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Gene Therapy of Pancreatic Cancer With Green Fluorescent Protein and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Fusion Gene Expression Driven by a Human Telomerase Reverse Transcriptase Promoter Matthew H. Katz, MD, Daniel E. Spivack, MD, Shinako Takimoto, BS, Bingliang Fang, MD, PhD, Douglas W. Burton, MS, A. R. Moossa, MD, Robert M. Hoffman, PhD, and Michael Bouvet, MD Background: Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) induces apo- ptosis in malignant cells but not in normal cells. Ad/g-TRAIL, an adenoviral vector in which expression of green fluorescent protein (GFP) and TRAIL is driven by a human telomerase reverse transcriptase promoter, has shown promise as a targeted antitumor agent. Methods: To investigate the effects of TRAIL gene therapy on pancreatic cancer , BxPC-3, MIA-PaCa-2, Panc-1, and ASPC-1 cells were treated with Ad/g-TRAIL. Transfection ...

Golf Outing and Barbecue Grandview Golf Course • 2779 Carlisle Road • York, PA 17404 Saturday, October 16, 2004 DEADLINE FOR SUBMISSION IS SEPTEMBER 18 Name Company Address City State Zip Phone E-mail Send ad and check made payable to PanCAN to: 5812 Barnsley Dr • Harrisburg, PA 17111 Questions Please call (717) 540-9110 or e-mail teamhopecpa@comcast.net PROGRAM ADVERTISEMENT OPPORTUNITIES Inside front or back cover (5” x 7 1/2”) . $200.00 each Full Page (5” x 7 1/2”) $100.00 each Half Page (5” x 3 1/2”) . $75.00 each In Honor/In Memory Of .. $50.00 each In Loving Memory Robert R. Moore 1961-1999 In memory of Linda G. Hammen September 5, 1942 - July 7, 2001 A wonderful Wife, loving Mother and Gram-mom with a ...

Teratogenesis, Carcinogenesis, and Mutagenesis 21:7–25 (2001) Published 2001 Wiley-Liss, Inc. † This article is a US Government work and, as such, is in the public domain in the United States of America. Risk Factors for Pancreatic Cancer : A Case-Control Study Based on Direct Interviews Debra T. Silverman* Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland The etiology of pancreatic cancer is poorly understood, partly because of the incon- sistency of findings among case-control studies of pancreatic cancer . Because of the unfavorable prognosis for pancreatic cancer , many case-control studies have been based largely on interviews with next of kin, who are known to report less reliable information on potential risk factors than original respondents. The ...

P5 CANCER . CLINICAL ASPECTS 130 Targeted Dietary Intervention after Pancreatic Resection for Malignancy. Effects on Bowel Function and Quality of Life T. Armstrong, E. Walters*, S. Varshney, C.D. Johnson University Surgical Unit and Department of Dietetics*, Southampton General Hospital, UK We have investigated long term survivors after pancreatectomy to determine whether specific dietary assessment and advice can improve gastrointestinal symptoms, bowel function and quality of life. Ten patients (7 men, median (range) age 61 (50–75) yr) were studied 16 (6–46) months after resection for malignancy, and after exclusion of recurrence by computed tomography. Detailed symptom enquiry, quality of life assessment (QoL) and dietary history were performed. All patients completed a 1 week weighed food dietary intake survey. Detailed advice was offered and patients were reassessed 8 weeks ...

A BASIC INFORMATION DESCRIPTION Uncontrolled growth of malignant cells in the pancreas. This is the 4th leading cause of cancer deaths in the U.S. The pancreas is an organ in the upper mid-abdomen that produces intestinal enzymes to help digest food and insulin to control blood sugar. Pancreas cancer affects adults ages 35-70 and men more often than women. FREQUENT SIGNS AND SYMPTOMS • Rapid, unexplained weight loss. • Pain in the back or upper abdomen that is often relieved by bending forward. • Blood clots in veins anywhere, especially the arms and legs. This is often an early sign. • Jaundice (yellow skin and eyes) from blockage of the nearby bile duct. Jaundice is usually accompanied by intense itching. • Depression. CAUSES Unknown. RISK INCREASES WITH • Chronic pancreatitis. • Diabetes mellitus. • Genetic factors: This is ...

pancreatic cancer PANCREATIC CANCER Dr. Smoot 1/30/04 RISK FACTORS FOR PANCREATIC CANCER -The adenocarcinomas are the most common and there are also cystic and hormonal tumors. The adenocarcinoma is the most frequent cancer found in the pancreas. There is a hereditary chronic pancreatitis and these people are at risk for cancer in the pancreas. It is good to screen these individuals for colon cancer as well. MEN Type I, HPNCC and FAP patients are also at risk for pancreatic cancer . Alcoholic pancreatitis complications may be diabetes followed by pancreatic cancer . DUCTAL ADENOCARCINOMA - Pancreatic cancer is associated with cigarette smoking, eating a lot of meat and fish (may not be a strong association with fish). Fruits and vegetables are protective but coffee is more than likely not. -2/3 of the carcinomas occur in the head ...

