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Stomach cancer – some possible causes Stomach cancer is more common in developing nations, while becoming less common in Western countries including Australia. At present, stomach cancer is still the fourth most common cause of death from cancer . There appear to be two types of gastric cancer . One type of gastric cancer is associated with infection by the Helicobacter pylori ( H. pylori ) bacterium. The H. pylori germ commonly lives in the lining of the stomach in up to four out of 10 adults. It is now known to be responsible for most duodenal ulcers and over two thirds of stomach ulcers. It also triggers symptoms like indigestion. H. pylori is always associated with superficial gastritis and, sometimes, with chronic atrophic gastritis, which can lead to the development of stomach cancer . However, only a minority of people infected with this bacterium ...

FOR PEOPLE WITH CANCER , THEIR FAMILIES AND FRIENDS FOR PEOPLE WITH CANCER , THEIR FAMILIES AND FRIENDS Telephone 13 11 20 for cancer information and support 13 11 20 13 11 20 IF YOU NEED TO TALK TO SOMEONE,CALL THE CANCER HELPLINE ON IF YOU NEED TO TALK TO SOMEONE,CALL THE CANCER HELPLINE ON Cancer Cancer Stomach Stomach and and Oesophageal Oesophageal Page 2 Cancer information in other languages Arabic Polish Cantonese Russian Greek Spanish Italian Vietnamese Mandarin For other languages please call 9209 0169. Tell us which language you speak and an interpreter will help you talk to a nurse. If you live outside Melbourne, you can leave your details when ...

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Support Organisations There are many organisations, which offer support and information to those with cancer . Listed below are the two major telephone support lines. There are local cancer support groups offering a variety of support , activities, and complementary therapies. Cancerbacup 0808 8001234 www.cancerbacup.org.uk Macmillan Cancerline 0808 808 2020 www.macmillan.org.uk We have a leaflet with details of local cancer support organisations- please ask for this. Introduction This leaflet gives you information about the treatment you will receive as someone who has been newly diagnosed with cancer of the stomach , and it explains the care pathway you are about to embark upon. Cancer of the Stomach Stomach cancer (also known as gastric cancer ) can be found in all parts of the stomach . Most i.e. 50 ...

Oesophago-gastric Cancer Centre Addenbrooke’s Hospital Papworth Hospital Date: 14 February 2005 File: PI 122 Page 1 of 4 Frequently asked questions about cancer of the stomach You have recently had some tests that tell us that you have a cancer in your stomach . We hope this information will help answer some of your questions – if you have any concerns and worries, please do not hesitate to ask us. We want you to understand what is happening so you can make informed decisions about what we do next for you. Where is the stomach and what does it do? The stomach is a J-shaped ‘bag’, which acts as a temporary storage area for any food and drink that you eat. It lies just below the diaphragm in your abdomen (tummy) and is next to your liver, gall bladder, spleen and pancreas. From above it, in the chest, the oesophagus (gullet) squeezes food and drink into ...

Oesophago-gastric Cancer Centre Addenbrooke’s Hospital Papworth Hospital Date: 14 February 2005 File: PI 122 Page 1 of 3 Frequently asked questions about cancer of the stomach You have recently had some tests that tell us that you have a cancer in your stomach . We hope this information will help answer some of your questions – if you have any concerns and worries, please do not hesitate to ask us. We want you to understand what is happening so you can make informed decisions about what we do next for you. Where is the stomach and what does it do? The stomach is a J-shaped ‘bag’, which acts as a temporary storage area for any food and drink that you eat. It lies just below the diaphragm in your abdomen (tummy) and is next to your liver, gall bladder, spleen and pancreas. From above it, in the chest, the oesophagus (gullet) squeezes food and drink into the stomach . In ...

Etiological factors are not precisely known; diets low in fresh fruits and vegetables and deficiencies of vitamins A and C are associated. Long term gastric infection of Helicobacter pylori organisms. Risk Factors Not available in the United States. Early Detection FIGURE 4 Average Annual Age-Adjusted Incidence and Mortality Rates* by Sex and Race, Pennsylvania Residents, 1999-2003 The 1999-2003 average annual age-adjusted incidence rate for invasive stomach cancer was more than twice as high among males, compared to females, (11.0 per 100,000 versus 4.9, respectively). Black males had the highest average annual age-adjusted incidence rate (17.9), compared to the other three sex/race groups. The lowest average annual rate (4.5) was recorded for white females. There were 1,064 new cases of invasive stomach cancer diagnosed among residents of the state in 2003 – the ...

