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PEDIATRIC HOME ABOUT PEDIATRIC THYROID CANCER Overview Statistics Causes Thyroid Nodules Symptoms Evaluation TREATMENTAND FOLLOW-UP Papillary, Follicular, Variants Treatment Overview Radiation: RAI, EBR Low-Iodine Diet TSH/ Thyroid Hormone Follow-UpTesting Medullary Treatment Overview Follow-UpTesting GeneticTesting of Relatives Physician Selection Doctor-Patient Relationships QuestionsToAskYour Doctor SUPPORT & INFORMATION FOR PATIENTS and CAREGIVERS E-Mail Support Group Family Stories Support for Caregivers MORE RESOURCES Web sites, Books, Research Papers THYCAHOME www.thyca.org Pediatric Thyroid Cancer Overview Welcome to the Pediatric Thyroid Cancer Web site. These pages offer information for everyone interested in learning more about thyroid cancer ...

A META-ANALYSIS OF THYROID CANCER GENE EXPRESSION PROFILING STUDIES IDENTIFIES IMPORTANT DIAGNOSTIC BIOMARKERS Obi L. Griffith 1,2 , Adrienne Melck 3 , Steven J.M. Jones 1,2 and Sam M. Wiseman 3,4,5 1.Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada; 2.Department of Medical Genetics, Faculty of Medicine, UBC, Vancouver, BC, Canada; 3.Department of Surgery, Faculty of Medicine, UBC, Vancouver, BC, Canada; 4.Genetic Pathology Evaluation Center, Prostate Research Center of Vancouver General Hospital & BC Cancer Agency, Vancouver, BC, Canada; 5.Department of Surgery, St. Paul's Hospital, Vancouver, BC, Canada. Introduction: An estimated 4-7% of the population will develop a clinically significant thyroid nodule during their lifetime. In as much as one third of these cases pre-operative diagnoses by needle ...

91 Arq Bras Endocrinol Metab vol 50 nº 1 Fevereiro 2006 ABSTRACT Thyroxine (T4) withdrawal or recombinant TSH is used for the stimulation of thyroglobulin (Tg), whole-body scanning (WBS) and iodine-131 treatment in patients with thyroid carcinoma. This study evaluated the T4 dose reduction protocol as an alternative for patients’ preparation. Fifty-one patients were submitted to total T4 withdrawal for WBS and Tg measure- ment. T4 treatment was then resumed and maintained until TSH reached levels = 0.3 mIU/l. The T4 dose was then decreased to 0.8 µg/kg/day and TSH was measured weekly. Tg was assayed when TSH was > 30 mIU/l. Patients diagnosed with the disease upon initial evaluation were treated. We also evaluated the clinical and laboratory changes observed for both preparations. Using the reduced dose protocol, TSH levels > 30 mIU/l were reached within 6 and 8 weeks in 84.6 and 100% of ...

Please complete and return to: CQ Travel srl – Via Pagliano 3 – 20149 Milano Email: congress@cq-travel.com Fax. +39-02-43911650 2 nd Milan Thyroid Cancer Conference Milan - 2nd /4th July 2006 HOTEL ACCOMMODATION FORM Surname Name Address Zip code Town Country Tel Fax E-mail Only for italian participants: Partita IVA o Codice fiscale HOTEL LIST Rates are in Euro and are per day, including breakfast and taxes. A bus shuttle transfer will be provided to/from the conference venue. HOTEL CAT. DOUBLE DOUBLE SINGLE USE Hotel Quark (Via Lampedusa 11/a – Milano) 4 € 170,00 € 140,00 Hotel Sporting (Via Sporting Mirasole – Opera) 4 € 145,00 € 105,00 Arrival date Departure date Total number of nights Signature Reservation deadline: ...

META-ANALYSIS OF THYROID CANCER EXPRESSION PROFILING STUDIES – IDENTIFICATION OF MOST PROMISING BIOMARKERS FOR TISSUE MICROARRAY ANALYSIS Obi L. Griffith, Sam M. Wiseman and Steven J.M. Jones Objective and Design It is estimated that 5-10% of the population will develop a clinically significant thyroid nodule during their lifetime. In one third or more of these patients, pre-operative diagnoses by needle biopsy are inconclusive. In many cases, a patient will undergo unnecessary surgery for what ultimately proves to be a benign lesion. Thus, there is a clear need for improved diagnostic tests to distinguish malignant from benign samples. The recent development of tissue microarray techniques should allow the rapid evaluation of potential new markers. However, researchers are faced with an overwhelming number of potential markers from numerous thyroid cancer profiling and classification studies. ...

