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Clinical Pancreatic Cancer 2 Localisation of Endocrine Pancreatic Tumours – The Role of Endoscopic and Intraoperative Ultrasound T. Winternitz, T.F. Tihanyi, M. Borsodi, J. Horányi, L. Flautner 1st Surgical Department of Medical Faculty, Semmelweis University, Budapest, Hungary Background: Although adequate pre and intraoperative localisation is remains a difficult problem associated with endocrine pancreatic tumours. Endoscopic ultrasonography (EUS) and intraoperative ultrasonography (IOUS) has shown promise for the detection of pancreatic insulomas. The aim of this study was to analyse the diagnostic power of the EUS and IOUS (LIOUS) for identification of small sized pancreatic insulinomas. Methods: We evaluated seventeen patients (15 women/2 men, mean age (44.1) with EUS and nineteen cases (6 men/13 women, mean age: 49.3) with IOUS of small sized ...

Clinical Pancreatic Cancer 23 Clinical Epidemiology of Pancreatic Neuroendocrine Tumours (PNTs): Comparison of Data from Three UK Cancer Registries (CRs) H.E. Doran 1 , R. Sutton 1 , E.M.I. Williams 2 Departments of 1 Surgery and 2 Public Health, University of Liverpool, Merseyside and Cheshire Cancer Registry, Liverpool, UK Background: We compared data from three UK CRs to determine the feasibility of a national approach to assess PNT clinical epidemiology. Methods: All PNT cases (including age, sex, treatment and survival) were identified from three CRs (West Midlands, North Western and Mersey) for 1996–2000. Results: Forty-three cases (median age 63 years, range 34–77; 23 male: 20 female) were identified from West Midlands CR (population 5.3 m; 1.6 per m per ...

Clinical Pancreatic Cancer 24 Enhancement of Cancer Registry (CR) Pancreatic Neuroendocrine Tumour (PNT) Data Using Royal Liverpool University Hospital (RLUH) Databases H.E. Doran 1 , F. Campbell 4 , L. Bosonnet 1 , W. Fraser 3 , J.P. Neoptolemos 1 , E.M.I. Williams 2 , R. Sutton 1 Departments of 1 Surgery, 2 Public Health and 3 Clinical Chemistry, University of Liverpool, Merseyside and Cheshire Cancer Registry, 4 Department of Pathology, Royal Liverpool and Broadgreen University Hospitals Trust, Liverpool, UK Background: We have assessed the completeness of CR case ascertainment by com- parison of contemporaneous CR and hospital records. Methods: All registered ...

Clinical Pancreatic Cancer 17 Analysis of Long Term Survival After R-0 Resection for Pancreatic and Periampullary Adenocarcinoma H.G. Smeenk 1 , T.C.K. Tran 1 , W.C.J. Hop 3 , J. Jeekel 1 , H. van Dekken 2 , C.H.J. van Eijck 1 1 Department of General Surgery, 2 Department of Pathology and 3 Department of Epidemiology & Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands Background: Numerous clinicopathological parameters have been demonstrated to predict the prognosis in patients with pancreatic carcinoma and periampullary tumours after surgical resection. Radical (R-0) resections are difficult to achieve. Factors most predictive for survival after R-0 resection (without microscopic evidence of residual ...

Basic Pancreatic Cancer 104 Pancreatic Adenocarcinoma – Gene Therapy is Better Adjuvant Treatment than Chemotherapy or Radiotherapy C.M. Halloran, P. Ghaneh, J.P. Neoptolemos, E. Costello Department of Surgery, University of Liverpool, UK Aim: To compare gene therapy, chemotherapeutic and radiation based strategies in reducing pancreatic adenocarcinoma survival in vitro. Methods: The Pancreatic adenocarcinoma cell line – Panc-1 (mt K-ras/p53, / p16INK4A, wt Rb) was 1. incubated with chemotherapeutic drugs, 5-flurouracil (5FU), gemcitabine or auristatin, singularly or in combination; 2. incubated with the above cytotoxic drugs before inoculation with adenoviral vectors harbouring the genes for p16INK4A (Adp16) or the control gene, firefly luciferase or 3. infected with adenoviral vectors, prior to irradiation with a gamma source (Cs137). Cellular ...

