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Photograph provided by Danielle Barfield, John Barfield Photography Refuse to Lose the Fight Against Pancreatic Cancer Pancreatic Cancer , "The Silent Killer" has a 99% fatality rate and is the fourth leading cause of cancer deaths in men & women. Contact Pamela Swanson for more info 404-391-2169

The Office of the Governor Executive Department State of Idaho Proclamation State Capitol Boise WHEREAS, November 2002 will be observed as Pancreatic Cancer Awareness Month to create awareness of pancreatic cancer , the number four cause of death of men and women in the United States; and WHEREAS, over 30,300 people will be diagnosed with pancreatic cancer this year in the United States and the 99% mortality rate for pancreatic cancer is the highest of any cancer ; and WHEREAS, there are currently no early detection methods and minimal treatment options for pancreatic cancer and by the time symptoms generally present themselves, it is too late for a positive prognosis and the average survival after diagnosis with the mestastatic disease is only 3-6 months; and WHEREAS, pancreatic cancer does ...

Pancreatic Cancer Risk and Nutrition-Related Methyl- Group Availability Indicators in Male Smokers Rachael Z. Stolzenberg-Solomon, Demetrius Albanes, F. Javier Nieto, Terryl J. Hartman, Joseph A. Tangrea, Matti Rautalahti, Jacob Sehlub, Jarmo Virtamo, Philip R. Taylor Background: Few risk factors for pan- creatic cancer have been identified, with age and cigarette smoking being the most consistent. The protective ef- fect associated with consumption of fruits and vegetables—the major di- etary sources of folate—is suggestive of a role for factors influencing cellular methylation reactions; however, to our knowledge, no study has investigated this relationship. Whether biochemical indicators of methyl-group availability are associated with exocrine pancreatic cancer risk was the focus of ...

URGENT FAX REFERRAL LINE (01242) 776655 GLOUCESTERSHIRE URGENT CANCER REFERRAL FORM SUSPECTED UPPER GI or PANCREATIC CANCER - 2 Week Wait Rule Patient Surname : Patient First Name : Address: NHS Number (New) Thi from CONFIDENTIAL s communication and any documents following are confidential and may be privileged disclosure. If you receive this communication in error, please telephone (01242) 272591 Hospital No : Date of Birth D D M M Y Y Y Y / / Male Female Telephone Number: Postcode : Preferred Preferred Outpatient Hospital point of consultation Direct Access Gastroscopy Date of Decision to Refer by GP : D D M M Y Y Y Y Referring GP : Registered or Usual GP: ...

P.O.Box 2345, Beijing 100023,China World J Gastroenterol 2003;9(8):1819-1823 Fax: +86-10-85381893 World Journal of Gastroenterology E-mail: wjg@wjgnet.com www.wjgnet.com Copyright © 2003 by The WJG Press ISSN 1007-9327 • CLINICAL RESEARCH • Pancreatic cancer mortality in China (1991-2000) Li Wang, Gong-Huan Yang, Xing-Hua Lu, Zheng-Jing Huang, Hui Li Li Wang, Hui Li, Department of Epidemiology, School of Basic Medical Sciences, PUMC, Institute of Basic Medical Sciences, CAMS, Beijing, 100005, China Gong-Huan Yang, Zheng-Jing Huang, Institute of Epidemiology and Microbiology, Center for Disease Control and Prevention of China, Beijing, 100050, China Xing-Hua Lu, Department of Internal Medicine, Peking Union Hospital, Beijing, 100730, China Supported by the Ministry of Public Health, No. 20010102 Correspondence to: Li Wang, Graduate School of Peking ...

Pancreatic cancer cells express interleukin-13 and -4 receptors, and their growth is inhibited by Pseudomonas exotoxin coupled to interleukin-13 and -4. Kornmann M, Kleeff J, Debinski W, Korc M. Department of Medicine, University of California, Irvine 92697, USA. mkorc@uci.edu BACKGROUND: Interleukin (IL)-13 and -4 are multifunctional cytokines that bind to specific cell-surface receptors. The aim of this study was to determine whether pancreatic cancer cells express either receptor, and to assess the growth suppressive effects of chimeric proteins composed of a Pseudomonas exotoxin (PE) A mutant (PE38QQR) fused to IL-13 (IL-13-PE38QQR) or IL-4 (IL-4-PE38QQR) in these cells. MATERIALS AND METHODS: Northern and Western blot analysis were used to analyze the expression of IL-4/-13 receptors and the common gamma chain (gamma c) in pancreatic cancer cell lines. MTT growth assays ...

Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. Kleeff J, Kornmann M, Sawhney H, Korc M. Division of Endocrinology, Diabetes, and Metabolism, Departments of Medicine, Biological Chemistry and Pharmacology, University of California, Irvine, CA 92697, USA. Pancreatic cancer cells are usually resistant to apoptosis induced by cytotoxic drugs, by activation of surface receptors such as Fas and TNF receptor or by serum or growth factor withdrawal. Actinomycin D (actD) is an inhibitor of RNA synthesis and acts as a potent inducer of apoptosis in several cell lines. In the present study, we investigated the effects of actD on PANC-1 pancreatic cancer cells. ActD caused apoptosis in PANC-1 cells in a dose-dependent manner, as determined by cell growth assays, DNA laddering and TUNEL assays. Induction of apoptosis correlated with activation of the JNK/SAPK ...

Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival. Kornmann M, Ishiwata T, Itakura J, Tangvoranuntakul P, Beger HG, Korc M. Department of Medicine, University of California, Irvine, USA. Cyclin D 1 belongs to a family of protein kinases that have been implicated in cell cycle regulation. In the present study we characterized cyclin D1 expression in 6 cultured human pancreatic cancer cell lines and in normal and cancerous human pancreatic tissues. A 4.4-kb cyclin D1 mRNA transcript was present in all cell lines and in all pancreatic tissues. Cyclin D1 mRNA levels were 2.1-fold higher in the pancreatic cancers than in normal pancreatic tissues (p < 0.0002). Cancer patients with lower cyclin D1 levels (n=16) had a median survival of 15.5 months whereas patients with higher levels (n=16) had a median survival of 6.5 ...

Fas and Fas-ligand expression in human pancreatic cancer . Kornmann M, Ishiwata T, Kleeff J, Beger HG, Korc M. Department of Medicine, University of California, Irvine 92697, USA. OBJECTIVE: To investigate Fas and FasL expression in pancreatic tissues and cultured pancreatic cancer cell lines, and to assess the ability of anti-Fas antibodies to induce apoptosis. SUMMARY BACKGROUND DATA: Activation of the Fas receptor by Fas-ligand (FasL) results in apoptosis, and dysregulation of this pathway may contribute to abnormal cell proliferation. METHODS: Northern blotting and immunohistochemistry were used to compare Fas and FasL expression in normal and cancerous tissues. DNA 3'-OH end labeling was used to detect apoptotic cells. The effects of Fas activation on cell growth and signaling pathways were investigated in culture. RESULTS: Pancreatic cancers exhibited increased Fas RNA levels, whereas ...

176 Am J Clin Nutr 2003;78:176–81. Printed in USA. © 2003 American Society for Clinical Nutrition Tooth loss, pancreatic cancer , and Helicobacter pylori 1–3 Rachael Z Stolzenberg-Solomon, Kevin W Dodd, Martin J Blaser, Jarmo Virtamo, Philip R Taylor, and Demetrius Albanes ABSTRACT Background: Poor dental health has been associated with increased risks of oral, esophageal, and gastric cancer and may also be associated with pancreatic cancer . In addition, Helicobac- ter pylori has been found in dental plaque and has been associated with periodontal disease and pancreatic cancer . Objective: The objective was to investigate prospectively the rela- tion between dentition history and pancreatic cancer in the Alpha- Tocopherol, Beta-Carotene Cancer Prevention Study cohort in Fin- land and the association between dentition history and H. ...

1115 Am J Epidemiol 2003;157:1115–1125 American Journal of Epidemiology Copyright © 2003 by the Johns Hopkins Bloomberg School of Public Health All rights reserved Vol. 157, No. 12 Printed in U.S.A. DOI: 10.1093/aje/kwg098 Dietary Meat, Dairy Products, Fat, and Cholesterol and Pancreatic Cancer Risk in a Prospective Study Dominique S. Michaud 1 , Edward Giovannucci 2,3,4 , Walter C. Willett 2,3,4 , Graham A. Colditz 2,4 , and Charles S. Fuchs 2,5 1 Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD. 2 Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA. 3 Department of Nutrition, Harvard School of Public ...

