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Pancreatic cancer remains a cancer with poor survival prospects. For males there has been no change in incidence or mortality over the last 20 years, and for females there has been only a slight increase in both measures. Background notes Pancreatic Cancer Page 2 Male Pancreatic Cancer - Incidence and Mortality* 1977-2000 All Ages Source - SA Cancer Registry Data 0 2 4 6 8 10 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 Year *Age Standardised for World Population Ra te/ 10 00 00 Incidence Mortality Male Pancreatic Cancer ~ Incidence and Mortality* 1977-2000 All Ages Source: SA Cancer Registry Data ...

KIMBA ROXBY DOWNS (M) COOBER PEDY (DC) UNINCORP. FAR NORTH UNINCORP. FLINDERS RANGES ROBE BERRI CLARE HAWKER CEDUNA TANUNDA WHYALLA MENINGIE WILLUNGA MAITLAND PORT PIRIE BORDERTOWN PORT LINCOLN PETERBOROUGH PORT AUGUSTA MOUNT GAMBIER PORT BROUGHTON 0 100 200 50 Kms Pancreatic Cancer Mortality in South Australia, 1991-2000 by Statistical Local Areas GAWLER GLENELG MODBURY WILLUNGA ADELAIDE WOODVILLE ELIZABETH MOUNT BARKER BEDFORD PARK NOARLUNGA CENTRE Annual Mortality/100,000 0.0 - 2.5 2.6 - 5.0 5.1 - 10.0 10.1 - 65.0 Towns Statistical Local Areas Produced by: Data Analysis and Consulting Unit, Information Management Services, and Epidemiology Branch, Department of Human Services. Data Sources: ...

KIMBA ROXBY DOWNS (M) COOBER PEDY (DC) UNINCORP. FAR NORTH UNINCORP. FLINDERS RANGES ROBE BERRI CLARE HAWKER CEDUNA TANUNDA WHYALLA MENINGIE WILLUNGA MAITLAND PORT PIRIE BORDERTOWN PORT LINCOLN PETERBOROUGH PORT AUGUSTA MOUNT GAMBIER PORT BROUGHTON 0 100 200 50 Kms Incidence of Pancreatic Cancer in South Australia, 1991-2000 by Statistical Local Areas GAWLER GLENELG MODBURY WILLUNGA ADELAIDE WOODVILLE ELIZABETH MOUNT BARKER BEDFORD PARK NOARLUNGA CENTRE Annual Incidence/100,000 0.0 - 2.5 2.6 - 5.0 5.1 - 10.0 10.1 - 75.0 Towns Statistical Local Areas Produced by: Data Analysis and Consulting Unit, Information Management Services, and Epidemiology Branch, Department of Human Services. Data Sources: ...

JOP. J Pancreas (Online) 2003; 4(5):165-168. JOP. Journal of the Pancreas – http://www.joplink.net – Vol. 4, No. 5 – September 2003 165 The Race from Chronic Pancreatitis to Pancreatic Cancer Giulia Martina Cavestro 1 , Giuseppe Comparato 1 , Antonio Nouvenne 1 , Mario Sianesi 2 , Francesco Di Mario 1 1 Department of Clinical Science, Chair of Gastroenterology; 2 Department of Surgical Science, General Surgery and Organ Transplantation; University of Parma. Parma, Italy The latest data on pancreatic cancer epidemiology were published in 2002 by the American National Cancer Institute. It was confirmed as the 5 th leading cause of death from cancer , causing more than 24,000 deaths each year. The fact that nearly all patients die ...

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2 nd Annual Race to Make a Difference for Pancreatic Cancer Research 5 5 5 k k k R R R u u u n n n / / / 2 2 2 M M M i i i l l l e e e W W W a a a l l l k k k D D D A A A T T T E E E : : : Saturday, June 21, 2003 Bay Village, Ohio Cahoon Memorial Park S S S T T T A A A R R R T T T / / / F F F I I I N N N I I I S S S H H H : : : Cahoon Memorial Park, corner of Wolf Road and Cahoon Road in Bay Village, Ohio R R R E E E G G ...

Abstract . Over 90% of human pancreatic cancers harbor an activating point mutation in the K-ras gene at codon 12. However, it is not clear whether all downstream K-ras are activated and which downstream contributes to the cell survival and proliferation of pancreatic cancer cells. MEK kinase 1 (MEKK1)-c-Jun N-terminal kinase (JNK)-c-Jun pathway has an important role in cell proliferation, survival and apoptosis in various cells. We previously demonstrated that the dominant negative form of MEKK1 (DN-MEKK) inhibits the survival of human pancreatic cancer cell lines. In this study we investigated whether JNK-c-Jun, the down- stream pathway of DN-MEKK, affects the survival of human pancreatic cancer cell lines. Colony formation assays indicated that c-Jun failed to inhibit the survival of pancreatic cancer cells, whereas c-Jun remarkably inhibited the cell survival ...

