AllDocs -> cancers

Vo l u m e 3 41 Nu m b e r 16 · 1165 The New England Journal of Medicine © C o py r ig ht , 19 9 9 , by t he Ma s s ac h u s e t t s Me d ic a l S o c ie t y V O L U M E 3 4 1 O C T O B E R 1 4 , 1 9 9 9 N U M B E R 1 6 TREATMENT OF HIGH-RISK NEUROBLASTOMA WITH INTENSIVE CHEMOTHERAPY, RADIOTHERAPY, AUTOLOGOUS BONE MARROW TRANSPLANTATION, AND 13- CIS -RETINOIC ACID K ATHERINE K. M ATTHAY , M.D., J UDITH G. V ILLABLANCA , M.D., R OBERT C. S EEGER , M.D., D ANIEL O. S TRAM , P H .D., R ICHARD E. H ARRIS , M.D., N ORMA K. R AMSAY , M.D., P ATRICK S ...

N Engl J Med, Vol. 346, No. 14 · April 4, 2002 · www.nejm.org · 1047 N E U R O B L ASTO M A S C R E E N I N G NEUROBLASTOMA SCREENING AT ONE YEAR OF AGE F REIMUT H. S CHILLING , M.D., C LAUDIA S PIX , P H .D., F RANK B ERTHOLD , M.D., R UDOLF E RTTMANN , M.D., N ATALJA F EHSE , M.D., B ARBARA H ERO , M.D., G ISELA K LEIN , P H .D., J OHANNES S ANDER , M.D., K ERSTIN S CHWARZ , M.D., J OERN T REUNER , M.D., U LRICH Z ORN , P H .D., AND ...

77 ? Thoracic Neuroblastoma Presented With Chronic Cough: Report Of One Case Mao-Tsair Lin, Shyh-Dar Shyur, Li-Hsin Huang, Jiunn-Yi Wu,Yi-Chun Ma, Der-Cherng Liang Department of pediatrics, Mackay Memorial Hospital, Taipei, Taiwan Abstract Chronic cough may be induced by pneumonia, gastroesophageal reflux, asthma, TB or lung neoplasms etc. Here we report a 4-year-old boy with chronic cough for nearly 2 months. Chest roentgenogram revealed a huge mediastinal mass. Neuroblastoma was proved by the pathology of open lung biopsy. In a patient with chronic cough, chest roentgenogram is indicated if there is no improvement after medical treatment. Key word: neuroblastoma , chronic cough Introduction Neuroblastoma is the most common solid tumor of childhood outside central nervous system neoplasm. It may be incidentally noted on a chest roentgenogram ...

Australia Tel (02) 9318 0322 Germany Tel 0800 6931 000 Japan Tel (03) 5443 0281 United Kingdom Tel 0115 9430 840 USA, Canada, Mexico Tel (800) 628-8470 E-mail address for technical inquiries: technical@calbiochem.com Find our current product data sheets on the web: http://www.calbiochem.com Revised: 14-Dec-98 Arf6, His-Tagged, Human Neuroblastoma (NIE115), Recombinant, E. coli Size Cat. No. 181329 2 µ g Description: ADP-ribosylation factors (Arfs) are GTP-binding proteins that are allosteric activators of NAD:arginine ADP-ribosyltransferase activity of cholera toxin. They are known to regulate intracellular vesicular traffic and stimulate the activity of phospholipase D. Arf6 is localized in cell plasma membranes and membranes of secretory chromaffin granules. It is thought to play a role in receptor-mediated ...

Australia Tel (02) 9318 0322 Germany Tel 0800 6931 000 Japan Tel (03) 5443 0281 United Kingdom Tel 0115 9430 840 USA, Canada, Mexico Tel (800) 628-8470 E-mail address for technical inquiries: technical@calbiochem.com Find our current product data sheets on the web: http://www.calbiochem.com Revised: 14-Dec-98 Arf5, His-Tagged, Human Neuroblastoma (NIE115), Recombinant, E. coli Size Cat. No. 181327 2 µ g Description: ADP-ribosylation factors (Arfs) are GTP-binding proteins that are allosteric activators of NAD:arginine ADP-ribosyltransferase activity of cholera toxin. They are known to regulate intracellular vesicular traffic and stimulate the activity of phospholipase D. Arf5 is predominantly cytosolic, but can be recruited to the Golgi membranes upon binding to a non-hydrolyzable analog of GTP. Provided as ...

