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PEDIATRIC GRAND ROUNDS THURSDAY, OCTOBER 14, 2004 8:00 TO 9:00 A.M. SPARROW HOSPITAL AUDITORIUM TARGETED RADIOTHERAPY FOR NEUROBLASTOMA USING 131I-MIBG GREGORY A. YANIK, M.D. Associate Professor Pediatric Hematology/Oncology Blood and Marrow Transplant Program University of Michigan

SLIT2 promoter methylation analysis in neuroblastoma , Wilms’ tumour and renal cell carcinoma D Astuti 1,7 , NF da Silva 1,2,7 , A Dallol 1 , D Gentle 1,2 , T Martinsson 3 , P Kogner 4 , R Grundy 1,5 , T Kishida 6 , M Yao 6 , F Latif 1,2 and ER Maher* ,1,2 1 Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham B15 2TT, UK; 2 Cancer Research UK Renal Molecular Oncology Research Group, University of Birmingham, The Medical School, Edgbaston, Birmingham B15 2TT, UK; 3 Department of Clinical Genetics, Gothenburg University, Sahlgrenska University Hospital/Ostra, S-416 85 Gothenburg, Sweden; 4 ...

Neuroblastoma - Overview © copyright 2004 U-M Comprehensive Cancer Center The University of Michigan Health System web site does not provide specific medical advice and does not endorse any medical or professional service obtained through information provided on this site or any links to this site. Use of the UMHS web site does not replace medical consultation with a qualified health or medical professional to meet the health and medical needs of you or others. While the content of the UMHS web site is frequently updated, medical information changes rapidly and therefore, some information may be out of date, and/or contain inaccuracies or typographical errors. Neuroblastoma (noor-oh-blas-TOME-ah) is the second most common solid tumor in childhood after brain tumors. The median age of diagnosis is two years and 85 percent of children diagnosed are less than 5. This tumor can arise in many ...

Section 4 – Your Child’s Diagnosis – Neuroblastoma Page 1 of 3 Neuroblastoma What is a Neuroblastoma ? Neuroblastoma is a tumour that begins in nerve tissues in the neck, chest, abdomen, or pelvis. About 50% of neuroblastomas start in the tissues of the adrenal glands located just above the kidneys. Often this tumour has spread before it is diagnosed. The common sites are the lymph nodes, liver, bones, and bone marrow. Neuroblastoma occurs in early childhood with 2/3 of the children younger than 5 years of age when they are diagnosed. Some neuroblastomas in infants can spontaneously regress and your doctor will discuss this with you. What causes a neuroblastoma ? As with most cancers, the cause of neuroblastoma is unknown. What are the signs and symptoms? The symptoms will vary depending on where the tumour is located. The most common ...

46.00 CASE REPORT - NEUROBLASTOMA OF FRONTAL CEREBRAL LOBE - 8 YEARS AFTER INTENSIVE THERAPY K. Bajerova , M. Bajer, H. Hrstkova 1 st Pediatric Clinic, Brno, Czech Republic mibaja@tiscali.cz History: The baby was born after a physiological pregnancy. Short after birth the baby has presented general convulsions. The CT scan of the CNS has discovered a neuroblastoma located in the left frontal lobe. An operation, complete removal of the tumour, was followed by a chemotherapy consisting of NB-A-89 protocol. No severe complications have occurred during the therapy, except anaemia and few respiratory infections. The clinical follow up went on after finishing therapy. Blood tests – no evidence of abnormities CT scan of CNS – cavity in position of left frontal lobe communicating with first chamber. No presence of tumour. Psychomotor development – psychomotorial ...

Targeting neuroblastoma with 131I-labeled and 67Cu-labeled antineuroblastoma antibody chCE7. (I. Novak-Hofer, J. Grünberg, K. Zimmermann, N. Venetz, in collaboration with C. A. Hoefnagel, The Netherlands Cancer Institute, Amsterdam) Neuroblastomas are tumors which arise during the development of the sympathetic nervous system. They can often be cured in Stages I to II, but patients with more advanced disease (stage III and IV) and recurrent tumors have a poor prognosis. Such relapses may appear as solid tumors, as bone marrow infiltrations, metastases in the bone or other distant metastases and current radiological methods cannot always determine the full extent of metastatic disease. Imaging with 123I-metaiodo-benzylguanidine (MIBG), a catecholamine analogue which is specifically taken up in tumor cells originating from the neural crest, is a very sensitive and specific modality to detect neuroblastoma , ...