pancreatic cancer PANCREATIC CANCER by John Isaac Annual incidence There is a regional difference with a 10x difference in the highest and lowest incidence countries. Hawaii ? 15.8/100000 USA (male) - 10/100000 USA (female) ? 6.2/100000 USA ? Ca pancreas is the 5 th leading cause of cancer deaths after lung, colon, breast and prostate Singapore (male) ? 4/100000 Singapore (female) ? 2.8/100000 Compared to other cancers it is an uncommon cancer in Singapore. Epidemiology Uncommon below 45 years. 80% of cases occur in the 60-80 age group. Male to female ration is 1.5:1 to 2:1 It remains uncertain whether geographic and racial differences in incidence reflect environmental or genetic factors. Most likely it is a combination. Risk factors are Smoking ...

By Russell G. Postier, M.D. John A. Schilling Professor and Chairman, Department of Surgery Pancreatic cancer is a dismal disease. Two years ago, 32,300 people in the U.S. were diagnosed with pancreatic cancer and 30,000 died. Fewer than 4 percent of patients diagnosed survive long-term. It is the fourth most common cause of cancer death in the United States. In 2001, a Progress Review Group (PRG) submitted a detailed analysis of the state of the disease to the National Cancer Institute (NCI). It was the feeling of this PRG that there had been little real progress made in pancreatic cancer understanding or treatment and that an increased awareness and funding on the part of the NCI was necessary if any real improvements were to be made. At OU Physicians, we are building a substantial clinical program for ...

N ORTHERN C ALIFORNIA C ANCER C ENTER , Cancer Incidence and Mortality in the Greater San Francisco Bay Area 151 Pancreatic Cancer • Between 1988 and 2000, pancreatic cancer incidence rates decreased slightly (Table 1). • Higher incidence rates of pancreatic cancer were observed in blacks compared to other racial/ethnic groups (Table 1). • Pancreatic cancer , a disease of advancing age, exhibited steadily increasing incidence rates after age 34 (Table 2). • Incidence rates of pancreatic cancer did not appear to differ markedly by county (Table 3). TABLE 1. Pancreatic Cancer . Annual Case Counts, Age-Adjusted Incidence Rates per 100,000 Population, a and 95% Confidence Intervals (CI), by Sex and Race/Ethnicity, 1988-2000, ...

Abstract. Peroxisome proliferator-activated receptor Á (PPAR Á ), a ligand activated transcription factor, forms a heterodimer with retinoid X receptor · (RXR · ), and its trans- criptional activity is thought to be maximal in the presence of both PPAR Á and RXR · ligands. Though previous studies suggested that thiazolidinediones (TZDs), known as PPAR Á ligands, inhibit the growth of certain types of cancer cells, little is known about the growth inhibitory effects mediated though activation of PPAR Á /RXR · . We examined the effects of troglitazone (one type of TZDs) and 9-cis retinoic acid, a RXR · ligand, on activation of PPAR Á /RXR · and growth inhibition of human pancreatic cancer cell lines ...

Dietary Sugar, Glycemic Load, and Pancreatic Cancer Risk in a Prospective Study Dominique S. Michaud, Simin Liu, Edward Giovannucci, Walter C. Willett, Graham A. Colditz, Charles S. Fuchs Background: Evidence from both animal and human studies suggests that abnormal glucose metabolism plays an impor- tant role in pancreatic carcinogenesis. We investigated whether diets high in foods that increase postprandial glu- cose levels are associated with an increased risk of pancre- atic cancer . Methods: In a cohort of U.S. women (n = 88 802) participating in the Nurses’ Health Study, 180 case subjects with pancreatic cancer were diagnosed during 18 years of follow-up. We used frequency of intake of individual foods as reported on a food-frequency questionnaire in 1980 to cal- culate sucrose, fructose, and carbohydrate intakes; glycemic index ...

TRANSDIFFERENTIATION IS A KEY STEP IN PANCREATIC CANCER DEVELOPMENT . M.W. Mueller, D.E. Bockman, P. Buechler, J. Guo, F. Bergman*, M.W. Buechler, H. Friess. Department of General Surgery and Pathology*, University of Heidelberg, Germany The process of pancreatic ductal adenocarcinoma development is still discussed controversial. A key question is whether the cells of origin of the tubular complexes that constitute precursor lesions are derived from a single cell type or from multiple types. Suggestions that they arise solely from centroacinar cells or ductal cells have been based on inference due to their morphological appearance in tissue from patients or investigation of limited numbers of tubular complexes in animal models later in the carcinogenic process. So this study was designed to monitor the development of pancreatic cancer immediately after implantation of the carcinogen DMBA. ...

pancreatic cancer Pancreatic Cancer Causes of Pancreatic Cancer Cancer of the pancreas occurs due to the mutation of DNA in pancreatic cells. These mutations can be inherited or acquired The inherited nature of some mutations means that pancreatic cancer seems to run in some families Otherwise cancer of the pancreas is caused in similar ways to other cancers by exposure to carcinogens such as those in cigarette smoke. The abnormalities in DNA are currently been investigated by techniques such as Spectral Karyotyping A Spectral Karyotype of a Pancreatic Cancer Sufferer &nb...

