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Abstract This paper presents a case of a neuroblastoma of the adrenal gland metastazing to the mandible of a 21 month old infant, which presented radio- graphically as the so-called ‘sun-ray’ appearance, c h a r a c t e r i s t i c of osteogenic sarcoma. Key words: Metastatic neuroblastoma , ‘sun-ray’ appearance, pattern recognition, osteogenic sarcoma, case report. (Received for publication July 1996. Revised November 1996. Accepted November 1996.) Introduction Metastatic lesions produce no pathognomonic r o e n t g e n o graphic appearance, although most metastases produce osteolytic lesions and thus appear as radiolucencies on the roentgenogram. Certain tumours produce osteoblastic lesions or lesions characterized by production of bone. 1 In this paper the radiographic appearance of a case of metastatic neuroblastoma ...

Web Immagini Gruppi Directory News Ricerca avanzata Preferenze Cerca nel Web Cerca solo le pagine in Inglese Spiacenti, nessun contenuto associato a questo URL Web La ricerca di - cache:WrBCzR_6DJEJ:jkms.kams.or.kr/2002/pdf/10674.pdf allintitle: neuroblastoma filetype:pdf OR filetype:doc OR filetype:ppt OR filetype:xls OR filetype:rtf - non ha prodotto risultati in nessun documento. Suggerimenti: - Assicurarsi che tutte le parole siano state digitate correttamente. - Provare con parole chiave diverse. - Provare con parole chiave più generiche. - Provare con un numero minore di parole chiave. ©2004 ...

INTRODUCTION Neuroblastoma is the most common malignant tumor in the neonatal period, and accounts for 20% of all malignancies duing period (1). Congenital neuroblastoma is uncommon, and about 80 cases have been described (2). Although neuro- blastoma can metastasize in utero, congenital neuroblas- tomas with multiple metastases are rare. We present a case of congenital neuroblastoma with multiple metastases, which is the first case among Koreans. CASE REPORT He was born by cesarian section at 38 weeks of gestation. He weighed 2,350 g and had Apgar score of 4 at 5 min. Mater- nal history (27-yr-old, 1-0-0-1) was unremarkable. Prenatal ultrasound at 36 weeks, gestation had shown an increased fetal abdominal circumference, but no abdominal mass was report- ed. During physical examination, the baby was pale and ta- chypnoic. The abdomen was markedly distended, while mul- ...

INTRODUCTION The herpes simplex virus (HSV) thymidine kinase (TK) gene is a suicide gene under study in both experimental and clin- ical protocols as a treatment for human cancer. Transfer of the TK gene into tumor cells results in tumor cell death upon exposure to the antiviral prodrug ganciclovir (GCV), as the TK protein phosphorylates the prodrug into a toxic nucleotide analog whose incorporation into nascent DNA results in ter- mination of DNA replication. Despite the in vivo HSV-TK gene transduction of approximately 10-20% of tumor cells, complete tumor eradication occurs in tumors (1). This phe- nomenon is probably due to a ‘bystander effect’associated uniquely with the HSV-TK/GCV system. It includes the transfer of the toxic metabolic products of GCV through gap junction (2), which have recently been shown to be dependent on connexin-mediated intercellular communication (3-5), the ...

Web Immagini Gruppi Directory News Novità! Ricerca avanzata Preferenze Cerca nel Web Cerca solo le pagine in Inglese Spiacenti, nessun contenuto associato a questo URL Web La ricerca di - cache:XvmjWZQSWigJ:jkms.kams.or.kr/2003/pdf/04184.pdf allintitle: neuroblastoma filetype:pdf OR filetype:doc OR filetype:ppt OR filetype:xls OR filetype:rtf - non ha prodotto risultati in nessun documento. Suggerimenti: - Assicurarsi che tutte le parole siano state digitate correttamente. - Provare con parole chiave diverse. - Provare con parole chiave più generiche. - Provare con un numero minore di parole chiave. ...

