[1951]
022296 Multiple Myeloma
From [content.nejm.org] Last viewed: 13.07.2004
C A S E R E P O R T
* Medical Specialist
** Sr. Consultant & Head
Department of Medicine
ESI Hospital, Basaidarapur, New Delhi-110 015.
JIACM 2002; 3(1): 93-5
Multiple Myeloma with
Extra-Medullary Dissemination in the Lung
Ramnik K Duggal*, KA Ramachandran**
Multiple myeloma (MM) represents malignant
disorder of plasma cells. This disorder presents
primarily in the elderly, with organ dysfunctions
and symptoms such as bone pains, renal
dysfunction, anaemia, susceptibility to infections,
hypercalcaemia, hyperviscosity, and
neurological manifestations. Despite
widespread distribution of plasma cells in the
body, the tumour extension is primarily within the
bone and bone-marrow
1
. We present here a case
of multiple myeloma , in whom the malignant
plasma cells had disseminated to the lung
parenchyma.
Case report ...
[1952]
Anti-a4 Integrin Antibody Suppresses Multiple Myeloma Tumor Burden ...
From [www.bloodjournal.org] Last viewed: 13.07.2004
MULTIPLE MYELOMA
BOTH SEXES
TABLE 3A. -- Characteristics of persons reported to the Connecticut Tumor Registry with an initial
multiple myeloma , 1935-82+
_
Category Male Female Total
_
No. with first primary cancer* 1,107 1,142 2,249
No. who developed a second primary cancer 46 27 73
Average age at diagnosis of first cancer, yr 64 67 65
Average yr of diagnosis of first cancer 1968 1969 1969
Person-yr of follow-up 2,258 2,247 4,505
Average follow-up, yr 2.0 2.0 2.0
Percent given radiotherapy for first cancer 39.7 36.6 38.1
_
+ ICD-O morphology codes = 9730-9731.
* Number excludes all persons who survived less than 2 mo after the diagnosis of their first primary
cancer or who developed a simultaneous cancer during this period. First primary cancers diagnosed only
at autopsy or by death certificate are also excluded as are in situ cancers.
TABLE 3B. -- Microscopic confirmation ...
[1953]
Identification of genes modulated in multiple myeloma using ...
From [www.bloodjournal.org] Last viewed: 13.07.2004
MULTIPLE MYELOMA
BOTH SEXES
TABLE 3A. -- Characteristics of persons reported to the Connecticut Tumor Registry with an initial
multiple myeloma , 1935-82+
_
Category Male Female Total
_
No. with first primary cancer* 1,107 1,142 2,249
No. who developed a second primary cancer 46 27 73
Average age at diagnosis of first cancer, yr 64 67 65
Average yr of diagnosis of first cancer 1968 1969 1969
Person-yr of follow-up 2,258 2,247 4,505
Average follow-up, yr 2.0 2.0 2.0
Percent given radiotherapy for first cancer 39.7 36.6 38.1
_
+ ICD-O morphology codes = 9730-9731.
* Number excludes all persons who survived less than 2 mo after the diagnosis of their first primary
cancer or who developed a simultaneous cancer during this period. First primary cancers diagnosed only
at autopsy or by death certificate are also excluded as are in situ cancers.
TABLE 3B. -- Microscopic confirmation ...
[1954]
Myeloma V and V Gene Sequences Reveal a Complementary Imprint of ...
[259,0 KB]
From [www.bloodjournal.org] Last viewed: 13.07.2004
MULTIPLE MYELOMA
BOTH SEXES
TABLE 3A. -- Characteristics of persons reported to the Connecticut Tumor Registry with an initial
multiple myeloma , 1935-82+
_
Category Male Female Total
_
No. with first primary cancer* 1,107 1,142 2,249
No. who developed a second primary cancer 46 27 73
Average age at diagnosis of first cancer, yr 64 67 65
Average yr of diagnosis of first cancer 1968 1969 1969
Person-yr of follow-up 2,258 2,247 4,505
Average follow-up, yr 2.0 2.0 2.0
Percent given radiotherapy for first cancer 39.7 36.6 38.1
_
+ ICD-O morphology codes = 9730-9731.
* Number excludes all persons who survived less than 2 mo after the diagnosis of their first primary
cancer or who developed a simultaneous cancer during this period. First primary cancers diagnosed only
at autopsy or by death certificate are also excluded as are in situ cancers.
