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ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2004 January/March, Volume 4, Issue 1 Joint Faculty in Founded Tbilisi State Medical University and Columbia-Missouri (USA) T he delegation of TSMU has been in USA from 23dr of May till 11th of June in 2004. The visit had several significant goals. The most important thing among them was the foundation of joint faculty with Columbia- Missouri University. It should be marked that the document has been signed by the Rector of TSMU, professor Ramaz Khetsuriani, by the Chancellor of Columbia-Missouri Medical School, Professor, William Christ, by the head of International organization “ACTS-International”-Patricia Blear. On the basis of this document joint Georgian- American faculty has been founded for preparing family physicians on post-graduating course. It was significant, that at the meeting in the Academy of American ...

ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2004 January/March, Volume 4, Issue 1 Tbilisi State Medical University EUA Evaluation Report EUA - European University Association Institutional Evaluation Programme TSMU, which was established in 1918 as a part of the Tbilisi State University, is the first university in Georgia to request a EUA Institutional Evaluation. The university gained its status as an independent medical school - Tbilisi State Medical Institute - in 1930, following the traditional soviet organisational model. In 1992 it was given its present name of Tbilisi State Medical University. At present the university has 9 faculties and just over 5,000 undergraduate students. I FO n 1994, the CRE, one of the founding members of the European University Association (EUA), started to offer its member institutions the possibility of being ...

ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2004 January/March, Volume 4, Issue 1 Curriculum Modifications in Tbilisi State Medical University Tbilisi state Medical University, Georgia T bilisi State Medical University, the first medical school in Georgia was established in 1918. Since 1930 it gained the status of independent high medical educational institution. At present the university has 9 faculties and just over 5,000 undergraduate students. In order to converge with European standards TSMU has implemented a full ranging reform of study programmes. Since 2000 the European Credit-Transfer System has been implemented at all faculties of TSMU. The core curriculum for Medicine has been revised in accordance with the European standards (the European Commission 93/16 Directive): the number of hours has been reduced from 8000 to 5760, the seven years ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 April/June, Volume 2, Issue 2 95 Contemporary Understanding ?f Etiopatogenesis ?f Preeclampsia Nino Merabishvili, Tamar Sanikidze, Ekaterine Sioridze Department of Gynecology, Tbilisi State Medical University Abstract Cardiovascular adaptations to pregnancy are essential to assure delivery of oxygen and nutrients to the placenta and fetus. Preeclampsia is a common (5-8% of all pregnancies) disorder of human pregnancy where the normal homodynamic development is compromised. The recent studies ascertain that abnormal migration of trophoblasts early in pregnancy predispose later pathologic changes in vascular endothelium function. Circulating factors produced during reduced perfusion of placenta may impair maternal vascular endothelial function, which in turn will cause such ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 July/September, Volume 3, Issue 3 Prospective Study of Combined Use of Bronchial Lavages and Brushings in Diagnosis and Typing of Centrally Located Lung Tumors Kakha Vacharadze**, Georgi Burkadze*, Gulisa Turashvili* *Tbilisi State Medical University, Department of Pathological Anatomy, **National Center of Tuberculosis and Lung Diseases, Georgia Abstract Objective: To determine the diagnostic accuracy of examining bronchial lavage (BAL) and brushing in pulmonary cytopathology and whether BAL and brushing can complement each other in routine practice among lung specialists. Design: A prospective study comparing 528 BAL and brushing results, conducted during 1999-2003. Tumors were confirmed by cytopathology, imaging techniques, or clinical outcome and imaging techniques ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 189 Biochemical Changes in Retinal Tissue During Vitreoretinal Pathology George Chichua,* Tamar Sanikidze,** Vladimer Bakhutashvili*** *The Clinic of Eye Diseases "MZERA"Ltd.; ** Scientific-Research