Neuroblastoma – the basics Disclaimer: This fact sheet is for education purposes only. Please consult with your doctor or other health professional to make sure this information is right for your child. This information sheet will tell you in simple terms: What is a neuroblastoma ? Why did the neuroblastoma happen? What problems does neuroblastoma cause? How did we find the neuroblastoma ? How do we treat neuroblastoma ? What is a neuroblastoma ? A neuroblastoma is a type of cancer - a lump of cells (tumour) which should not be there. Neuroblastoma is a cancer that only children get. It starts from primitive (very simple) nerve cells found in areas where nerves join together. The most common areas where these are found are in the abdomen (especially the adrenal gland), chest and neck. Why did the neuroblastoma happen? In most cases, we do not know ...

Infant Neuroblastoma – the basics Disclaimer: This fact sheet is for education purposes only. Please consult with your doctor or other health professional to make sure this information is right for your child. This information sheet will tell you in simple terms: What is a neuroblastoma ? Why did the neuroblastoma happen? How did we find the neuroblastoma ? How do we treat neuroblastoma ? What is a neuroblastoma ? A neuroblastoma is a type of cancer - a lump of cells (tumour) which should not be there. Neuroblastoma is a cancer that only children get. It starts from primitive (very simple) nerve cells found in areas where nerves join together. The most common areas where these are found are in the abdomen (especially the adrenal gland), chest and neck. Why did the neuroblastoma happen? Neuroblastoma is the most common type of cancer in babies. In most ...

Abstract. The aim of this study was to investigate gene expression changes in disseminated neuroblastoma by cDNA array technique. Three stage IV neuroblastomas and one neuroblastoma cell line (SK-N-FI) were analyzed. Expression profiles were confirmed by semiquantitative RT-PCR and in some instances by Northern blotting. Comparison of expression profiles identified several genes which were highly expressed as well as some which were down-regulated in tumor samples relatively to SK-N-FI cells. The tumors studied lacked N- myc overexpression, while showing up-regulation of basic trans-cription factors, growth factors and receptors such as NSEP, c-myc binding protein MM1, thymosin ß10 (TMSB10), TNF-R superfamily member 10A (TNFRSF10A) and FZ9. These results suggest that cDNA array technology is a powerful tool to identify a set of genes involved in neuroblastoma genesis and progression. ...

neuroblastoma PHENOTYPIC PROPERTIES OF CHOLINERGIC SN56 MOUSE NEUROBLASTOMA CELLS TRANSFECTED WITH CHOLINE ACETYLTRANSFERASE GENE H.Bielarczyk, M. Tomaszewicz, B. Madziar, M. Gniezdzinska, A. Szutowicz Chair of Clinical Biochemistry, Department of Laboratory Medicine, Medical University of Gdansk, Poland Particular susceptibility of cholinergic neurons to neurodegenerative insults may result from the fact that they require extra amounts of choline and acetyl-CoA for acetylcholine (ACh) synthesis. Cholinergic hybrid neuroblastoma SN56 cells of septal origin display several features of septal cholinergic neurons but express relatively low choline acetyltransferase (ChAT) activity. To restore ChAT activity similar to that present in brain cholinergic neurons, native SN56 cells were transfected with plasmid PSRNEO containing rat cDNA ChAT and geneticin resistance gene. Stable transfection yielded cells (SN56ChAT) with ChAT ...

D ATA S HEET Rev 030502D Neuroblastoma Marker Ab-1 (Clone NB84a) Mouse Monoclonal Antibody Cat. #MS-492-S0, -S1, or -S (0.1ml, 0.5ml, or 1.0ml Supernatant) Cat. #MS-492-R7 (7.0ml) (Ready-to-Use for Immunohistochemical Staining) Cat. #MS-492-PCS (5 Slides) (Positive Control for Histology) #&&( ÃXrvtu?rÃ9? ÃA?r?Ã86ÃÃ(#$"(ÃVT6Ã Ury)Ã ' Ã'!' %!'ÃÃAh?)Ã $ Ã(( !'!%Ã @?hvy)Ãyhi?v?v?5yhi?v?v? pÃÃXri?v?r)Ã yhi?v?v? p Comments: Ab-1 recongizes a protein of 57kDa which is found in a wide range of normal tissues, including most epithelia and endothelial cells. Ab-1 is useful in identification of pediatric, small round blue cell tumors. Approximately 90% of neuroblastomas are stained by this antibody whereas all other tumor types such as leukemia, rhabdomyosarcomas, and Wilm’s tumors are ...