Last Revised: 3/8/2004 UM Cancer Center Patient Education Document #0007 Mar04 Ed. Online version: http://www.cancer.med.umich.edu/learn/percpathways.htm University of Michigan Comprehensive Cancer Center Patient Education Resource Center (PERC) INFORMATION GUIDE Childhood Cancer: Neuroblastoma The purpose of this information guide is to help parents of children newly diagnosed with Neuroblastoma find sources of information and support. This list is not meant to be comprehensive, but rather to provide starting points for information seeking. The materials can be found at the Patient Education Resource Center at the University of Michigan Comprehensive Cancer Center in room B1-361. Article Available in the Patient Education Resource Center level B1 room 361 Reynolds, Patrick C. Treating High-Risk Neuroblastoma at the ...

Texas Children?s Cancer Center and Hematology Service Neuroblastoma What is neuroblastoma ? Neuroblastoma is a type of cancer that arises from the autonomic nervous system in the body. The autonomic nervous system controls things like blood pressure in the arteries, movement within the intestines, sweating, and many other activities. Parts of the autonomic nervous system lie along the spine and in the adrenal glands above the kidneys. Neuroblastoma may start in any of these areas. Most often, it starts in the abdomen—either in the adrenal glands or around the spinal cord. Neuroblastoma can also start around the spinal cord in the chest, neck, or pelvis. It can spread to lymph nodes, liver, skin, bone marrow, bone, lungs and brain. Neuroblastoma is one of the most common kinds of cancer in children. It occurs most often in ba- bies and ...

Poster no. 4 Transformation of a Neuroblastoma Cell Line by constitutive PAX5 expression Baumann Florian , Maag Charlotte and Himmelmann Andreas W. University Hospital Zurich, Medical Oncology, Zurich PAX5 is an essential transcription factor for B-cell maturation and the development of the nervous system. In addition PAX5 has been implicated in the genesis of certain lymphomas and medulloblastoma. For the first time we detected PAX5 expression in neuroblastoma cell lines. Interestingly, PAX5 expression was strictly restricted to the malignant N-type neuroblastoma cell lines, but was absent in all non- tumorigenic S-type sublines. Thus, neuroblastoma cells presented a suitable model system to study the oncogenic potential of PAX5. Independent clones of the S-type cell line CA-2E with constitutive expression of PAX5-cDNA (PAX5 + ) showed clear phenotypic changes. We observed a ...

[CANCER RESEARCH 63, 5266 –5273, September 1, 2003] Genome-wide Array CGH Analysis of Murine Neuroblastoma Reveals Distinct Genomic Aberrations which Parallel those in Human Tumors 1,2 Christopher S. Hackett, 3 J. Graeme Hodgson, 2 Mark E. Law, Jane Fridlyand, Kazutoyo Osoegawa, Pieter J. de Jong, Norma J. Nowak, Daniel Pinkel, Donna G. Albertson, Ajay Jain, Robert Jenkins, Joe W. Gray, and William A. Weiss 4 Departments of Neurology [C. S. H., W. A. W.], Pediatrics [C. S. H., W. A. W.], Neurological Surgery [C. S. H., W. A. W.], Laboratory Medicine [J. G. H., D. P., A. J., J. W. G., W. A. W.], Cancer Center [J. G. H., J. F., D. P., D. G. A., A. J., W. A. W.], and Cancer Research Institute [J. F., D. G. A., A. J., J. W. G.], University of California, San Francisco, California 94143-0114; Department of Laboratory Medicine and Pathology, Mayo ...

3 body’s white cells — a hypothesis that has since been proven at the bench — and is now being tested at the bedside. In animal studies Cheung used purified glucan taken from barley and oats for oral administration. “We tested their effec- tiveness in laboratory mice carrying neurob- lastoma tumors,” Che- ung explains. “When used alone it was not effective. But when we used it along with the anti-GD2 mon- oclonal anti- body 3F8, tumor growth was nearly total- ly suppressed.” Cheung believes that when the glu- can molecule arrives at certain parts of the gastrointestinal tract, it attach- es to “receptor cells,” activating them to release cancer-fighting leukocytes to attack the tumor. This action, however, is dependent on the antibodies that lay down certain proteins on the surface of tumor cells. “They are natural ...

