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What you need to know about OvarianCancer Page 2 What is Ovarian Cancer ? Ovarian cancer is cancer that develops in the cells of the ovaries. The ovaries are two small oval shaped organs which form part of the female reproductive system. The ovaries produce eggs and the female hormones oestrogen and progesterone which regulate the menstrual cycle. Each year approximately 6,900 women are diagnosed with the disease in the UK. More than 4,000 women die each year from the disease, making it the fourth most common cause of cancer death for women in the UK after breast, lung and large bowel cancer . The exact cause of ovarian cancer is unknown, however several factors are known to affect your risk (see Risk Factors). Age: The risk of ovarian cancer increases ...

FY02 Ovarian Cancer Research Program Peer Reviewers Bai, Wenlong Ph.D. Baron, Andre T. Ph.D. Biochemistry and Molecular Biology, Mayo Clinic Foundation Batra, Surinder K. Ph.D. Dept. of Biochemistry and Molecular Biology, Univ of Nebraska Medical Ctr., Eppley Cancer Ctr Beck, William T. Ph.D. Department of Biopharmaceutical Sciences, University of Illinois at Chicago Benbrook, Doris M. Ph.D. Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center Bieberich, Charles J. Ph.D. Department of Biological Sciences, University of Maryland Baltimore County Bigbee, William L. Ph.D. Cancer Epidemiology Program, University of Pittsburgh Cancer Institute Blay, Jonathan Ph.D. Dept of Pharmacology, Dalhousie University Faculty of Medicine Bouhassira, Eric E. Ph.D. ...

FACTS Ovarian Cancer : Early Diagnosis, More Treatments Needed Ovarian cancer , like all cancers, starts out in a single cell. That cell starts dividing haphazardly, making millions and billions of copies of itself. Eventually, these cells amass to form a tumor. And because it is generally asymptomatic, the cancer may have progressed to Stage III or Stage IV with distant metastases before the woman feels any symptoms. What is ovarian cancer ? Ovarian cancer is a disease of the ovaries. Epithelial carcinoma is the most common form of ovarian cancer and affects the cells covering the surface of the ovary. The other two types of ovarian tumors are germ cell tumors, which begin in the egg-producing cells, and stromal tumors, which begin in the supportive tissue of the ovaries. Both of these latter kinds of cancer are rare. ...

Ovarian Cancer often shows no obvious signs or symptoms until the disease has advanced which may include: • General abdominal discomfort and/or pain; • Nausea, diarrhea, constipation or frequent urination; • Loss of appetite; • Bloating or feeling of fullness even after a light meal; • Weight gain or loss with no known reason; and • Abnormal bleeding from the vagina. Even though women may have these signs and symptoms, these findings do not indicate symptoms of ovarian cancer . September is Ovarian Cancer Awareness Month 8-24-05 What is an ovary? What is ovarian cancer ? The ovary is the reproductive organ, generally two, in a woman’s pelvic area. The ovaries are the primary source for the female sex hormone, estrogen. O varian cancer occurs at the cellular level either on or in the ovaries. Ovarian cancer is ...

Obesity makes ovarian cancer more deadly, a new studyreports. Obese women with advanced ovari- an cancer havea shorter time torecur- rence and a shorter overall survival time than women of ideal weight — and not because obese people often haveother medical problems. Obesity itself, the researchers sug- gest, is the problem. Ovarian cancer , said lead researcher Dr. Andrew J. Li, is “the fifth most common cancer in women, and the fifth most lethal." The scientists reviewed the medical records of 216 patients who had surgery for epithelial ovarian cancer . Half had ideal weight, with a body mass index (BMI) from 18.5 to 24.9, while 26 per cent were overweight, with BMIs exceeding 25, and 16 per cent wereobese, with BMIs morethan 30. Among patients at the most ad- vanced stages of the disease, those with BMIs higher than 25 survived dis- ...

Then “Turn UP the Volume: Raise Your Voice for Change” at the largest gathering of ovarian cancer survivors in the U.S. Whether newly diagnosed or a long-term survivor, this conference is for you! Are You an Ovarian Cancer Survivor? Are You an Ovarian Cancer Survivor? Learn about the latest research, treatments and clinical trials Network with hundreds of women with similar experiences Meet with lawmakers to advocate for more federal funds for research Gain hope and strength to change the future for yourself and other women The Ovarian Cancer National Alliance is the nation’s voice for ovarian cancer issues. The Alliance leads the national movement to conquer ovarian cancer by uniting local, state and national organizations that reach 800,000 people. For more INFORMATION and to REGISTER, visit: www.ovariancancer.org/conference ...