TABLE 3B. -- Microscopic confirmation ...
[1955]
Title: Osteoclasts enhance myeloma cell growth and survival via ...
From [www.bloodjournal.org] Last viewed: 13.07.2004
MULTIPLE MYELOMA
BOTH SEXES
TABLE 3A. -- Characteristics of persons reported to the Connecticut Tumor Registry with an initial
multiple myeloma , 1935-82+
_
Category Male Female Total
_
No. with first primary cancer* 1,107 1,142 2,249
No. who developed a second primary cancer 46 27 73
Average age at diagnosis of first cancer, yr 64 67 65
Average yr of diagnosis of first cancer 1968 1969 1969
Person-yr of follow-up 2,258 2,247 4,505
Average follow-up, yr 2.0 2.0 2.0
Percent given radiotherapy for first cancer 39.7 36.6 38.1
_
+ ICD-O morphology codes = 9730-9731.
* Number excludes all persons who survived less than 2 mo after the diagnosis of their first primary
cancer or who developed a simultaneous cancer during this period. First primary cancers diagnosed only
at autopsy or by death certificate are also excluded as are in situ cancers.
TABLE 3B. -- Microscopic confirmation ...
[1956]
RHAMM overexpression, a hallmark of multiple myeloma, induces ...
From [www.bloodjournal.org] Last viewed: 13.07.2004
MULTIPLE MYELOMA
BOTH SEXES
TABLE 3A. -- Characteristics of persons reported to the Connecticut Tumor Registry with an initial
multiple myeloma , 1935-82+
_
Category Male Female Total
_
No. with first primary cancer* 1,107 1,142 2,249
No. who developed a second primary cancer 46 27 73
Average age at diagnosis of first cancer, yr 64 67 65
Average yr of diagnosis of first cancer 1968 1969 1969
Person-yr of follow-up 2,258 2,247 4,505
Average follow-up, yr 2.0 2.0 2.0
Percent given radiotherapy for first cancer 39.7 36.6 38.1
_
+ ICD-O morphology codes = 9730-9731.
* Number excludes all persons who survived less than 2 mo after the diagnosis of their first primary
cancer or who developed a simultaneous cancer during this period. First primary cancers diagnosed only
at autopsy or by death certificate are also excluded as are in situ cancers.
TABLE 3B. -- Microscopic confirmation ...
[1957]
1 Characterization of Clonogenic Multiple Myeloma Cells William ...
From [www.bloodjournal.org] Last viewed: 13.07.2004
MULTIPLE MYELOMA
BOTH SEXES
TABLE 3A. -- Characteristics of persons reported to the Connecticut Tumor Registry with an initial
multiple myeloma , 1935-82+
_
Category Male Female Total
_
No. with first primary cancer* 1,107 1,142 2,249
No. who developed a second primary cancer 46 27 73
Average age at diagnosis of first cancer, yr 64 67 65
Average yr of diagnosis of first cancer 1968 1969 1969
Person-yr of follow-up 2,258 2,247 4,505
Average follow-up, yr 2.0 2.0 2.0
Percent given radiotherapy for first cancer 39.7 36.6 38.1
_
+ ICD-O morphology codes = 9730-9731.
* Number excludes all persons who survived less than 2 mo after the diagnosis of their first primary
cancer or who developed a simultaneous cancer during this period. First primary cancers diagnosed only
at autopsy or by death certificate are also excluded as are in situ cancers.
TABLE 3B. -- Microscopic confirmation ...
[1958]
RANK ligand and osteoprotegerin in myeloma bone disease
[68,2 KB]
From [www.bloodjournal.org] Last viewed: 13.07.2004
MULTIPLE MYELOMA
BOTH SEXES
TABLE 3A. -- Characteristics of persons reported to the Connecticut Tumor Registry with an initial
multiple myeloma , 1935-82+
_
Category Male Female Total
_
No. with first primary cancer* 1,107 1,142 2,249
No. who developed a second primary cancer 46 27 73
Average age at diagnosis of first cancer, yr 64 67 65
Average yr of diagnosis of first cancer 1968 1969 1969
Person-yr of follow-up 2,258 2,247 4,505
Average follow-up, yr 2.0 2.0 2.0
Percent given radiotherapy for first cancer 39.7 36.6 38.1
_
+ ICD-O morphology codes = 9730-9731.
