AllDocs -> cancers

Neuroblastoma Incidence in Illinois: 1986-1994 Neuroblastomas are childhood tumors of the autonomic nervous system. The annual incidence rate among children under 15 years of age in the United States is nine to 11 cases per million. In Illinois, according to data reported to the Illinois State Cancer Registry for 1986 through 1994, the annual incidence rate was 10.3 per million. Table 1 lists numbers of neuroblastoma incidence among children less than 15 years of age by county in Illinois from 1986 though 1994. As one would expect, counties with a large population, such as Cook and Du Page, tend to have more cases. In order to detect unusually high incidence of neuroblastoma , numbers in Table 1 need to be related to their population denominators, compared with the expected number of cases based on the overall neuroblastoma incidence in Illinois, and expressed in terms of probabilities. This was done by calculating ...

Tribromophenol induces the differentiation of SH-SY5Y human neuroblastoma cells in vitro J.C. Rió a, b ,G. Repetto a, c, * ,A. Jos a ,A. del Peso a ,M. Salguero a ,A. Cameán c , M. Repetto a, c a National Institute of Toxicology, PO Box 863, 41080, Sevilla, Spain b CITUC, School of Medicine, Pontificia Universidad Católica de Chile, Chile c Area of Toxicology, Universidad de Sevilla, Sevilla, Spain Accepted 31 May 2003 Abstract Tribromophenol is a pesticide with fungicide activity,presently used as a replacement of pentachlorophenol as a wood pre- servative,and as a flame retardant in electronic and electrotechnical devices. Retinoic acid differentiated and non-differentiated SH- SY5Y human neuroblastoma cell cultures were ...

Dopamine Induces Autophagic Cell Death and -Synuclein Increase in Human Neuroblastoma SH-SY5Y Cells Cristina Gómez-Santos, 1 Isidre Ferrer, 2 Antonio F. Santidrián, 1 Marta Barrachina, 2 Joan Gil, 1 and Santiago Ambrosio 1 * 1 Unitat de Bioquim Departament de Cie`ncies Fisiolo`giques II, Universitat de Barcelona, Barcelona, Spain 2 Unitat de Neuropatologia, Departament Biologia Cel-lular i Anatomia Patolo`gica, Universitat de Barcelona, Barcelona, Spain Free cytoplasmic dopamine may be involved in the gen- esis of neuronal degeneration in Parkinson’s disease and other such diseases. We used SH-SY5Y human neuro- blastoma cells to study the effect of dopamine on cell death, activation of stress-induced pathways, and ex- pression of -synuclein, the characteristic ...

29 OLFACTORY NEUROBLASTOMA : CLINICAL PRES- ENTATION AND MANAGEMENT Stamenov B., Tzvetanov P., Simeonova V., Nikolova M. * , Philipov P. Department of Neurology and Neurosurgery * Department of Pathology University Hospital of Pleven, Bulgaria ABSTRACT Olfactory neuroblastoma (ONB) is a rare tumor. There is greater agreement for separating “neuroblasto- ma-like” forms from tumors arising in the same location and manifest morphological and immunohistochemical characteristics of neuroendocrine carcinoma. The aim of present study is to describe the typical clinical, histological and immunohistochemical findings of ONB in 58-year old woman which help us to exclude non-Hodgkin’s lymphoma and endocrine carcinoma. Key words: olfactory neuroblastoma , neuroblast- oma like forms, neuroendocrine carcinoma Olfactory neuroblastoma ...

DCI SUPPLEMENT INSERT Neuroblastoma Information * * If this is a report of a second (or subsequent) transplant, check here and go to Q.216 Month Day Year FOR REGISTRY USE ONLY: I.D. – – Date received: Registry (circle one): IBMTR ABMTR 2. Date of report: (Institutional Unique Blood or Marrow Transplant Identification Number) M Month Day Year DCI Disease Supplement Inserts TEAM: IUBMID: 1. Date of first DCI for which this form is being completed: Statistical Center Medical College of Wisconsin P.O. Box 26509, 8701 Watertown Plank Road Milwaukee, WI 53226 Telephone: 414-456-8325 Fax: 414-456-6530 Email: ibmtr@mcw.edu IBMTR/ABMTR Reporting Form DCI-NEU (9/03) Page 1 of 1 Line of Therapy 1st 2nd ...

