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What are the facts on Prostate Cancer ? Garvan Institute of Medical Research What is prostate cancer ? The prostate is a walnut- sized gland located immediately beneath the bladder and surrounding the urethra. It is found only in men, with its main function being the production of some of the seminal fluid that nourishes sperm. In normal situations, prostate cells divide under the control of hormones, maintaining the size and functions of the gland. In abnormal situations, this cell division process is uncontrolled, causing a build up of constantly replicating cells. If these cells continue to build up and extend into neighbouring tissues or organs, or move to other parts of the body, then the abnormal condition becomes prostate cancer . Most prostate cancers are very slow- developing and neither the patient nor doctor may ever notice any sign of ...

The Use of PSA and the Early Diagnosis of Prostate Cancer Summary of the Alberta Clinical Practice Guideline for the use of PSA and the Early Detection of Prostate Cancer , June 1997 Administered by the Alberta Medical Association For complete guideline refer to the TOP Website: www.topalbertadoctors.org Revised Dec 2005 ? PSA testing is critical in the management of men with prostate cancer . ? Although the mortality rates from prostate cancer are declining, it is unclear whether this decline is attributable to prostate specific antigen (PSA) testing. ? To provide guidance about the appropriate use of PSA testing. ? To help physicians and their patients make informed decisions about the early diagnosis of prostate cancer in asymptomatic men of any age. ? PSA testing detects prostate cancer at an earlier stage. ? The benefit ...

The above recommendations are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. They should be used as an adjunct to sound clinical decision making Guideline for the Use of PSA and the Early Diagnosis of Prostate Cancer 2006 Update Administered by the Alberta Medical Association ISSUES ? PSA testing is critical in the management of men with prostate cancer ? Although the mortality rates from prostate cancer are declining, it is unclear whether this decline is attributable to prostate specific antigen (PSA) testing. GOALS ? To provide guidance about the appropriate use of PSA testing ? To help physicians and their patients make informed decisions about the early diagnosis of prostate ...

doi:10.1016/j.ijrobp.2006.02.044 EDITORIAL INDUCED SECOND CANCERS AFTER PROSTATE - CANCER RADIOTHERAPY: NO CAUSE FOR CONCERN? D AVID J. B RENNER , D.S C . Center for Radiological Research, Columbia University Medical Center, New York, NY The absolute risks of a radiation-induced second cancer among long-term radiotherapy survivors are not large, typ- ically a few percent in older patients ( 1–4 ). Hence the very real concern, expressed by Kendal et al. ( 5 ) in this issue, that prostate cancer patients may be unduly influenced in their treatment decision by unbalanced media reports of second- cancer risks. It is certainly the responsibility of the radiation oncologist to communicate a balanced assessment of the potential risks, be they short- or long-term, in the context of the potential benefits ...

P A A C T , I N C. PROSTATE CANCER COMMUNICATION PROSTATE CANCER COMMUNICATION NEWSLETTER • VOLUME 21, NUMBER 2 • June 2005 FOUNDER: LLOYD J. NEY, SR. – FOUNDED 1984 President and Chairperson: Janet E. Ney Board of Directors: Edwin Kuberski Treasurer Newton Dilley Helen Mellema Peter Noor Jr. Richard H. Profit Jr. Anthony Staicer Honorary Board Members: Russell Osbun Frank Perry Medical Advisory Board: Richard J. Ablin, Ph.D. V. Elayne Arterbery, M.D. Robert A. Badalament, M.D. Duke K. Bahn, M.D. Israel Barken, M.D. E. Roy Berger, M.D. Michael J. Dattoli, M.D. Fernand Labrie, M.D. Fred Lee Sr. M.D. Robert Leibowitz, M.D. Mark Moyad, M.D., M.P.H. Charles E. Myers Jr. M.D. Gary M. Onik, M.D. Haakon Ragde, M.D. Oliver Sartor, M.D. Stephen B. Strum, ...

6/7/2006 OUR NEXT MEETING WILL BE HELD AT 7:00 P.M. ON TUESDAY, JUNE 13, 2006 Our summer closing Pot Luck and Social Evening with light music! And a lucky draw offers great prizes! [Tickets available at the sign-in desk.] Bring along your favorite dish and a food item as well! ;-) Send any suggestions for the evening to: Fred Norris, Chairman , 905-877-8092 or e-mail fred.norris@ustoo-brampton.com . We look forward to seeing you in Room #2, The Terry Miller Recreation Center, 1295 Williams CANADIAN PROSTATE CANCER NETWORK BRAMPTON CHAPTER Web Site: http://www.ustoo- brampton.com Wednesday, June 7, 2006 Newsletter Page 2 Parkway at the southwest corner ...