Stimulation of using a Human Neuroblastoma Cells Planar Microelectrode Array Page 2 A thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the University of Glasgow. October 2000 Carolyn Audrey McEwan Centre for Cell Engineering University of Glasgow Stimulation of using a Human Neuroblastoma Cells Planar Microelectrode Array

D ATA S HEET Rev 030502D Neuroblastoma Marker Ab-1 (Clone NB84a) Mouse Monoclonal Antibody Cat. #MS-492-S0, -S1, or -S (0.1ml, 0.5ml, or 1.0ml Supernatant) Cat. #MS-492-R7 (7.0ml) (Ready-to-Use for Immunohistochemical Staining) Cat. #MS-492-PCS (5 Slides) (Positive Control for Histology) #&&( ÃXrvtu?rÃ9? ÃA?r?Ã86ÃÃ(#$"(ÃVT6Ã Ury)Ã ' Ã'!' %!'ÃÃAh?)Ã $ Ã(( !'!%Ã @?hvy)Ãyhi?v?v?5yhi?v?v? pÃÃXri?v?r)Ã yhi?v?v? p Comments: Ab-1 recongizes a protein of 57kDa which is found in a wide range of normal tissues, including most epithelia and endothelial cells. Ab-1 is useful in identification of pediatric, small round blue cell tumors. Approximately 90% of neuroblastomas are stained by this antibody whereas all other tumor types such as leukemia, rhabdomyosarcomas, and Wilm’s tumors are ...

Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation Anders Edsjo¨ 1 , Hele´n Nilsson 1 , Jo Vandesompele 2 , Jenny Karlsson 1 , Filip Pattyn 2 , Lloyd A Culp 3 , Frank Speleman 2 and Sven Pa°hlman 1 1 Department of Laboratory Medicine, Molecular Medicine, Lund University, University Hospital MAS, Malmo¨, Sweden; 2 Center of Medical Genetics, Ghent University Hospital, Ghent, Belgium and 3 Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA Amplification of MYCN in neuroblastoma strongly correlates to unfavorable outcome, but little is known of how the high MYCN expression translates into an aggressive tumor phenotype. ...

neuroblastoma THE NEUROBLASTOMA SOCIETY The Society prepares the following formal report and financial statements in accordance with its duties under the Charities Act, and also publishes an Annual Report for the general reader. Both are produced here. REPORTS AND FINANCIAL STATEMENTS For the year ended 31 December 2003 CONTENTS Page Trustees’ annual report 2 - 3 Auditor’s report 4 Income and expenditure account 5 Statement of financial activities 6 Balance sheet 7 Notes to the financial statements 8 – 10 Annual Report 11 - 17 THE NEUROBLASTOMA SOCIETY - TRUSTEES’ REPORT TRUST DEED AND OBJECTIVES The Neuroblastoma Society was established ...

Brochure More information from http://www.researchandmarkets.com/reports/6168 Medicines in Development for Neuroblastoma Description: Database Table: Medicines in Development for Neuroblastoma Database Tables are proprietary data sources covering specific information for the diagnostic, medical device, biotechnology and healthcare sectors. Over 600 database tables are now available from Research and Markets A Note on Database Tables at Research and Markets: Please note that these database tables are very focused one or two page tables/charts. They are great as a quick snapshot of a given market, or to incorporate into your own presentations/forecasts. But they not give the detailed analysis and the comprehensive information found in the full industry/market reports. If you do require more detailed market research please visit the following categories at Research and Markets: ...

neuroblastoma F-17 DISTINCT CYTOGENETIC PATHWAYS OF ADVANCED STAGE NEUROBLASTOMA TUMORS DETECTED BY SPECTRAL KARYOTYPING Batia Stark1,2, Marta Jeison1, Irit Bar-Am3, Leticia Galser-Gabay1, Jacques Mardoukh1, Yacov Goshen2, Jerry Stein2, Rina Zaizov2, Isaac Yaniv2. 1Cancer Cytogenetic Laboratory, 2Pediatric Hematology/Oncology Center, Schneider Children?s Medical Center of Israel, Petah-Tikva, Sackler Faculty of Medicine, Tel Aviv University and 3Applied Spectral Imaging, Migdal Haemek, Israel. Molecular studies have explored the genetic heterogeneity of advanced-stage neuroblastoma (NBL). Using the recently developed technique of spectral karyotyping (SKY) we sought to refine the cytogenetic information, and identify hidden recurrent structural chromosomal abnormalities. Thirteen samples of metaphase spread from 11 patients with advanced-stage NBL were analyzed by SKY. Most of them were found ...

Vo l u m e 3 41 Nu m b e r 16 · 1165 The New England Journal of Medicine © C o py r ig ht , 19 9 9 , by t he Ma s s ac h u s e t t s Me d ic a l S o c ie t y V O L U M E 3 4 1 O C T O B E R 1 4 , 1 9 9 9 N U M B E R 1 6 TREATMENT OF HIGH-RISK NEUROBLASTOMA WITH INTENSIVE CHEMOTHERAPY, RADIOTHERAPY, AUTOLOGOUS BONE MARROW TRANSPLANTATION, AND 13- CIS -RETINOIC ACID K ATHERINE K. M ATTHAY , M.D., J UDITH G. V ILLABLANCA , M.D., R OBERT C. S EEGER , M.D., D ANIEL O. S TRAM , P H .D., R ICHARD E. H ARRIS , M.D., N ORMA K. R AMSAY , M.D., P ATRICK S ...