* Number excludes all persons who survived less than 2 mo after the diagnosis of their first primary
cancer or who developed a simultaneous cancer during this period. First primary cancers diagnosed only
at autopsy or by death certificate are also excluded as are in situ cancers.
TABLE 3B. -- Microscopic confirmation ...
[1959]
Myeloma is on the move
[37,5 KB]
From [www.bloodjournal.org] Last viewed: 13.07.2004
MULTIPLE MYELOMA
BOTH SEXES
TABLE 3A. -- Characteristics of persons reported to the Connecticut Tumor Registry with an initial
multiple myeloma , 1935-82+
_
Category Male Female Total
_
No. with first primary cancer* 1,107 1,142 2,249
No. who developed a second primary cancer 46 27 73
Average age at diagnosis of first cancer, yr 64 67 65
Average yr of diagnosis of first cancer 1968 1969 1969
Person-yr of follow-up 2,258 2,247 4,505
Average follow-up, yr 2.0 2.0 2.0
Percent given radiotherapy for first cancer 39.7 36.6 38.1
_
+ ICD-O morphology codes = 9730-9731.
* Number excludes all persons who survived less than 2 mo after the diagnosis of their first primary
cancer or who developed a simultaneous cancer during this period. First primary cancers diagnosed only
at autopsy or by death certificate are also excluded as are in situ cancers.
TABLE 3B. -- Microscopic confirmation ...
[1960]
New insights into the knowledge of graft- versus-myeloma
[65,9 KB]
From [www.bloodjournal.org] Last viewed: 13.07.2004
MULTIPLE MYELOMA
BOTH SEXES
TABLE 3A. -- Characteristics of persons reported to the Connecticut Tumor Registry with an initial
multiple myeloma , 1935-82+
_
Category Male Female Total
_
No. with first primary cancer* 1,107 1,142 2,249
No. who developed a second primary cancer 46 27 73
Average age at diagnosis of first cancer, yr 64 67 65
Average yr of diagnosis of first cancer 1968 1969 1969
Person-yr of follow-up 2,258 2,247 4,505
Average follow-up, yr 2.0 2.0 2.0
Percent given radiotherapy for first cancer 39.7 36.6 38.1
_
+ ICD-O morphology codes = 9730-9731.
* Number excludes all persons who survived less than 2 mo after the diagnosis of their first primary
cancer or who developed a simultaneous cancer during this period. First primary cancers diagnosed only
at autopsy or by death certificate are also excluded as are in situ cancers.
TABLE 3B. -- Microscopic confirmation ...
[1961]
SOCS1 and SHP1 hypermethylation in multiple myeloma: implications ...
From [www.bloodjournal.org] Last viewed: 13.07.2004
MULTIPLE MYELOMA
BOTH SEXES
TABLE 3A. -- Characteristics of persons reported to the Connecticut Tumor Registry with an initial
multiple myeloma , 1935-82+
_
Category Male Female Total
_
No. with first primary cancer* 1,107 1,142 2,249
No. who developed a second primary cancer 46 27 73
Average age at diagnosis of first cancer, yr 64 67 65
Average yr of diagnosis of first cancer 1968 1969 1969
Person-yr of follow-up 2,258 2,247 4,505
Average follow-up, yr 2.0 2.0 2.0
Percent given radiotherapy for first cancer 39.7 36.6 38.1
_
+ ICD-O morphology codes = 9730-9731.
* Number excludes all persons who survived less than 2 mo after the diagnosis of their first primary
cancer or who developed a simultaneous cancer during this period. First primary cancers diagnosed only
at autopsy or by death certificate are also excluded as are in situ cancers.
TABLE 3B. -- Microscopic confirmation ...
[1962]
Insights into the multistep transformation of MGUS to myeloma ...
From [www.bloodjournal.org] Last viewed: 13.07.2004
MULTIPLE MYELOMA
BOTH SEXES
TABLE 3A. -- Characteristics of persons reported to the Connecticut Tumor Registry with an initial
multiple myeloma , 1935-82+
_
Category Male Female Total
_
No. with first primary cancer* 1,107 1,142 2,249
No. who developed a second primary cancer 46 27 73
Average age at diagnosis of first cancer, yr 64 67 65
Average yr of diagnosis of first cancer 1968 1969 1969
Person-yr of follow-up 2,258 2,247 4,505
Average follow-up, yr 2.0 2.0 2.0
Percent given radiotherapy for first cancer 39.7 36.6 38.1
_
+ ICD-O morphology codes = 9730-9731.
