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Efficacy of Complete Resection for High-Risk Neuroblastoma : A Children’s Cancer Group Study By E. Stanton Adkins, Robert Sawin, Robert B. Gerbing, Wendy B. London, Katherine K. Matthay, and Gerald M. Haase Columbia, South Carolina; Seattle, Washington; Arcadia, California; Gainesville, Florida; San Francisco, California; and Denver, Colorado Background/Purpose: Previous reports indicate that com- plete resection of high-risk neuroblastoma improves out- come but may entail high surgical complication rates. The authors evaluated the effect of complete primary site resec- tion on event-free survival (EFS), overall survival (OS), and complication rates in patients entered on a high-risk neuro- blastoma treatment protocol. Methods: A total of 539 eligible patients with high-risk neu- roblastoma were entered on protocol CCG-3891. Patients were assigned randomly to continuation chemotherapy ...

Detection of Amplification in Neuroblastoma Using Polymerase Chain Reaction and Its Impact on Survival A P RATAP , S S INHA , DK G UPTA Molecular biology has revolutionized the medicine and added a new dimension to our knowledge of disease processes, especially in the field of oncology. Proto oncogenes are proteins normally present in the genome and they may be converted to oncogenes by mutations, rearrangements, translocation and deletion. One such protooncogene is the N-myc proto-oncogene seen in neuroblastoma . Amplification of the N-myc oncogene identifies a group of patients who have a poor prognosis. At present, it is generally agreed that the amplification of N-myc is still the most important prognostic factor to be investigated in every patient with neuroblastoma because of it’s reliability as a prognostic indicator. ...

Dopamine Induces Autophagic Cell Death and -Synuclein Increase in Human Neuroblastoma SH-SY5Y Cells Cristina Gómez-Santos, 1 Isidre Ferrer, 2 Antonio F. Santidrián, 1 Marta Barrachina, 2 Joan Gil, 1 and Santiago Ambrosio 1 * 1 Unitat de Bioquim Departament de Cie`ncies Fisiolo`giques II, Universitat de Barcelona, Barcelona, Spain 2 Unitat de Neuropatologia, Departament Biologia Cel-lular i Anatomia Patolo`gica, Universitat de Barcelona, Barcelona, Spain Free cytoplasmic dopamine may be involved in the gen- esis of neuronal degeneration in Parkinson’s disease and other such diseases. We used SH-SY5Y human neuro- blastoma cells to study the effect of dopamine on cell death, activation of stress-induced pathways, and ex- pression of -synuclein, the characteristic ...