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European Association of Urology GUIDELINES ON TESTICULAR CANCER * P. Laguna, G. Pizzocaro, O. Klepp, F. Algaba, L. Kisbenedek, O. Leiva. Page 2 TABLE OF CONTENTS PAGE 1. Background 3 2. Classification 3 2.1 Staging 3 3. Risk factors 5 3.1 Screening 5 4. Diagnosis 5 4.1 Diagnostic tools 6 4.2 Serum tumour markers 6 4.3 Inguinal exploration and orchiectomy 7 4.4 Pathology of the testis 7 4.5 Abdominal, mediastinal and supraclavicular nodes, and state of the viscera 7 4.6 Guidelines on diagnosis and staging of testicular cancer 8 4.7 References 8 5. Treatment: stage I germ cell tumours 10 5.1 Stage I seminoma 10 5.2 Guidelines for the treatment of seminoma stage I 11 5.3 NSGCT stage I 11 ...

Candidate Genes for Testicular Cancer Evaluated by In Situ Protein Expression Analyses on Tissue Microarrays 1 Rolf I. Skotheim * , Vera M. Abeler y , Jahn M. Nesland y , Sophie D. FossaÊ z , Ruth Holm y , Urs Wagner §,¶ , Vivi Ann Flù renes y , Nina Aass z , Olli P. Kallioniemi ¶,# and Ragnhild A. Lothe * Department of *Genetics, Institute for Cancer Research and Departments of y Pathology and z Medical Oncology and Radiotherapy, The Norwegian Radium Hospital, Oslo, Norway; § Institute for Pathology, University of Basel, Basel, Switzerland; ¶ Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA; # Medical ...

Quality of life of testicular cancer survivors Joke Fleer FYN Werk-Fleer proefschrift.indb1 1 11-1-2006 23:43:44 Page 2 Joke Fleer Quality of life of testicular cancer survivors Thesis University of Groningen ISBN 90-771-1340-1 Cover design STUDIO FRANK & LISA (www.studiofrank-lisa.nl) Lay out FYN Werk (www.fynwerk.nl) Printed by Drukkerij C. Regenboog Groningen This research was supported by a grant from The Dutch Cancer Society, no. RUG 99-2130 Financial support for this thesis was kindly given by AstraZenecaBV; Fleremaheerd Erfgoedlogies (www.fleremaheerd.nl); Integraal Kanker- centrum Noord-Nederland; KWF Kankerbestrijding; Northern Centre for Healthcare Research Groningen; Stichting Werkgroep Interne Oncologie Groningen ©2006, Joke Fleer, Groningen, The Netherlands All rights reserved FYN Werk-Fleer ...

Quality of life of testicular cancer survivors and the relationship with sociodemographics, cancer -related variables and life events Joke Fleer Harald J Hoekstra Dirk Th Sleijfer Marrit A Tuinman Ed C Klip Josette EHM Hoekstra-Weebers Supportive Care in Cancer (2005): published online Sep 17 FYN Werk-Fleer proefschrift.indb41 41 11-1-2006 23:43:52 Page 2 FYN Werk-Fleer proefschrift.indb42 42 11-1-2006 23:43:52 Page 3 3 43 Introduction Testicular cancer (TC) affects men in a period of life when intimate relationships, star- ting a family, and career are major concerns. Since the introduction of cisplatin-based chemotherapy in the late 1970s, TC has become one of the most curable malignancies, with cure rates between 85 and 90% [1;2]. As a consequence, the majority ...

Objective and subjective predictors of cancer -related stress symptoms in testicular cancer survivors Joke Fleer Dirk Th Sleijfer Harald J Hoekstra Marrit A Tuinman Ed C Klip Josette EHM Hoekstra-Weebers Patient Education and Counseling, in press (slightly adapted version) FYN Werk-Fleer proefschrift.indb81 81 11-1-2006 23:44:01 Page 2 FYN Werk-Fleer proefschrift.indb82 82 11-1-2006 23:44:01 Page 3 5 83 Introduction Testicular cancer is most prevalent among men between the ages of 15 and 45, a phase of life during which people tend to enter into intimate relationships,have children,and build careers.Almost 90% survives after treatment and will live the largest part of their life as a cancer survivor [1;2].Research into the physical sequel of treatment for testicu- ...

