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Session: Genetic Epidemiology – 2, Sept. 14, 11:00 Testicular cancer – Familial and maternal characteristics B ROMEN K, A HRENS W, B AUMGARDT -E LMS C, J AHN I, S TEGMAIER C, Z IEGLER H Uniklinik Essen, Inst. f. Med. Informatik, Biom. u. Epidemiologie, katja.bromen@uni-essen.de Session: Genetic Epidemiology – 2, Sept. 14, 11:00 Introduction Several studies have shown an increased risk of testicular cancer among fathers and brothers of testicular cancer patients. It is still unclear whether this is explained by underlying genetic mechanisms or shared familial and prenatal factors. Among these, in-utero estrogen exposure has been suggested as a risk factor. To examine the prevalence of testicular cancer in fathers and brothers of study participants ...

Testicular Cancer What is Testicular Cancer ? Testicular Cancer is a cancer in one or both testicles that usually occurs between the ages of fifteen (15) and forty (40). Statistics show that 95% of testicular tumors begin in cells within the testicles. It can be treated and cured, when detected at an early stage. Most men discover a lump themselves. A man should talk with his medical doctor, if he notices anything unusual about his testicles between regular checkups. Anatomy. The testicles, also called testes, are a pair of male sex glands. They produce sperm and male hormones. The testicles are located under the penis in a sac-like pouch called the scrotum. Risk Factors A man is at risk if: • his testicle did not move down into the scrotum. • he had surgery to move the testicle down into the scrotum. • he had previous testicular ...

Chapter 8 Predicting retroperitoneal histology in postchemotherapy testicular germ cell cancer : a model update and multicentre validation with 1094 patients Abstract Patients treated with chemotherapy for advanced testicular germ cell cancer may undergo resection of retroperitoneal lymph nodes, that often contain only necrosis or fibrosis (benign tissue). To improve the selection of candidates for resection, we previously developed a logistic regression model with six variables to predict the probability of benign tissue. The aim of the present study was to update the model using new patient data and to study the validity of the updated model. We combined the data of 544 patients that were used before to develop the model with data of 550 new patients and performed a new logistic regression analysis. In total data of 1094 patients were available from five large international ...

Testicular Cancer Stage III Stage II Stage I T1- Tumor limited to the testis and epidymis without lymphatic/vascular invasion T2- Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis T3- Tumor invades the spermatic cord with or without vascular/lymphatic invatsion T4- Tumor invades the scrotum with or without vascular/lymphatic invasion N0- No lymph node metastasis N1- Metastasis in a single lymph node 2cm or less in greatest dimension N2- Metastasis in a single lymph node 2-5 cm in greatest dimension; or multiple lymph nodes , none >5cm in greatest dimension N3- Metastasis in a lymph node >5cm in dimension M0- No distant metastasis M1- Distant metastasis M1a- Nonregional nodal or pulmonary metastasis M1b- Distant metastasis other than to nonregional nodes and ...

Perinatal determinants of germ-cell testicular cancer in relation to histological subtypes L Richiardi* ,1,2 , O Akre 3 , R Bellocco 1 and A Ekbom 3,4 1 Department of Medical Epidemiology, Karolinska Institute, Berzelius väg 15C, SE-17177 Stockholm, Sweden; 2 Unit of Cancer Epidemiology and Center for Oncologic Prevention, University of Turin, V. Santena 7, 10126 Torino, Italy; 3 Unit of Clinical Epidemiology, Department of Medicine, Karolinska Hospital, L1:00 SE-171 76 Stockholm, Sweden; 4 Department of Epidemiology, Harvard School of Public Health, Boston, USA We aimed to investigate the role of perinatal determinants on the risk for germ-cell testicular cancer , with respect to the aetiological heterogeneity between seminomas and non-seminomas. A case–control study of 628 case patients ...

© 20 04 B JU I N TER N A TI O N A L | 9 3, 118 3– 11 87 | doi:10.1111/j.1464-410X.2004.04837.x 11 83 Blackwell Science, LtdOxford, UKBJUBJU International1464-410XBJU InternationalJune 2004 939 •••• Review Article PRACTICAL MANAGEMENT FOR BILATERAL TESTICULAR CANCER B.J.R. BARRASS et al. Practical management issues in bilateral testicular cancer B.J.R. BARRASS, R. JONES*, J.D. GRAHAM and R.A. PERSAD Bristol Royal Infirmary, Bristol, and *University Hospital of North Staffordshire, Staffs, UK Accepted for publication 27 October 2003 be unnecessary [4]. Testicular biopsy can lead to problems with subsequent tumour diagnosis, pain, infection, infertility, testicular dysfunction and emotional distress, so this could generate significant excess morbidity [8]. Patients with risk factors (e.g. testicular atrophy, ...

Essay Testicular cancer is most commonly found in adolescents or young adults. To any young man in my situation, I would highly recommend the book, It's Not About the Bike My Journey Back to Life by Lance Armstrong. One of the keys to physical, mental, and emotional survival during cancer treatment is maintaining a positive outlook. A cancer patient needs a positive attitude and a persistent hope that health will be restored and the cancer will be defeated. In this way, Lance Armstrong's story is an excellent motivator. Lance not only had cancer in the testicle but it had spread throughout his body. He had surgery and chemotherapy. His was just about the worst possible scenario with the best possible outcome. Reading his story gives a cancer patient hope that he, too, can overcome the many obstacles of cancer , no matter how bad things look at the beginning. Lance is a great ...

TROUBLE WITH YOUR WATERWORKS ? How to carry out a testicular self-examination You should perform these easy steps regularly. A thorough examination may be easier after a warm bath or shower as the scrotal skin relaxes. 1 Most lumps found on the testicles are benign but any changes in size, shape or weight should be checked by your GP. 2 Support the scrotal sac in the palm of your hand and become familiar with the size and weight of each testicle. 3 Examine each testicle by rolling it between your fingers and thumb. Press gently to feel for lumps, swellings, or changes in firmness. 4 Remember each testicle has a tubular structure at the top which carries sperm to the penis. Don’t panic if you ...

Summary of Recommendation The U.S. Preventive Services Task Force (USPSTF) recommends against routine screening for testicular cancer in asymptomatic adolescent and adult males. D recommendation. The USPSTF found no new evidence that screening with clinical examination or testicular self-examination is effective in reducing mortality from testicular cancer . Even in the absence of screening, the current treatment interventions provide very favorable health outcomes. Given the low prevalence of testicular cancer , limited accuracy of screening tests, and no evidence for the incremental benefits of screening, the USPSTF concluded that the harms of screening exceed any potential benefits. Clinical Considerations • The low incidence of testicular cancer and favorable outcomes in the absence of screening make it ...

Methods We searched MEDLINE ® for articles focusing on meta-analysis, systematic reviews, randomized controlled trials (RCTs), and controlled trials or well-designed cohort or case control studies reporting demonstrable health outcomes (morbidity and/or mortality) in humans that were published in English between the years 1994 and 2001. The Cochrane Library and National Guideline Clearinghouse were also searched for pertinent articles or recommendations. The search strategy employed for MEDLINE combined the exploded MeSH heading of Testicular Neoplasm with Germinoma (limited to male) and crossed the result with Mass Screening, yielding 19 articles. These articles were further limited to RCTs by the exploded headings—randomized controlled trial/single-blind method/double-blind method/random allocation, for which no articles were identified. Limiting to reviews ...