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Quality of life of testicular cancer survivors Joke Fleer FYN Werk-Fleer proefschrift.indb1 1 11-1-2006 23:43:44 Page 2 Joke Fleer Quality of life of testicular cancer survivors Thesis University of Groningen ISBN 90-771-1340-1 Cover design STUDIO FRANK & LISA (www.studiofrank-lisa.nl) Lay out FYN Werk (www.fynwerk.nl) Printed by Drukkerij C. Regenboog Groningen This research was supported by a grant from The Dutch Cancer Society, no. RUG 99-2130 Financial support for this thesis was kindly given by AstraZenecaBV; Fleremaheerd Erfgoedlogies (www.fleremaheerd.nl); Integraal Kanker- centrum Noord-Nederland; KWF Kankerbestrijding; Northern Centre for Healthcare Research Groningen; Stichting Werkgroep Interne Oncologie Groningen ©2006, Joke Fleer, Groningen, The Netherlands All rights reserved FYN Werk-Fleer ...

Quality of life of testicular cancer survivors and the relationship with sociodemographics, cancer -related variables and life events Joke Fleer Harald J Hoekstra Dirk Th Sleijfer Marrit A Tuinman Ed C Klip Josette EHM Hoekstra-Weebers Supportive Care in Cancer (2005): published online Sep 17 FYN Werk-Fleer proefschrift.indb41 41 11-1-2006 23:43:52 Page 2 FYN Werk-Fleer proefschrift.indb42 42 11-1-2006 23:43:52 Page 3 3 43 Introduction Testicular cancer (TC) affects men in a period of life when intimate relationships, star- ting a family, and career are major concerns. Since the introduction of cisplatin-based chemotherapy in the late 1970s, TC has become one of the most curable malignancies, with cure rates between 85 and 90% [1;2]. As a consequence, the majority ...

Objective and subjective predictors of cancer -related stress symptoms in testicular cancer survivors Joke Fleer Dirk Th Sleijfer Harald J Hoekstra Marrit A Tuinman Ed C Klip Josette EHM Hoekstra-Weebers Patient Education and Counseling, in press (slightly adapted version) FYN Werk-Fleer proefschrift.indb81 81 11-1-2006 23:44:01 Page 2 FYN Werk-Fleer proefschrift.indb82 82 11-1-2006 23:44:01 Page 3 5 83 Introduction Testicular cancer is most prevalent among men between the ages of 15 and 45, a phase of life during which people tend to enter into intimate relationships,have children,and build careers.Almost 90% survives after treatment and will live the largest part of their life as a cancer survivor [1;2].Research into the physical sequel of treatment for testicu- ...

Quality of life of survivors of testicular germ cell cancer : a review of the literature Joke Fleer Harald J Hoekstra Dirk Th Sleijfer Josette EHM Hoekstra-Weebers Supportive Care in Cancer (2004) 12: 476-486 FYN Werk-Fleer proefschrift.indb17 17 11-1-2006 23:43:47 Page 2 FYN Werk-Fleer proefschrift.indb18 18 11-1-2006 23:43:47 Page 3 2 19 Introduction Men between 15 and 45 years are in the prime of life. Major issues that concern them are career, interpersonal relationships and starting a family. Life-threatening illnesses and the possibility of dying do not fit their outlook in this period of life [1;2]. Nevertheless, a small percentage of these men will develop the most common neoplasm in young men: testicular germ cell cancer (TC). Despite increases in incidence,TC ...

27 lenges are made even more complex by concerns about immediate and late effects from the disease and its treat- ment. Such concerns, if not addressed, may contribute to the negative sexual self-image of adolescent and young adulthood cancer survivors and lead to later difficulties with sexual self-esteem and sexual function. Dr. Andrea Canada received a two-year grant from the LAF to develop and evaluate a brief counseling intervention to facilitate healthy sexual develop- ment in adolescents and young adults with cancer . Project participants, age 15 to 25, were recruited from The University of Texas M.D. Anderson Cancer Center’s Adolescent and Young Adult Program. Dr. Canada found that participation in the intervention increased the patients’ cancer -specific knowledge regarding sexual issues, improved their body and self-image, ...

