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Testicular Cancer Patient Information Jane Robson Oncology Nurse Practitioner Testicular Cancer Issue No: 1.1 / June 2003 Page 1 Issued by the WEST ANGLIA CANCER NETWORK Review date: April 2004 Ref: W:\Core Info\Patient Information Folder\ Testicular \ TESTICULAR INFO.2.doc Page 2 Index Foreword.. 3 Addenbrookes Hospital Contact Numbers: . 4 Signs and Symptoms of Testicular Cancer . 7 Post-diagnosis and Staging. 8 What are tumour markers?.. 9 Oncology New Patient Clinic 10 The Specialist Oncology Nurse Practitioner for Testicular Cancer 11 Treatment Specific Information .. 12 Treatment Options for Stage I Testicular Seminoma 12 Treatment for Metastatic Testicular Seminoma (Stage IIA/B) 14 EP Chemotherapy. 15 Treatment ...

Copyright © 1998 by W.B. Saunders Company. All rights reserved. 478 A BASIC INFORMATION DESCRIPTION Uncontrolled growth of malignant cells in the testicle. There are several types of testicular cancer , some more dangerous than others. This is the most common form of cancer in young men. Affects all ages, but more often is found in men ages 20-40. FREQUENT SIGNS AND SYMPTOMS • A firm swelling in one testicle discovered by accident or by self-examination. • No pain (90% of cases). • Sense of fullness in the scrotum. CAUSES Unknown. RISK INCREASES WITH • Undescended testicle(s) in infancy even if the testicle was surgically moved into the scrotum. • Caucasian race. • Estrogen administration to the mother during preg- nancy. PREVENTIVE MEASURES Males should examine testicles routinely at least once a month. Will ...

Chapter 5 Residual mass histology in testicular germ cell cancer : development and validation of a clinical prediction model Abstract After chemotherapy for metastatic non-seminomatous testicular germ cell cancer , surgical resection is a generally accepted treatment to remove remnants of the initial metastases, since residual tumour may still be present (mature teratoma or viable cancer cells). In this paper, we review the development and external validation of a logistic regression model to predict the absence of residual tumour. Three sources of information were used. A quantitative review identified six relevant predictors from 19 published studies (996 resections). Second, a development data set included individual data of 544 patients from six centres. This data set was used to assess the predictive relationships of five continuous predictors, which resulted in dichotomization ...

Chapter 8 Predicting retroperitoneal histology in postchemotherapy testicular germ cell cancer : a model update and multicentre validation with 1094 patients Abstract Patients treated with chemotherapy for advanced testicular germ cell cancer may undergo resection of retroperitoneal lymph nodes, that often contain only necrosis or fibrosis (benign tissue). To improve the selection of candidates for resection, we previously developed a logistic regression model with six variables to predict the probability of benign tissue. The aim of the present study was to update the model using new patient data and to study the validity of the updated model. We combined the data of 544 patients that were used before to develop the model with data of 550 new patients and performed a new logistic regression analysis. In total data of 1094 patients were available from five large international ...

Testicular Cancer Fact Sheet Testicular cancer is one of the more rare forms of cancer . For every 100,000 men, only 6 are found to have testicular cancer every year. Young men are more likely to develop testicular cancer , with about half of all new cases under the age of 33 years. Risk factors for testicular cancer include: o Age (from 15 to 40) o Being born with an undescended testicle o A family history of testicular cancer o A history of testicular cancer in the other testicle Since none of the current known risks for testicular cancer can be prevented, the best protection is awareness of risks, signs and symptoms; and early detection, and prompt treatment. The earlier you find testicular cancer the easier it is to treat. ? When found and treated early, testicular ...

Is Testicular Cancer Related to Gulf War Deployment? Evidence from a Pilot Population-Based Study of Gulf War Era Veterans and Cancer Registries Contributors: Paul H. Levine, MD; Heather A. Young, PhD; Samuel J. Simmens, PhD; Danielle Rentz, MPH; Vincent E Kofie, PhD; Clare M. Mahan, PhD; Han K. Kang, DPH Military Medicine , 170, 2:149, 2005 Abstract The possible relationship between military deployment and the subsequent increase in cancer rates has been prominent since the Vietnam War. The objective of this study was to investigate whether any form of cancer was increased among veterans deployed to the Persian Gulf in the 1991 conflict. This study matched data from central cancer registries in the District of Columbia and New Jersey with the records of the 1.4 million Gulf War era veterans; i.e., 621,902 veterans who arrived in the Persian Gulf before March ...