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Page 2 Mortality trends in England; ICD9 (151), ICD10 (C16); File: Sepho 96-04 V2 Stomach cancer in England 1996 to 2004. Mortality trends Authors: Michael Goldacre, Marie Duncan, Paula Cook-Mozaffari, Matthew Davidson, Henry McGuiness, Daniel Meddings Published by: Unit of Health-Care Epidemiology, Oxford University, and South-East England Public Health Observatory, 2006 This document provides a profile of trends in mortality for stomach cancer in England. The period covered is January 1 1996 to December 31 2004. The data are analysed from mortality files supplied to the South East England Public Health Observatories (SEPHO) by the Office for National Statistics (ONS). Mortality rates were calculated for the condition certified as the underlying cause of death and for the disease certified as any mention on the death certificates. Age-specific ...

A209: Stomach cancer tissues (formalin fixed) For research use only Specifications: • No. of cases: 50 • Tissue type: Stomach cancer tissues • No. of spots: 2 spots from each cancer case (100 spots) 4 non-neoplastic spots (4 spots) • Total spots: 104 • Corresponding normal tissues with cancers: No • Diameter: 1. 0 mm Documents : • Product specification: layout, summary of tissue spots • H&E stained images • Detailed pathological information Layout: Page 2 A209: Stomach cancer tissues (formalin fixed) Summary of tissue spots For research use only No. Sex Age Specimen Key Word Grade Stage 1 1(NormalQ C) M 43 stomach signet ring cell carcinoma 2 2(NormalQ C) M ...

Stomach Cancer Incidence (SRR with 95% CI), 2000-2002, All Ages by LA Notes Incidence of stomach cancer (ICD10 C16) Indirectly standardised registration ratios (SRR) All ages 2000-02 (Pooled) England 2000-02 = 100 (Standard rates are England annual age-specific rates 2000-02) Data are based on ONS population estimates (October 2004 revision). The current Compendium results may differ from those of previous issues because of changes in methodology to extract data by area, and also because of data enhancements by ONS. Cancer registrations are continuously being updated retrospectively and ONS records will have been updated since previous analyses Highlights In St Albans CD the stomach cancer incidence ratio was significantly lower than the ratio for England FOR MORE INFORMATION Please contact David Edwards, Public Health Intelligence Specialist, PHIU (david.edwards@phi-bedsherts.nhs.uk) ...

Stomach Cancer Incidence (SRR with 95% CI), 1999-2001, All Ages by LA Notes Incidence of stomach cancer (ICD10 C16) Indirectly standardised registration ratios (SRR) All ages 1999-2001 (Pooled) England 1999-2001 = 100 (Standard rates are England annual age-specific rates 1999-2001) Data are based on ONS population estimates (October 2004 revision). The current Compendium results may differ from those of previous issues because of changes in methodology to extract data by area, and also because of data enhancements by ONS. Cancer registrations are continuously being updated retrospectively and ONS records will have been updated since previous analyses Highlights Male stomach cancer incidence ratios were significantly lower than the ratio for England in Three Rivers CD, St Albans CD and East Hertfordshire CD FOR MORE INFORMATION Please contact David Edwards, Public Health Intelligence ...

Hong Kong Cancer Fund Hong Kong Cancer Fund was established in 1987 to provide support, information and care to those living with cancer and to increase awareness and knowledge of cancer in our community. Our CancerLink Care Centres offer professional support and connect various can- cer patient support groups to form an extensive support network for cancer patients and families, offering emotional support and practical assistance to those touched by cancer . This publication is one in a series of cancer information booklets which discuss different aspects of the disease, including possible treatment, side effects and emotional issues. They are intended to inform the public about available treat- ment and care. You can also download the information from our website: www. cancer -fund.org. The free services offered by Hong Kong Cancer Fund are made possible only because of donation from ...