Institute of Experimental and Clinical Medicine, Tbilisi State Medical University; ***Institute of Medical Biotechnology of the Academy of Sciences Abstract We have investigated the mechanism of the protective effect of Plaferon LB, a synthesized preparation from the amniotic membrane of human placenta, on the retinal tissue in the experimental model of the proliferative vitreoretinopathy (PVR). On the basis of ESR spectroscopic studies it became clear that the lowering of the level of the regenerated NAD.H, decrease of the intensity of ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 July/September, Volume 3, Issue 3 The Influence of Early Therapeutic Intervention on Outcome of Cerebral Palsy Maia Gabunia Center of Child Neurology and Neurorehabilitation, Tbilisi, Georgia Abstract The aim of the study was to determine the effectiveness of early therapeutic intervention in children with cerebral palsy, as long-term study on effectiveness of therapeutic intervention, has not yet performed. While estimating functional independence of patients at the age of five years and severity of cerebral palsy in cases of early (before 1 year of age - Group I) and late (after 1 year of age - Group II) intervention revealed, that: the early and adequate management of cerebral palsy does not change the severity of cerebral palsy, but statistically significantly improves the ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 October/December, Volume 2, Issue 4 323 Existing Conditions of the Implementing Health Education and Life Skill in the Secondary Schools of Georgia Nino Uznadze, Irma Manjavidze The Chair of UNESCO Health Life, Tbilisi State Medical University, Georgia Abstract It is presented situational analysis about child and adolescence health condition, cause of sicknesses and mortality and spreading the diseases. In order to evaluate school environment in the secondary schools it was used various methods (confident ional assessment, interview and group works) with teachers, school children, parents and school directors. During the pupil's interviews it was seen the existence of general factors in the motivation of the education, autocratic regime, non-existence of free choice, ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 October/December, Volume 2, Issue 4 331 Nerve Conduction Abnormalities in Children with Type I Diabetes David Chkhartishvili, Nana Khachapuridze, George Natriashvili, Nana Geladze, Nana Kapanadze Department of Child Neurology, Tbilisi State Medical University, Georgia Abstract Neuropathy is the most frequent symptomatic complication of diabetes. Diabetic polyneuropathy (DPN) is the most common variety of neuropathy, which represents chronic symmetrical sensorimotor polyneuropathy. (DPN) typically begins as a generalized asymptomatic dysfunction of peripheral nerve fibers, which may be revealed by electroneurography. However, nerve conduction study (NCS) is a sensitive method for early detecting of peripheral neuropathy. We have performed NCS in 69 children with poorly compensated ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 April/June, Volume 2, Issue 2 130 Dynamics of Lipid Change Indexes on the Background of Physical Rehabilitation of Patients Affected with Myocardial Infarction Naira Chabashvili Medical Rehabilitation Department of Tbilisi State Medical University Abstract In our study have been determined changes of lipid indexes (total cholesterol, a-cholesterol, ß-cholesterol, pre-ß-cholesterol, triglycerids) in blood serum on the background of physical rehabilitation in 307 patients with myocardial infarction. The results of study showed that the statistical improvement of these data takes place in patients undergone physical rehabilitation together with the appropriate diet and hypolipidemic therapy. Keywords: myocardial infarction, lipid indexes, physical rehabilitation, ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 January/March, Volume 3, Issue 1 77 International Conventions and Development of the Legislative Base of Chemical Safety for the Population in Georgia Alexander Mindorashvili Inspectorate for the State Supervision of Sanitary-Hygienic Norms and Rules Ministry of Labor, Health and Social Affairs, Tbilisi, Georgia Address for Correspondence : 23, A. Kazbegi, Tbilisi, Georgia, Tel: +995 32 393205, E-mail: Ann-gfa@gol.ge Abstract Chemical safety of the population on an up to date stage is of particular significance. Fulfillment of International Conventions and development of corresponding legal base related to the indicated problems is one of the basis for creating the safe environment for the population of each country as well as the ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 217 Causes of Death in Patients with Diphtheria Malvina Javakhadze Tbilisi State Medical Academy of Post-diploma Education, Department of Infectious Diseases Abstract On the basis of analyzing the patients who died of diphtheria in the Center of Infection Pathology in 1993-2001 we have studied clinical and functional peculiarities, course and results of diphtheria complications. Reasons causing death during diphtheria were determined. 