910 – 17 th Street, N.W. • Suite 413 • Washington, DC 20006 Telephone: 202-331-1332 • FAX: 202-331-2292 • http://www.ovariancancer.org FOR IMMEDIATE RELEASE Contact: Beverly Silverberg September 28, 2005 Phone: 301-779-0861 www.ovariancancer.org Email: Bev@brscomm.net Ovarian Cancer Researcher Honored Dr. Barbara Goff, a physician and a distinguished ovarian cancer researcher at the University of Washington, will receive the prestigious Rosalind Franklin Excellence in Ovarian Cancer Research Award for her findings regarding ovarian cancer symptoms. The Ovarian Cancer National Alliance (OCNA) will honor Dr. Goff at their Eighth Annual Conference in Atlanta on Saturday, October 1, 2005. “Dr. Goff’s study demonstrates her dedication to advancing the areas of ovarian cancer knowledge, early detection and treatment,” said ...

(more) Media Contact: Simi Singer Telephone: (310) 423-7798 E-mail: simi.singer@cshs.org EMBARGOED UNTIL AUGUST 28, 12:01 A.M. EST OBESITY LEADS TO MORE AGGRESSIVE OVARIAN CANCER , CEDARS-SINAI RESEARCH SHOWS New study suggests that excess fat may affect tumor biology Los Angeles, CA (August 28, 2006) – Whether or not a woman is obese will likely affect her outcome once she has been diagnosed with ovarian cancer , according to a new study from Cedars-Sinai Medical Center. The study, published online on Aug. 28 in the American Cancer Society’s journal Cancer , showed that obesity affected survival rates, shortened the length of time to recurrence of the disease, and led to earlier death from the cancer than for women diagnosed at their ideal body weight. “This study is the first to identify weight as an independent factor in ovarian cancer in disease progression ...

Breast & Ovarian Cancer Risk Profile Benefits to Hospitals and Physicians Attract New Patients by providing clinicians with tools supporting innovative healthcare Improves Patient Outcomes by identifying elevated-risk patients before cancer is diagnosed Increases Clinician Efficiency by integrating and summarizing important clinical information on patient reports Ease Patient Anxiety by fully assessing their risk for genetic and sporadic cancer Breast & Ovarian Cancer Risk Profile The POINT ONE ® Breast & Ovarian Cancer Risk Profile provides a clinical tool to systematically identify the patients who are at elevated risk for both hereditary and sporadic breast and ovarian cancer . Problem: Women with BRCA1 or BRCA2 ...

By AMY STALLINGS Director of the First-Year Seminar program is the newest title Donna Dahlgren, associate professor of psychology, has held during her academic career. Dahlgren, who holds a doctorate in psychology, has accepted the position formerly held by Curtis Peters, professor of philosophy. Peters, who is officially retiring in September, has been director of the program since it began in 2002. “Dr. Dahlgren will make a tremendous director of the program,” Peters said. Dahlgren, who is also faculty co-adviser for the National Honor Society in Psychology, Psi Chi, creative classroom editor for the Mid-Western Psychological Association and a member of the Council of Teachers of Undergraduate Psychology, said FYS helps students deal with the stresses and challenges that come with ...

NYU Cancer Institute and its multidisciplinary Gynecologic Oncology program present Caring and Curing for the Ovarian Cancer Patient Shifting Trends In Managing Patients Living With Ovarian Cancer A Day-Long Seminar at the NYU Clinical Cancer Center hosted by the Oncology Nurses of the NYU Cancer Institute September 14, 2006 7:30 am—4:15 pm “This continuing nursing education activity has been submitted to the New York State Nurses Association as an accrediting approver by the American Nurses Credentialing Center’s Com- mission on Accreditation for 7.8 hours.” Page 2 Caring and Curing is a highly informative educational program for Oncology Nurses, Nurse Practitioners, Physicians Assistants, Social Workers and other healthcare professionals interested in learning more about ...