Mortality from Stomach Cancer Across Bedfordshire and Hertfordshire (SMR) 2002-2004 Pooled, All Ages, by Primary Care Trust (PCT) Notes Mortality from stomach cancer (ICD10 C16) Indirectly standardised ratios (SMR) All ages 2002-04 (Pooled) England 2002-04 = 100 (Standard rates are England annual age-specific rates 2002-04) Data are based on the original underlying cause of death. Data are based on the latest revisions of ONS population estimates for the respective years, current as of the 20th December 2005. Highlights All persons stomach cancer mortality ratios were significantly lower than England in Luton PCT and St Albans & Harpenden PCT. The highest mortality ratio was in South East Hertfordshire PCT, which was not significantly different from England. For More Information Please Contact David Edwards, Public Health Intelligence Epidemiologist (david.edwards@p...

Although men have a higher incidence and mortality rate from stomach cancer than women, the time trends for both genders are similar. For both men and women incidence and mortality has decreased by 20-35% over the last 20 years. Background notes Stomach Cancer Page 2 Male Stomach Cancer - Incidence and Mortality* 1977-2000 All Ages Source - SA Cancer Registry 0 4 8 12 16 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 Year *Age Standardised for World Population R a t e / 1 0 0 0 0 0 Incidence Mortality Male Stomach Cancer Incidence and Mortality* 1977-2000 All Ages Source: SA Cancer Registry Data ...

TAXOTERE ® RECEIVES U.S. FDA APPROVAL FOR USE IN ADVANCED STOMACH CANCER TAXOTERE ® -based regimen demonstrates a 23% reduction in the risk of mortality in patients with advanced stomach cancer Paris, France – March 23, 2006 – Sanofi-aventis announced today that following a priority review of the supplemental new drug application (sNDA), the U.S. Food and Drug Administration (FDA) has approved TAXOTERE ® (docetaxel) Injection Concentrate in combination with cisplatin and 5-fluorouracil for the treatment of patients with advanced stomach (gastric) cancer , including cancer of the gastro esophageal (GE) junction, who have not received prior chemotherapy for advanced disease. This is the first FDA approval of an advanced stomach cancer treatment demonstrating a survival advantage in more than a decade, thereby offering physicians ...

TAXOTERE® RECEIVES U.S. FDA APPROVAL FOR USE IN ADVANCED STOMACH CANCER TAXOTERE®-based regimen demonstrates a 23% reduction in the risk of mortality in patients with advanced stomach cancer Bridgewater, NJ – March 23, 2006 – Sanofi-aventis announced today that following a priority review of the supplemental new drug application (sNDA), the U.S. Food and Drug Administration (FDA) has approved TAXOTERE® (docetaxel) Injection Concentrate in combination with cisplatin and 5-fluorouracil for the treatment of patients with advanced stomach (gastric) cancer , including cancer of the gastro esophageal (GE) junction, who have not received prior chemotherapy for advanced disease. This is the first FDA approval of an advanced stomach cancer treatment demonstrating a survival advantage in more than a decade, thereby offering physicians and their patients an important new option for treating ...

16.1. INTRODUCTION AND SUMMARY Table 16.1. Summary of incidence and mortality statistics: stomach cancer INCIDENT CASES DEATHS males females both sexes males females both sexes All cancers (invasive, in situ and uncertain) (ICD-O-2 C16) 1997 cases 301 175 476 233 141 374 % of all cancers 2.9% 1.6% 2.2% 5.8% 4.0% 5.0% Incidence and mortality rates (per 100,000 persons per year) crude rate 16.6 9.5 13.1 12.9 7.7 10.3 World age-standardised rate 12.7 5.9 9.6 4.5 European age-standardised rate 19.3 8.7 14.8 6.9 cumulative risk (0-74) 1.5% 0.7% 1.1% 0.6% mortality/incidence ratio 0.774 0.806 0.786 Time trends (all cancers) 1994 cases 304 179 483 241 179 ...