1) In 92% of death cases miocarditis was developed, in 89% of them it caused death; among them early miocarditis prevailed (62%). 2) Infection-toxic shock was developed in 11% and in all the cases it caused death. 3) Polyneuritis was developed in 32% of the patients and nephrosis in 27%, but none of them died ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 April/June, Volume 2, Issue 2 114 The Surgical Treatment of Traumatic Injury of the Spleen Givi Tsetskhladze, Zurab Chomakhashvili, Akaki Beridze, Nodar Lomidze Medical Faculty of Shota Rustaveli Batumi State University; Department of Private Surgery of Tbilisi Medical State University: The Clinic N1 of surgical maladies of Tbilisi Medical State University Abstract The questions connected with the surgical treatment of traumatic Injury of the spleen are of great variety. But at the same time according to the data from thematic literature, splenectomy is the best way of treatment, but it does not give satisfactory result. According to the above mentioned information we have come across 2 methods of surgical treatment of the spleen trauma. The first method is transference ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 251 The Criteria for Assessment of Operative Treatment's Outcome of Dysplastic Coxarthrosis with Endoprothesis of Hip Joint Tornike Nozadze, Tamaz Katsitadze The Scientific - Pedagogical Center of Urgent Surgery and Traumatology, State Medical Academy of Georgia Abstract On the basis of results of Endoprothesis in 131 patients, in age from 22 to 78 years, the criteria for assessment of results of treatment are defined, the system is worked out, which makes possible to estimate efficiency of treatment for each patient. The presence of a pain, ability to walk and work has the most diagnostic value. Key words: endoprothesis, coxarthrosis, diagnostic criteria Introduction espite, the certain history of Endoprothesis, ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 207 Adverse Drug Reaction Monitoring Program in Georgia Nikoloz Gongadze,* Zaza Chapichadze,* Bondo Kobulia,** Levan Schalamberidze,* Irina Jashi,** Tamar Tchelidze** *Pharmacological Committee, Ministry of Health of Georgia **National Drug Monitoring Center of Pharmacovigilance Abstract Background: Due to the fact that the information about the adverse drug reactions (ADR) registered during pre-marketing period is incomplete and according the recommendations and guidelines of the WHO, the drug monitoring program and the system of pharmacovigilance was established in Georgia according the order of the minister of health in 1997 to monitor the safety of medicinal products and detect adverse drug reactions. Methods: According the international ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 235 Immunomorphological Peculiarities of Spleen According to Microbial State and Age of Body Besik Kochlamazashvili Department of Pathology, Tbilisi State Medical University, Georgia Abstract The aim of study is immunomorphologic investigation of regular (conventional) and Germfree (gnotobionts) white rats during aging. The results of study showed that generally spleen lymphoid tissue of gnotobionts unlike conventional ones don't reduce during aging. In follicles, despite of simplifying antigenic loading, has been increased (in comparison with the control) phagocytic activity, enhancing with the aging process. Has been indicated aging increasing of T-lymphocytes' number on the background of unchanged number (comparing with the control, ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 Surgical Treatment of Head and Neck Regions' Locally Spread Skin Carcinoma Tamar Baramidze, Konstantin Mardaleishvili, Lia Kharchilava National Center of Oncology, Tbilisi, Georgia Abstract Has been stated, that increase in frequency of skin carcinoma of head and neck regions is accompanied by the marked increase in number of patients suffering from spread form of disease. Supporting conditions are the low level of daily conditions; absence