You're invited to attend the Thyroid Cancer Mid-Atlantic Survivors' Workshop Come and hear presentations by physician specialists, and receive answers to your questions. Learn and share with other thyroid cancer survivors and families in roundtables. This educational and supportive day is for people at all stages of testing, treatment, and follow-up for all types of thyroid cancer . We also welcome caregivers, friends, and everyone interested. Saturday, May 13, 2006 FREE 9 a.m.— 5 p.m. Takoma Park, Maryland (near Washington, DC) Washington Adventist Hospital, 7600 Carroll Avenue, Takoma Park, MD 20912. FREE Parking. • Physician Speakers: Kenneth D. Burman, M.D., Director of Endocrinology, Washington Hospital Center, DC; Professor, Uniformed Services University of the Health Sciences, Georgetown University Medical ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 January/March, Volume 2, Issue 1 42 Diagnostic - and Tactic Mistakes in Thyroid Cancer Levan Bakanidze, Konstantine Mardaleishvili National Cancer Center, Tbilisi, Georgia Address for Correspondence: Levan Bakanidze National Cancer Center, Lisi Lake 380077 Tbilisi, Georgia Tel: +995 99 504646 E-mail: levanb@nacc.org.ge Abstract The aim of the study was to determine the reasons of thyroid cancer locally advanced forms development. In group of the patients with such forms of disease were selected the cases with diagnostic- and tactic mistakes of medical doctors. According to received results, mistakes generally are concerned with unmotivated and long time follow-up and endocrinology treatment of patients with the thyroid nodule (24,9%), ignoring of ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 January/March, Volume 2, Issue 1 63 Periareolar Mammoplasty in Surgical Treatment of Gynecomastia Iva Kuzanov, Alexander Kalantarov Chair of Reconstructive-plastic Microsurgery of Tbilisi State Medical Academy; Clinic of aesthetic, reconstructive and plastic surgery "CARAPS MEDLINE", Tbilisi Address for Correspondence: Alexander M. Kalantarov Clinic of aesthetic, reconstructive and plastic surgery "CARAPS MEDLINE" 5, Chavchavadze av., Tbilisi, 380079, Georgia Tel: +995 32 224417, +995 99 905126; Fax: +995 32 225769; E-mail: doctor@wanex.net Abstract Trans- and periareolar accesses have proven to be versatile in treating many types of breast deformities such as resection of benign tumors or excess glandular tissue (as in gynecomastia). We used modified periareolar ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 January/March, Volume 2, Issue 1 34 Administration of Hypoxytherapy in Patients with Bronchial Asthma George Kalandarishvili, Gedevan Gelbakhiani, Marina Janjgava, George Gurgenidze, Zurab Zedania Department of Diagnostics and Therapy of Internal Diseases of Tbilisi State Medical University Abstract The aim of the study was to determine the reasons of thyroid cancer locally advanced forms development. In- group of the patients with such forms of disease were selected the cases with diagnostic- and tactic mistakes of medical doctors. According to received results, mistakes generally are concerned with unmotivated and long time follow-up and endocrinology treatment of patients with the thyroid nodule (24,9%), ignoring of diagnostic methods (41,6%) and non-radical surgeries (29,8%). ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 January/March, Volume 2, Issue 1 45 Testosterone, Adrenocorticotrophic Hormone and Cortisol Changes in Number the Prostate Cancer Alexander Khuskivadze, Givi Gzirishvili Department of Urology of Tbilisi State Medical University Abstract The experiments proved that in the blood serum of patients with prostate gland cancer unlike those from controlled group, the ACTH, cortisol and testosterone concentration increases. The ACTH changes in number in blood serum of patients with prostate cancer and it is notably different with correlation 1:2,17; cortisol - 1:6 and testosterone 1:2. According to the presented data the considerable increase of testosterone, ACTH and cortisol during the prostate cancer once again confirms and indicates that not only androstendion of adrenal ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 October/December, Volume 3, Issue 4 233 The Malignant Tumor Growth and Reactive Forms of Oxygen and Nitrogen Nino Bezhitashvili, Vakhtang Kipiani, Ketevan Gambashidze, Tamar Sanikidze, Natalia Pavliashvili Department of Pathophysiology, Tbilisi State Medical University, Georgia ABSTRACT The purpose of this study was investigation of lipid peroxidation and nitric oxide (NO) concentration in blood and cancer tissue (in center and periphery) during sarcoma C-45 growth with the use of Electronic- paramagnetic-resonance method (EPR). Experiments have been carried out on 30 rats of mixed population (body mass 120-150 g). For detection of free NO concentration in blood, the spin-traps - Na diethyl-dithio- carbamate was used. The received data were analyzed statistically using ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 January/March, Volume 3, Issue 1 8 Breast Cancer Screening Nino Kartvelishvili, Gia Nemsadze, Vasil Tkeshelashvili, Neli Chachanidze, Giorgi