Last Revised: 3/5/2003 UM Cancer Center Patient Education Document #0007 Mar03 Ed. Online version: http://www.cancer.med.umich.edu/learn/percpathways.htm University of Michigan Comprehensive Cancer Center Patient Education Resource Center (PERC) INFORMATION GUIDE Childhood Cancer: Neuroblastoma The purpose of this information guide is to help parents of children newly diagnosed with Neuroblastoma find sources of information and support. This list is not meant to be comprehensive, but rather to provide starting points for information seeking. The materials can be found at the Patient Education Resource Center at the University of Michigan Comprehensive Cancer Center in room B1-361. Article Available in the Patient Education Resource Center level B1 room 361 Reynolds, Patrick C. Treating High-Risk Neuroblastoma at the ...

1 DIAGNOSTIC IMAGING IN NEUROBLASTOMA Hans Ringertz, M.D., Ph.D. INTRODUCTION Neuroblastoma is a biologically very special neoplasm that is unique to child- hood. As can be seen from Table 1 it is the fourth most common paediatric malignancy in the Nordic countries and constitutes around 6% of all malignancies in children. Neoplasm in patients below 16 years of age in the Nordic countries during the years 1985 and 2001 in order of frequency No. of new cases % 1 Leukaemia 3249 34 2 Central nervous system and intracranial and intraspinal neoplasm 2596 27 3 Lymphomas and other reticuloendothelial neoplasm 1116 11 4 Sympathetic nervous system tumours 595 6 5 Renal tumours 556 6 6 Soft tissue sarcomas 540 5 7 Malignant bone tumours 297 3 8 Germ-cell, trophoblastic ...

I78 NEUROBLASTOMA SCREENING STUDY ENABLES ADEQUATE DECISION ON FURTHER DEVELOPMENT OF LEGISLATIVE EARLY DETECTION PROGRAMME B. Metzinger, IKK-Bundesverband (Bergisch Gladbach) Studies about the effectiveness of screening are rare and far between in Germany. Realization of such studies usually is declined because of alleged ethical reasons. Consequently screening examinations are executed without previous effectiveness checks and quality management. Especially examinations in healthy individuals require evidence for their benefit. Necessarily the risk (including the risk of further examination) vs. benefit (better prognosis for early detected diseases) have to be weighed. The pilot project " Neuroblastoma screening" is a positive example for the intention of all persons concerned realizing a study to proove the benefit of a screening test. The result of the project answers the question whether screening ...

!"#$ P O ! VP S NMU ABSTRACT A child with neuroblastoma was hospitalized due to fever on November 6, 2003. During the hospitalization (11/06/ 2003-12/06/2003), the peripheral stem cells were collected from this child. The caring duration of the author was from November 20, 2003 through November 26, 2003. This article describes the medical and nursing interventions imple- mented for solving this child's health problems. As Gordon's 11 Functional Health Assessment served as an assessment guide, four health problems, such as risk for infection, altered oral mucous membrane, hyperthermia, and pain, were identified. In order to solve four health problems mentioned above, nursing goals were first identified and nursing inter- ventions were then implemented. After evaluating the nursing care planed for this child, four health problems were either improved or solved. This care experience may provide health ...

Negative Regulation of Neuroblastoma Cell Growth by Carbohydrate-dependent Surface Binding of Galectin-1 and Functional Divergence from Galectin-3* Received for publication, June 5, 2001, and in revised form, July 12, 2001 Published, JBC Papers in Press, July 12, 2001, DOI 10.1074/jbc.M105135200 Ju ¨ rgen Kopitz‡, Carolina von Reitzenstein‡, Sabine Andre´§, Herbert Kaltner§, Johannes Uhl‡, Volker Ehemann ¶ , Michael Cantz‡ , and Hans-Joachim Gabius§ From the ‡ Institut fu ¨ r Pathochemie und Neurochemie and the ¶ Pathologisches Institut, Klinikum der Ruprecht-Karls- Universita¨t, Im Neuenheimer Feld 220, D-69120 Heidelberg, Germany and the § Institut fu ¨ r Physiologische Chemie, Tiera¨rztliche Fakulta¨t, Ludwig-Maximilians-Universita¨t, Veterina¨rstr. 13, D-80539 Mu ¨ nchen, Germany The cell density-dependent growth inhibition ...