PO Box 2345, Beijing 100023, China World J Gastroenterol 2004;10(15):2292-2294 Fax: +86-10-85381893 World Journal of Gastroenterology E-mail: wjg@wjgnet.com www.wjgnet.com Copyright © 2004 by The WJG Press ISSN 1007-9327 • BRIEF REPORTS • Effect of octreotide on human pancreatic cancer cells after transfected with somatostatin receptor type 2 gene Zheng-Ren Liu, Ren-Yi Qin, Gao-Song Wu, Qing Chang, Da-Yu Wang, Sheng-Quan Zou, Fa-Zu Qiu Zheng-Ren Liu, Ren-Yi Qin, Gao-Song Wu, Qing Chang, Da- Yu Wang, Sheng-Quan Zou, Fa-Zu Qiu, Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Supported by the Natural Science Foundation of Hubei Province, No. 2000J068 Correspondence to: Professor Ren-Yi Qin, Department of General Surgery, Tongji Hospital, Tongji ...

SINGLE-TOPIC MINI-SYMPOSIUM MOLECULAR INSIGHTS INTO PANCREATIC CANCER Monday, July 26, 2004 The rest of the program listed below will be held in the same location as noted above from 1:15 – 4:00 p.m. (lunch provided from 1:15 – 1:45 p.m.). *********Reservations required for the following program ********** Call (323) 442-3121 by Wednesday, July 21, 2004 to reserve a seat, lunch and parking. Program Time Speaker Topic 1:45 – 2:05 p.m. Anna S. Gukovskaya, PhD VAGLAHS / UCLA, Dept of Medicine The role of NADPH oxidase in pancreatic cancer cell survival 2:10 – 2:25 p.m. Mouad Edderkaoui, PhD Student VAGLAHS / UCLA, Dept of Medicine Extracellular matrix proteins regulate death pathways in pancreatic cancer cells 2:30 – 2:50 p.m. Guido Eibl, MD UCLA, Department of Surgery ...

Date: October 16, 2004 Location: Panther Creek State Park-Spoon Shelter Registration: 8:00 a.m. Walk/Run Begins: 9:00 a.m. Start/Finish: Old Wagon Trail Course: 5K/3.1 M (cross country trail) Entry Fee: ? $20 through October 2, 2004 ? $25 Day of Event Registration: ? Mail in entries must be received by October 2, 2004 ? Register online @ www.active.com ? Day of event @ Spoon Shelter Event Packets: ? All registered participants will receive a T-shirt, PanCAN purple cloth pin, and a chance to win raffle prizes ? Pick up your packet the day of the event at the Spoon Shelter in Panther Creek Park Parking: ? Parking available at the Park For more information, please contact: Leslie Frantom at lfrantom@pancan.org or (423) 581-3016 PanCan National Headquarters: 877-272-6226 •www.pancan.org ...

Berkshire Priorities Committee Policy Statement 40 Gemcitabine for Pancreatic Cancer Date of Issue August 2001 Review Date April 2004 Pancreatic adenocarcinoma causes about 11 per 100,000 deaths each year in England and Wales (just under 6,000 people). In Berkshire this equates to approximately 90 residents, national data suggests that at least 80% (70) of these residents have locally advanced or metastatic disease. It is assumed 4% would be suitable for potentially curative surgery, 25 – 35% (18 – 24) could be suitable for chemotherapy with about 50% (9-12) accepting treatment with Gemcitabine. The National Institute of Clinical Excellence (NICE) reviewed the effectiveness of Gemcitabine in five RCT studies. One single blind RCT compared Gemcitabine with the chemotherapy agent 5FU in 126 patients. The Gemcitabine patients had an 18% one year survival ...

JOP. J Pancreas (Online) 2004; 5(4):253-257. JOP. Journal of the Pancreas – http://www.joplink.net – Vol. 5, No. 4 – July 2004. [ISSN 1590-8577] 253 ROUND TABLE Pancreatic Cancer Imaging: Which Method? Erwin Santo Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center. Tel Aviv, Israel Summary Pancreatic cancer is the 10 th most common malignancy and the 4 th largest cancer killer in adults. Surgery offers the only chance of curing these patients. Complete surgical resection is associated with a 5-year survival rate of between 20 and 30%. The challenge is how to best select those patients for curative surgery. Early studies demonstrated excellent sensitivity of EUS in detecting pancreatic tumors in comparison to CT. Similarly, EUS showed an 85-94 % accuracy rate for ...