Neuroblastoma Incidence in Illinois: 1986-1997 Neuroblastoma is one of the most commonly diagnosed solid tumors in young children. The disease originates from neural cell ectoderm that gives rise in the developing fetus to the sympathetic nervous system, the adrenal medulla, and the adrenergic and cholinergic neuroblasts along the sympathetic chain and cranial ganglia. The annual incidence rate among children under 15 years of age in the United States is nine to 11 cases per million (1). In Illinois, according to data reported to the Illinois State Cancer Registry from 1986 through 1997, the annual incidence rate was 10.5 per million. Neuroblastoma incidence at state and county levels has been reported previously for 1986 through 1994 by the Illinois State Cancer Registry (2). The current study updates the previous report through adding three more recent years of data to the original analysis.During the 12-year period ...

Insulin-like growth factor-I signaling in human neuroblastoma cells Bhumsoo Kim* ,1 , Cynthia M van Golen 1 and Eva L Feldman 1 1 Department of Neurology, University of Michigan, 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109-0588, USA Neuroblastoma is a heterogeneous tumor consisting of N (neuronal) and S (stromal) cells. We report that more tumorigenic and motile N cells express higher levels of IGF-I receptor (IGF-IR) than less tumorigenic, more adherent S cells. Shc, one of the two major docking partners of IGF-IR, is equally expressed in N and S cell lines. IGF-I treatment phosphorylates Shc in N cells, but only weakly activates Shc in S cells. Expression of the second partner, insulin receptor substrate (IRS), is cell type specific. S cells exclusively express IRS-1 that undergoes sustained phosphorylation by IGF-I. In ...

The RET and TRKA pathways collaborate to regulate neuroblastoma differentiation Suzanne Peterson 1 and Emil Bogenmann 1 * 1 Childrens Hospital Los Angeles, Division of Hematology Oncology, 4650 Sunset Boulevard, Los Angeles, CA, USA Neuroblastoma (NB) is a childhood cancer that arises in the adrenal gland and often shows differentiated neuronal and glial elements. The RET receptor signal pathway is functional in most NB, while loss of nerve growth factor (NGF) receptor (trkA) gene expression correlates with an aggressive phenotype. Thus, we hypothesized that the RET and TRKA signal pathways collaborate to instruct NB differentiation, reminiscent of normal neuronal maturation. Here, we demonstrate that activation of the RET receptor by glial cell line-derived neurotrophic factor (GDNF) increases expression of the RET receptor complex in ...

Tribromophenol induces the differentiation of SH-SY5Y human neuroblastoma cells in vitro J.C. Ri´os a, b ,G. Repetto a, c, * ,A. Jos a ,A. del Peso a ,M. Salguero a ,A. Camea´n c , M. Repetto a, c a National Institute of Toxicology, PO Box 863, 41080, Sevilla, Spain b CITUC, School of Medicine, Pontificia Universidad Cato´lica de Chile, Chile c Area of Toxicology, Universidad de Sevilla, Sevilla, Spain Accepted 31 May 2003 Abstract Tribromophenol is a pesticide with fungicide activity,presently used as a replacement of pentachlorophenol as a wood pre- servative,and as a flame retardant in electronic and electrotechnical devices. Retinoic acid differentiated and non-differentiated SH- SY5Y human neuroblastoma cell cultures were ...

390 Research Program H Genome Research and Bioinformatics Division H0400 Tumour Genetics DKFZ 2003: Research Report 2001/2002 Scientists Dr. Hanxiang An (-12/02) Dr. Larissa Savelyeva Dr. Christian Praml (-3/01) Dr. Frank Westermann Dr. Isabel Matzner Guest Scientist Michail Repin (3/02-, Moscow, Russia) Graduate Students Katrin Arnold (1/01-) Stefan Brouwers Andreas Claas (-4/01) Anne Fechter (1/02-) Kai-Oliver Henrich Min-Kyoung Kim (10/00-) Britta Mädge (-8/01) Tobias Paffhausen (10/02-) Andrea Pillmann (-4/01) Vitaliya Sagulenko (10/01-) Jens Schmitt (2/02-) Isabel Wittke (-5/02) Ruprecht Wiedemeyer Sabine Zitzmann (-6/02) Assistants Young-Gyu Park Marc Matuszewska (7/02-) Secretary Cornelia Kirchner Genes, chromosomes and cancer Genomic lesions are considered to be central players in ...