march 2/vol19/no25/2005 nursing standard 45 By reading this article and writing a practice profile, you can gain a certificate of learning. You have up to a year to send in your practice profile. Guidelines on how to write and submit a profile are featured at the end of this article. Testicular cancer : epidemiology, assessment and management NS281 McCullagh J, Lewis G (2005) Testicular cancer : epidemiology, assessment and management. Nursing Standard . 19, 25, 45-53. Date of acceptance: November 25 2004. Author Jo McCullagh BSc(Hons), MPhil, is senior health promotion specialist, Sefton Health Improvement Support Service; and Gareth Lewis RN, BSc(Hons), is men’s health nurse, South Sefton Primary Care Trust, Liverpool. Email: gareth.lewis@south sefton-pct.nhs.uk Summary Testicular cancer is the most ...

The recommended pathological classification (modified World Health Organization) is shown below. 1. Germ cell tumours ¼ Intratubular germ cell neoplasia ¼ Seminoma (including cases with syncytiotrophoblastic cells) ¼ Spermatocytic seminoma (mention if there is sarcomatous component) ¼ Embryonal carcinoma ¼ Yolk sac tumour: - Reticular, solid and polyvesicular patterns - Parietal, intestinal, hepatoid and mesenchymal differenti- ation ¼ Choriocarcinoma ¼ Teratoma (mature, immature, with malignant component) ¼ Tumours with more than one histological type (specify % of individual components) 2. Sex cord stromal tumours ¼ Leydig cell tumour ¼ Sertoli cell tumour (typical, sclerozing, large cell calcifying) ¼ Granulosa (adult and juvenile) ¼ Mixed ¼ Unclassified 3. Mixed germ cell/sex cord stromal tumours ...

FACT SHEET Testicular Cancer In 2004, approximately 9,000 males will be diagnosed with testicular cancer . When found early, testicular cancer is one of the most treatable forms of cancer , with an overall cure rate above 90 percent. PREVENTION • Talk to your health care professional about screening. RISKS • All men • Men with a history of cryptorchidism – undescended testicle(s) • Men with a personal or family history of testicular cancer • Caucasian men are at higher risk SYMPTOMS Most testicular cancer can be found at an early stage. Some of the symptoms that may appear include: • A lump on either testicle • Enlargement of either testicle • Heaviness or aching in the lower abdomen or scrotum • Pain or discomfort ...

JCI 00 M 4/2004 Material for this fact sheet was adapted from the American Cancer Society’s Detailed Guide: Testicular Cancer web page, last revised 6/9/03. Testing can save your life Testicular cancer is one of the most curable forms of cancer , especially when detected and treated early. Testing can help you check for testicular cancer before there are symptoms. The Karmanos Cancer Institute recommends the following testing for testicular cancer : • monthly testicular self-examination for all men, especially if they have any of the known risk factors Regular self-exams will help you become familiar with what is normal and what is different for you. Always tell your doctor about any lumps or changes. Lower the risk for testicular cancer Here are some things you can do to reduce your risk of testicular ...

testicular cancer TESTICULAR CANCER A Service of the Long Beach V A M C Patient Education Series 1998 What Is This? Growth of cancer cells in the testicle. Affects all ages, but more often is found in men ages 20-40. How Can I Know If I Have This? A firm swelling in one testicle discovered by accident or by self-examination. No pain (usually). Sense of fullness in the scrotum. What Causes This? Unknown. You Are More Likely To Get This If? Caucasian race. How Can I Keep From Getting This? Males should examine testicles routinely. Will not prevent the cancer , but may detect a tumor early enough to provide chance of cure. What Can I Expect If I Get This? Most types are curable with surgery and other treatment. Removal of one testicle does not interfere with normal ...