Dzagnidze National Cancer Center, Tbilisi, Georgia Abstract Has been detected, that usage of special questionnaire (algorithmically based epidemiological questionnaire for detection of risk factors) of female population and routine and cost-effective methods (physical + cytological examination), formation of high-risk groups, contribute to effective secondary prevention of breast cancer . The selection of high-risk groups and screening permits detection of precancer diseases and chronic inflammation processes resulting cancer prevention. The optimal scheme of screening makes possible the breast cancer early detection and treatment, ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 October/December, Volume 2, Issue 4 345 Microflora of Pericancerous Zone in Patients with Gastric Cancer Zurab Khetsuriani*, Alexander Tsalugelashvili*, Zurab Chkheidze*, Klara Khetsuriani** * National Cancer Center of Georgia ** Department of Molecular Microbiology of Institute of Experimental and Clinical medicine, Tbilisi State Medical University, Georgia Abstract This article shows the prevalence of H.pylori strains in microflora of patients with gastric cancer (72,85±5,31 cases) on example of National Cancer Center of Georgia. The 10 spacies of microorganisms (H.pylori, Staphylococcus spp., Streptococcus spp., E.coli, Proteus spp., Clostridium spp., Lactobacillus spp., Bacteroides spp., Trichomonas spp., Candida spp.) were obtained (all - 113 strains). ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 275 Hematological Parameters in Patients with Helicobacter Pylori-Associated Gastric Cancer Zurab Khetsuriani*, Alexander Tsalugelashvili*, Remi Gvamichava**, Klara Khetsuriani*** * National Cancer Center of Georgia; ** Department of Oncology, Tbilisi State Medical University; ** Department of Molecular Microbiology of Institute of Experimental and Clinical Medicine, Tbilisi State Medical University Abstract Hematological parameters in patients with H.pylori-associated gastric cancer in comparison with H.pylori- negative patients with same pathology were studied. There aware high differences between these two groups. In patients with H.pylori-associated gastric cancer were a higher disturbance of hematological parameters, ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 Biological Therapy of Prostate Cancer Vakhtang Shoshiashvili, Vili Pachkoria National Center of Oncology, Tbilisi, Georgia; Department of Topographical Anatomy of Tbilisi State Medical University, Georgia Abstract Biological therapy strategies of prostate cancer are based on antigenic structure of malignant cells and contribute correction of immune reaction and enhancement of immunogenity of malignant cells. There are used as specific as non-specific methods of immune therapy such as: cytokine therapy, vaccine therapy, gene therapy, treatment with dendrite cells and their combinations together with other traditional methods. Mainly, the subjects for clinical studies are patients with disseminated androgen-undefended prostate cancer . The obtained data ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 July/September, Volume 3, Issue 3 The Influence of Mechanic Jaundice on Liver Regeneration after Partial Hepatectomy George Megrelishvili, Diana Dzidziguri, Dimitri Kordzaya, Ekaterine Bakuradze K. Eristavi National Center of Experimental and Clinical Surgery I. Javakhishvili Tbilisi State University, Georgia Abstract The present study was aimed to detect the molecular mechanisms of early response genes expression inactivation under influence of cholestasis in hepatocytes stimulated towards proliferation. Has been revealed, that occlusion of common bile duct affects the expression of early response genes in hepatocytes stimulated towards proliferation. Suppressive effect of cholestasis upon liver regeneration is realized only at the level of expression of cell proliferation ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 July/September, Volume 3, Issue 3 Biological Features of Local Helicobacter Pylori Strains Shorena Khetsuriani*, Baadur Rachvelishvili**, Zurab Khetsuriani***, Klara Khetsuriani* * Department of Molecular Microbiology of Institute of Experimental and Clinical Medicine, Tbilisi State Medical University, Georgia; ** Institute of Radiation and Intervention diagnostic, The Georgian Academy of Sciences; *** National Cancer Center of Georgia Abstract H.pylori is variable in all aspects – from genetically profile, to biological features. It is established they differ in relation to geographical regions, sex, age ethics, social and economical characteristics. Because of changing of spread and different biological features of this bacterium. This effects on the clinic of difference ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 January/March, Volume 2, Issue 1 38 The Perioperative Immunocorrection by Plaferon for Colorectal Cancer Patients Ilia Bakradze*, Vladimer Bakhutashvili**, Archil Aladashvili*, Mikheil Shavdia*, Tengiz Aroshidze* * Department of Oncology, Tbilisi State Medical University. ** Institute of Morphology and Medical Biotechnology of Georgian Academy of Sciences