* Number excludes all persons who survived less than 2 mo after the diagnosis of their first primary
cancer or who developed a simultaneous cancer during this period. First primary cancers diagnosed only
at autopsy or by death certificate are also excluded as are in situ cancers.
TABLE 3B. -- Microscopic confirmation ...
[1963]
Treatment of multiple myeloma
[58,0 KB]
From [bmj.bmjjournals.com] Last viewed: 13.07.2004
results on the health of others. This is one
interpretation of the close link between income
inequality and homicide that has been noted
internationally and among American states. Even in
one city, Chicago, among 77 neighbourhoods a close
relation was found between the degree of income
inequality and rates of homicide.
5
What is the link with
self esteem? Accounts of life in the inner city
emphasise the salience of respect and self esteem. “No
small amount of mayhem is committed every year in
the name of injured pride.”
6
Putting this together with
income inequality, the hypothesis is that unequal distri-
bution of resources leads to increased competition for
status among young men who have little to lose other
than their self esteem and the respect of others. The
results are violent confrontation and homicide.
If we link, as Sennett does, the concepts of respect, ...
[1964]
Multiple myeloma in a patient with fever of unknown origin and ...
[248,9 KB]
From [www.cmaj.ca] Last viewed: 13.07.2004
results on the health of others. This is one
interpretation of the close link between income
inequality and homicide that has been noted
internationally and among American states. Even in
one city, Chicago, among 77 neighbourhoods a close
relation was found between the degree of income
inequality and rates of homicide.
5
What is the link with
self esteem? Accounts of life in the inner city
emphasise the salience of respect and self esteem. “No
small amount of mayhem is committed every year in
the name of injured pride.”
6
Putting this together with
income inequality, the hypothesis is that unequal distri-
bution of resources leads to increased competition for
status among young men who have little to lose other
than their self esteem and the respect of others. The
results are violent confrontation and homicide.
If we link, as Sennett does, the concepts of respect, ...
[1965]
Multiple Myeloma: What’s New
[40,0 KB]
From [caonline.amcancersoc.org] Last viewed: 13.07.2004
results on the health of others. This is one
interpretation of the close link between income
inequality and homicide that has been noted
internationally and among American states. Even in
one city, Chicago, among 77 neighbourhoods a close
relation was found between the degree of income
inequality and rates of homicide.
5
What is the link with
self esteem? Accounts of life in the inner city
emphasise the salience of respect and self esteem. “No
small amount of mayhem is committed every year in
the name of injured pride.”
6
Putting this together with
income inequality, the hypothesis is that unequal distri-
bution of resources leads to increased competition for
status among young men who have little to lose other
than their self esteem and the respect of others. The
results are violent confrontation and homicide.
If we link, as Sennett does, the concepts of respect, ...
[1966]
Overexpression of the myeloma-associated oncogene fibroblast ...
[217,0 KB]
From [www.bloodjournal.org] Last viewed: 13.07.2004
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[1967]
Serum osteoprotegerin levels are reduced in patients with multiple ...
[62,1 KB]
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[1968]
The AKT kinase is activated in multiple myeloma tumor cells
[141,4 KB]
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[1969]
Image-guided radiovirotherapy for multiple myeloma using a ...
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[1970]
Melphalan-mobilized blood stem cell components contain minimal ...
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[1971]
Induction of myeloma-specific cytotoxic T cells using dendritic ...
[129,0 KB]
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[1972]
BAFF and APRIL protect myeloma cells from apoptosis induced by ...
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[1973]
Multiple myeloma tumor progression in the 5T2MM murine model is a ...
[368,7 KB]
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[1974]
Characterization of clonogenic multiple myeloma cells
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[1975]
Osteoblasts make for good neighbors Myeloma: targeted therapies ...
[91,8 KB]
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[1976]
Osteoprotegerin is bound, internalized, and degraded by multiple ...
[326,2 KB]
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[1977]
Tumor lysate–specific cytotoxic T lymphocytes in multiple ...
[91,1 KB]
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[1978]
A molecular compendium of genes expressed in multiple myeloma
[1594,7 KB]
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[1979]
Light-chain only multiple myeloma is due to the absence of ...
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[1980]
Targeting the Mitochondria: An Exciting New Approach to Myeloma ...
[44,7 KB]
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