of oncological vigilance, delayed applies of patients for treatment to specialized institutions etc. Up-dating of methodological aspects of combined and combined-extended operations, studying of technique and tactic issues of plastic reconstructive operations used in case of various localization skin carcinoma of head ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 Effect of Plaferon LB in Ischemia/Reperfusion of the Pancreas Rusudan Rukhadze, Tamar Sanikidze, Malkhaz Mirtskhulava, Manana Papava TSMU Scientific Research Institute of Experimental and Clinical Medicine, Georgia Abstract The aim of the present study was to find out whether plaferon LB, a well-known antioxidant and membrane stabilizer could be applied in pancreas preservation for protection pancreatic tissue from cell damage, which occurs during ischemia/reperfusion. To evaluate the protective effect of plaferon LB part of animals received widely used protectors a tocopherol, unithiol and vitamin C. According to received data plaferon LB appears to protect the pancreas from ischemia reperfusion injury by reducing the peroxidation of the pospholipids ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 October/December, Volume 3, Issue 4 Clinical - Immunological Aspects of the Effectiveness of "Unguentum Rhodopesum 5,0%" during the Herpetic Stomatitis Natia Nizharadze, Boris Korsantia, Nutsa Chipashvili, Ketevan Shalashvili Department of Therapeutic Dentistry, Tbilisi State Medical University, Georgia; Institute of Medical Biotechnology of Georgian Academy of Sciences; Institute of Farmacochemistry at the Academy of Sciences of Georgia ABSTRACT Has been studied effect of the preparation "Unguentum Rhodopesum 5,0%" on the immune competency of patients with stomatological herpes. Recurrence of herpes was characterized by decrease in all immunological parameters, the dynamics of which was less depended on the gravity of the disease process. In case of etiotropic therapy (aciklovir) ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 October/December, Volume 3, Issue 4 274 The Cardiac and Hemodynamic Indices of the Young Men Undergoing the Influence of the Weak Electromagnetic Fields in the Sound Range Levan Tvildiani,* Zaza Dumbadze,** Alexandre Tsibadze,** Irina Kvatchadze*** *Department of Internal Medicine #1; **Department of the Medical Physics, Biophysics and Cybernetics; ***Department of Normal Physiology; Tbilisi State Medical University, Georgia ABSTRACT The cardiac and hemodynamic indices of the young men undergoing the influence of the weak electromagnetic fields in the sound range. We aimed to assess the effect of the sound range weak electromagnetic field on the autonomic nervous system. The method of the heart rate variability analysis was chosen for the characterization of the functional ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 October/December, Volume 3, Issue 4 Study of Protective Action of Plaferon and Phenowine on Some Indices of Experimental Influenza in White Mice Maia Johnson, Andrey Chilaia, Teimuraz Koridze Institute of Medical Biotechnology, Academy of Sciences of Georgia ABSTRACT The main purpose of our investigation was to study action of influenza virus on several immune indices, its mutagenic and embriotoxic effects in white mice, and evaluate a potential protective effect of plaferon-LB and phenowine. These preparations were highly successful in reversing immunosuppression, caused by influenza virus. Results of immunocorrective therapy proved, that heterologous plaferon demonstrated strong protective action in white mice. Plaferon/phenowin-therapy resulted in fewer aberrant metaphases of chromosomes ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 October/December, Volume 3, Issue 4 Carotid Artery Eversion Endarterectomy Versus Open Thromboendarterectomy and Patch Plasty Kakha Kuntelia,* Dieter Raithel** *Vascular Surgery Unit, Surgery Department N 1, Tbilisi State medical University, Georgia; **Vascular and Endovascular Surgery Department, Klinikum Sud, Nurnberg, Germany ABSTRACT Objective: For last years we changed gradually our treatment for stenosis of the internal carotid artery (ICA) from open thromboendarterectomy and Dacron-patch plasty (TEA) to eversion endarterectomy (EEA). Design: retrospective study. Methods: We have selected 250 patients operated by EEA technique and 250 TEA techniques, between January 1996 and December 1998. These results were compared. Results: clamping and operation time were significantly ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 July/September, Volume 3, Issue 3 Differential Diagnostical Criteria and Treatment of Children Stuttering Alexi Mindadze, Nana Geladze, Giorgi Natriashvili Department of child neurology, Pediatric clinic of the Tbilisi State Medical University Abstract Stuttering affects about 5 percent of the population, that its incidence is highest during preschool years, and that remission rates are high, especially during the first twelve to eighteen months after onset. The aim of present paper is elucidate differential-diagnostical criteria of stuttering and select optimal therapeutical tactic. 