1672 Main St. Ste. E #264 • Ramona, CA 92065 • Tel: 760.789.8928 • Fax: 760.789.8929 • Toll Free: 800.475.1955 • www.proteinbiotechnologies.com HUMAN STOMACH ADENOCARCINOMA CANCER TISSUE ARRAY Catalog Number: TMA-103 Each core represents a diseased tissue spot from one individual specimen that was selected and pathologically confirmed Cases: 72 Cores: 72 Diameter: 1.5mm Thickness: 5 µm Standard IHC: L-CK confirmed Layout : 8 x 9 1 2 3 4 5 6 7 8 9 A 1 2 3 4 5 6 7 8 9 B 10 11 12 13 14 15 16 17 18 C 19 20 21 22 23 24 25 26 27 D 28 29 30 31 32 33 34 35 36 E ...

Deaths at Home from Stomach Cancer (Percentage) 2002-2004, All Ages by Strategic Health Authority (SHA) Notes Deaths at home from stomach cancer (ICD10 C16) Percent (%) All ages 2002-04 (Pooled) Data are based on the original underlying cause of death. Comments on numerator data - Information about the place of death is found on the mortality record in the communal establishment field. It contains one of: - A 5 digit code identifying a communal establishment or institution (e.g. hospital, nursing home, residential home); - An “H” code which indicates that the person is certified as having died at their home address and that this is not a communal establishment or; · An “E” code which indicates that the person died elsewhere. The communal establishments are themselves classified into 84 categories (e.g. general hospital, mental nursing home, nursing home etc) and can be further distinguished ...

Deaths at Home from Stomach Cancer (ISR) 2002-2004, All Ages by Strategic Health Authority (SHA) Notes Deaths at home from stomach cancer (ICD10 C16) Indirectly age-standardised rates (ISR) per 100 deaths (Standard rates are England annual age-specific rates 2002-04) All ages 2002-04 (Pooled) Data are based on the original underlying cause of death. Comments on numerator data - Information about the place of death is found on the mortality record in the communal establishment field. It contains one of: - A 5 digit code identifying a communal establishment or institution (e.g. hospital, nursing home, residential home); - An “H” code which indicates that the person is certified as having died at their home address and that this is not a communal establishment or; · An “E” code which indicates that the person died elsewhere. The communal establishments are themselves classified into 84 categories ...

Mortality from Stomach Cancer (SMR) 2002-2004 Pooled, All Ages, at Local Authority (LA) level Notes Mortality from stomach cancer (ICD10 C16) Indirectly standardised ratios (SMR) All ages 2002-04 (Pooled) England 2002-04 = 100 (Standard rates are England annual age-specific rates 2002-04) Data are based on the original underlying cause of death. Data are based on the latest revisions of ONS population estimates for the respective years, current as of the 1st September 2005. Highlights Three LA's had significantly lower stomach cancer mortality ratios than England; South Bedfordshire CD (SMR 59, CI 35-94), Luton UA (SMR 64, CI 42-93) and St Albans CD (SMR 57, CI 35-88). Only one LA had a higher (NOT significantly) stomach cancer mortality ratio than England, Broxbourne CD with an SMR of 122 (CI 82-175). For More Information Please Contact David Edwards, Public Health ...

1672 Main St. Ste. E #264 • Ramona, CA 92065 • Tel: 760.789.8928 • Fax: 760.789.8929 • Toll Free: 800.475.1955 • www.proteinbiotechnologies.com HUMAN STOMACH CANCER TISSUE ARRAY Catalog Number: TMA-099 Each dot represents a DISEASED or NORMAL tissue spot from specimen that was selected and pathologically confirmed (Carcinoma of stomach , liver and rectum tissue array) Cases: 45 Cores: 48 Diameter: 1.5mm Thickness: 5 µm Standard IHC: P53 confirmed Layout : 6 x 8 1 2 3 4 5 6 7 8 A 1 2 3 4 5 6 7 8 B 9 10 11 12 13 14 15 16 C 17 18 19 20 21 22 23 24 D 25 26 27 28 29 30 31 32 E 33 34 ...