Biochem. J. (2001) 360, 569–577 (Printed in Great Britain) 569 RB2/p130 ectopic gene expression in neuroblastoma stem cells : evidence of cell-fate restriction and induction of differentiation Francesco P. JORI*, Umberto GALDERISI † 1 , Elena PIEGARI †, Gianfranco PELUSO‡, Marilena CIPOLLARO†, Antonio CASCINO†, Antonio GIORDANO § and Mariarosa A. B. MELONE* *Department of Neurological Sciences, Second University of Naples, Via Pansini 5, 80100 Naples, Italy, †Department of Experimental Medicine, Section of Biotechnology and Molecular Biology, Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy, ‡Institute of Biochemistry of Proteins and Enzymology, C. N. R., Arco Felice, Naples, Italy, and §Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, and Sbarro Institute for Cancer Research and Molecular Medicine, 1020 Locust ...

Survival of children with neuroblastoma : time trends and regional di?erences in Europe, 1978±1992 C. Spix a, *, T. Aareleid b,c , C. Stiller d , C. Magnani e , P. Kaatsch a , J. Michaelis a a Institute for Medical Statistics and Documentation, German Childhood Cancer Registry, University Mainz, 55101 Mainz, Germany b Department of Epidemiology and Biostatistics, Institute of Experimental and Clinical Medicine, Tallinn, Estonia c Estonian Cancer Registry, Estonian Cancer Centre, Tallinn, Estonia d National Registry of Childhood Tumours, Childhood Cancer Research Group, Oxford, UK e Childhood Cancer Registry of Piedmont. Regional Centre for Cancer Epidemiology and Prevention in Piedmont. Turin, Italy Received 27 September 2000; accepted 27 December 2000 Abstract ...

Induction of Apoptosis in Neuroblastoma Analysis of apoptotic pathways and putative apoptosis-mediating receptors A Dissertation in the Partial Fulfillment of the Requirements for the Degree of Doctor of Natural Science by Sven Heiligtag University of Hamburg Cancer Research Center of Hawaií Hamburg 2001 Page 2 The present work was done between June 1998 and December 2000 in the Department of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany (June 1998 - February 1999) and the Cancer Research Center of Hawaii, Honolulu, Hawaii, USA (June 1999 - December 2000) in the laboratory of Prof. Dr. Dr. Carl-Wilhelm Vogel. Page 3 This work is dedicated to my parents for their indefatigable support over 29 years Page 4 Abstract ...

1 Expression of Recombinant Prion Protein in Mouse Neuroblastoma Cell Lines Sebastian Mathews, Foo Cheung, Ph.D, Clarence J. Gibbs, MD ABSTRACT : In an attempt to eventually determine the best way to inhibit the expression of abnormal Prion protein, the causative agent of Transmissible Spongiform Encephalopathies, an experiment was conducted in which genomic DNA was extracted from the white blood cells of three patients, each carrying different genetic mutations for the familial Prion protein disease known as Creutzfeldt-Jakob syndrome. Once extracted, the Prion protein coding region of the DNA was PCR amplified, ligated into an Eukaryotic expression vector (pCR 3.1), and transfected into mouse neuroblastoma cell lines for transient protein expression. Production of recombinant Prion protein was successful. It was found that the proteins derived from the three mutations ...

Biochem. J. (1996) 318, 1033–1039 (Printed in Great Britain) 1033 Agonist regulation of adenylate cyclase activity in neuroblastoma iglioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the ß 2 -adrenoceptor Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity David J. M AC EWAN, Gun-Do KIM and Graeme MILLIGAN* Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Stable cell lines, derived from NG108-15 cells and transfected to express both the ß#-adrenoceptor and adenylate cyclase type II, were produced and examined. The absence of adenylate cyclase type II in the parental cells and its presence in these clones was ...

1 DIAGNOSTIC IMAGING IN NEUROBLASTOMA Hans Ringertz, M.D., Ph.D. INTRODUCTION Neuroblastoma is a biologically very special neoplasm that is unique to child- hood. As can be seen from Table 1 it is the fourth most common paediatric malignancy in the Nordic countries and constitutes around 6% of all malignancies in children. Neoplasm in patients below 16 years of age in the Nordic countries during the years 1985 and 2001 in order of frequency No. of new cases % 1 Leukaemia 3249 34 2 Central nervous system and intracranial and intraspinal neoplasm 2596 27 3 Lymphomas and other reticuloendothelial neoplasm 1116 11 4 Sympathetic nervous system tumours 595 6 5 Renal tumours 556 6 6 Soft tissue sarcomas 540 5 7 Malignant bone tumours 297 3 8 Germ-cell, trophoblastic ...

1 The transcription factor EGR-1 promotes apoptosis of neuroblastoma cells. Short title: Role of EGR-1 in neuroblastoma cell death. Miguel Pignatelli *‡ , Rosario Luna-Medina *‡ , Arturo Pérez-Rendón * , Angel Santos † & Ana Perez-Castillo * ‡ Both authors contributed equally to this paper * .- Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas- Universidad Autónoma, 28029-Madrid. † .- Departamento de Bioquímica y Biología Molecular, Facultad de.Medicina, Universidad Complutense, Madrid. Requests for reprints: - Ana Perez-Castillo. Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas-Universidad Autónoma, 28029-Madrid. Spain. Phone: 34-91-5854625, Fax: 34-91-5854587, E-mail: aperez@iib.uam.es . Or ...