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Overview: Testicular cancer is the most common form of cancer in men between age 20 and 34; it accounts for 19% of all cancers in that age group. In the 1990s, somewhere between 6,000 and 7,000 testicular cancers were diagnosed each year. Due to frequent early diagnosis, testicular cancer is often removed before it has the chance to metastasize (spread beyond the area of origin). Approximately 350 deaths occur annually as a result of testicular cancer and related complications. Different cell types are found in testicular cancers. The most common form of testicular cancer are germ cell cancers (both seminomas and nonseminomas ) accounting for 95% of the condition. Non-germ cell testicular cancers come from a variety of cell types, some of which may originate from other malignancies, such as lymphoma. Diagnostic procedures include blood and urine studies. Other procedures ...

24 ADVANCE FOR NURSES • GREATER PHILADELPHIA • SEPTEMBER 3, 2001 P A T I E N T H A N D O U T It is well known that the monthly breast self-exam is an effective part of early breast cancer detection for women. However, most men do not realize that following a similar self-exam routine for testicles is just as important. According to the Testicular Cancer Resource Center, men should perform monthly self-exams of the tes- ticles as early as age 15. In fact, though testicular cancer only accounts for 1 percent of all cancers in men, it is the most common form of cancer in men 15-35 years old. The risk is greater in white American men, who are five times more likely to be diagnosed with testicular cancer than African-American males. WHEN TO PERFORM A SELF-EXAM The best time to perform a self-exam ...

TESTICULAR CANCER What Is Cancer ? Cancer is a group of many related diseases. All forms of cancer involve out-of-control growth and spread of abnormal cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person's life, normal cells divide more rapidly until the person becomes an adult. After that, normal cells of most tissues divide only to replace worn-out or dying cells and to repair injuries. Cancer cells, however, continue to grow and divide, and can spread to other parts of the body. These cells accumulate and form tumors (lumps) that may compress, invade, and destroy normal tissue. If cells break away from such a tumor, they can travel through the bloodstream, or the lymph system to other areas of the body. There, they may settle and form "colony" tumors. In their new location, the cancer cells continue growing. The spread of a ...

For Internal Use Only. Not For Use With The Public. This material is intended for insurance informational purposes only and is not personal medical advice for clients. Testicular Cancer Although overall it is uncommon, testicular cancer is the most common type of cancer in young men age (15-35). The incidence of testicular cancer has been increasing, but mortality rates are improving due to dramatic advances in its treatment. The usual presentation of this cancer is a painless mass. Risk Factors ? Cryptorchidism (undescended testicle) ? Previous testicular cancer in opposite testis ? History of mumps orchitis, inguinal hernia, or hydrocele in childhood ? High socioeconomic status Germ cell cancers account for 95% of testicular cancer and can be subdivided in to seminomas and nonseminomas. Non-germ cell cancers account for the other ...

The Orchid Cancer Appeal Team Patron: Steve Davis MBE President: Michael Parkinson Vice Presidents: Pat Cash, Jason Cundy, Sir Geoff Hurst MBE, Martin Peters MBE, Geoff Thompson MBE and Ronnie Whelan. Trustees: Colin Osborne CHAIRMAN , Judge Graham Boal QC, Professor Tim Oliver MD FRCP and Dr Mary Quigley FRCP FRCR Centres In The Anglian Cancer Research Group Supported By The Orchid Cancer Appeal Leaflets Sponsored by Charterhouse Printing Ltd. London Designed by The Orchid Cancer Appeal © The Orchid Cancer Appeal 1997 IPSWICH NORWICH COLCHESTER CAMBRIDGE SOUTHEND OLDCHURCH ROYAL HOSPITALS TRUST TESTICULAR CANCER AWARENESS LEAFLET The Orchid Cancer Appeal Formed in June 1996 by former testis cancer ...

Session: Genetic Epidemiology – 2, Sept. 14, 11:00 Testicular cancer – Familial and maternal characteristics B ROMEN K, A HRENS W, B AUMGARDT -E LMS C, J AHN I, S TEGMAIER C, Z IEGLER H Uniklinik Essen, Inst. f. Med. Informatik, Biom. u. Epidemiologie, katja.bromen@uni-essen.de Session: Genetic Epidemiology – 2, Sept. 14, 11:00 Introduction Several studies have shown an increased risk of testicular cancer among fathers and brothers of testicular cancer patients. It is still unclear whether this is explained by underlying genetic mechanisms or shared familial and prenatal factors. Among these, in-utero estrogen exposure has been suggested as a risk factor. To examine the prevalence of testicular cancer in fathers and brothers of study participants ...