Testicular Cancer In 2005, it was estimated that 8,010 males would be diagnosed with testicular cancer . When found early, testicular cancer is one of the most treatable forms of cancer , with an overall cure rate above 90 percent. PREVENTION • Talk to your health care professional about screening. RISK • All men • Men with a history of cryptorchidism — testicle(s) that have not descended • Men with a personal or family history of testicular cancer • Caucasian men are at higher risk SYMPTOMS Most testicular cancer can be found at an early stage. Some of the symptoms that may appear include: • A lump on either testicle • Enlargement of either testicle • Heaviness or aching in the lower abdomen or scrotum • Pain or discomfort in a testicle or in the scrotum • A collection of fluid in the scrotum • Breast growth ...

DCI SUPPLEMENT INSERT Testicular Cancer /Germ Cell Tumors Information * * If this is a report of a second (or subsequent) transplant, check here and go to Q.216 Month Day Year FOR REGISTRY USE ONLY: I.D. – – Date received: Registry (circle one): IBMTR ABMTR 2. Date of report: (Institutional Unique Blood or Marrow Transplant Identification Number) M Month Day Year DCI Disease Supplement Inserts TEAM: IUBMID: 1. Date of first DCI for which this form is being completed: Statistical Center Medical College of Wisconsin P.O. Box 26509, 8701 Watertown Plank Road Milwaukee, WI 53226 Telephone: 414-456-8325 Fax: 414-456-6530 Email: ibmtr@mcw.edu IBMTR/ABMTR Reporting Form DCI-TC (9/03) Page 1 of 1 Line of Therapy ...

TEAM: IUBMID: Date of transplant for which this form is being completed: FOLLOW-UP INSERT XXXII Testicular Cancer Follow-up Information* * Report data for date of last contact as reported in Q.3 of Follow-up Core Form or immediately prior to death IBMTR/ABMTR Follow-up Form 095-TCFU (6/00) Page 1 of 5 Month Day Year FOR REGISTRY USE ONLY: I.D. – – Date received: Registry (circle one): IBMTR ABMTR Date of report: (Institutional Unique Blood or Marrow Transplant Identification Number) M Month Day Year DEFINITIONS Overall Response Use the following codes to indicate patient's overall radiographic/cytologic/tumor marker response: 0 = Continued Complete Response (CCR) = continued absence of all disease after a complete response to a previous line of therapy. 1 = Complete ...

1. Date of pathologic diagnosis of testicular cancer : Origin of primary tumor at diagnosis (check all that apply) : Testicular cancer histology at diagnosis (check all that apply) : Indicate tumor mass at diagnosis: 19. Nonseminoma: 1 Yes———— 0 No TEAM: IUBMID: Date of transplant for which this form is being completed: INSERT XXXII Testicular Cancer Pretransplant Information* * If this is a report of a second (or subsequent) transplant, check here and go to Q.211 IBMTR/ABMTR Reporting Form 095-TC (8/05) Page 1 of 11 Month Day Year FOR REGISTRY USE ONLY: I.D. – – Date received: Registry (circle one): IBMTR ABMTR Date of report: (Institutional Unique Blood or Marrow Transplant Identification Number) M Month Day Year Month ...

1 Testicular cancer : a preventable disease EMHF Fact sheet • Testicular cancer is the most common malignancy in young men - those between 20 and 34 years of age. Estimates suggest around 50,000 cases worldwide, with approximately 21,000 occurring in Europe (1) • It is more often seen in white populations than in black or Asian ones, and seems to be more likely to affect men from relatively prosperous backgrounds • Although it is relatively rare (around 1% of cancers in men), it is the number one cancer killer of men in their 20s and 30s. Unfortunately, the incidence of the disease continues to rise worldwide • Testicular cancer is more frequent in men who have a testicle that has failed to descend and in those with a family history of the disease. It is not associated with vasectomy or sporting injuries. Some scientists ...

Early detection saves lives Testicular cancer is nearly always curable if it’s found early. Early detection means simpler, more effective treatment with fewer side-effects. Symptoms See your GP if you notice any of the following • a hard lump on the front or side of a testicle • swelling or enlargement of a testicle • an increase in firmness of a testicle • pain or discomfort in a testicle or in the scrotum • an unusual difference between one testicle and the other Other warning signs may include • a heavy feeling in the scrotum • a dull ache in the lower stomach, groin or scrotum Be body aware Do a regular self check in the bath or shower, or soon afterwards. Remember • know what is normal for you • know what changes to look out for • report any changes without delay Further information ...