Strategic Plan for Addressing the Recommendations of the Pancreatic Cancer Progress Review Group Prepared: September 2002 Page 2 Strategic Plan for Addressing the Recommendations of the Pancreatic Cancer Progress Review Group Table of Contents Message From the NCI Director Table 1. New Activities and immediate strategies for pancreatic research New Activities Immediate Strategies Table 2. Short-, medium- and long-term proposed new strategies for pancreatic research Short-term strategies Medium-term strategies Long- term strategies Strategic Plan Section 1 Health of the Field 1 Develop sustained, expanded training and career development efforts in pancreatic cancer research and care 2 Establish centers of excellence for pancreatic ...

Gene Therapy for Pancreatic Cancer Using an Adenovirus Vector Encoding Soluble flt-1 Vascular Endothelial Growth Factor Receptor *Tohru Hoshida, †Makoto Sunamura, †Dan G. Duda, †Shinichi Egawa, *Shukichi Miyazaki, *Ryuzaburo Shineha, §Hirofumi Hamada, ‡Haruo Ohtani, *Susumu Satomi, and †Seiki Matsuno Divisions of *Advanced Science and Technology, †Gastroenterological Surgery, and ‡Histopathology, Tohoku University Graduate School of Medicine, Sendai, Japan; and §Department of Molecular Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan Introduction: Vascular endothelial growth factor (VEGF) plays an important role in tumor angiogenesis. The soluble form of flt-1 VEGF receptor inhibits VEGF activity in a dominant-negative manner. Aim: This study demonstrated the regional tumor sup- pression effect of adenovirus-mediated soluble flt-1 in human pan- creatic cancer ...

JOP. J Pancreas (Online) 2003; 4(4):163-164. JOP. Journal of the Pancreas – http://www.joplink.net – Vol. 4, No. 4 – July 2003 163 Helicobacter pylori and Pancreatic Cancer . A Working Hypothesis from Epidemiological Studies Stefan Wöhrer, Michael Hejna, Markus Raderer Department of Medicine I, Clinical Division of Oncology, University Hospital Vienna. Vienna, Austria Dear Sir: We have read the informative article about Helicobacter pylori (HP) and pancreatic disease written by Manes et al . with great interest [1]. We were, however, slightly puzzled by the statement that no data on a potential association between Helicobacter pylori infection and pancreatic cancer are available. According to recent data, two articles and one letter about an association between the bacteria and pancreatic cancer have been published. In the ...

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Center for Environmental Health Studies (617) 482-9485 44 Farnsworth Street, Boston, MA 02210 http://www.jsi.com * Findings were statistically significant (strong evidence) + Evidence of a dose-response relationship (strongest evidence) Page 84 Pancreatic Cancer and Exposure to Ionizing Radiation Summary : Some evidence has been recorded of a possible connection between cancers of the pancreas and exposure to ionizing radiation. This possible connection is supported by evidence from studies conducted at Los Alamos National Laboratory and other studies of nuclear workers at other sites who have been exposed to ionizing radiation. The National Research Council’s, on the other hand, has determined that the pancreas is relatively insensitive to ionizing radiation. Pancreatic cancers are designated as “specified” cancers ...

By Russell G. Postier, M.D. John A. Schilling Professor and Chairman, Department of Surgery Pancreatic cancer is a dismal disease. Two years ago, 32,300 people in the U.S. were diagnosed with pancreatic cancer and 30,000 died. Fewer than 4 percent of patients diagnosed survive long-term. It is the fourth most common cause of cancer death in the United States. In 2001, a Progress Review Group (PRG) submitted a detailed analysis of the state of the disease to the National Cancer Institute (NCI). It was the feeling of this PRG that there had been little real progress made in pancreatic cancer understanding or treatment and that an increased awareness and funding on the part of the NCI was necessary if any real improvements were to be made. At OU Physicians, we are building a substantial clinical program for ...