1 Cancer Letters, Special Issue 2003: “Neural development and Cancer” (Mini-review) Comprehensive genomics linking between neural development and cancer: Neuroblastoma as a model Akira Nakagawara*, Miki Ohira Division of Biochemistry, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba 260-8717, Japan * Corresponding author. Tel: +81-43-264-5431; Fax: +81-43-265-4459. E-mail address: akiranak@chiba-ccri.chuo.chiba.jp (A. Nakagawara) Page 2 2 Abstract Cancer cells are derived from their precursor cells, which normally develop to the matured cells to form individual organs. Neuroblastoma , one of the most common pediatric solid tumors, originates from possible cancer stem cells derived from the neural crest. During the development, neural crest cells segregate into several lineages such as sensory, enteric and ...

Neuroblastoma ANBL00B1 Biology Perinatal Low Risk Intermediate Relapse High Risk COG P9641 Primary Surgical Therapy COG A3961 CTX, VP-16, CBDCA, DOX COG A3973 Phase III: PBSCT ANBL00P2 Expectant Observation K E Y Pending Suspended Open Revised 11/19/03 Team Leader Signature and Date COG P9761 Phase II: Irinotecan *1st Priority COG P9963 Phase II: Rebeccamycin Analog *2nd Priority ADVL 0122 Phase II: Gleevec *3rd Priority ANBL-0321 Phase II: Fenretinide *4th Priority

Abstract. Neuroblastoma , originated from neural crest cells, is the most common extracranial solid tumor in childhood. In the present study, we evaluated in vitro the oncolytic effect of live- attenuated poliovirus on human neuroblastoma cell lines, and in vivo its therapeutic efficacy in human neuroblastoma - bearing athymic mice. Live-attenuated poliovirus killed 27 (93%) of 29 established neuroblastoma cell lines in vitro . It induced cleavage of eukaryotic translation initiation factor 4G, leading to cell death through a mechanism involving activation of caspase-9, caspase-3 and poly(ADP-ribose)polymerase. For the in vivo experiments, an animal model was established using athymic mice xenotransplanted with SJ-N-JF neuroblastoma cells on both flanks. Inoculation of live- attenuated poliovirus into one of the two tumors caused a dramatic and complete regression of ...

LACK OF PHOSPHOLIPASE A 2 MUTATIONS IN NEUROBLASTOMA , MELANOMA AND COLON-CANCER CELL LINES Frank G. H ALUSKA 1 *, Carol T HIELE 3 , Alisa G OLDSTEIN 4 , Hensin T SAO 5 , Eric P. B ENOIT 1 and David H OUSMAN 2 1 Department of Hematology/Oncology, Massachusetts General Hospital, Boston, MA, USA 2 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA 3 Cell and Molecular Biology Section, Pediatric Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA 4 Genetic Epidemiology Branch, National Institutes of Health, Bethesda, MD, USA 5 Department of Dermatology, Harvard Medical School, Boston, MA, USA A candidate murine tumor-suppressor ...

Neuroblastoma Imaging Using a Combined CT Scanner–Scintillation Camera and 131 I-MIBG H. Roger Tang, Angela J. Da Silva, Katherine K. Matthay, David C. Price, John P. Huberty, Randall A. Hawkins, and Bruce H. Hasegawa Departments of Radiology and Pediatrics, University of California, San Francisco, California High-dose administration of 131 I-metaiodobenzylguanidine ( 131 I- MIBG) continues to be a promising treatment for neuroblastoma . However, currently used methods of estimating 131 I-MIBG uptake in vivo may be too inaccurate to properly monitor patient radiation exposure doses. To improve localization and uptake measure- ments over currently practiced techniques, we evaluated different methodologies that take advantage of the correlated patient data available from a combined CT–scintillation camera imaging sys- tem. ...

Neuroblastoma Authors: Doctors Matthias Schell 1 and Christophe Bergeron Creation date: October 2003 Scientific Editor: Professor Thierry Philip 1 Centre Léon Bérard, Service de Pédiatrie, 69373 Lyon cedex 08, France. schell@lyon.fnclcc.fr Abstract Key-words Disease name and synonyms Definition Differential diagnosis Etiology Clinical description Outcome Diagnostic methods Epidemiology Treatment Unresolved questions References Abstract Neuroblastoma is a malignant tumour of neural crest cells which give rise to the sympathetic nervous ...