Patient management framework Gynaecological tumourstream: ovarian cancer a guide to consistent cancercare Page 2 Page 3 Patient management framework Gynaecological tumour stream: ovarian cancer Page 4 Published by Metropolitan Health and Aged Care Services Division, Victorian Government Department of Human Services, Melbourne Victoria Australia May 2006 © Copyright State ofVictoria, Department of Human Services, 2006. This publication is copyright. No part may be reproduced by any process except in accordance with the provisions of the Copyright Act 1968. Also published on www.health.vic.gov.au/ cancer Authorised by the Victorian Government, 50 Lonsdale Street, Melbourne. Printed by GT Graphics Pty Ltd, 34 Stanley Street, Collingwood. Acknowledgements ...

910 – 17 th Street, N.W. • Suite 1190 • Washington, DC 20006 Telephone: 202-331-1332 • FAX: 202-331-2292 • http://www.ovariancancer.org The Facts About Ovarian Cancer Ovarian cancer is a killer disease of women. • Ovarian cancer , the deadliest of all gynecologic cancers, is the fifth leading cause of cancer death among women living in the U.S. • Ovarian cancer occurs in 1 out of 68 women. • About 20,000 American women will be diagnosed with the disease in 2006. • About 15,000 American women will die from ovarian cancer in 2006. Early detection is the difference between life and death. • Ovarian cancer can be difficult to diagnose because symptoms are sometimes subtle and easily confused with those of other diseases. • In cases where ovarian cancer is detected before it has spread beyond the ovaries, approximately ...

910 – 17 th Street, N.W. • Suite 1190 • Washington, DC 20006 Telephone: 202-331-1332 • FAX: 202-331-2292 • http://www.ovariancancer.org A Snapshot of the Ovarian Cancer National Alliance WHO: The Ovarian Cancer National Alliance is the nation’s voice for ovarian cancer issues. The Alliance leads the national movement to conquer ovarian cancer by uniting local, state and national organizations reaching more than one million people. As a 501(c)(3) nonprofit organization, the Alliance is funded through a mix of corporate and foundation gifts as well as individual contributions. WHY: Ovarian cancer knows no boundaries or borders, prematurely killing women of every age, ethnicity and socioeconomic status. It is the deadliest of all the cancers of the reproductive system and a leading cause of cancer death among women. Its symptoms are subtle, difficult to diagnose ...

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Women’s Healthcare ONCOLOGY a report by Maurie Markman , MD Department of Gynecologic Medical Oncology,The University of Texas, M D Anderson Cancer Center Introduction For several reasons, ovarian cancer is relatively unique among the malignant conditions of greatest concern to women (see Table 1 ). Knowledge of these disquieting facts has played an important role in the opinions frequently expressed by newly diagnosed patients, and their families, that efforts to aggressively treat ovarian cancer are largely futile. Further, many continue to believe that the quality of life of individuals following confirmation of the malignancy and during treatment is miserable. In fact, it is a true statement that a small percentage of women do exhibit a relatively rapid downhill course despite receiving appropriate primary therapy, but ...

ovarian cancer Prevention of Ovarian Cancer Roberta B. Ness , M.D., M.P.H., Chair of the Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health What Puts Women at Risk? Family history of ovarian and breast cancers Infertility Endometriosis Talc use Hormone replacement therapy Does Anything Prevent Ovarian Cancer ? Oral contraceptives Pregnancies Breast feeding (long duration) Tubal ligation Oophorectomy and hysterectomy Controversies NSAIDS Fertility drugs Androgens Diet: fat, coffee Ovarian Cancer Risk and Protection ...

A SYSTEMS BIOLOGY CASE STUDY OF OVARIAN CANCER DRUG RESISTANCE Jake Y. Chen 1 , 2,* , Changyu Shen 3 , Zhong Yan 1 , Dawn P. G. Brown 4 , Mu Wang 4 1 Indiana University School of Informatics, IUPUI, Indianapolis, IN 46202; 2 Department of Computer and Information Science, Purdue University School of Science, IUPUI, Indianapolis, IN 46202; 3 Division of Biostatistics, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202; 3 Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 * Corresponding Author. Email: jakechen@iupui.edu In ovarian cancer treatment, the chemotherapy drug cisplatin often induce drug resistance after prolonged ...