1. Date of diagnosis: Location of primary tumor(s) at diagnosis : 31. Were metastases present at diagnosis ? 1 Yes——— 0 No 8 Unknown Radiographic tests used for evaluation of disease status at diagnosis : TEAM FOR REGISTRY USE ONLY: IUBMID Date of transplant for which this form is being completed: Date of report: INSERT XVII NEUROBLASTOMA Date received: I.D. Pretransplant Information Registry (circle one) : IBMTR ABMTR 2. 1 0 Mediastinum 3. 4. 1 0 Adrenal gland 5. 6. 1 0 Paraspinal ganglion 7. 8. 1 0 Lymph nodes 9. 10. 1 0 Liver 11. 12. 1 0 Bone ...

TEAM FOR REGISTRY USE ONLY: IUBMID (Institutional Unique Blood or Marrow Transplant ID #) Date of transplant for which this form is being completed: Date of report: FOLLOW-UP INSERT XVII Neuroblastoma Date received: I.D. Followup Information Registry (circle one) : IBMTR ABMTR Form 095-NEUFU (6/98) Page 1 of 2 * Report data for date of last contact or immediately prior to death. Date of progression or recurrence Yes No Month Day Year Unknown 1. Did disease recur or progress since last report? 1 Yes————————— 0 No—— Go to Q.40 Indicate the region(s) of progression or recurrence since last report: 2. 1 0 Mediastinum 3. 4. 1 0 Adrenal gland 5. 6. ...

Overexpression of a DEAD Box Protein (DDX1) in Neuroblastoma and Retinoblastoma Cell Lines* (Received for publication, November 17, 1997, and in revised form, June 2, 1998) Roseline Godbout‡, Mary Packer, and Wenjun Bie From the Department of Oncology, Cross Cancer Institute and University of Alberta, 11560 University Ave., Edmonton, Alberta T6G1Z2, Canada The DEAD box gene, DDX1 , is a putative RNA helicase that is co-amplified with MYCN in a subset of retinoblas- toma (RB) and neuroblastoma (NB) tumors and cell lines. Although gene amplification usually involves hun- dreds to thousands of kilobase pairs of DNA, a number of studies suggest that co-amplified genes are only overex- pressed if they provide a selective advantage to the cells in which they are amplified. Here, we further character- ize DDX1 by identifying its putative transcription and translation ...

Abstract. Neuroblastoma , originated from neural crest cells, is the most common extracranial solid tumor in childhood. In the present study, we evaluated in vitro the oncolytic effect of live- attenuated poliovirus on human neuroblastoma cell lines, and in vivo its therapeutic efficacy in human neuroblastoma - bearing athymic mice. Live-attenuated poliovirus killed 27 (93%) of 29 established neuroblastoma cell lines in vitro . It induced cleavage of eukaryotic translation initiation factor 4G, leading to cell death through a mechanism involving activation of caspase-9, caspase-3 and poly(ADP-ribose)polymerase. For the in vivo experiments, an animal model was established using athymic mice xenotransplanted with SJ-N-JF neuroblastoma cells on both flanks. Inoculation of live- attenuated poliovirus into one of the two tumors caused a dramatic and complete regression of both the inoculated and ...

Web Immagini Gruppi Directory News altro » Ricerca avanzata Preferenze Cerca nel Web Cerca solo le pagine in Inglese Spiacenti, nessun contenuto associato a questo URL Web La ricerca di - cache:jT19o6S94vwJ:www.fda.gov/ohrms/dockets/AC/01/slides/3756s1_07_REYNOLDS.PPT neuroblastoma filetype:pdf OR filetype:doc OR filetype:ppt OR filetype:xls OR filetype:rtf - non ha prodotto risultati in nessun documento. Suggerimenti: Assicurarsi che tutte le parole siano state digitate correttamente. Provare con parole chiave diverse. Provare con parole chiave più generiche. Provare con un numero minore di ...

TANG, Xao X. PhD 1 My research concerns neuroblastoma ( NB ), a childhood tumor that exhibits two different phenotypes: favorable and unfavorable. Favorable NB undergo regression or maturation even without treatment or can be cured by surgical removal with or without adjuvant chemotherapy. In contrast, the prognosis of unfavorable NB is poor despite the most intensive treatment. Current survival rate of children with unfavorable NB is about 20-25%. Neuroblastoma is thus one of the last pediatric tumors to be conquered. For decades, NB research has focused mainly on “unfavorable features” of the tumor such as 1p deletion and MYCN amplification, assuming that these features determine the malignant phenotype of NB. However, our studies have revealed that expression levels of a set of genes ( Favorable Neuroblastoma Genes ) in fact determine the benign or malignant phenotype of this tumor. Favorable NB genes ...

