AllDocs -> cancers

Teratogenesis, Carcinogenesis, and Mutagenesis 21:7–25 (2001) Published 2001 Wiley-Liss, Inc. † This article is a US Government work and, as such, is in the public domain in the United States of America. Risk Factors for Pancreatic Cancer : A Case-Control Study Based on Direct Interviews Debra T. Silverman* Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland The etiology of pancreatic cancer is poorly understood, partly because of the incon- sistency of findings among case-control studies of pancreatic cancer . Because of the unfavorable prognosis for pancreatic cancer , many case-control studies have been based largely on interviews with next of kin, who are known to report less reliable information on potential risk factors than original respondents. The ...

Summer, 2002 GWCCS Cancer Support Group & Internet Resource Guide Page 1 www.gwccs.org Greater Washington Coalition for Cancer Survivors (202) 364-6422 Pancreatic , Kidney & Liver Cancer Resources Organization/Phone Logo Web Site (URL) American Foundation for Urologic Disease (410) 468-1800 http://www.afud.org/ CancerAnswers (888) 226-8287 Http:www.canceranswers.com The Cancer Group Institute (305) 651-5070 Http:www.cancergroup.com Cancer Information and Support International Http:www. cancer -info.com/pancreas Ronald Hirshberg Foundation (310) 472-6310 http:www. pancreatic .org Johns Hopkins Medical Institutions (410) 955-5718 Http:www.path.jhu.edu/pancreas Kidney ...

A Novel Red Fluorescent Protein Orthotopic Pancreatic Cancer Model for the Preclinical Evaluation of Chemotherapeutics Matthew H. Katz, M.D.,* Shinako Takimoto, B.S.,* Daniel Spivack, M.D.,* A. R. Moossa, M.D.,* Robert M. Hoffman, Ph.D.,* , † and Michael Bouvet, M.D.* ,1 * Department of Surgery, University of California at San Diego, San Diego, California; and † AntiCancer, Inc., San Diego, California Submitted for publication April 18, 2003 Background. Realistic models of pancreatic cancer are necessary to develop effective drugs for the dis- ease. More aggressive tumor models enhanced by brighter fluorescent biomarkers to follow the disease in real time would enhance the ability to predict ac- curately the effect of novel therapeutics on this par- ticularly malignant human cancer . Materials and methods. A novel, highly fluorescent, ...

Fas and Fas-ligand expression in human pancreatic cancer . Kornmann M, Ishiwata T, Kleeff J, Beger HG, Korc M. Department of Medicine, University of California, Irvine 92697, USA. OBJECTIVE: To investigate Fas and FasL expression in pancreatic tissues and cultured pancreatic cancer cell lines, and to assess the ability of anti-Fas antibodies to induce apoptosis. SUMMARY BACKGROUND DATA: Activation of the Fas receptor by Fas-ligand (FasL) results in apoptosis, and dysregulation of this pathway may contribute to abnormal cell proliferation. METHODS: Northern blotting and immunohistochemistry were used to compare Fas and FasL expression in normal and cancerous tissues. DNA 3'-OH end labeling was used to detect apoptotic cells. The effects of Fas activation on cell growth and signaling pathways were investigated in culture. RESULTS: Pancreatic cancers exhibited increased Fas RNA levels, whereas ...