Fox Chase Cancer Center 2005 Scientific Report 1 Robert F. Ozols, M.D., Ph.D., Senior Member, Senior Vice President, Medical Science, Audrey Weg Schaus and Geoffrey Alan Weg Chair in Medical Science Louis M. Weiner, M.D., Senior Member, Chairman, Medical Oncology, Vice President, Translational Research, G. Morris Dorrance Jr. Endowed Chair in Medical Science Mary B. Daly, M.D., Ph.D., Senior Member Thomas C. Hamilton, Ph.D., Senior Member Andres J.P. Klein-Szanto, M.D., Senior Member Joseph R.Testa, Ph.D., Senior Member Paul Cairns, Ph.D., Member Andrew K. Godwin, Ph.D., Member Russell J. Schilder, M.D., Member Xiang-Xi (Mike) Xu, Ph.D., Member Gregory P. Adams, Ph.D., Associate Member Denise C. ...

Fox Chase Cancer Center 2005 Scientific Report 1 Loss of vitamin A metabolism in ovarian onco- genesis. Cvetkovic, S. Williams, Hamilton Ovarian cancer is postulated to arise from alter- ations in the epithelial cells regenerated during successive rounds of ovulation. This theory is supported by clinical observations that ovarian cancer risk is reduced by factors that decrease ovulation, such as pregnancy and oral contra- ceptives. To model this theory, an in vitro rat transformation model of ovarian cancer has been developed. A consistent loss of genes involved in vitamin A (retinol) metabolism has been discovered in this model. One of the genes consistently lost was cellular retinol- binding protein 1 (CRBP1), which is consid- ered critical for vitamin A homeostasis. Similar findings have been reported in breast cancer , such as loss of expression ...

Program Overview: Approximately $175,000 is available from the Marsha Rivkin Center for Ovarian Cancer Research to fund up to 5 awards to be allocated based on merit between the Pilot Study and Scientific Scholar Award Programs. The Scientific Scholar Award is intended to assist promising laboratory and clinical young scientists to pursue a career in ovarian cancer research. The Scientific Scholar Award will provide 50% salary support up to $30,000 for one year with a possible second year upon reapplying. Funds are for direct costs only; institutional overhead and indirect costs will not be included in the award. Eligibility: Potential candidates will have an MD, PhD, or equivalent degree with career goals focused on ovarian cancer . Clinicians will have completed their residency (ex. gynecologic oncology, medical oncology, radiation oncology, or pathology). ...

Since its inception in 1996, the Marsha Rivkin Center for Ovarian Cancer Research has been instrumental in supporting and organizing the research community to find solutions to ovarian cancer . Founded by renowned oncologist Dr. Saul Rivkin and his five daughters in memory of his wife who passed away after a long battle with ovarian cancer , the Marsha Rivkin Center works closely with its distinguished partners: Swedish Application Format: Applicants should submit a proposal to the Marsha Rivkin Center including a scientific plan, budget & budget justification, short CV, other Support and 100- word lay abstract. The scientific plan should be no more than five pages in length and show be written in NIH format (Arial Font, 12 point, 0.5” margins), addressing each of the following areas: Specific Aims, Background and Significance, Preliminary Results (if available), Experimental Methods ...

Gilda Radner Familial Ovarian Cancer Registry www.ovariancancer.com 1-800- OVARIAN 716-845-4503 We are proud to announce that the Registry presently has available the following items for ovarian cancer awareness . 1. Ovarian Cancer Awareness Quilt Note Cards. These cards are available in packages of 10 cards and envelopes. A picture of the quilt is on the front of the 6 x 4.5 inch card, the inside is blank and the back is printed with ovarian cancer awareness information. To order these cards for a $10.00 donation. 2. Polo Shirts – 25 Year Anniversary. These teal polo shirts have the Gilda Radner Familial Ovarian Cancer Registry 25 Year logo on the left sleeve. These beautiful 100% cotton polo shirts come in Women ’s S, M, L, XL and XXL may be ordered for a $20.00 donation . The Men ’s polo shirts are slightly darker teal and come in sizes M, L, XL, XXL and may be ...

ovarian cancer Ovarian Cancer Zachary B. Self, M3 Incidence/Prevalence: ~25,000 new cases diagnosed annually in U.S. #5 cancer in US women, #3 gyn cancer Most common cause of cancer death from gynecologic tumors in the United States. 1-2% lifetime risk (general population). 15-54% lifetime risk of ovarian cancer for women with a deleterious mutation in BRCA1 or BRCA2 gene. BRCA1 & BRCA2 Mutations: Associated with early onset of breast or ovarian cancer . Inheritance follows an AUTOSOMAL DOMINANT transmission. It can be inherited from either parent. Most cases are related to the BRCA1 gene mutation. BRCA1 is a TUMOR SUPPRESSOR GENE that inhibits cell growth when functioning properly. The inheritance ...