Basic Pancreatic Cancer 102 Genes Differentially Expressed during In Vitro Malignant Transformation of Bovine Pancreatic Duct Cells R. Jesnowski 1 , D. Zoubakov 2 , J. Ringel 1 , J. Hoheisel 2 , M. Löhr 1 1 Department of Medicine II, Medical Faculty of Mannheim, University of Heidelberg, 2 DKFZ Heidelberg, Functional Genome Analysis, Heidelberg, Germany Background and Aim: Recently we established an in vitro model recapitulating first steps in the carcinogenesis of the pancreas. Upon k-ras transfection of SV40 large T anti- gen immortalizated bovine pancreatic duct cells they formed intrapancreatic adenocar- cinoma tumors after orthotopic injection in the nude mouse pancreas. Here we tried to identify genes differentially expressed in the course of ...

Basic Pancreatic Cancer 92 Immunohistochemical Analysis of DPC4 Expression in Pancreatic Adenocarcinoma (PA) and Chronic Pancreatitis (CP) R. Talar-Wojnarowska 1 , A. Gasiorowska 1 , A. Sasor 2 , J. Strzelczyk 3 , A. Janiak 3 , E. Malecka-Panas 1 1 Department of Digestive Tract Diseases, Medical University, Lodz, 2 Department of Clinical Patomorphology, Military Medical University, Warsaw, 3 Department of General Surgery and Transplantology, Medical University, Lodz, Poland DPC4 inactivation is one of the more common genetic alterations in pancreatic adenocar- cinoma (PA). The aim of the study was to evaluate the DPC4 value in chronic pancreatitis (CP) and PA differential diagnosis. The study included 22 patients with ...

Basic Pancreatic Cancer 118 Antiproliferative Efficacy of a Focused Library of Tyrosine-Kinase Inhibitors E.Z. Szabó, R. Schwab, G. Bökönyi, F. Hollósy, F. Waczek, B. Bánhegyi, B. Hegymegi-Barakonyi, B. Németh, E. Várkondi, E. Schafer, S. Radinovic, T. Gyökeres, J. Hamvas, L. Örfi, M. Idei, G. Kéri, Á. Pap MTA-TKI Peptide Biochemistry R.G., Department of Gastroenterology, MÁV Hospital, Co-operation Research Centre, Semmelweis University, Budapest, Hungary Background: Inhibition of false proliferative signals is one of the major targets of drug development, today. Tyrosine kinase enzymes (TK) are considered among the key molecular targets in this respect. Our aim was to characterise the antiproliferative effi- cacy of a focused library of compounds with known TK inhibitory potential, that are used in Quantitative Structure Relationship (QSAR) predictive models for ...

Basic Pancreatic Cancer 108 Delay of Tumour Growth in Nude Mice by Expression of Suppressor Enhancer Line (SEL1L) Gene in Pancreatic Carcinoma Cell Lines A. Bonora, S. Beghelli 1 , C. Bassi, M. Cattaneo 2 , C. Sorio 1 , I. Biunno 2 , A. Scarpa 1 , P. Pederzoli Departments of Surgical Sciences and 1 Pathology, University of Verona, 2 Institute for Biomedical Technologies (National Research Council), Milan, Italy Reduction of in vitro proliferation in SEL1L cell lines treated with dexamethasone (DEX) suggested a possible role for this gene in pancreatic carcinoma. In order to further investigate the effects of SEL1L overexpression in tumour growth, SUIT-2 cell lines transfected with pDEX.1 and SEL1L-pDEX.1 construction were used. ...