Abstract We investigated the clinical and immunological effects (non-specific resistance and specific immunological status) of "Placentar Interferon" (native product) therapy in large intestine cancer patients. Several immune parameters (The number of C.D.16, C.D.19 and C.D.3, subsets C.D.4 and C.D.8, C.D.4/C.D.8 ratio, C.E.A. and C.A. 19.9 antigens) were analyzed in patients treated by immunocorective therapy in addition ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 October/December, Volume 3, Issue 4 Profile of Interleukin-4 and Interferon-Gamma in Patients with Benign Prostatic Hyperplasia David Ebralidze Department of Urology, Tbilisi State medical University, Georgia ABSTRACT Etiologic factors of Benign Prostatic Hyperplasia (BPH) are still obscure. According to literature, infiltrated lymphocytes found in prostate during BPH, may produce improper type of cytokines, which can activate several type of growth factors and thus promote the initiation of hyperplastic processes. Some of cytokines has anti-apoptotic features also. The expression of improper type of cytokines by infiltrated lymphocytes in Prostate and thus the development of Th2 type immune response was observed. Type 2 T-cells cytokines can be found in up to 35% of BPH tissue compared ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 April/June, Volume 2, Issue 2 148 Variations of Prostate-Specific Antigen and Cytokines in Patients with Benign Prostatic Hyperplasia David Ebralidze, David Kochiashvili Department of urology, Tbilisi State Medical University Abstract The etiology of benign prostatic hyperplasia (BPH) is still obscure. Data supporting an interaction connecting prostate hyperplasia and immune disregulation is accumulating. Serum levels of pro-inflammatory and anti- inflammatory cytokines measured by enzyme-linked immunosorbent assay in 3 groups of patients with BPH. The groups included 12 men who had mean prostate specific antigen (PSA) serum concentration 95±13 ng/ml, 14 man, with mean PSA - 4,4±1,2 ng/ml and 11 man, with mean PSA - 10,7±2,3 ng/ml. It was found that level of anti-inflammatory ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 The Importance of Immunofermental and Ultrasound Examinations in the Diagnosis and Estimation of Effective Treatment of Non-Hodgkin's Lymphomas in Children Tengiz Zukhbaia, Alexander Chikvashvili, Nana Atuashvili National Center of Oncology, Tbilisi, Georgia Abstract Lymph sarcoma represents the comprehensive problem in pediatric oncology. The results of treatment at the present time are much norse compared to other diseases. According to results of our study the tumor marker on NSE immunofermentive analyses is the specific test for diagnoses and biological behavior monitoring of the disease. NSE expression is directly correlated with neoplastic changes in certain cases and the prognosis of progress of disease is possible according to its levels ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 196 Biophysical and Biochemical Parameters of Organism During Experimental Malignant Tumor Growth Ketevan Gambashidze, Nino Kipiani, Maka Topuridze Department of Pathophysiology, Tbilisi State Medical University Abstract Have been studied biophysical parameters of blood, liver, spleen and cancer tissue by the method of Electronic-Paramagnetic-Resonance (EPR), activity of antioxidant enzyme catalase by the method of H. Aebi and ceruloplasmin concentration in the blood serum by the method of N. Babenko in white rats with Sarcoma C-45. Investigations revealed, that during Sarcoma C-45 growth antioxidant properties of blood are reduced, mitochondrial superoxiddismutase of tissues is inactivated, production of Mn 2+ , NO, ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 April/June, Volume 2, Issue 2 167 Determination of Heavy Metals in Biological Objects by Method of Differential Impulse Polarography Nino Shavgulidze, Omar Gabrichidze, George Gabrichidze, Vladimer Shavgulidze Tbilisi State Medical University, Georgian Technical University Abstract The new microanalytical methods have been worked out for determination of copper, lead, cadmium and zinc in the samples of biological materials by method of differential impulse polarography. Key words: blood serum, hairs, polarography copper, lead, cadmium, zinc Introduction owadays the polarographical methods of analysis are the most wide-spread in analytical practice. Among them the method of differential impulse polarography is especially ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 January/March, Volume 3, Issue 1 1 Possible Role of Placental Apoptosis in Etiopathogenesis of Preeclampsia Akaki Bakradze, Nino Merabishvili Department of Gynecology, Tbilisi State Medical University, Georgia Address for Correspondence : Maternity House #2, Tbilisi, Georgia, Tel: +995 32 964717, E-mail: akaki.bakradze@mymail.ge Abstract The course of pregnancy in 6-8% cases is complicated by preeclampsia, and every year it is responsible for about 50000 maternal deaths all over the world. Etiology of preeclampsia is unknown. Currently the following hypotheses related to the etiology of preeclampsia are popular: a) placental ischemia; b) endothelial dysfunction; c) immunologic maladaptation; d) genetic and e) elevated peroxide oxidation of lipids. ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 January/March, Volume 3, Issue 1 48 Moral Problems of Gene Therapy Bella Mamulashvili Department of Social Sciences, Tbilisi State Medical University, Georgia Abstract Increasing progress of medical genetics is accompanied by numerous moral and juridical problems, solving of which is associated with great human pain and conceiving values of the mankind. This problem became more acute after conducting reproductive cloning. Using of screening programs for genetic diseases often there is a moral conflict, associated with observing of the confidentiality and fulfillment of obligations, which makes the physician obliged to tell the patient about possibility of heavy disease. At the same time medical-genetic aid is a right of each human, what, correspondingly should be guaranteed by ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 October/December, Volume 3, Issue 4 Tobacco Consumption and Drug Addiction Among Girls-Teenagers in Georgia Nino Mirzikashvili Department of Public health and Management, Tbilisi State Medical University, Georgia ABSTRACT In the beginning of XXI century the tobacco consumption and drug addiction are considered as the main problems of public health in the world. According to the data of WHO, there exist 1,1 billion smokers and 1/3 of them are teenagers. With the purpose of studying and estimating the real situation in Georgia on distribution of tobacco consumption and drug abuse have been carried out biographical anonymous interrogation of 300 girls - teenagers. The questionnaire consisted of 12 questions. Only 45,5% interrogated never tried a cigarette. The hobby for smoking usually ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 July/September, Volume 3, Issue 3 Restoration of Continuity of the Colon after Hartman's Operation George Bakradze*, Alexander Tsalugelashvili*, Ilia Bakradze** *Proctology Clinic of National Cancer Center, Tbilisi, Georgia ** Oncology Department of Tbilisi State Medical University, Georgia Abstract Have been investigated a total of 36 patients who underwent restoration of colon continuity during the period from 7 month to 3 year after the colorectal cancer resection by the Hartman's method. Of the 22 patients (61,2%) with standard Hartman's operation, in 6 cases (16,6%), the basic operation was combined with resection of adjacent and distant organs. For exclusion of metastases or recurrences, preoperative complex examination of patients were performed. The colon continuity was ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 January/March, Volume 3, Issue 1 42 Basic Principles of Diagnostic of Extra-organ Small Pelvis Tumors Ilia Bakradze, Tamar Rukhadze Department of Oncology, Tbilisi State Medical University, Georgia Address for Correspondence: National Cancer Center, Lisi Lake, 380060, Tbilisi, Georgia, Tel: +995 32 358742, E-mail: tanmuna_39a@hotmail.com Abstract Clinics, diagnostics and surgical treatment of extra-organ small pelvis tumors is one of the most acute problems of the oncology. The main signs of extra-organs tumors of the small pelvis reveal in their pressing the adjacent organs what would cause pain in and dysfunction of the latter. All these would create difficulties and sometimes even unsolvable problems during their diagnosing. We have studied 24 ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 April/June, Volume 2, Issue 2 163 Ultrasonic Diagnostics of Lymphogranulomata Spreading in Children Alexi Mindadze Oncological National Center of Tbilisi Abstract 192 patients have been examined for the purpose of exposing diagnostic means of ultrasonic with Lymphogranulomata in children. Spleenomegalia has been observed in 75 children, Hepatomegalia- in 13 ones. Affection of spleen had characteristics of the hearth. Lesion of liver has been defined to 4 patients. From the retroperitoneal lymphatic knots, para-aortal ones have been more often affected (87,0%), lesion of iliac lymphoknots has rarer been observed (35,2%). Decrease of frequency of lymphatic knots affection including para-aortal and iliac ones is the evidence of spreading Lymphogranulomata towards kranio-caudal ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 January/March, Volume 2, Issue 1 1 Frequency of Anomalies of Maxillo- Dental System Among the Children with Endemic Goiter in Georgia Manana kalandadze, Tinatin Mikadze, Vladimer Margvelashvili Department of pediatric dentistry and prevention of dental diseases of TSMU here are many factors that provide normal development of a child. Among them the leader one is the right formation of a digestive tract and especially right formation of all the circular structure of chewing mechanism, for their normal functioning greatly depends on health of milk and permanent teeth. Milk teeth play an important role in formation of height of malocclusion and rows of teeth. They provide normal development (growing) of jaws, duly incision of permanent teeth and their right situation ...