THORACOSCOPIC SPLANCHNICECTOMY FOR PAIN RELIEF IN UNRESECTABLE PANCREATIC CANCER Pietrabissa A, Vistol F, Adami D, Del Chiaro M, Mosca F Division of General and Transplant Surgery, University of Pisa, Pisa, Italy Background: Unbearable pain (P) in patients (pts) with unresectable or locally recurrent pancreatic cancer (PC) is a still undertreated condition. Thoracoscopic splanchnicectomy (TS), has recently been introduced as an attractive alternative in the management of upper abdominal P syndromes. Aims: The aim of this prospective study was to evaluate the effects of unilateral thoracoscopic trunkal splanchnicectomy on P scores and quality of life measures in patients with unresectable PC. Materials and methods: Between September 1997 and January 2000, 36 pts (19 men and 17 women; mean age of 62, 7 years, range 48 to 82 years), underwent 38 attempted TS. Indications were primary unresectable ...

pancreatic cancer PANCREATIC CANCER 4th leading cause of cancer deaths in G and E . 25,000 cases/yr in the U.S. and nearly that # of deaths. Vast majority of pts present w/unresectable disease & 5 yr survival is ~ 5%. Cause of tumor is unknown. Risk factors include smoking & chronic pancreatitis. 1/2 of pancreatic Ca arise in the head, 1/2 in the body and tail. Distal common bile duct runs through pancreatic head. Pancreatic Ca most often occur in this area making this tumor the most commonly associated w/malignant biliary obstruction. Courvoisier' s law: Obstructing malignancies of the distal CBD produce a palpable non-tender gallbladder. Why? Because common duct stones (the main DDx) are usually associated w/chronic cholecystitis à contracted gallbladder. Pancreatic Adenocarcinoma Clinical manifestations depend on location where ...

O8 PANCREATIC CANCER . FURTHER BASIC ASPECTS 29 Ectopic Cytoplasmic Expression of -Catenin Correlates with Cyclin D1 Overexpression in Pancreatic Cancer M. Ramadani, Q. Qiao, F. Gansauge, S. Gansauge, G. Leder and H.G. Beger Department of General Surgery, University of Ulm, Germany -catenin is a component of the E-cadherin–catenin cell adhesion complex. It plays also a role in the intracellular signalling and can function as an oncogene when it binds to the T cell factor 4 (Tcf4)-binding site in the promoter region of cyclin D1 and transactivates genes after translocation to the nucleus. We evaluated the expression of -catenin in relationship with cyclin D1 overexpression, tumor grade, clinicopathological parameters and patients’ survival in 43 adenocarcinomas of the pancreas and in 5 normal pancreatic tissues by immunohistochemistry. We could show that, both, ...

O8 PANCREATIC CANCER . FURTHER BASIC ASPECTS 27 Differential Activation of P42ERK2 and P125FAK by Cholecystokinin and Bombesin in Secretion and Proliferation in AR42J Cells K. Kiehne, K.H. Herzig, U.R. Fölsch Dept. Int. Medicine, Christian-Albrechts Universität Kiel, Germany Purpose: AR42J rat pancreatic acinar carcinoma cells have retained the potential to secrete digestive enzymes in addition to their ability to proliferate upon stimulation with regulatory peptides. We investigated the involvement of p42 ERK2 and p125 FAK activation by cholecystokinin and bombesin stimulation with regard to secretion and mitogenesis. Methods: p42 ERK2 kinase activity was measured by kinase assay and p125 FAK activity by anti-phosphotyrosine Western Blot analysis of p125 FAK immunoprecipitates. Expression ...

P5 CANCER . CLINICAL ASPECTS 123 Mass-Forming Pancreatitis (MFP) and Pancreatic Cancer (PC): A Diagnostic Problem L. Frulloni, C. Liani, P. Bovo, B. Vaona, B. Calore, A. Cantone, R. Turrini, G. Gasparini, S. Carrara, G. Cavallini Dept of Surgical and Gastroenterological Sciences, University of Verona, Verona, Italy Background: We postulated an immune-mediated pathogenesis for chronic pancreatitis. Among autoimmune pancreatitis, MFP is an inflammatory process that involves only partially the pancreas and may be confused by mistake with PC. Aim: of this work is to identify the clinical and radiological characteristics helpful to differentiate MFP from PC at the onset of the disease. Materials and Methods: We studied consecutively 10 patients suffering from MFP (8 males, 2 females, mean age 41.5 years, range 17–63) and 11 from PC (10 males, 1 female; mean age 61, ...

