Cells Some of these differences are Generic and some are more Specific to the Type of Cancer, the Subtype, or even to the Individual Person Customized Cancer Medicine Generic Treatments Cancer Starts from One Cell in One Place Surgery- Early Detection Cancer Cells Divide Faster Chemotherapy and Radiotherapy Cancer Type Specific Treatments Hormone Responsive Prostate/Breast Tissue Type Thyroid Receptors Monoclonal Antibodies Customized Cancer Medicine ...