Kent Hildebrandt Testicular cancer is most commonly found in adolescents or young adults. To any young man in my situation, I would highly recommend the book, It's Not About the Bike My Journey Back to Life by Lance Armstrong. One of the keys to physical, mental, and emotional survival during cancer treatment is maintaining a positive outlook. A cancer patient needs a positive attitude and a persistent hope that health will be restored and the cancer will be defeated. In this way, Lance Armstrong's story is an excellent motivator. Lance not only had cancer in the testicle but it had spread throughout his body. He had surgery and chemotherapy. His was just about the worst possible scenario with the best possible outcome. Reading his story gives a cancer patient hope that he, too, can overcome the many obstacles of cancer , no matter how bad things look at the beginning. Lance is a great ...

testicular cancer TESTICULAR CANCER : WHAT A YOUNG MAN SHOULD KNOW. Testicular cancer represents only 1-2 percent of all malignances; however, recent data has shown that in the past 40 years the incidence has doubled worldwide. It is estimated that 7,500 cases of germ cell testicular cancer (its most common form) will be diagnosed yearly in the United States. Though this represents a small fraction of cancers, it is the MOST COMMON form of solid tumor in men between ages 15 and 40. Who is at risk for testicular cancer ? The only undisputed risk factor is a history of cryptorchidism, or undescended testicle, which has an overall 5% risk increase. Other factors associated with higher incidences of testicular cancer include being Caucasian (five times the risk), a history of abnormal testicular development, ...

© 20 04 B JU I N TER N A TI O N A L | 9 3, 118 3– 11 87 | doi:10.1111/j.1464-410X.2004.04837.x 11 83 Blackwell Science, LtdOxford, UKBJUBJU International1464-410XBJU InternationalJune 2004 939 •••• Review Article PRACTICAL MANAGEMENT FOR BILATERAL TESTICULAR CANCER B.J.R. BARRASS et al. Practical management issues in bilateral testicular cancer B.J.R. BARRASS, R. JONES*, J.D. GRAHAM and R.A. PERSAD Bristol Royal Infirmary, Bristol, and *University Hospital of North Staffordshire, Staffs, UK Accepted for publication 27 October 2003 be unnecessary [4]. Testicular biopsy can lead to problems with subsequent tumour diagnosis, pain, infection, infertility, testicular dysfunction and emotional distress, so this could generate significant excess morbidity [8]. Patients with risk factors (e.g. testicular atrophy, ...

TESTICULAR CANCER - All Sections TESTICULAR CANCER What Is Cancer ? Cancer develops when cells in a part of the body begin to grow out of control. Although there are many kinds of cancer , they all start because of out-of-control growth of abnormal cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person's life, normal cells divide more rapidly until the person becomes an adult. After that, cells in most parts of the body divide only to replace worn-out or dying cells and to repair injuries. Because cancer cells continue to grow and divide, they are different from normal cells. Instead of dying, they outlive normal cells and continue to form new abnormal cells. Cancer cells develop because of damage to DNA. This substance is in every cell and directs all its activities. Most of the time when DNA becomes damaged, either ...

CODE: VIP CCO Formulary Revised November, 2004 A REGIMEN NAME VINBLASTINE-IFOSFAMIDE-CISPLATIN (VIP) Chemotherapy Cancer Testicular Cancer - Salvage Therapy Curative Intent Regimen Category Core: Standard therapy; a regimen widely used by most Regional Cancer Centres Rationale and Indication First or second line treatment of testicular cancer with curative intent B DRUG REGIMEN CISPLATIN (Round to nearest 1mg) 20mg/m² IV Daily for 5 days - day 1 IFOSFAMIDE (Maximum dose = 1.75g - Round to nearest 25mg) 1200mg/m² IV Daily for 5 days - day 1 VINBLASTINE (Round to nearest 1mg) 0.11mg/Kg IV Days 1 & 2 MESNA (Round to nearest 0.3mg) 120mg/m² IV bolus Prior to Ifosfamide ...

CODE: PIE CCO Formulary Revised November, 2004 A REGIMEN NAME CISPLATIN-IFOSFAMIDE-ETOPOSIDE (PIE) Chemotherapy Cancer Testicular Cancer - Salvage Therapy Curative Intent Regimen Category Core: Standard therapy; a regimen widely used by most Regional Cancer Centres Rationale and Indication First or second line treatment of testicular cancer with curative intent B DRUG REGIMEN CISPLATIN (Round to nearest 1mg) 20mg/m² IV Days 1 to 5 IFOSFAMIDE (Maximum dose = 1.75g – Round to nearest 25mg) 1200mg/m² IV Days 1 to 5 ETOPOSIDE (Round to nearest 10mg) 75-100mg/m² IV Days 1 to 5 MESNA (Round to nearest 0.3mg) 120mg/m² IV bolus Prior to Ifosfamide on Day 1 ...