Parity, Reproductive Factors, and the Risk of Pancreatic Cancer in Women 1 Halcyon G. Skinner, 2 Dominique S. Michaud, Graham A. Colditz, Edward L. Giovannucci, Meir J. Stampfer, Walter C. Willett, and Charles S. Fuchs Department of Epidemiology [H. G. S., G. A. C., E. L. G., M. J. S., W. C. W.] and Department of Nutrition, Harvard School of Public Health [G. A. C., E. L. G., M. J. S., W. C. W.], Boston, Massachusetts 02115; The Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115 [H. G. S., G. A. C., E. L. G., M. J. S., W. C. W., C. S. F.]; Department of Adult Oncology, Dana- Farber Cancer Institute, Boston, Massachusetts 02115 [C. S. F.]; and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892 [D. S. M.] Abstract ...

Gallstones, cholecystectomy, and the risk for developing pancreatic cancer ES Schernhammer* ,1,2 , DS Michaud 3 , MF Leitzmann 4,5 , E Giovannucci 1,4 , GA Colditz 1,5,6,7 and CS Fuchs 1,8 1 Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA; 2 Ludwig Boltzmann-Institute for Applied Cancer Research, KFJ-Spital, Vienna, Austria; 3 National Cancer Institute, Nutritional Epidemiology Branch, 6120 Executive Blvd., Rockville, MD 20852, Maryland, USA; 4 Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115, Massachusetts, USA; 5 Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA; 6 ...

Occupation and Pancreatic Cancer Risk in Shanghai, China Bu-Tian Ji, MD, DrPH , 1,2 * Debra T. Silverman, ScD , 1 Mustafa Dosemeci, PhD , 1 Qi Dai, MD , 2 Yu-Tang Gao, MD , 2 and Aaron Blair, PhD 1 Background Any association between occupation and pancreatic cancer risk has not been conclusively demonstrated. A population-based case-control study was conducted to examine occupational risks of pancreatic cancer in Shanghai, China. Methods The study included 451 pancreatic cancer patients newly diagnosed in 1990–1993 and 1,552 controls randomly selected from Shanghai residents. Information on a lifetime job history and other factors was obtained ...

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 36:260±270 (1999) Occupational Risk Factors for Pancreatic Cancer : A Case-Control Study Based on Death Certificates From 24 U.S. States Gabriela J. Kernan, MSc , MPH , 1,3 Bu-Tian Ji, MD , DrPH , 2Ã , Mustafa Dosemeci, PhD , 2 Debra T. Silverman, ScD , 2 John Balbus, MD , 3 and Shelia Hoar Zahm, ScD 2 Background The relation between occupational exposure and pancreatic cancer is not well established. A population-based case-control study based on death certi®cates from 24 U.S. states was conducted to determine if occupations/industries or work-related exposures to solvents were associated with pancreatic cancer death. Methods ...

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pancreatic cancer Kas 6-18E: Patient with ascites due to pancreatic cancer 48-year-old man P.R, technician, married, he comes for gradual loss of weight in several last months and one month gradual enlargement of abdomen Family history: father 74 years has diabetes mellitus, last 5 years treated with drugs, mother 73 years has arterial hypertension, 2 healthy sisters and 2 healthy children Personal history: He had common children´s ailments, in 10 years he had appendectomy, in 12 years he had hepatitis A, in 40 years he had meniscectomy on left lower limb, in 46 years he had right inguinal herniotomy. Nearly 9 months he is treated for vertebral algesic syndrome, he goes for rehabilitation. No smoker, he drinks alcohol occasionally, has no allergy, his social conditions are good Drugs: sometimes analgesics for backache. Present illness: For 1 month he has been observing ...

OVEREXPRESSION OF HER2 IN HUMAN PROSTATE, BREAST AND PANCREATIC CANCER CELLS AS A MOLECULAR TARGET FOR TARGETED ALPHA THERAPY Y Zhang, C Qu, Y Li, S Rizvi, C Raja & BJ Allen Center for Experimental Radiation Oncology, Cancer Care Center, St. George Hospital, Kogarah, NSW The epidermal growth factor receptor (HER2) is one member of the erbB family of transmembrane tyrosine kinases. HER2 signaling is associated with enhanced breast cancer cell proliferation. The aims of this study are to investigate if HER2 in human prostate, breast and pancreatic cancer cells is a molecular target of a new treatment with targeted alpha therapy (TAT) for metastatic cancer using the humanized monoclonal antibody, Herceptin. Human prostate cancer cell lines (PC-3, DU145 and LNCaP-LN-3), breast cancer cell lines (BT-474 and SK-BR-3) and pancreatic cancer cell lines (CAPAN-1, CFPAN-1 and PANC-1) were ...