Testis Cancer survival, incidence and mortality in NSW 1994–2000 48 The Cancer Council NSW Testis cancer • The five-year relative survival from testis cancer in NSW between 1994 and 2000 was 95.6% • There was no area variation in the adjusted relative risks of excess death due to testis cancer after shrinking • There were 935 new cases of testis cancer in NSW in 1994 to 1998 and 53 deaths • There were no Area Health Services in which the number of deaths from testis cancer was different from expected, and there was no area variation in the excess number of new cases of testis cancer Table 22a: Five-year relative survival, relative risk of excess deaths due to cancer and excess cancer deaths after shrinking with 95% confidence intervals and potential lives savable by Area Health Services in NSW 1994 – 2000. Testis cancer ...

National Cancer Institute National Institutes of Health NIH Publication No. 02-5189 August 2002 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health Familial Testicular Cancer Clinical Genetics Branch* Division of Cancer Epidemiology and Genetics ABOUT THE RESEARCH TEAM Mark H. Greene, M.D. , is the lead investigator for the study and Chief of the NCI Clinical Genetics Branch. He has been caring for and studying patients with familial and hereditary cancers for 25 years. W. Marston Linehan, M.D., Ph.D. , is the Chief of the NCI Urologic Oncology Branch. He is one of the world’s leading authorities on hereditary cancers arising in the genitourinary system. Joan L. Kramer, M.D. , is board certified in internal medicine and ...

75 REV. HOSP. CLÍN. FAC. MED. S. PAULO 58(2):75-80, 2003 From the Center for Advanced Research in Human Reproduction and Infertility, Urological Institute, Cleveland, EUA. Received for publication on June 10, 2002. DETECTION OF TESTICULAR CANCER IN MEN PRESENTING WITH INFERTILITY Fabio Firmbach Pasqualotto, Eleonora Bedin Pasqualotto, Ashok Agarwal and Anthony Joseph Thomas Jr. PASQUALOTTO FF et al. - Detection of testicular cancer in men presenting with infertility. Rer. Hosp. Clín. Fac. Med. S. Paulo 58 (2):75-80, 2003. PURPOSE: Infertility is one of the less common presenting features associated with testicular tumors. We evaluated the histologic and biochemical findings, and pregnancy outcome in patients presenting with infertility who were found to have testicular tumors. METHODS: Seven patients with infertility were found to have testicular ...

Center for Environmental Health Studies (617) 482-9485 44 Farnsworth Street, Boston, MA 02210 http://www.jsi.com * Findings were statistically significant (strong evidence) + Evidence of a dose-response relationship (strongest evidence) Page 96 Testicular Cancer and Exposure to Ionizing Radiation Summary: Evidence varies on whether there may be an connection between testicular cancer and exposure to ionizing radiation. This connection is supported by some evidence from studies of nuclear workers in England who have been exposed to ionizing radiation. The National Research Council’s, on the other hand, has determined that the testis are relatively insensitive to ionizing radiation. Testicular cancer is not designated as a “specified” cancer under the Energy Employees Occupational Illness Compensation Program Act. Historically, ...

Request for Applications Illinois Prostate and Testicular Cancer Program July 1, 2003 – June 30, 2004 Illinois Department of Public Health Office of Health Promotion Division of Chronic Disease Prevention and Control Men’s Health Program 535 West Jefferson, 2 nd Floor Springfield, Illinois 62761 Phone: 217-782-3300 Fax: 217-782-1235 Page 2 Illinois Prostate and Testicular Cancer Program Page 2 Illinois Department of Public Health Office of Health Promotion Illinois Prostate and Testicular Cancer Program April 1, 2003 Request for Application for State Fiscal Year 2004 Application Package Contents: • Background and Purpose • General Information • Instructions for Application • Grant Application Forms Page 3 Illinois ...

information helpline Action Cancer has introduced an information helpline specifically to answer your questions or concerns on testicular or prostate cancer . Telephone 028 9024 4200 and ask to speak to someone in the men’s health department. clinic Action Cancer also offers clinics at Action Cancer House, 1 Marlborough Park, Belfast, staffed by qualified medical personnel. For further information, or to make an appointment, telephone: 028 9024 4200. email: info@actioncancer.org www.actioncancer.org the service is completely confidential for further information Action Cancer has been helping people in Northern Ireland to fight for freedom from cancer since 1973. Action Cancer provides: early detection Early detection services can save lives. Action Cancer offers a clinic ...