Basic Pancreatic Cancer 91 A Novel Biodegradable Biliary Stent for Hepatico- Jejunal Anastomosis (HJ) with Non-Dilated Bile Ducts J. Laukkarinen, J. Sand, P. Chow, J. Isola, H. Juuti, J.P. Nuutinen, S. Yu, S. Somanesan, I. Kee, I.C. Song, N. Teck Hin, I. Nordback Departments of Surgery and Pathology, Tampere University Hospital, Tampere, Finland, Departments of Experimental Surgery and Nuclear Medicine, Singapore General Hospital, Singapore and Institute of Biomaterials, Tampere University of Technology, Tampere, Finland Introduction: In Whipple operations with non-dilated bile ducts (BD), e.g. with small non-ampullary tumours such as endocrine and uncinate pancreatic and duodenal tumours, there is an increased risk for HJ complications. A biodegradable biliary stent (BDBS) could be one solution. Materials: Thirty 50-kg pigs underwent cholecystectomy plus Roux-Y ...

Basic Pancreatic Cancer 120 Protein Kinase Bioassay Platform for Screening Inhibitory Compound-Libraries E. Schäfer 1,2 , E. Várkondi 1 , G. Bökönyi 3 , T. Gyökeres 2 , J. Hamvas 2 , L. Örfi 2 , G. Kéri 3 , R. Schwab 1,2 , Á. Pap 2 1 Department of Gastroenterology, MÁV Hospital, 2 Co-operation Research Centre, Semmelweis University, 3 MTA-TKI Peptide Biochemistry R.G., Budapest, Hungary Introduction: Receptor tyrosine kinases (TK) play a crucial role in mediating growth factor signals from the cell surface and represent potential pharmaceutical targets for therapeutic intervention in disorders associated with false proliferative signals, like cancer . Increased ...

Basic Pancreatic Cancer 121 Different Effects of Kinase Inhibitors on the Cell Cycle and Apoptosis S. Radinovic, F. Pinter, B.B. Németh, E. Várkondi, E. Schafer, T. Gyökeres, J. Hamvas, L. Örfi, G. Kéri, I. Peták, R. Schwab, Á. Pap Co-operation Research Centre, Semmelweis University, Department of Gastroenterology, MÁV Hospital, Budapest, Hungary Introduction: Kinases often play a key role in unregulated cell growth, and represent widely investigated targets for potential therapies for tumours including pancreatic can- cer (PC). Our aim was to establish a flow cytometric model on A431 cells overexpress- ing the EGF receptor that is implicated in the molecular pathogenesis of PC, for the detection of cell cycle block and induction of apoptosis as separate end points. Methods: Flow cytometry was used with various indicators of cell cycle and cell survival: ...

Basic Pancreatic Cancer 99 Clinicopathological and Immunohistochemical Analysis of Intraductal Papillary-Mucinous Tumors of the Pancreas H. Sawai, M. Tanaka, H. Funahashi, M. Yamamoto, Y. Okada, T. Hayakawa, T. Manabe Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan Intraductal papillary-mucinous tumors (IPMTs) of the pancreas are intraductal tumors with variable amounts of papilla formation, mucin production, and cytoarchitectural atypia. We previously reported that strong expression of 6-integrin subunit and weak expression of 5 1-integrin in tumor cells significantly correlated with poor prognosis in pancreatic ductal adenocarcinoma patients. In this study, we investigated the clinico- pathologic features of 22 IPMT cases, and whether these molecular markers, especially integrins, IL-1RI, p53, ...

Basic Pancreatic Cancer 96 Expression of the Cholecystokinin-2/Gastrin Receptor (CCK-2R) in the Murine Pancreas Affects Cell Adhesion and Cell Differentiation In Vivo C. Bierkamp, A. Mathieu, P. Clerc, D. Fourmy, L. Pradayrol, C. Seva, M. Dufresne INSERM U531, Department of Digestive Pathology, Institut Louis Bugnard, CHU Rangueil, France The CCK-2 receptor and its hormone gastrin regulate gastric acid secretion and growth of the gastro-intestinal system. We recently showed the modulation of cellular adhesion in epithelial cells upon CCK-2R activation. Moreover, transgenic mice with ectopic acinar expression of the CCK-2R (ElasCCK2), develop with age hyperplasia and carci- nomas in the exocrine pancreas. Using immunofluorescence we analyzed the localization of cell adhesion molecules, cytoskeleton, digestive enzymes and differentiation factors in pancreas of control ...