Session: Prognostic models in oncology – 2, Sept. 14, 12:00 Residual mass histology in testicular cancer : development and validation of a clinical prediction rule S TEYERBERG EW, K EIZER HJ, H ABBEMA JDF AND THE R E H I T S TUDY G ROUP Dept. of Public Health, Ee 2091, Erasmus University, steyerberg@ckb.fgg.eur.nl Session: Prognostic models in oncology – 2, Sept. 14, 12:00 Introduction Metastatic testicular cancer can be cured by cis-platin based chemotherapy in over 80% of the patients. After chemotherapy, remnants of the initial metastases may be detected on CT scans. Resection of these 'residual masses' may reveal malignant or benign tissue. Since resection of benign tissue has no therapeutic value, we aimed to predict this histology. Methods ...

Session: Frailty models in multivariate survival analysis – 1, Sept. 17, 10:00 A frailty model for the incidence of testicular cancer A ALEN OO, T RETLI S University of Oslo, Section of Medical Statistics, odd.aalen@basalmed.uio.no Session: Frailty models in multivariate survival analysis – 1, Sept. 17, 10:00 Introduction There are two distinct statistical features concerning the incidence of cancer of the testis. Firstly, the incidence has been increasing for many years. Secondly, the incidence is highest among younger men and then declines with age, this being very atypical compared to most cancers. A statistical model to account for these features is suggested. Methods and Results The model is based on the frailty thinking which is now common in survival analysis. Individuals are assumed to have different risks according to whether a ...

Gonadotrophin secretion patterns in testicular cancer patients with greatly increased human chorionic gonadotrophin serum concentrations S Madersbacher 1,2 , R Gerth 1 , K Mann 3 , S Dirnhofer 1 and P Berger 1 1 Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria, 2 Department of Urology, University of Vienna, Austria and 3 Department of Internal Medicine, University of Essen, Germany (Requests for offprints should be addressed to P Berger, Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Rennweg 10, A-6020 Innsbruck, Austria) Abstract Despite the fact that a number of alterations of the hypothalamic–pituitary–gonadal hormone axis have been identified in patients with testicular ...

TESTICULAR CANCER 383 CHAPTER 18 Testicular cancer Patrick J. Loehrer, MD , Thomas E. Ahlering, MD , and Alan Pollack, MD , P h D Testicular cancer , although an uncommon malignancy, is the most frequently occurring cancer in young men. In the year 2003, an estimated 7,600 cases of testicular cancer will be diagnosed in the United States. For unknown reasons, the incidence of this cancer has increased since the turn of the century, from 2 cases per 100,000 population in the 1930s, to 3.7 cases per 100,000 population from 1969 to 1971, to 5.4 cases per 100,000 population from 1995-1999. Most testicular tumors are of germ-cell origin. These cancers are uniquely sensitive to chemotherapy and are considered the model for the treatment of solid tumors. Perhaps the most ...

Gene Linked to Testicular Cancer DURHAM, N.C. In a study to be published in the June 6, 2002, issue of the journal Oncogene, researchers at Duke University Medical Center have identified the first gene known to be highly correlated to testicular cancer . The gene, called hiwi, belongs to the piwi family of genes discovered in 1997 in the laboratory of Haifan Lin, Ph.D., an associate professor of cell biology at Duke and senior author of the new study in Oncogene, a science journal published by the Nature Publishing Group. Lin's new research, which was funded by the National Institutes of Health, shows that 63 percent of men, who inherit the overactive form of the hiwi gene, could develop seminoma, which is a testicular cancer that originates from reproductive cells. According to the National Cancer Institute, testicular cancer accounts for about 1 percent of all cancers in men. Testicular ...

This booklet has been written to help you understand testicular cancer . It has been prepared and checked by cancer doctors, other relevant specialists, nurses and patients. The information contained in this booklet represents an agreed view on this cancer , its diagnosis and management, and the key aspects of living with it. If you are a patient, your doctor or nurse may wish to go through the booklet with you and mark sections that are particularly important for you. You can make a note below of the contact names and information that you may need quickly. testicular cancer Understanding Specialist nurse/contact names Hospital Phone Treatments Family doctor Surgery address Phone Review dates If you like, you can also add: Your name Address Page 2 ¦ Understanding testicular cancer ...

Testis Cancer survival, incidence and mortality in NSW 1994–2000 48 The Cancer Council NSW Testis cancer • The five-year relative survival from testis cancer in NSW between 1994 and 2000 was 95.6% • There was no area variation in the adjusted relative risks of excess death due to testis cancer after shrinking • There were 935 new cases of testis cancer in NSW in 1994 to 1998 and 53 deaths • There were no Area Health Services in which the number of deaths from testis cancer was different from expected, and there was no area variation in the excess number of new cases of testis cancer Table 22a: Five-year relative survival, relative risk of excess deaths due to cancer and excess cancer deaths after shrinking with 95% confidence intervals and potential lives savable by Area Health Services in NSW 1994 – ...