TNFerade TM , in Pancreatic Cancer : Preliminary Results of the Dose-Escalating Phase of a Major Randomized Study in Patients with Locally Advanced Pancreatic Cancer Nader Hanna 1 , Theodore Chung 2 , J. Randolph Hecht 3 , Stephen Vogel 4 , Alexander Rosemurgy 5 , John Nemunaitis 6 , Milind Javle 7 , Tony Reid 8 , Paul Kessler 9 , Mitchell Posner 10 , Kenneth Chang 11 , Neil Senzer 6 1 University of Kentucky, Lexington, KY; 2 Medical College of Virginia, Richmond, VA; 3 University of California at Los Angeles; 4 University of Florida, Gainesville, FL; 5 University ...

Clinical Pancreatic Cancer 13 Pancreatico-Biliary Inflammation and Hyperinsulinemia are Risk Factors of Pancreatic Cancer B. Isaksson 1 , F. Jonsson 2 , M. Feychting 2 , J. Permert 1 1 Department of Surgery, Karolinska Institutet at Huddinge University Hospital, 2 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Background: Even though pancreatic cancer (PC) is a common cause of cancer death, little is known about it’s etiology. Our aim was to investigate inflammatory pancreatic and biliary disorders, and lifestyle related disorders as potential risk factors of PC. Methods: A population-based case-control study was carried out by using all cases of PC reported to The Swedish Cancer Registry in 1987–1999 (n 15,001). Population- ...

Clinical Pancreatic Cancer 10 Delayed Gastric Emptying after Pancreaticoduodenectomy is Associated with Post- Operative Pancreatic or Splenic Complications S. Räty, J. Sand, I. Nordback Department of Surgery, Tampere University Hospital, Finland Background: Although hospital mortality after pancreaticoduodenectomy is minimal the morbidity is not. The most common single complication is delayed gastric empty- ing. The aim of this study was to analyse the possible association of delayed gastric emptying and post-operative pancreatic complications after pancreaticoduodenectomy. Patients and Methods: 20 consecutive patients undergoing pylorus preserving pancre- aticoduodenectomy were included – 13 females and 7 males (62 [range 30–80] years): 8 pancreatic cancer , 3 bile duct cancer , 2 ampullary cancer , 1 duodenal cancer , 1 carci- noid tumour, ...

Basic Pancreatic Cancer 111 Rac1/cdc42 are Involved in MAPK Phosphorylation in Pancreatic Cancer Cells X.Z. Ding, X.Q. Li, R. Hennig, T.E. Adrian Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA Introduction: The signaling pathways that regulate pancreatic cancer growth are poorly understood. 5-lipoxygenase (5-LOX) is involved in pancreatic cancer cell proliferation. The 5-LOX metabolite, 5-hydroxyeicosatetraenoic acid (5-HETE) stimulates pancreatic cancer cell proliferation via activation of MAPK. The roles of Rac1/cdc42 in 5-HETE- induced MAPK activation were investigated. Materials and Methods: Phosphorylation of ERK1/2, P38 kinase, PAK and Raf-1 were measured by western blotting. Activities of Rac1 and cdc42 were measured by selective affinity precipitation of cdc42-GTP with immobilized ...

Basic Pancreatic Cancer 100 Invasion System of Pancreatic Cancer : Enhancement of Integrin Expression by Glial Cell Line-Derived Neurotrophic Factor (GDNF) H. Funahashi, H. Sawai, M. Yamamoto, Y. Okada, T. Hayakawa, M. Tanaka, T. Manabe First Department of Surgery, Nagoya City Unversity Medical School, Nagoya, Japan Introduction: The factor and the mechanism that determine the metastatic and invasive behavior of pancreatic tumor cells are incompletely understood. Methods: The expression of integrin subunits and the alteration of their expression by GDNF were examined by flow-cytometric analysis and cellular enzyme-linked assay in pancreatic cancer cell lines. Adhesion and invasion assays of cancer cells to ECM proteins were performed. Results: Pancreatic cancer cell lines were all found to express the RET and GFR -1 ...