Basic Pancreatic Cancer 119 Comparison of Elisa-Based Tyrosine Kinase Assays for Screening EGFR Inhibitors E. Várkondi 1 , E. Schäfer 1,2 , G. Bökönyi 3 , T. Gyökeres 2 , J. Hamvas 2 , G. Kéri 3 , R. Schwab 1 , Á. Pap 2 1 Co-operation Research Centre, Semmelweis University, 2 Department of Gastroenterology, MÁV Hospital, 3 MTA-TKI Peptide Biochemistry R.G., Budapest, Hungary Background: EGF receptor subtypes have been found overexpressed in many GI tumours. Recently, a great number of ATP-like, heterocyclic compounds have been identified with selective inhibitory potential. Our aim was comparison of established, non-radioactive ELISA-based tyrosine kinase assays that would enable testing large ...

Web Immagini Gruppi Directory News Novità! Ricerca avanzata Preferenze Cerca nel Web Cerca solo le pagine in Inglese Spiacenti, nessun contenuto associato a questo URL Web La ricerca di - cache:XVeiLeRGcPQJ:www.pancreasweb.com/Abstracts/pdf/0001556.pdf allintitle: pancreatic cancer filetype:pdf OR filetype:doc OR filetype:ppt OR filetype:xls OR filetype:rtf - non ha prodotto risultati in nessun documento. Suggerimenti: - Assicurarsi che tutte le parole siano state digitate correttamente. - Provare con parole chiave diverse. - Provare con parole chiave più generiche. - Provare con un numero minore di parole chiave. ...

Clinical Pancreatic Cancer 4 Systemic Inflammatory Response to Resectable Ductal Adenocarcinoma of the Head of Pancreas, and its Effect on Survival P. Glen, N.B. Jamieson, D.C. McMillan, C.J. McKay, C.R. Carter, C.W. Imrie Lister Department of Surgery, Glasgow Royal Infirmary, Scotland Introduction: This study examines the relationship between clinico-pathological status, the systemic inflammatory response and survival in patients undergoing resection of ductal adenocarcinoma of head of pancreas (CAP). Materials and Methods: Pre-operative C-Reactive Protein (CRP), pathological and survival data were obtained on patients undergoing resection for CAP at our centre between 1993 and 2001. Peri-operative deaths (0–30 days) and patients with proven infection were excluded from analysis. Results: On multivariate analysis, tumour size (p 0.05), vascular ...

Clinical Pancreatic Cancer 12 Periampullary Gangliocytic Paraganglioma: A Report of Two Cases G.R. Fronda, D. Campra, P. De Paolis, G. Avagnina, S. Perardi 1 , M. Bernardi 2 , G. Palestro 3 7 Department of Surgery-ASO S. Giovanni Battista (Molinette)- Turin, 1 Department of Gastroenterology-ASO S. Luigi Gonzaga- Orbassano (TO), 2 I and 3 II Department of Pathology, University of Turin, Italy Introduction: Gangliocytic paraganglioma (GP) is rare tumor usually located in peri- ampullary region with uncertain histogenesis and behavior. Methods: Case 1 . 40-years-old male presented with gastrointestinal bleeding and anaemia. Upper endoscopy found an ulcerated polyps near papilla of Vater, confirmed by CT-scan and EUS. No metastases were found. Surgical excision ...