“ Testicular Cancer ” Oncological Sciences Center Symposium Stephen D. Williams, MD IU Cancer Center Page 2 Germ Cell Neoplasms 1. Testis 2. Ovarian 3. Extra-gonadal A. Retroperitoneal B. Mediastinal Page 3 Pathology Seminoma Embryonal carcinoma Teratoma Yolk sac tumors Choriocarcinoma Mixed germ cell tumors Non-seminoma Page 4 Staging Work-up HCG, alphafetoprotein Abdominal CT scan Chest x-ray / CT scan Other studies as warranted Page 5 Stages I (A). Confined to testis II (B). Testis plus retroperitoneal nodes III (C). Supradiaphragmatic or visceral involvement Page 6 PVB ...

www.mcare.org Cancer of the testicles, the primary male sex glands, accounts for only about 1 percent of all cancers in men. It is, though, the most common type of cancer in males aged 20 to 35, but can occur in other age groups. It strikes about 5,000 males a year. Often, only one testicle is affected. The cause of testicular cancer is not known. Risk factors, though, have been given. These are : • Undescended testicles (that are not cor- rected) in infants and young children. (Parents should see that their infant boys are checked at birth for undescended tes- ticles.) • A family history of testicular cancer • Having an identical twin with tes- ticular cancer • Injury to the scrotum Testicular cancer is almost always curable if it is found and treated early. Surgery is done to remove the testicle. Other things can further ...

1 Joke Fleer Quality of life of testicular cancer survivors Promotiedatum: 1 maart 2006 Summary Men who are diagnosed with testicular cancer are generally young. As a consequence of the treatment they receive nowadays, they are likely to cure from the dis ease, even when they have metastases. This means that they have to live with possible short- and long-term sequel of diagnosis and treatment for many years. Survivors who do not have the resources necessary to cope with such physical and psychosocial sequel, may find it more difficult to adjust to their altered life situation and experience an impaired quality of life. These men might need professional assistance to enhance their skills to competently manage their lives as a cancer survivor. Yet, how do health care providers know which testicular cancer survivor is at risk for distress and might benefit from an intervention? Therefore, ...

Familial Testicular Cancer Clinical Genetics Branch* Division of Cancer Epidemiology and Genetics ABOUT THE RESEARCH TEAM Mark H. Greene, M.D. , is the lead investigator for the study and Chief of the NCI Clinical Genetics Branch. He has been caring for and studying patients with familial and hereditary cancers for 25 years. W. Marston Linehan, M.D., Ph.D. , is the Chief of the NCI Urologic Oncology Branch. He is one of the world’s leading authorities on hereditary cancers arising in the genitourinary system. Larissa Korde, M.D., M.P.H. , is board certified in internal medicine and medical oncology, with special training in epidemiology. She has a major research interest in cancer prevention in persons at increased risk of malignancy, and is the lead clinical investigator for the Familial Testicular Cancer ...

An Interview With Lawrence Einhorn, MD: Testicular Cancer — Don’t Settle for the Status Quo Any discussion of the treatment of testicular cancer will almost certainly include mention of Lawrence Einhorn, MD, of Indiana University. Dr. Einhorn has created a major program in clinical investigation and he himself is credited with major advances in the curative treatment of this cancer , most notably in the clinical use of platinum-based chemotherapy. He performed undergraduate work at Indiana University in Bloomington, Indiana, and then went to medical school in Iowa. He did an oncology fellowship at M.D. Anderson Cancer Center in Houston, Texas, before returning to Indiana to join the faculty at Indiana University in 1973. He has been there for 32 years. The Journal of Oncology Practice contacted Dr. Einhorn at the university, ...

Last revised: 10/27/2005 UM Comprehensive Cancer Center Patient Education Document #0040 Nov5 Ed. Online version: http://www. cancer .med.umich.edu/learn/percpathways.htm 1 University of Michigan Comprehensive Cancer Center Patient Education Resource Center (PERC) INFORMATION GUIDE Testicular Cancer The purpose of this information guide is to help patients newly diagnosed with Testicular Cancer and their families to find sources of information and support. This list is not meant to be comprehensive, but rather to provide starting points for information seeking. The materials can be found at the Patient Education Resource Center (PERC) of the University of Michigan Comprehensive Cancer Center in room B1-361. Article Available at the Patient Education Resource Center on Level B-1 Feder, David. Testicular Cancer ...