Italian April 2002 [BHC-6055] 1 / 2 D E P A R T M E N T Cancro alla prostata: quale cura potrai scegliere? Prostate cancer : what are the treatment options? Ogni uomo ha la prostata, una piccola ghiandola che produce parte del fluido dello sperma. La prostata è posta alla base della vescica, attorno alla uretra (il tubo che porta l’urina dalla vescica al pene). Ad una certa età, uno su dieci uomini in Australia è affetto dal cancro alla prostata. Di solito questa forma di cancro colpisce gli uomini dopo i 50 anni di età, e nel corso delle ultime decadi è stato registrato un forte aumento di casi, tanto che adesso il cancro alla prostata viene considerato una malattia molto comune. Comunque, siccome questa tipo di cancro ha una crescita abbastanza lenta, non causa la morte della maggior parte delle persone affette. Cos’è il cancro alla prostata? Dopo la mezz’età ...

English April 2002 [BHC-6055] 1 / 2 D E P A R T M E N T Prostate cancer : what are the treatment options? Every man has a prostate , a small gland that produces some of the fluid in semen. It is found at the base of the bladder and surrounds the urethra (the tube which takes urine from the bladder to the penis). At some time in their lives, one in ten men in Australia will be diagnosed with prostate cancer . This usually affects men after the age of 50, and becomes increasingly common over the following dec- ades. However, this cancer tends to grow slowly - most men who have it don’t die from the disease. What is prostate cancer ? It’s normal for the prostate to get bigger after middle age. This can cause symp- toms, such as needing to pass water more often. But an enlarged prostate isn’t the same as cancer . Cancer is a malignant growth in the ...

Study 1 Links Early Exposure to Bisphenol A With Prostate Cancer in Aging Rats Researchers Also Identify Markers That Could Warn Men of Higher Risk A study being published in the June 1 issue of Cancer Research reports the first evidence of a direct link between development of prostate cancer and early life exposure to two estrogenic chemicals, the natural human estrogen, estradiol, and bisphenol A (BPA), a chemical that leaches out of polycarbonate plastics and related epoxy resins. The findings indicate that exposure during development to environmental and natural estrogens can affect the behavior of prostate genes and promote prostate disease during aging. The research team, led by Drs Gail Prins and Shuk-Mei Ho from the University of Illinois at Chicago and University of Cincinnati, respectively, examined what happened to adult rats after they had been exposed ...

Recurrent Prostate Cancer After Radiation Treatment By Stephen Scionti, M.D. and Karen Barrie, M.S . If your prostate cancer was treated with any form of radiation therapy and your PSA is rising, it is important to find out early why it’s rising and what your options are. What does a rise in PSA mean after radiation treatment for prostate cancer ? A rise in PSA after radiation (beam, seeds, or combination beam + seeds) does not automatically mean prostate cancer has come back (recurrence). Rising PSA can mean • Irritation, infection or inflammation • Other benign condition (non-cancerous) • Recurrent prostate cancer How can you know if your prostate cancer is back (recurrence)? Only diagnostic tests under physician guidance can rule out cancer . These may include • Another PSA test and digital rectal exam • Ultrasound image and/or color Doppler ultrasound ...

PROSTATE CANCER Prostate cancer is the most common form of cancer and is the second leading cause of cancer death in men. The walnut-sized gland located below the bladder is the prostate . The prostate is responsible for secreting about 30 percent of the seminal fluid. Older men often live with prostate cancer for years without knowing they have it. It generally grows slowly and remains within the gland itself. However, in some instances, it can spread rapidly and cause death. KNOW THE RISK FACTORS • age (Over 80 percent of all prostate cancers occur in men over age 65.) • heredity • a high-fat diet • being an African-American male • high levels of the male hormone testosterone • prolonged exposure to certain chemicals • tobacco use SIGNS AND SYMPTOMS • frequent ...

Prostate Cancer Prostate Cancer important information for you What is Prostate Cancer ? Prostate cancer is a disease that starts in the prostate . The prostate is a male sex gland about the size of a walnut. It is located just below the bladder. After skin cancer , prostate cancer is the most common cancer in men.The good news is that thousands of men across America have survived it. Am I at Risk for Prostate Cancer ? Anyone can get prostate cancer but there are reasons why some men are more likely to get it than others.These reasons are called risk factors. Risk factors for prostate cancer are: • Age. The risk for prostate cancer increases as you get older. • Family history. If you have a close relative, such as a father or brother, with prostate cancer , your risk for prostate cancer increases. • Hormones. High levels of the male hormone, testosterone, ...