P5 CANCER . CLINICAL ASPECTS 125 Pancreatic Enucleation: Limits of an Attractive Procedure A. Sauvanet, B. Dousset, C. Proye, D. Jaeck, J.P. Arnaud, J.F. Gigot, C. Leborgne, C. Partensky, C. Letoublon, P.L. Fagniez, S. Berdah, P. Le Treut The French Pancreatic Club, CHU Rangueil, 31403, Toulouse, France Purpose of the study: To expose the results of a collective series of pancreatic enucleation, and to underline the limits of this technique. Methods: From 1990 to 1998, 76 patients (mean age 47 23 years) underwent PE for endocrine tumor (n 56, including 51 insulinomas), benign cystadenoma (n 13), lymphangioma or lymphoepithelial cyst (n 4), or other benign (n 2) or malignant (n 1) tumors. PE was associated with another procedure in 9 cases (12%): multiple PE in 4, major pancreatic resection in 3, and digestive resection in 2. Tumors were enucleated from the ...

P5 CANCER . CLINICAL ASPECTS 127 The Role of Pancreatic Resection for Metastatic Tumors to the Pancreas C. Sperti, C. Pasquali, L. Pinciroli, A. Ferronato, S. Pedrazzoli Department of Medical and Surgical Sciences, University of Padova, Italy Introduction: Solitary metastatic lesion occurring in the pancreas is uncommon and may be difficult to differentiate from pancreatic adenocarcinoma. Resection of metastatic tumors to the pancreas has been occasionally reported and its role in improving survival or quality of life of the patients is not clearly defined. We evaluated the outcome of patients resected for isolated metastatic tumors of the pancreas, in our Institution over a 20-years period. Methods: From 1980 to 2000, among 222 patients resected for cancer , 6 patients who underwent pancreatic resection for metastatic malignancies were identified. Medical records ...

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KIMBA ROXBY DOWNS (M) COOBER PEDY (DC) UNINCORP. FAR NORTH UNINCORP. FLINDERS RANGES ROBE BERRI CLARE HAWKER CEDUNA TANUNDA WHYALLA MENINGIE WILLUNGA MAITLAND PORT PIRIE BORDERTOWN PORT LINCOLN PETERBOROUGH PORT AUGUSTA MOUNT GAMBIER PORT BROUGHTON 0 100 200 50 Kms Incidence of Pancreatic Cancer in South Australia, 1991-2000 by Statistical Local Areas GAWLER GLENELG MODBURY WILLUNGA ADELAIDE WOODVILLE ELIZABETH MOUNT BARKER BEDFORD PARK NOARLUNGA CENTRE Annual Incidence/100,000 0.0 - 2.5 2.6 - 5.0 5.1 - 10.0 10.1 - 75.0 Towns Statistical Local Areas Produced by: Data Analysis and Consulting Unit, Information Management Services, and Epidemiology Branch, Department of Human Services. Data Sources: ...

A Novel Red Fluorescent Protein Orthotopic Pancreatic Cancer Model for the Preclinical Evaluation of Chemotherapeutics Matthew H. Katz, M.D.,* Shinako Takimoto, B.S.,* Daniel Spivack, M.D.,* A. R. Moossa, M.D.,* Robert M. Hoffman, Ph.D.,* , † and Michael Bouvet, M.D.* ,1 * Department of Surgery, University of California at San Diego, San Diego, California; and † AntiCancer, Inc., San Diego, California Submitted for publication April 18, 2003 Background. Realistic models of pancreatic cancer are necessary to develop effective drugs for the dis- ease. More aggressive tumor models enhanced by brighter fluorescent biomarkers to follow the disease in real time would enhance the ability to predict ac- curately the effect of novel therapeutics on this par- ticularly malignant human cancer . Materials and methods. A novel, highly fluorescent, ...

Pancreatic Cancer Risk and Nutrition-Related Methyl- Group Availability Indicators in Male Smokers Rachael Z. Stolzenberg-Solomon, Demetrius Albanes, F. Javier Nieto, Terryl J. Hartman, Joseph A. Tangrea, Matti Rautalahti, Jacob Sehlub, Jarmo Virtamo, Philip R. Taylor Background: Few risk factors for pan- creatic cancer have been identified, with age and cigarette smoking being the most consistent. The protective ef- fect associated with consumption of fruits and vegetables—the major di- etary sources of folate—is suggestive of a role for factors influencing cellular methylation reactions; however, to our knowledge, no study has investigated this relationship. Whether biochemical indicators of methyl-group availability are associated with exocrine pancreatic cancer risk was the focus of ...