RISING RISK OF TESTICULAR CANCER BY BIRTH COHORT IN THE UNITED STATES FROM 1973 TO 1995 JAMES M. M C KIERNAN, ERIK T. GOLUBOFF, GARY L. LIBERSON, ROBERT GOLDEN AND HARRY FISCH From the Department of Urology, Columbia Presbyterian Medical Center, Columbia University, New York, New York, and Environmental Risk Sciences, Washington, D. C. ABSTRACT Purpose: Recent epidemiological studies have demonstrated an increasing incidence of testic- ular cancer in white men which appears to be correlated with the period of birth. Because this birth cohort phenomenon can explain etiological factors in testicular cancer , we determine whether this trend is present throughout the United States based on an analysis of testicular cancer incidence by birth cohort. Materials and Methods: Testicular cancer incidence was obtained from the National Cancer Institute ...

TESTICULAR CANCER Client's Name __ If your client has had testicular cancer , please answer the following: (the client may need to contact the physician's office for this information) 1. Please list date of diagnosis: 2. How was the cancer treated (check all that apply)? surgery chemotherapy radiation therapy 3. Please list date treatment completed: __ 4. Is your client on any medications? yes, please give details no 5. What stage was the cancer ? Stage I Stage II Stage III 6. Has there been any evidence of recurrence? yes, please give details no 7. Please give date and result of most recent AFP or hCG test: _ 8. Has your client smoked cigarettes in the last 12 months? yes, please give details: __ no 9. Does your client have any other major health problems ...

POSITION STATEMENT TESTICULAR CANCER Overview The testicles are two egg-shaped gland s found in men. They produce semen and sex hormones. Testicular cancer is one of the more rare forms of cancer with an estimated incidence of approximately 6 in every 100,000 men. 1 Young men are more commonly affected by testicular cancer , with about half of the new diagnoses being made in men under the age of 33 years. 2 There are two different types of testicular cancer , non-seminoma, a cancer of the mature germ cells affecting mostly the 15-35 male year old age group and seminoma, cancer formed from immature germ cells, which generally affects the 25-55 male age group. The outlook for men diagnosed with testicular cancer has improved dramatically since the 1970s when chemotherapy was introduced to treat the disease. Five-year relative ...

Contact: Joanne Dolinar Coordinator of Public Relations 631-548-6088 FOR IMMEDIATE RELEASE Monday, October 20, 2003 Dr. Musto to Speak on Prostate and Testicular Cancer Dr. Richard Musto will speak on “Prostate and Testicular Cancer ” at a seminar co- sponsored by Westhampton Hadassah and Central Suffolk Hospital on Wednesday, October 22, at 8 pm in the Hospital’s Ruth C. Laboda Conference Rooms. Certified by the American Board of Urology and a Diplomate/Fellow of the American College of Surgeons, Dr. Musto received his training at Downstate Medical Center and St. Vincent’s Hospital in New York. Dr. Musto is on the staff of Central Suffolk Hospital and has a private practice in Riverhead. One in five men will be diagnosed with prostate cancer in their lifetimes. Testicular cancer is the most common cancer in males ages 25 to 40. The event is open to the ...

153 Burden of Suffering Testicular cancer is a relatively uncommon disease, with an overall annual incidence of about 4/100,000 men. 1 It is, however, the most common form of cancer in young men between ages 20 and 35, 2 accounting for an esti- mated 7,100 new cases and 370 deaths in the U.S. in 1995. 3 The peak an- nual incidence ranges from 8 to 14/100,000 men between 20 and 35 years of age, with a smaller peak in early childhood. 4 The incidence in black men is less than one fifth that of white men. 4 The major predisposing risk factor is cryptorchidism. 1 In men with a history of cryptorchidism, 80–85% of testicular tumors occur in the cryptorchid testicle, while 15–20% occur in the contralateral testicle. Other risk factors include previous cancer in the other testicle, a history of mumps orchitis, ...