1 TESTICULAR CANCER Neil Fleshner MD MPH FRCSC Associate Professor of Surgery University of Toronto Head, Division of Urology University Health Network Head, Genitourinary Cancer Program Princess Margaret Hospital Head of Research, Department of Surgical Oncology, University Health Network TESTICULAR CANCERS • Most common solid tumours among men 18-40 • Vast majority: Germ Cell Tumours • Cell of origin: seminferous tubular epithelium • Risk Factor: cryptorchidism(18 fold) – Both sides at higher risk Page 2 2 GERM CELL TUMOURS: HISTOLOGY • SEMINOMA (50%) – Anaplastic – Spermatocytic – Classic • NON-SEMINOMA (NSGCT) (50%) – Embryonal – Choriocarcinoma – Yolk Sac – Teratoma Page 3 3 GERM CELL ...

Request for Applications Illinois Prostate and Testicular Cancer Education and Awareness Program July 1, 2002 – June 30, 2003 Illinois Department of Public Health Office of Health Promotion Division of Chronic Disease Prevention and Control Men’s Health Program 535 West Jefferson, 2 nd Floor Springfield, Illinois 62761 Phone: 217-782-3300 Fax: 217-782-1235 Page 2 Illinois Prostate and Testicular Cancer Page 2 Education and Awareness Program Illinois Department of Public Health Office of Health Promotion Illinois Prostate and Testicular Cancer Education and Awareness Program April 1, 2002 Request for Application for State Fiscal Year 2003 Application Package Contents: • Background and Purpose • General Information • Instructions for Application ...

Current Status of Retroperitoneal Lymph Node Dissection and Testicular Cancer : When to Operate Richard Foster, MD, and Richard Bihrle, MD Background: Historically, retroperitoneal lymph node dissection (RPLND) has been used in the therapy of both low-stage and high-stage testicular cancer after chemotherapy. As other therapies have developed, the role of RPLND has also evolved. Methods: The authors review the current indications for RPLND in the therapy of testicular cancer . Results: Metastatic testicular cancer can be cured in 50% to 75% of cases by surgical removal using RPLND, depending on the volume of metastasis. In postchemotherapy disease, the surgical removal of teratoma or carcinoma also confers a therapeutic benefit to the patient. Conclusions: The therapeutic capability of RPLND in low-stage testicular cancer is underappreciated. In postchemotherapy ...

Alison Clark MSc, BN, RNT, RCNT, RNT, is Nurse Teacher, Nottingham School of Nursing (Undergraduate Division). Patricia Jones RGN, is former Staff Nurse, Oncology Unit, Nottingham City Hospital. Steve Newbold RGN, is Health Promotion Specialist, Health Promotion Unit, Nottingham Community Trust. James Spencer, Mark Wilson and Kevin Brandwood are members of the testicular cancer self-help group. august 30/vol14/no50/2000 nursing standard 41 art & science men’s health nursing standard: clinical · research · education There have been numerous articles and health education leaflets published in the past five years that have helped to raise awareness about testicular cancer , for example, Cook (1995), Halle (1999), Peate (1998), Paolozzi (1994), Snell (1999) and the Imperial Cancer Research Fund (1998). ...

April 2002 • ADVANCE for Nurse Practitioners 33 www.advanceforNP.com The Facts About Testicular Cancer ? Patient Information Additional Notes: ————————————————————————————————————— ————————————————————————————————————— ————————————————————————————————————— Testicular cancer is the most common form of cancer in young men between the ages of 15 and 35. Risk Factors The causes of testicular cancer are unknown. However, studies show that several factors increase a man’s risk for developing tes- ticular cancer , including: • An undescended testicle (cryptorchidism). Men with an undescended testicle are at greater risk, even if surgery is per- formed to place the testicle in the scrotum. • Abnormal testicular development • Klinefelter syndrome (a sex chromosome disorder that may be characterized by low ...