Clinical Pancreatic Cancer 3 Tumor M2-Pyruvate Kinase: Is it a New Useful Marker for Neuroendocrine Tumors? R. Pezzilli 1 , M. Migliori 1 , A.M. Morselli Labate 1 , E. Romboli 1 , D. Campana 1 , M. Ventrucci 2 , P. Tomassetti 1 , R. Corinaldesi 1 1 Department of Internal Medicine and Gastroenterology, Sant’Orsola – M. Malpighi Hospital, University of Bologna, 2 Department of Internal Medicine, Hospital of Bentivoglio, Bologna, Italy Objective: M2 pyruvate kinase isoenzyme (M2-PK) is expressed by undifferentiated or proliferating tissue. The aim of the study was to establish the diagnostic role of tumor M2-PK (TM2-PK) in patients with neuroendocrine tumors and to compare its diagnos- tic value with that ...

Basic Pancreatic Cancer 106 The Influence of Inflammatory Cytokines on the Adhesion of Human Pancreas Carcinoma Cells to Microvascular Endothelium M. ten Kate, W. van Grevensteijn, L. Hofland, J. Jeekel, C.H.J. van Eijck Erasmus Medical Center, Rotterdam, The Netherlands Introduction: The surgical trauma provokes an inflammatory response with secretion of cytokines. We hypothesise that inflammatory cytokines play a crucial role in tumour cell adhesion in the lung by activating the microvascular endothelium. Methods: In a reproducible in vitro human tumour cell adhesion model the adhesion of three pancreas carcinoma cell lines (Panc-1, Miapaca and Bxpc-3) to monolayers of HMVEC-L was assessed. To study the influence of cytokines, monolayers of HMVEC- L were pre-incubated with IL-1 , TNF- and IL-6 for varying times and with varying concentrations. Pre-incubation ...

Clinical Pancreatic Cancer 11 Improved National Results in Pancreaticoduodenectomy – Are we Satisfied? I. Nordback, J. Sand, S. Räty, M. Parviainen, H. Kuivanen Department of Surgery, Tampere University Hospital, Finland Background: The hospital mortality is a well defined scale of quality control in some elective surgery. In several studies the hospital mortality after pancreaticoduodenec- tomy is dependent on the number of cases annually operated (hospital volume). Since 1996, based on the results between 1990–1994 (In detail Scand J Gastroenterol 2002;37:1454–1460), we have repeatedly talked in the national meetings for voluntary concentration of these operations. The aim of this study was to see whether concentra- tion has taken place and whether mortality has changed. Methods: The national hospital discharge database was used to study the annual number of panc...

Last revised: 4/10/03 UM Cancer Center Patient Education Document #0033 Apr03 Ed. Online version: http://www. cancer .med.umich.edu/learn/percpathways.htm University of Michigan Comprehensive Cancer Center Patient Education Resource Center (PERC) INFORMATION GUIDE Pancreatic Cancer The purpose of this information guide is to help patients newly diagnosed with Pancreatic Cancer and their families to find sources of information and support. This list is not meant to be comprehensive, but rather to provide starting points for information seeking. The materials can be found at the Patient Education Resource Center at the University of Michigan Comprehensive Cancer Center in room B1-361. Brochure Available free at the Patient Education Resource Center on Level B-1 room 361 National Cancer Institute. ...

INHERITED PREDISPOSITION C URRENT O NCOLOGY — V OLUME 5, S UPPLEMENT 1 S12 Inherited predisposition to pancreatic cancer M. Redston MD R E V I E W A R T I C L E 1. INTRODUCTION In the past few years we have witnessed an explosion in our understanding of the genetic basis of human cancer . In addition to identifying the vast number of somatic altera- tions of key growth control genes, significant advances have been made in identifying the genes involved in cancer predisposition. While unusual and distinctive familial can- cer syndromes have long been recognised (such as familial adenomatous polyposis and multiple endocrine neoplasia), many of the genes causing common cancer syndromes (such as familial ...