Neuroscience Letters 394 (2006) 184–189 Autophagy of amyloid beta-protein in differentiated neuroblastoma cells exposed to oxidative stress Lin Zheng a , c , * , Karin Roberg b , Fredrik Jerhammar c , Jan Marcusson a , Alexei Terman c a Division of Geriatric Medicine, Faculty of Health Sciences, Linkoping University, 58185 Linkoping, Sweden b Division of Otorhinolaryngology, Faculty of Health Sciences, Linkoping University, 58185 Linkoping, Sweden c Division of Experimental Pathology, Faculty of Health Sciences, Linkoping University, 58185 Linkoping, Sweden Received 16 June 2005; received in revised form 14 September 2005; accepted 10 October 2005 Abstract Oxidative stress is considered important for the pathogenesis of Alzheimer disease (AD), which is characterized by ...

All Records First Record Next Record Make PDF Universität Zürich > Medizinische Fakultät > Kinderspital Zürich > Klinische Chemie und Biochemie, Abteilung für > Prof. Dr. Claus W. Heizmann Summary / Zusammenfassung Common tumors in children include leukemia, brain tumors and neuroblastoma . Current treatments of childhood malignancies such as radiotherapy and chemotherapy are inefficient, due to the resistance of the tumor cells to apoptotic signals. Promising new therapies are, however, emerging, which are based on blocking receptor tyrosine kinase (RTK) signalling to some of their downstream signalling targets such as phosphoinositide 3-kinase (PI3K), protein kinase B (PKB) /Akt, the mammalian target of rapamycin (mTOR) or mitogen-activated extracellular signal- regulated kinase activating kinase (MEK). We want to further study the potential of targeting PI3K signalling as a novel ...

Abstract. Thalidomide has previously been shown to have anti- angiogenic properties. More recently, clinical efficacy of this agent has been demonstrated in multiple myeloma and prostate cancer. Neuroblastoma is the most frequent solid tumor of the abdomen of childhood, yet children with this disease frequently have metastases at presentation. Such patients have a very poor prognosis with current therapies. Thus, new approaches are needed. We have previously shown that VEGF antagonists can inhibit neoangiogenesis and tumor growth in experimental neuroblastoma . In this study, we investigated the anti-angiogenic and anti-tumor properties of thalidomide in a xenograft model of human neuroblastoma . Tumors were induced in athymic mice using the human neuroblastoma cell line NGP. Intraperitoneal thalidomide (100 mg/kg/dose) or vehicle was administered beginning one week after implantation, and animals ...

of the file http://63.240.199.20/ohrms/dockets/ac/01/slides/3756s1_07_REYNOLDS.PPT . G o o g l e automatically generates html versions of documents as we crawl the web. To link to or bookmark this page, use the following url: http://www.google.com/search?q=cache:gd_dd70i0CcJ:63.240.199.20/ohrms/dockets/ac/01/slides/3756s1_07_REYNOLDS.PPT+neuroblastoma+filetype:pdf+OR+filetype:doc+OR+filetype:ppt+OR+filetype:xls+OR+filetype:rtf&hl=it&ct=clnk&cd=136&lr=lang_en Google is neither affiliated with the authors of this page nor responsible for its content. These search terms have been highlighted: neuroblastoma 1581 Neuroblastoma and Small Cell Carcinoma of the Lung (SCLC) Differences and Similarities C. Patrick Reynolds, MD PhD ChildrensHospital LosAngeles 1901 2001 ...

Neuroblastoma since its description in the late 19 th and early 20 th century has been well known as an enigmatic disease. Cushing and Wolbach described in 1927 the case of a 2-year old boy whose thoracic paravertebral sympathetic neuroblastoma over the course of 10 years transformed into a completely differentiated ganglioneuroma. 1 The only treatment at the time was injection of Coley’s bacterial toxins. At the opposite end of the spectrum, the majority of neuroblastomas in older children present with widespread metastases and have a poor survival even with intensive chemotherapy and bone marrow trans- plantation (BMT). Our understanding of the basis for the diverse behavior of neuroblastoma has been greatly increased by our discov- ery of the molecular and genetic abnormalities in the tumors. This chapter reviews the biologic and clinical features of neuroblastoma ...