A systematic review of prostate cancer biopsy schemes Prostate Cancer Biopsy Schemes ¦ Prostate cancer is the second leading cause of male cancer death in Europe and North America. ¦ Generally, men with raised PSA levels or abnormal rectal digital examination undergo ultrasound guided transrectal needle biopsy to obtain samples of prostate for diagnosis. ¦ The sextant biopsy scheme has been standard for many years, however a number of more extended prostate biopsy schemes are now being used in practice. ¦ The sextant scheme showed a significantly lower cancer yield than most of the more extensive biopsy schemes. ¦ The addition of laterally directed cores from the lateral peripheral zone to the mid lobe peripheral zone increases ...

Clinical Application Notes, June 2001 1 Successful treatment of locally confined prostate cancer with the SeedNet™ system - Preliminary multicenter results Yan Moore, MD Paul Sofer, MD Galil Medical, Yokneam, Israel UPDATED: June 2001 Introduction Prostate cancer , most commonly diagnosed during the sixth decade of life, is the second most common malignancy found in men, and the second most common cause of cancer deaths in men after lung cancer (Landis 1998). Please see the American Cancer Society website which may be a reference for more recent information on statistics. Currently, a patient diagnosed with early stage prostate cancer is basically offered two options - Radical Prostatectomy [RP] and various types of Radiation Therapy [RT] (implanting internal radioactive seeds, external beam irradiation, or a combination of the two). ...

A Proposal for Dissertation Research on Development of a Computational Paradigm for Laser Treatment of Prostate Cancer David Fuentes CAM Fellow Institute for Computational Engineering and Sciences The University of Texas at Austin Austin, Texas May 15, 2006 Page 2 Goals of the proposed research To develop a dynamic-data-driven control system for the thermal treatment of prostate cancer wherein the continual interaction between computer simulation of bioheat transfer processes and thermal imaging equipment will enhance the success of thermal therapies. 1 Page 3 Contributions of the proposed research • Development of sufficient conditions to guarantee the well-posedness of optimization problems subject to the constraints of the equations ...

101 Proclamations Proc. 7920 ovarian cancer cases are diagnosed at an advanced stage, however, because no reliable screening test exists for the disease. Because the early signs of ovarian cancer are easy to miss and often resemble the signs of other condi- tions, it is important for women to talk with their doctors about detection and be aware of the risk factors and symptoms of this cancer . There is more we need to learn about how best to prevent, detect, and treat ovarian cancer . The National Cancer Institute (NCI) is currently sponsoring a study on genetic and environmental factors that may increase the risk of ovarian cancer . In addition, the NCI is sponsoring clinical trials to explore new ways to screen for and detect ovarian cancer . Researchers are studying new treatment options, including biological therapies, anticancer drugs, vaccines, and other therapies to treat ...

Prostate Cancer DR QIHAN DONG Reginald Ward and Adrian Cotter Foundation Grant Recipient 2005 P rostate cancer is the second most common cause of cancer - related death in men causing about 2,800 deaths in Australia each year. Dr Dong has set his mission to develop an innovative therapeutic regimen to treat patients with advanced prostate cancer . His team is the first in the world to find aberrant silence of annexin II, a calcium dependent phospholipid binding protein, in prostate cancer . Recently, they found that a phospholipase enzyme, which normally is kept in check by annexin II, is abnormally active in prostate cancer . They have demonstrated in cancer cells grown in the laboratory and in animals carrying human cancer cells that targeting phospholipase A2 can inhibit prostate cancer cell growth.To further determine how cancer cells ...

For personal use. Only reproduce with permission from The Lancet Publishing Group. PROSTATE CANCER II This review, the second in The Lancet series in prostate cancer , follows on from the review on epidemiology and precedes the articles on clinical management and screening, but is relevant to all three. Pathology Relation between prostatic intraepithelial neoplasia and cancer High-grade prostatic intraepithelial neoplasia consists of architecturally benign prostatic acini lined by cells that seem to be malignant. 1,2 Prostates with carcinoma have more of these foci than do those without carcinoma. 3 Prostate glands with extensive high-grade prostatic intraepithelial neoplasia also have more multifocal carcinomas. That carcinomas have zones of high-grade prostatic intraepithelial neoplasia from which glands of carcinoma seem to ...