2 ½ year old female • Presents to OSH in respiratory distress. – 5 days of sore throat, dysphagia, and poor PO intake – 1 day PTA Fever 103 – Increasing cervical adenopathy • At OSH XR neck ?compromised airway/pre- vertebral swelling. • CXR +RUL collapse • Pt intubated with difficulty, sedated and paralyzed • Dexamethasone single dose. • Started on broad spectrum antibiotics. Page 2 Outside Hospital Course • Initially hypotensive and poorly perfused, requiring IVF and dopamine • ECHO normal. Creatine normal. • Local CT/MRI with numerous neck/chest masses/nodes • Continued to have daily fevers despite negative blood & urine cultures. • Transferred to SLCH Pediatric ICU on Hosp d#5 Page 3 Page 4 • PMH : – – – ...

NEUROBLASTOMA - All Sections NEUROBLASTOMA What Is Cancer? Cancer is a group of many related diseases. All forms of cancer cause cells in the body to change and grow in an abnormal way. Normal body cells divide and grow in an orderly fashion. But cancer cells divide and grow out of control. This out-of-control growth damages normal body tissues and disrupts the ability of organs to function as they should. During the early years of a person's life, normal cells divide more rapidly until adult size is reached. After that, normal cells of most tissues divide only to replace worn-out tissue and to repair injuries. Cancer cells, however, continue to grow. Often the cells form tumors (lumps) that compress, invade, and destroy normal tissue. Unless the cancer is treated, the tumors can grow and spread. If cells break away from such a tumor, they can travel through the bloodstream or ...

Olfactory neuroblastomas are relatively uncommon tu- mors that originate from the olfactory epithelium in the upper nasal cavity in the region of the cribriform plate. Although some controversy persists, their primary modal- ity of therapy is resection, usually performed by an an- terior craniofacial approach and with the provision of ad- juvant radiation therapy. 29 In addition, recent experience suggests that there may be a therapeutic role for adjuvant chemotherapy. 4 A variety of other neoplastic lesions occur in the same anatomical region as ONs. Tumors such as NEC, melanoma, sinonasal lymphoma, SNUC, and pitu- itary adenoma can all present with similar clinical, histo- logical, and radiological features as ON. The prognosis and therapeutic modalities for these different tumors are variable, and physicians treating neoplasms arising from the paranasal sinus region ...

Letter to the Editor Expression of the caspase-8 gene in neuroblastoma cells is regulated through an essential interferon- sensitive response element (ISRE) Cell Death and Differentiation (2004) 11, 131–134. doi: 10.1038/ sj.cdd.4401327 Published online 7 November 2003 Dear Editor, It is well known that caspase-8 is an ‘initiator’ caspase acting at the top of the apoptotic cascade. 1–3 Specific ligand engagement by death receptors of the TNF-R superfamily or CD95/FAS induces receptor aggregation and recruitment of the Fas-associated death domain and caspase-8 mole- cules. 4,5 Thus, caspase-8 becomes activated and further activates, by enzymatic cleavage, the downstream ‘effector’ caspases. 6,7 The silencing of caspase-8 gene was observed in several tumors, where it was related to resistance to death- inducing ligands, ...

Neuroblastoma ANBL00B1 Biology Perinatal Low Risk Intermediate Relapse High Risk COG P9641 Primary Surgical Therapy COG A3961 CTX, VP-16, CBDCA, DOX COG A3973 Phase III: PBSCT ANBL00P2 Expectant Observation K E Y Pending Suspended Open Revised 11/19/03 Team Leader Signature and Date COG P9761 Phase II: Irinotecan *1st Priority COG P9963 Phase II: Rebeccamycin Analog *2nd Priority ADVL 0122 Phase II: Gleevec *3rd Priority ANBL-0321 Phase II: Fenretinide *4th Priority

Abstract. Thalidomide has previously been shown to have anti- angiogenic properties. More recently, clinical efficacy of this agent has been demonstrated in multiple myeloma and prostate cancer. Neuroblastoma is the most frequent solid tumor of the abdomen of childhood, yet children with this disease frequently have metastases at presentation. Such patients have a very poor prognosis with current therapies. Thus, new approaches are needed. We have previously shown that VEGF antagonists can inhibit neoangiogenesis and tumor growth in experimental neuroblastoma . In this study, we investigated the anti-angiogenic and anti-tumor properties of thalidomide in a xenograft model of human neuroblastoma . Tumors were induced in athymic mice using the human neuroblastoma cell line NGP. Intraperitoneal thalidomide (100 mg/kg/dose) or vehicle was administered beginning one week after implantation, ...