A PICTURE IS WORTHMUCH NEEDED FUNDS FOR OVARIAN CANCER FOR IMMEDIATE RELEASE TORONTO, ON August 1, 2006 – The National Ovarian Cancer Association is delighted to announce that it is one of the recipients of funds from MillionArtists.com, a website devoted to creating the world’s largest collaborative work of art while raising money for medical charities. Donor-“artists” simply log onto the site and sponsor a coloured pixel which will be added randomly to an abstract painting. Founded by, Eugene Pik and Anthony Barker, the aim is to reach a million people with this initiative. “NOCA is very excited to be a part of this creative initiative! We encourage everyone to raise the flag for ovarian cancer by choosing our colour, a teal pixel and selecting National Ovarian Cancer Association as your charity,” said NOCA Executive Director Elisabeth Ross. Please visit www.MillionArtists.com ...

Southwest Oncology Group Operations Office 14980 Omicron Drive • San Antonio, TX 78245-3217 • Telephone 210-677-8808 • FAX 210-677-0006 • http://swog.org FOR IMMEDIATE RELEASE Jan. 6, 2006 Contact: Rosanne Fohn Phone: 210-677-8808 E-mail: rfohn@swog.org Southwest Oncology Group contributes to new NCI recommendation for treating advanced ovarian cancer The Southwest Oncology Group conducted studies that have collectively contributed to the evidence that the delivery of chemotherapy delivered both intravenously and into the abdominal cavity after surgery improves overall survival for women with advanced ovarian cancer . On Jan. 5, the National Cancer Institute issued an announcement recommending the combined regime. Data show that overall survival is improved by about a year. An intergroup trial led by the Southwest Oncology Group and a second trial ...

Page 1 of 9 Coverage Position Number: 0321 C IGNA H EALTH C ARE C OVERAGE P OSITION Subject Stem-Cell Transplant for Ovarian Cancer Revised Date ..4/15/2006 Original Effective Date .4/15/2005 Coverage Position Number . 0321 Table of Contents Coverage Position..1 General Background .1 Coding/Billing Information..7 References.8 Hyperlink to Related Coverage Positions INSTRUCTIONS FOR USE Coverage Positions are intended to supplement certain standard CIGNA HealthCare benefit plans. Please note, the terms of a participant’s particular benefit plan document [Group Service Agreement (GSA), Evidence of Coverage, Certificate of Coverage, Summary Plan Description (SPD) or similar plan document] may differ significantly from the standard ...

Decision Resources, Inc. • 260 Charles Street, Waltham, Massachusetts 02453 • Tel +1.781.296.2500 • Fax +1.781.296.2550 • www.decisionresources.com • Decision Resources publications, including print and electronic formats, are to be used only within the single location purchasing the report. Multisite and enterprisewide access is available. Additional access licenses may be obtained by contacting your administrator or by calling Decision Resources: North America: +1.781.296.2500, Europe: +32.2.357.06.16, Japan: +81.3.5401.2615 2-1 Press Date: July 20, 2006 A Service of Decision Resources, Inc. Biomarkers and Diagnostics Emerging Diagnostic Biomarkers in Ovarian Cancer Jude Nelson Decision Resources, Inc. In This Issue Worldwide, ovarian cancer (CaO) is the leading cause of death from gynecological cancer and the fourth most common cause of cancer death ...

Pacific Ovarian Cancer Research Consortium Patient Advocacy Group Bridging the Gap Between Science and Community Minutes January 25, 2002 The meeting started with Advocate introductions. Nicole Urban, POCRC Principal Investigator “Screening Study for Average Risk Women with Symptoms” Nicole Urban , POCRC Principal Investigator, began the round table discussion by defining the 2 screening studies already under way. The Quest Study, which enrolled average risk women, is almost finished. The intent was to look at quality of life issues. The study was designed to see if one kind of testing caused more stress than another. The intent was to not worry women with a positive result, which became a concern during a similar trial for breast cancer . The Quest trial was to show the importance of screening, without creating a group of women with anxiety like the breast cancer trial. ...