1672 Main St. Ste. E #264 • Ramona, CA 92065 • Tel: 760.789.8928 • Fax: 760.789.8929 • Toll Free: 800.475.1955 • www.proteinbiotechnologies.com HUMAN STOMACH CANCER TISSUE ARRAY Catalog Number: TMA-096 This is a COMBINATION ARRAY PANEL from diseased, normal and adjacent (1.5cm) to specimen that was selected and pathologically confirmed ( stomach adenocarcinoma tissue array) Cases: 21 Cores: 63 Diameter: 1.5mm Thickness: 5 µm Standard IHC: PCNA confirmed Layout : 7 x 9 1 2 3 4 5 6 7 8 9 A 1 2 3 4 5 6 7 8 9 B 10 11 12 13 14 15 16 17 18 C 19 20 21 22 23 24 25 26 27 D 28 29 30 31 32 33 34 ...

1672 Main St. Ste. E #264 • Ramona, CA 92065 • Tel: 760.789.8928 • Fax: 760.789.8929 • Toll Free: 800.475.1955 • www.proteinbiotechnologies.com HUMAN STOMACH CANCER TISSUE ARRAY Catalog Number: TMA-097 This is a COMBINATION ARRAY PANEL from diseased, normal and adjacent (1.5cm) to specimen that was selected and pathologically confirmed ( stomach adenocarcinoma tissue array) Cases: 21 Cores: 63 Diameter: 1.5mm Thickness: 5 µm Standard IHC: L-CK confirmed Layout : 7 x 9 1 2 3 4 5 6 7 8 9 A 1 2 3 4 5 6 7 8 9 B 10 11 12 13 14 15 16 17 18 C 19 20 21 22 23 24 25 26 27 D 28 29 30 31 32 33 34 ...

1672 Main St. Ste. E #264 • Ramona, CA 92065 • Tel: 760.789.8928 • Fax: 760.789.8929 • Toll Free: 800.475.1955 • www.proteinbiotechnologies.com HUMAN STOMACH CANCER TISSUE ARRAY Catalog Number: TMA-101 Each three (3) dots from three different tissue spots represents one single specimen selected and pathologically confirmed. (Normal stomach tissue (multi-sites) array) Cases: 21 Cores: 63 Diameter: 1.5mm Thickness: 5 µm Standard IHC: Actin confirmed Layout : 7 x 9 1 2 3 4 5 6 7 8 9 A 1 2 3 4 5 6 7 8 9 B 10 11 12 13 14 15 16 17 18 C 19 20 21 22 23 24 25 26 27 D 28 29 30 31 32 33 34 35 ...

1672 Main St. Ste. E #264 • Ramona, CA 92065 • Tel: 760.789.8928 • Fax: 760.789.8929 • Toll Free: 800.475.1955 • www.proteinbiotechnologies.com HUMAN STOMACH CANCER TISSUE ARRAY Catalog Number: TMA-102 Each dot represents a NORMAL tissue spot from one individual specimen that was selected and pathologically confirmed Cases: 70 Cores: 72 Diameter: 1.5mm Thickness: 5 µm Standard IHC: Actin confirmed Layout : 8 x 9 1 2 3 4 5 6 7 8 9 A 1 2 3 4 5 6 7 8 9 B 10 11 12 13 14 15 16 17 18 C 19 20 21 22 23 24 25 26 27 D 28 29 30 31 32 33 34 35 36 E 37 38 39 ...

1672 Main St. Ste. E #264 • Ramona, CA 92065 • Tel: 760.789.8928 • Fax: 760.789.8929 • Toll Free: 800.475.1955 • www.proteinbiotechnologies.com HUMAN STOMACH CANCER TISSUE ARRAY Catalog Number: TMA-098 This is a COMBINATION ARRAY PANEL from diseased, normal and adjacent (1.5cm) to specimen that was selected and pathologically confirmed ( stomach adenocarcinoma tissue array) Cases: 21 Cores: 63 Diameter: 1.5mm Thickness: 5 µm Standard IHC: CK confirmed Layout : 7 x 9 1 2 3 4 5 6 7 8 9 A 1 2 3 4 5 6 7 8 9 B 10 11 12 13 14 15 16 17 18 C 19 20 21 22 23 24 25 26 27 D 28 29 30 31 32 33 34 35 ...