Clinical Categories of Neuroblastoma Are Associated with Different Patterns of Loss of Heterozygosity on Chromosome Arm 1p Jaume Mora,* Nai-Kong V. Cheung,* Brian H. Kushner,* Michael P. LaQuaglia, ‡ Kim Kramer,* Melissa Fazzari, † Glenn Heller, † Lishi Chen, § and William L. Gerald § From the Departments of Pediatrics, * Biostatistics, † Pediatric Surgery, ‡ and Pathology, § Memorial Sloan-Kettering Cancer Center, New York, New York Deletion of the short arm of chromosome 1 is fre- quently observed in neuroblastoma (NB). We per- formed loss of heterozygosity (LOH) analysis of 120 well characterized NB to better define specific regions of 1p loss and any association with clinical and bio- logical prognostic features (DNA index , MYCN ...

Section 4 – Your Child’s Diagnosis – Neuroblastoma Page 1 of 3 Neuroblastoma What is a Neuroblastoma ? Neuroblastoma is a tumour that begins in nerve tissues in the neck, chest, abdomen, or pelvis. About 50% of neuroblastomas start in the tissues of the adrenal glands located just above the kidneys. Often this tumour has spread before it is diagnosed. The common sites are the lymph nodes, liver, bones, and bone marrow. Neuroblastoma occurs in early childhood with 2/3 of the children younger than 5 years of age when they are diagnosed. Some neuroblastomas in infants can spontaneously regress and your doctor will discuss this with you. What causes a neuroblastoma ? As with most cancers, the cause of neuroblastoma is unknown. What are the signs and symptoms? The symptoms will vary depending on where the tumour is located. The most common ...

15 Cadmium-Induced Apoptosis in MES 23.5 Mouse Neuroblastoma Cells Presenter Wei-Wei Cheng Collaborators Li-xin Liu, Angela Gentles, Jean Strhlendrof, Louise Chiodo and Ernest Smith, Texas Tech University Department Cell and Molecular Biology Abstract Exposure to the heavy metal, cadmium (Cd2+), has been linked to adverse environmental and human health effects. The present studies addressed the mechanisms of Cd2+-induced cell death in the mouse neuroblastoma X rat mesencephalon (MES-23.5) wild type cell line. Toxicity initially was indexed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenytetrazolium bromide (MTT) assay following exposure to Cd2+ (1-10_M) for 7 to 72 h. Cell death was observed to be both concentration- and time-dependent. The highest concentration resulted in 100% cell death following 72 h exposure via the culture medium. We directly evaluated ...

C y t o t o x i c i t y S c r e e n i n g N E U R A L N O T E S I S S U E 2 1 2 0 0 2 I N VITRO C YTOTOXICITY S CREENING OF H UMAN N EUROBLASTOMA C ELLS by Randy Hoffman, B.S., and Megan Buros, Promega Corporation Introduction Robotic integration of cell-based assays for in vitro toxicity screening of chemical compounds is becoming an increasingly important aspect of the drug discovery process. Development of assays that simplify the automation process is crucial for the success of this high- throughput screening. Promega has recently introduced the CytoTox-ONE™ Homogeneous Membrane Integrity Assay (a) , a fluorometric method for estimating the number of non-viable cells present in multiwell plates. Combining this assay with Promega’s Apo-ONE™ ...

1 The transcription factor EGR-1 promotes apoptosis of neuroblastoma cells. Short title: Role of EGR-1 in neuroblastoma cell death. Miguel Pignatelli *‡ , Rosario Luna-Medina *‡ , Arturo Pérez-Rendón * , Angel Santos † & Ana Perez-Castillo * ‡ Both authors contributed equally to this paper * .- Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas- Universidad Autónoma, 28029-Madrid. † .- Departamento de Bioquímica y Biología Molecular, Facultad de.Medicina, Universidad Complutense, Madrid. Requests for reprints: - Ana Perez-Castillo. Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas-Universidad Autónoma, 28029-Madrid. Spain. Phone: 34-91-5854625, Fax: 34-91-5854587, E-mail: aperez@iib.uam.es . Or ...