VINCENT C URRENT O NCOLOGY — V OLUME 5, S UPPLEMENT 1 S27 The role of adjuvant radiotherapy in pancreatic cancer L.S. Vincent MD R E V I E W A R T I C L E 1. INTRODUCTION Adenocarcinoma of the pancreas is the fifth leading cause of cancer deaths in the United States and killed almost 28 000 people last year. Sadly, the incidence rates are also virtually identical to the mortality rates. Radiation therapy has always played a limited role in the management of this disease, mainly because local control is only one aspect of treatment. It is known that pancreaticoduodenectomy will offer an actuarial 5-year survival of 21–36% and a median survival of 15–19 months 1 . Residual tumour re- mains in up to 90% of the ...

AN EFFICIENT IMMUNE RESPONSE AGAINST PANCREATIC CANCER THROUGH SPECIFICALLY STIMULATED BONE MARROW T-CELLS F.H. Schmitz-Winnenthal, MD. P. Beckhove, MD*, V. Schirrmacher, PhD*, C. Volk, B.M. Schmied, MD, M.W. Büchler, MD and K. Z'graggen, MD Department of General Surgery, University of Heidelberg and *Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany Background: Memory T-cells specifically reactive to tumor antigens should be an ideal source to generate therapeutic effector cells against pancreatic cancer . This may be of particular value after radical surgery. To our knowledge functionally active, specific memory T-cells have not been demonstrated in pancreatic cancer patients. To investigate if functional memory T -cells are present in the bone marrow of pancreatic cancer patients, we performed in vitro stimulation with tumor associated ...

N ORTHERN C ALIFORNIA C ANCER C ENTER , Cancer Incidence and Mortality in the Greater San Francisco Bay Area 151 Pancreatic Cancer • Between 1988 and 2000, pancreatic cancer incidence rates decreased slightly (Table 1). • Higher incidence rates of pancreatic cancer were observed in blacks compared to other racial/ethnic groups (Table 1). • Pancreatic cancer , a disease of advancing age, exhibited steadily increasing incidence rates after age 34 (Table 2). • Incidence rates of pancreatic cancer did not appear to differ markedly by county (Table 3). TABLE 1. Pancreatic Cancer . Annual Case Counts, Age-Adjusted Incidence Rates per 100,000 Population, a and 95% Confidence Intervals (CI), by Sex and Race/Ethnicity, 1988-2000, ...

A BASIC INFORMATION DESCRIPTION Uncontrolled growth of malignant cells in the pancreas. This is the 4th leading cause of cancer deaths in the U.S. The pancreas is an organ in the upper mid-abdomen that produces intestinal enzymes to help digest food and insulin to control blood sugar. Pancreas cancer affects adults ages 35-70 and men more often than women. FREQUENT SIGNS AND SYMPTOMS • Rapid, unexplained weight loss. • Pain in the back or upper abdomen that is often relieved by bending forward. • Blood clots in veins anywhere, especially the arms and legs. This is often an early sign. • Jaundice (yellow skin and eyes) from blockage of the nearby bile duct. Jaundice is usually accompanied by intense itching. • Depression. CAUSES Unknown. RISK INCREASES WITH • Chronic pancreatitis. • Diabetes mellitus. • Genetic factors: This is ...

Laparoscopic Staging for Potentially Resectable and Locally Advanced Pancreatic Cancer Richard S. Swanson, M.D. Brigham and Women’s Hospital Harvard Medical School Page 2 Pancreatic Cancer Surgeons’ Philosophy Regarding Staging Laparoscopy • Ardent Opponents: – Pisters and Evans: • Nothing beats a good CT scan – Yeo: • It does not help the Hopkins’ algorithm • Die-hard Proponents: – It is vitally important in the management of pancreatic cancer • In-between: – Use it selectively – Don’t use it but can see why others do – Use it, but beginning to question the value Page 3 Staging Laparoscopy for Pancreatic Cancer • First suggested by Bernheim – Ann Surg 53:764, 1911 • Introduced by Cuschieri et al. – Gut 19:672, ...