TESTICULAR CANCER What Is Cancer ? Cancer is a group of many related diseases. All forms of cancer involve out-of-control growth and spread of abnormal cells. Normal body cells grow, divide, and die in an orderly fashion. During the early years of a person's life, normal cells divide more rapidly until the person becomes an adult. After that, normal cells of most tissues divide only to replace worn-out or dying cells and to repair injuries. Cancer cells, however, continue to grow and divide, and can spread to other parts of the body. These cells accumulate and form tumors (lumps) that may compress, invade, and destroy normal tissue. If cells break away from such a tumor, they can travel through the bloodstream, or the lymph system to other areas of the body. There, they may settle and form "colony" tumors. In their new location, the cancer cells continue growing. The spread of a tumor to a new ...

Testicular Cancer : What Every Guy Should Know NATIVE HAWA IIAN CANCER AWARENESS SERIES For more information contact: Native Hawaiian Health Care System Moloka‘i Na¯ Pu‘uwai (808) 560-3653 O‘ahu Ke Ola Mamo (808) 845-3388 Hawai‘i Hui Ma¯lama Ola Na¯ ‘Oiwi (808) 969-9220 Kaua‘i, Ni‘ihau Ho‘o¯la La¯hui (808) 240-0100 Maui Hui No Ke Ola Pono (808) 244-4647 La¯na‘i Ke Ola Hou O La¯na‘i (808) 565-6608 Cancer Information 1-800-4- CANCER Service (1-800-422-6237) www. cancer .gov American Cancer 1-800-227-2345 Society www. cancer .org Halehuki circa 1940 FEB 2005 ‘Imi Hale Native Hawaiian Cancer Network A Program of Papa Ola Lo¯kahi This pamphlet was developed by ‘Imi Hale ...

Copyright © 1998 by W.B. Saunders Company. All rights reserved. 478 A BASIC INFORMATION DESCRIPTION Uncontrolled growth of malignant cells in the testicle. There are several types of testicular cancer , some more dangerous than others. This is the most common form of cancer in young men. Affects all ages, but more often is found in men ages 20-40. FREQUENT SIGNS AND SYMPTOMS • A firm swelling in one testicle discovered by accident or by self-examination. • No pain (90% of cases). • Sense of fullness in the scrotum. CAUSES Unknown. RISK INCREASES WITH • Undescended testicle(s) in infancy even if the testicle was surgically moved into the scrotum. • Caucasian race. • Estrogen administration to the mother during preg- nancy. PREVENTIVE MEASURES Males should examine testicles routinely at least once a month. Will not ...

Testicular Cancer What is Testicular Cancer ? Testicular Cancer is a cancer in one or both testicles that usually occurs between the ages of fifteen (15) and forty (40). Statistics show that 95% of testicular tumors begin in cells within the testicles. It can be treated and cured, when detected at an early stage. Most men discover a lump themselves. A man should talk with his medical doctor, if he notices anything unusual about his testicles between regular checkups. Anatomy. The testicles, also called testes, are a pair of male sex glands. They produce sperm and male hormones. The testicles are located under the penis in a sac-like pouch called the scrotum. Risk Factors A man is at risk if: • his testicle did not move down into the scrotum. • he had surgery to move the testicle down into the scrotum. • he had previous testicular cancer . ...

www.mcare.org Cancer of the testicles, the primary male sex glands, accounts for only about 1 percent of all cancers in men. It is, though, the most common type of cancer in males aged 20 to 35, but can occur in other age groups. It strikes about 5,000 males a year. Often, only one testicle is affected. The cause of testicular cancer is not known. Risk factors, though, have been given. These are : • Undescended testicles (that are not cor- rected) in infants and young children. (Parents should see that their infant boys are checked at birth for undescended tes- ticles.) • A family history of testicular cancer • Having an identical twin with tes- ticular cancer • Injury to the scrotum Testicular cancer is almost always curable if it is found and treated early. Surgery is done to remove the testicle. Other things can further ...