Essay Testicular cancer is most commonly found in adolescents or young adults. To any young man in my situation, I would highly recommend the book, It's Not About the Bike My Journey Back to Life by Lance Armstrong. One of the keys to physical, mental, and emotional survival during cancer treatment is maintaining a positive outlook. A cancer patient needs a positive attitude and a persistent hope that health will be restored and the cancer will be defeated. In this way, Lance Armstrong's story is an excellent motivator. Lance not only had cancer in the testicle but it had spread throughout his body. He had surgery and chemotherapy. His was just about the worst possible scenario with the best possible outcome. Reading his story gives a cancer patient hope that he, too, can overcome the many obstacles of cancer , no matter how bad things look at the beginning. Lance is a great ...

TESTICULAR CANCER Client's Name __ If your client has had testicular cancer , please answer the following: (the client may need to contact the physician's office for this information) 1. Please list date of diagnosis: 2. How was the cancer treated (check all that apply)? surgery chemotherapy radiation therapy 3. Please list date treatment completed: __ 4. Is your client on any medications? yes, please give details no 5. What stage was the cancer ? Stage I Stage II Stage III 6. Has there been any evidence of recurrence? yes, please give details no 7. Please give date and result of most recent AFP or hCG test: _ 8. Has your client smoked cigarettes in the last 12 months? yes, please give details: __ no 9. Does your client have any other major ...

American Journal of Industrial Medicine 20:219 - 227 (1991) Testicular Cancer in Young Men and Parental , Occupational Exposure , Jan W.P.F. Kardaun, MD, PhD, Richard B. Hayes, DDS,PhD, Linda M. Pottern, PhD, Linda Morris Brown, MPH, and Robert N. Hoover, MD, ScD To investig a te whether parental oc c up a tion, especia l ly during the 12 month period before birth, could be responsible for elevated rates of testicular cancer in young men, we used data from a case-control study of 223 cases and 212 controls conducted in the Washington, DC area. For all histologic types of testicular cancer combined, no sig- nificant associations were found for specific occupations, nor for the broad occupational categories of professional, other white collar, or blue collar workers. However, for cases with seminomas, excess risks were seen for those with parents employed in the follow- ...

information helpline Action Cancer has introduced an information helpline specifically to answer your questions or concerns on testicular or prostate cancer . Telephone 028 9024 4200 and ask to speak to someone in the men’s health department. clinic Action Cancer also offers clinics at Action Cancer House, 1 Marlborough Park, Belfast, staffed by qualified medical personnel. For further information, or to make an appointment, telephone: 028 9024 4200. email: info@actioncancer.org www.actioncancer.org the service is completely confidential for further information Action Cancer has been helping people in Northern Ireland to fight for freedom from cancer since 1973. Action Cancer provides: early detection Early detection services can save lives. Action Cancer ...

Alison Clark MSc, BN, RNT, RCNT, RNT, is Nurse Teacher, Nottingham School of Nursing (Undergraduate Division). Patricia Jones RGN, is former Staff Nurse, Oncology Unit, Nottingham City Hospital. Steve Newbold RGN, is Health Promotion Specialist, Health Promotion Unit, Nottingham Community Trust. James Spencer, Mark Wilson and Kevin Brandwood are members of the testicular cancer self-help group. august 30/vol14/no50/2000 nursing standard 41 art & science men’s health nursing standard: clinical · research · education There have been numerous articles and health education leaflets published in the past five years that have helped to raise awareness about testicular cancer , for example, Cook (1995), Halle (1999), Peate (1998), Paolozzi (1994), Snell (1999) and the Imperial Cancer Research ...

Session: Frailty models in multivariate survival analysis – 1, Sept. 17, 10:00 A frailty model for the incidence of testicular cancer A ALEN OO, T RETLI S University of Oslo, Section of Medical Statistics, odd.aalen@basalmed.uio.no Session: Frailty models in multivariate survival analysis – 1, Sept. 17, 10:00 Introduction There are two distinct statistical features concerning the incidence of cancer of the testis. Firstly, the incidence has been increasing for many years. Secondly, the incidence is highest among younger men and then declines with age, this being very atypical compared to most cancers. A statistical model to account for these features is suggested. Methods and Results The model is based on the frailty thinking which is now common in survival analysis. Individuals are assumed to have different risks according to whether a ...