1354 ARTICLES Journal of the National Cancer Institute, Vol. 97, No. 18, September 21, 2005 Second Cancers Among 40 576 Testicular Cancer Patients: Focus on Long-term Survivors Lois B. Travis , Sophie D. Fosså , Sara J. Schonfeld , Mary L. McMaster, Charles F. Lynch , Hans Storm , Per Hall , Eric Holowaty, Aage Andersen , Eero Pukkala , Michael Andersson , Magnus Kaijser, Mary Gospodarowicz , Timo Joensuu , Randi J. Cohen , John D. Boice , Jr. , Graça M. Dores , Ethel S. Gilbert Background: Although second primary cancers are a leading cause of death among men with testicular cancer , few studies have quantified risks among long-term survivors. Methods: Within 14 population-based tumor registries in Europe and North America (1943–2001), we identified 40 576 1-year sur- vivors of testicular cancer and ascertained data on any new incident solid tumors ...

6.34 5/24/05 Page 1 Testicular Cancer : Questions and Answers 1. What is testicular cancer ? Testicular cancer is a disease in which cells become malignant (cancerous) in one or both testicles. The testicles (also called testes or gonads) are a pair of male sex glands. They produce and store sperm and are the main source of testosterone (male hormones) in men. These hormones control the development of the reproductive organs and other male physical characteristics. The testicles are located under the penis in a sac-like pouch called the scrotum. Based on the characteristics of the cells in the tumor, testicular cancers are classified as seminomas or nonseminomas. Other types of cancer that arise in the testicles are rare and are not described here. Seminomas may be one of three types: classic, anaplastic, or spermatocytic. Types of nonseminomas include choriocarcinoma, ...

The Marie Keating Foundation has been established to provide cancer information and awareness free of charge to the general public throughout Ireland. Our Mobile Units carry information on Breast, Testicular , Prostate, Bowel, Lung, Skin, Ovarian and Cervical cancer . Our service is provided through our registered Nurses on board the Units, leaflet information, teaching aids, presentations, exhibitions and seminars. The Marie Keating Foundation offers Medical and Nursing Scholarships. Our future projects include Marie Keating Foundation waiting rooms within Cancer Care Hospitals. As the Marie Keating Foundation is not government funded we depend on private and corporate donations. We at the Marie Keating Foundation would like to thank Breast Check, The Irish Cancer Society, Action Cancer Northern Ireland, Cancer Research UK and health care professionals specializing in cancer ...

Accredited by Accreditation Association for Ambulatory Health Care, Inc. Reference: Medscape.com on the World Wide Web. Go to http://www.medscape.com/ for more information. The Leading Cancer of Young Men Testicular cancer occurs most commonly in young males between the ages of 16 to 35. Males with a history of late descending or undescended testicles have a higher risk of developing testicular cancer . The testicles develop inside the stomach of unborn males. The testicles then begin to descend at birth or during the first year. Late descending testicles usually develop toward the end of the first year or beginning of the second year. If the testicles do not descend by then, surgery is required to assist this process. Testicular cancer can affect everyone, even famous athletes. In 1993, Philadelphia baseball player John Kruk was diagnosed with testicular ...

Support Care Cancer (2005) 13: 540–548 DOI 10.1007/s00520-004-0758-3 ORIGINAL ARTICLE Marrit A. Tuinman Joke Fleer Dirk Th. Sleijfer Harald J. Hoekstra Josette E. H. M. Hoekstra-Weebers Received: 31 August 2004 Accepted: 24 November 2004 Published online: 20 January 2005 # Springer-Verlag 2005 Marital and sexual satisfaction in testicular cancer survivors and their spouses Abstract Goal: To compare marital and sexual satisfaction of men who survived testicular cancer (TC) and their spouses to a reference group, and to compare marital and sexual satis- faction of couples who had a relation- ship at time of diagnosis (couples during TC) to couples who developed a relationship after completion of treatment (couples after TC). Patients and methods: Two hundred and nineteen couples during TC and 40 couples ...

Review Male sexuality after cancer treatment—needs for information and support: testicular cancer compared to malignant lymphoma Grieteke Jonker-Pool a,b ,* , Harald J. Hoekstra c , Gustaaf W. van Imhoff d , D.J.A. Sonneveld c , Dirk Th. Sleijfer d , Mels F. van Driel e , Heimen Schraffordt Koops c , Harry B.M. van de Wiel b a Northern Centre for Health Care Research, University of Groningen, P.O. Box 30001, Groningen RB 9700, The Netherlands b Department of Medical Psychology, University Medical Center Groningen, Groningen, The Netherlands c Department of Surgical Oncology, University Medical Center Groningen, Groningen, The Netherlands d Department of Medical Oncology, University Medical Center Groningen, ...