676 N ORTH S T . C LAIR , S UITE 1200 C HICAGO , I LLINOIS 60611-3013 (312) 695-1304 For immediate release: May 8, 2006 For more information, contact: Elizabeth Crown at (312) 503-8928 or at e-crown@northwestern.edu Broadcast Media: Tamara Kerrill Field at (847) 491-4888 or tlk@northwestern.edu MAJOR GENETIC RISK FACTOR FOR PROSTATE CANCER DISCOVERED CHICAGO --- Scientists from The Robert H. Lurie Comprehensive Cancer Center of Northwestern University participated in a discovery of a common genetic variant that predisposes men to prostate cancer . The gene discovery is described in a study in the online edition of Nature Genetics and will appear in the journal’s June print edition. The gene variant was discovered by the deCODE genetics ...

HuGE Fact Sheet Androgen Receptor Gene and Prostate Cancer Rovshan Ismailov, MD, MPH (University of Pittsburgh) PUBLISHED: May 2002 AR Gene The androgen receptor ( AR ) gene is located in the Xq11.2–q12 chromosome and consists of eight exons. This gene is a member of the steroid/nuclear receptor gene superfamily. There are two domains that are directly responsible for the transactivation activity of the AR protein. Of these domains, the ligand-independent AF-1 is encoded within exon 1. Prevalence Of Gene Variants There are three known AR gene polymorphisms: the (CAG)n trinucleotide repeat, the (GGC)n trinucleotide repeat, and the R726L single nucleotide polymorphism (1). Studies have suggested that twenty-seven alleles ranging from 5 to 31 repeats were observed in various populations. Short CAG repeats (less than or equal to 22 repeats) were found to be more prevalent in African- ...

5.23 11/10/03 Page 1 Early Prostate Cancer : Questions and Answers 1. What is the prostate ? The prostate is a gland in the male reproductive system. The prostate makes and stores a component of semen and is located near the bladder and the rectum. The prostate surrounds part of the urethra, the tube that empties urine from the bladder. A healthy prostate is about the size of a walnut. If the prostate grows too large, the flow of urine can be slowed or stopped. Key Points • The prostate is a gland in the male reproductive system (see Question 1). • The most common risk factor for prostate cancer is age (see Question 3). • Prostate cancer often does not cause symptoms for many years. By the time symptoms occur, the disease may have spread beyond the prostate (see Question 4). • The symptoms of prostate cancer can also be caused by noncancerous ...

Prostate Cancer What you need to know 1 888 939-3333 | www. cancer .ca Page 2 Cover photograph: © Getty Images, Inc. Page 3 ] ( ) ( ) (metastases) O © Canadian Cancer Society 2004 Page 4 P ] (adenocarcinomas) • — 65 (50 ) • • (testosterone) • ( ) Page 5 © Canadian Cancer Society 2004 Q ] (DRE digital rectal examination) (PSA prostate specific antigen) PSA (Biopsy) Gleason 2 10 (Imaging studies) X CT ( X ) MRI ( ) Page 6 ] TNM T2N1M0 T (Tumour) N (Nodes) ...

FACTS ABOUT PROSTATE CANCER Prostate cancer is the most common cancer in American men. According to the American Cancer Society, about 235,000 men will be diagnosed with prostate cancer in 2006. More than 27,000 men are expected to die of the disease in 2006. One in six men will get prostate cancer in his life- time. However, only one in 34 men will die of the disease. RADIATION THERAPY for PROSTATE CANCER Facts to Help Patients Make an Informed Decision THE AMERICAN SOCIETY FOR THERAPEUTIC RADIOLOGY AND ONCOLOGY Targeting Cancer Care 8280 Willow Oaks Corporate Drive, Suite 500 Fairfax, VA 22031 Phone: 1-800-962-7876 • 703-502-1550 Fax: 703-502-7852 www.astro.org www.rtanswers.org RISK FACTORS FOR PROSTATE CANCER Age: The chance of getting ...

PCADM-1: A Novel Urine Marker for Prostate Cancer Abstract Authors Mark E. Stearns Youji Hu Min Wang Fernando U. Garcia Drexel University College of Medicine Department of Pathology and Laboratory Medicine Philadelphia, PA 19102 Akira Ohkia Kurume University School of Medicine Department of Surgery Asahi-machi, Kurme-shi, 830, Japan Alfred Schöller Gerhard Lunglmayr Weinviertel Klinikum Departments of Pathology and Urology Mistelbach, Austria Page 2 Development of markers for the early detection of prostate cancer is essential to improved treatment of the disease. Recently, we have developed ‘DNA-protein’ binding assays for the identification of novel transcriptional regulatory proteins associated with the development of prostate cancer (PCA). ...