Pyrazoloacridine Is Active in Multidrug-resistant Neuroblastoma Cell Lines with Nonfunctional p53 1 Nino Keshelava, Denice Tsao-Wei, and C. Patrick Reynolds 2 Division of Hematology-Oncology, Children’s Hospital Los Angeles, and Departments of Pediatrics [N. K., C. P. R.], Pathology [C. P. R.], and Preventive Medicine [D. T-W.], University of Southern California Keck School of Medicine, Los Angeles, California 90033 ABSTRACT Purpose : The purpose of this study was to determine the activity of pyrazoloacridine (PZA) in neuroblastomas that have acquired high-level resistance to multiple drugs (not associated with multidrug resistance-associated protein or P-glycoprotein) during therapy, including those with loss of p53 function. Experimental Design : We determined the activity of PZA in 12 drug-sensitive and 10 multidrug-resistant (MDR) ...

Calcium Protects Differentiating Neuroblastoma cells During 50 Hz Electromagnetic Radiation R. Tonini, M.D. Baroni E. Masala, M. Micheletti + , A. Ferroni, and M. Mazzanti # . Dipartimento di Fisiologia e Biochimica Generali, I a Università di Milano, I-20133 Milano, Italy. + DIBIT, HSR, I-20100 Milano, Italy. # Dipartimento di Biologia Cellulare e dello Sviluppo, Università “La Sapienza”, I-00185 Roma, Italy. Running title: Magnetic field modulates NG 108-15 cells differentiation Keywords: extremely low frequency electromagnetic field (ELF-EMF), neuroblastomaXglioma cells (NG 108-15), BT2-cAMP induced differentiation, resting potential modulation, Calcium current. Corresponding author: Prof. Michele Mazzanti Dipartimento di Biologia Cellulare e dello Sviluppo Università "La Sapienza" P.le Aldo Moro 5, I-00185, ...

doi:10.1016/S0360-3016(02)04506-6 CLINICAL INVESTIGATION Pediatrics IMPACT OF RADIOTHERAPY FOR HIGH-RISK NEUROBLASTOMA : A CHILDREN’S CANCER GROUP STUDY D APHNE A. H AAS -K OGAN , M.D.,* P ATRICK S. S WIFT , M.D., † M ICHAEL S ELCH , M.D., ‡ G ERALD M. H AASE , M.D., § R OBERT C. S EEGER , M.D., ¶ R OBERT B. G ERBING , M.A., # D ANIEL O. S TRAM , P H .D., ** AND K ATHERINE K. M ATTHAY , M.D. †† Departments of *Radiation Oncology and †† Pediatrics, University of California ...

Detection of Amplification in Neuroblastoma Using Polymerase Chain Reaction and Its Impact on Survival A P RATAP , S S INHA , DK G UPTA Molecular biology has revolutionized the medicine and added a new dimension to our knowledge of disease processes, especially in the field of oncology. Proto oncogenes are proteins normally present in the genome and they may be converted to oncogenes by mutations, rearrangements, translocation and deletion. One such protooncogene is the N-myc proto-oncogene seen in neuroblastoma . Amplification of the N-myc oncogene identifies a group of patients who have a poor prognosis. At present, it is generally agreed that the amplification of N-myc is still the most important prognostic factor to be investigated in every patient with neuroblastoma because of it’s reliability as a prognostic indicator. There are many conventional ...

The amazing race against Neuroblastoma . When: July 26 th 2003 Where: All over Toronto Why: Joe made me do it. This was sort of a “fun” event. Nothing to serious really, just for a good cause. So I figured “why not”. The guys who put this on pretty much wanted to create a small version of the TV Series “The Amazing Race” and in a total of 24 teams was supposed to hunt down clues all over downtown Toronto. Joe came up with the perfect team name: “The Eh! Team” (If you don't get it you're not Canadian or have not been here). So on Saturday morning at 9:30am we all met at the place of the first clue. The description for this read as follows: 'To start the race off with ease, We made the first clue a breeze. At the court yard of King and Bay, Meet us there, where the cows lay.' So, at 9:30 I strolled onto the plaza behind the Toronto Dominion Centre and a minute ...