PO Box 2345, Beijing 100023, China World J Gastroenterol 2004;10(10):1466-1470 Fax: +86-10-85381893 World Journal of Gastroenterology E-mail: wjg@wjgnet.com www.wjgnet.com Copyright © 2004 by The WJG Press ISSN 1007-9327 • BASIC RESEARCH • Overexpression of annexin 1 in pancreatic cancer and its clinical significance Xiao-Feng Bai, Xiao-Guang Ni, Ping Zhao, Shang-Mei Liu, Hui-Xin Wang, Bing Guo, Lan-Ping Zhou, Fang Liu, Jin-Sheng Zhang, Kun Wang, Yong-Qiang Xie, Yong-Fu Shao, Xiao-Hang Zhao Xiao-Feng Bai, Xiao-Guang Ni, Ping Zhao, Shang-Mei Liu, Hui- Xin Wang, Lan-Ping Zhou, Fang Liu, Jin-Sheng Zhang, Yong- Qiang Xie, Yong-Fu Shao, Xiao-Hang Zhao, National Laboratory of Molecular Oncology, Department of Abdominal Surgery, Department of Pathology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing ...

Gene Therapy for Pancreatic Cancer Using an Adenovirus Vector Encoding Soluble flt-1 Vascular Endothelial Growth Factor Receptor *Tohru Hoshida, †Makoto Sunamura, †Dan G. Duda, †Shinichi Egawa, *Shukichi Miyazaki, *Ryuzaburo Shineha, §Hirofumi Hamada, ‡Haruo Ohtani, *Susumu Satomi, and †Seiki Matsuno Divisions of *Advanced Science and Technology, †Gastroenterological Surgery, and ‡Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan; and §Department of Molecular Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan Introduction: Vascular endothelial growth factor (VEGF) plays an important role in tumor angiogenesis. The soluble form of flt-1 VEGF receptor inhibits VEGF activity in a dominant-negative manner. Aim: This study demonstrated the regional tumor sup- pression effect of adenovirus-mediated soluble flt-1 in human pan- creatic cancer ...

Abstract. The gastrointestinal peptides gastrin and cholecysto- kinin (CCK) stimulate growth of human pancreatic cancer by a receptor-mediated process. The purpose of this study was to investigate the molecular and functional characteristics of the receptor associated with peptide-induced pancreatic cancer proliferation. Utilizing total RNA from human pancreatic cancer cells a cDNA was cloned and sequenced by RT-PCR and rapid amplification of cDNA ends methodology. The molecular characteristics of the receptor cDNA were studied by Northern analysis and protein structure by Western analysis. An antibody raised against the novel receptor was utilized to investigate the role of the CCK-C receptor on pancreatic cancer cellular growth using in vitro technology. A spliced variant of the CCK-B receptor was identified which differed from the CCK-B receptor by the presence ...

Summer, 2002 GWCCS Cancer Support Group & Internet Resource Guide Page 1 www.gwccs.org Greater Washington Coalition for Cancer Survivors (202) 364-6422 Pancreatic , Kidney & Liver Cancer Resources Organization/Phone Logo Web Site (URL) American Foundation for Urologic Disease (410) 468-1800 http://www.afud.org/ CancerAnswers (888) 226-8287 Http:www.canceranswers.com The Cancer Group Institute (305) 651-5070 Http:www.cancergroup.com Cancer Information and Support International Http:www. cancer -info.com/pancreas Ronald Hirshberg Foundation (310) 472-6310 http:www. pancreatic .org Johns Hopkins Medical Institutions (410) 955-5718 Http:www.path.jhu.edu/pancreas Kidney ...

Pancreatic Cancer Risk and Nutrition-Related Methyl- Group Availability Indicators in Male Smokers Rachael Z. Stolzenberg-Solomon, Demetrius Albanes, F. Javier Nieto, Terryl J. Hartman, Joseph A. Tangrea, Matti Rautalahti, Jacob Sehlub, Jarmo Virtamo, Philip R. Taylor Background: Few risk factors for pan- creatic cancer have been identified, with age and cigarette smoking being the most consistent. The protective ef- fect associated with consumption of fruits and vegetables—the major di- etary sources of folate—is suggestive of a role for factors influencing cellular methylation reactions; however, to our knowledge, no study has investigated this relationship. Whether biochemical indicators of methyl-group availability are associated with exocrine pancreatic cancer risk was the focus of ...

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