Evidence For A Prostate Cancer Associated Diagnostic Marker 1, PCADM-1: Immunohistochemistry And In situ Hybridization Studies Running Title Evidence For A Prostate Cancer Diagnostic Marker Key Words • prostate cancer • PCADM-1 • in situ hybridization • immunohistochemistry Authors *Akira Ohkia Youji Hu Min Wang Fernando U. Garcia **Mark E. Stearns Affiliations **Drexel University College of Medicine Department of Pathology and Laboratory Medicine Philadelphia, PA 19102 *Kurume University School of Medicine Department of Surgery Asahi-machi, Kurme-shi, 830 Japan Page 2 Abbreviations EMSA: electrophoretic mobility shift assay HGPIN: high grade prostatic intraepithelial neoplasm BPH: ...

Automatic Recognition of Topic-Classified Relations between Prostate Cancer and Genes from Medline Abstracts Hong-Woo Chun 1 Yoshimasa Tsuruoka 2 1. Department of Computer Science, Graduate School of Information Science and Technology, The University of Tokyo 2. School of Informatics, University of Manchester { chun,tsuruoka,jdkim } @is.s.u-tokyo.ac.jp Jin-Dong Kim 1 Rie Shiba 3 Naoki Nagata 4 3. Japan Biological Information Research Center, Japan Biological Informatics Consortium 4. Biological Information Research Center, National Institute of Advanced Industrial Science and Technology { rshiba,nnagata,t-hishiki } @jbirc.aist.go.jp Teruyoshi Hishiki 4 Jun’ichi Tsujii 1 , 2 , 5 5. SORST, Japan Science and Technology Corporation tsujii@is.s.u-tokyo.ac.jp ...

COLORECTAL AND COLORECTAL AND PROSTATE CANCER PROSTATE CANCER Page 2 WHAT IS COLORECTAL CANCER ? WHAT IS COLORECTAL CANCER ? Page 3 WHAT CAUSES COLORECTAL WHAT CAUSES COLORECTAL CANCER ? CANCER ? While we do not know the exact cause of most colorectal cancer , there are certain known risk factors such as: Family history Ethnic background History of polyps Having had colorectal cancer before History of bowel syndrome Age Lack of a good diet and exercise Obesity Smoking and alcohol Page 4 CAN COLORECTAL CANCER BE CAN COLORECTAL CANCER BE PREVENTED? PREVENTED? Even though we don't know exactly what causes colorectal ...

Principal Investigator/Program Director (Last, first, middle): Hersh, Louis B. PHS 398 (Rev. 05/01) Page 187 Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. Project 5: Dissecting the Cell Surface Proteome of Prostate Cancer PI: Haining Zhu, Ph.D. Mentor: Natasha Kyprianou, Ph.D. Co-mentor Tom Vanaman, Ph.D. No human subjects or human subject materials involved in this project. No Vertebrate animals will be used in this project. Page 2 Principal Investigator/Program Director (Last, first, middle): Hersh, Louis B. PHS 398 (Rev. 05/01) Page 187 Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. DESCRIPTION: State the application’s broad, long-term objectives and specific aims, making ...

An Introduction to Prostate Cancer Page 2 B eing diagnosed with prostate cancer can be a life-altering experience.It requires making some very difficult decisions about treatments that can affect not only the life of the man diagnosed, but also the lives of his family members in significant ways for many years to come. Over 234,000 men in the United States will be diagnosed with prostate cancer this year, and each and every one of them will need to make very personal and individualized decisions about treatment options and diet and lifestyle changes. But most importantly, each and every one of them will have to find a strong, knowledgeable team of physicians, nurses, and other healthcare providers to help guide him through the process at each step of the way. This brief introductory guide is designed to help men and their families and friends understand ...

FY05 Prostate Cancer Research Program Peer Reviewers Abcouwer, Steve Ph.D. Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine Abdulkadir, Sark Ph.D. Department of Clinical Pathology, University of Alabama at Birmingham Adams, David Ph.D. Department of Medicine, Duke Comprehensive Cancer Center Ahmed, Khalil Ph.D. Cellular & Molecular Biochemistry Lab., University of Minnesota & VA Medical Center Arlen, Philip M.D. Department of Laboratory of Tumor Immunology & Biology, NIH, National Cancer Institute Armato, Samuel Ph.D. Department of Radiology, University of Chicago Artemov, Dmitri Ph.D. Department of Radiology, Johns Hopkins University School of Medicine Ayala, Gustavo M.D. Pathology, Baylor College of Medicine ...