533 Second Malignancies After Testicular Cancer To the Editor: Testicular cancer has become the paradigm of a curable malignancy, with a 5-year relative survival rate of greater than 90%. 1 This markedly improved outlook underscores the need for quantitative data on the late complications of therapy, especially second malignancies. However. given the rarity of testicular cancer , 1 most surveys contain only small numbers of patients, as reviewed recently by Dieckmann et al, 2 precluding estimation of site-specific risks. To clarify these risks, we have quantified the occurrence of second malignancies among more than 9,700 men with testicular cancer , using resources of the National Cancer Institute’s Surveil- lance, Epidemiology, and End Results Program (1973 to 1991) and the earlier years of the Connecticut Tumor Registry ...

Factsheet 15 September 30, 2001 Meridian Broadcasting Limited 2001 Testicular Cancer Testicular cancer is the most common form of cancer in young men, primarily affecting the 15 to 49 year old age group. Testicular cancer is a form of cancer that responds particularly well to treatment with over 90% of patients recovering from the condition. Testicular Cancer is a malignant t umour t hat develops from cells within the testes . Testes are the two small oval shaped organs located on either side of the penis that produce and store sperm and provide the main source of the Hormone Testosterone responsible for male sexual characteristics. Over 95% of testicular cancers develop in the germ line cells that divide to produce and give rise to new sperm, with other cancers developing from the supportive and hormone producing tissue. ...

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Copyright © 1998 by W.B. Saunders Company. All rights reserved. 478 A BASIC INFORMATION DESCRIPTION Uncontrolled growth of malignant cells in the testicle. There are several types of testicular cancer , some more dangerous than others. This is the most common form of cancer in young men. Affects all ages, but more often is found in men ages 20-40. FREQUENT SIGNS AND SYMPTOMS • A firm swelling in one testicle discovered by accident or by self-examination. • No pain (90% of cases). • Sense of fullness in the scrotum. CAUSES Unknown. RISK INCREASES WITH • Undescended testicle(s) in infancy even if the testicle was surgically moved into the scrotum. • Caucasian race. • Estrogen administration to the mother during preg- nancy. PREVENTIVE MEASURES Males should examine testicles routinely at least once a month. Will ...

Lan ce Arm str on g Foun dati on P.O. Bo x 161150 Austin, TX 78716-1150 www .laf.or g What are the statistics? While rare, testicular cancer strikes primarily young, white men between the ages of 15 and 35. It is the most common form of cancer among American white males between 20 and 34 and the second most common malignancy for American white males between 15 and 19. This year alone, the American Cancer Society estimates that 7,000 to 8,000 new cases of testicular cancer will be diagnosed in the United States. For men living in the US, incidence rates for testicular cancer have doubled over the last two decades. Overall, testicular tumors have a 96% malignancy rate, leading to the deaths of approximately 400 American men each year. Fortunately, from 1983 to 1990, the overall survival rate for men ...

The Testicular Cancer Resource Center Dick Foley: We'll touch further, too, on attitude a little later, but let's talk about educating oneself and others about testicular cancer . We've touched on this a little bit. How aware were all of you of testicular cancer , particularly for men in your age group, which is young, before the disease struck you? Anybody thought about it or talked about it with anyone, with your doctor? Talon: This is Talon, and you're talking about before cancer ? Dick Foley: Yes. Talon: Not at all! I mean, even in the medical profession it was considered to be pretty rare. There wasn't really a lot known about it. In fact, I didn't even know [laughs] who Lance Armstrong was. My doctor was trying to comfort me, thinking that if he told me about Lance Armstrong that that would mean something to me. "Well, he had it, and he beat it, and it's real easy, it's ...

A Greater Openness in Discussing Testicular Cancer Dick Foley: I'm anxious to ask all three of you, actually, because I remember back to another campaign some years ago where another cancer was called, "The cancer nobody wants to talk about." Is testicular cancer like that in some ways? Did your response to symptoms and your willingness to talk about your symptoms; was it changed because of the fact that this was involving your testicles? Anybody who has a first thought on that can jump in. Scott: This is Scott. I don't have a problem about talking about it, but I think it's because people know. [laughs] I was bald for a while from chemotherapy so to say I've had testicular cancer , I don't shy away from it rather than being lung cancer or throat cancer . To me, it's not taboo to talk about. Dick Foley: Sure. Scott: I guess I'd rather talk about it with people. ...

Chapter 5 Residual mass histology in testicular germ cell cancer : development and validation of a clinical prediction model Abstract After chemotherapy for metastatic non-seminomatous testicular germ cell cancer , surgical resection is a generally accepted treatment to remove remnants of the initial metastases, since residual tumour may still be present (mature teratoma or viable cancer cells). In this paper, we review the development and external validation of a logistic regression model to predict the absence of residual tumour. Three sources of information were used. A quantitative review identified six relevant predictors from 19 published studies (996 resections). Second, a development data set included individual data of 544 patients from six centres. This data set was used to assess the predictive relationships of five continuous predictors, which resulted in dichotomization ...