137 patients with stuttering of age from 2 to 14 years have been investigated. Patients were divided into 2 groups: organic form of stuttering (62 patients) and neurotic form of stuttering (75 patients). All patients ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 October/December, Volume 3, Issue 4 Hyperandrogenia and Visceral Obesity in Women Mikheil Sabakhtarashvili, Tamar Gulbani, Maka Gegechkori Zhordania Institute of Human Reproduction, Tbilisi, Georgia ABSTRACT The purpose of the present work was study of clinical peculiarities of insulin-resistant metabolic syndrome and secretion of insulin and free testosterone (Free T) regarding to visceral obesity. With the use of prospective investigation a total of 108 patients aged 16 to 40 years with polycystic ovary (PCO) and 23 healthy volunteers (women) were studied. Anamnesis, objective and clinical investigations, detection of immunoreactive insulin (IRI) and Free T in blood serum was carried out. The obtained data were analyzed statistically using the Student's t test. Investigations have shown ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 October/December, Volume 3, Issue 4 Quantitative Electroencephalography in the Children with Various Types of Tic Disorders Sophia Natriashvili Department of Child Neurology, Tbilisi State Medical University, Georgia ABSTRACT Despite the long period of scientific study of hyperkinesis in children it remains one of the most prominent challenge for contemporary neurologists. The aim of present paper is to estimate the role of computer electroencephalographic (EEG) findings in establishing the etiology, pathogenesis of tic disorders for prognozing the course of disease and choosing adequate therapy. 242 patients (194 males, 48 females) with various types of tic disorders in the age from 4 to 15 years old were investigated. 67 children were subjected to Quantitative EEG investigation, which ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 April/June, Volume 2, Issue 2 110 Stab Wound Age Estimation by Changes of Basophilic Granulocytes After Injection of Different Substances Rusudan Beriashvili Department of Forensic Medicine, Tbilisi State Medical University Abstract In the present study are described the changes of basophilic granulocites' response on injection of different substances. There are evaluated possibilities to use the changes of these leukocytes as a criterion for injected stub wound age estimation. The experimental study was carried out on formalin-fixed paraffin-embedded material from rat skin. Results show that changes of basophilic granulocytes and their response depend on time since injury and injected substance and use of this particular cell response as a criterion for stub wound ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 October/December, Volume 3, Issue 4 Evaluation of Efficiency of Various Methods of Interruption of Pregnancy in II Trimester Archil Khomasuridze, Maia Parcauli Zhordania Research Institute of Human Reproduction, Tbilisi, Georgia ABSTRACT The work was aimed to evaluate efficiency of interruption of late pregnancy with the use of anti-progesterone. Has been used the Russian analogue of mifepristone - "Penkrofton" (company "Penkroft-Farma"). Penkrofton was tested on 102 women with gestation period ranged from 14 to 22 weeks. The control group was consisted of 80 pregnant women, who were subjected to intra-amniotic infusions of 20% sodium chloride solution. Among these 102 patients 90 had spontaneous motor activity of uterus. In 11 cases additionally were used prostaglandin E 1 ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 July/September, Volume 3, Issue 3 Some Aspects of Protective Effect of Plaferon LB During Bronchial Asthma Mariam Maisuradze, Nestan Abdushelishvili, Magy Dumbadze Department of Children's Infectious Diseses, Tbilisi State Medical University, Georgia Abstract Modern anti-inflamatory means used for treatment of bronchial asthma are characterized by comparative efficiency and side effects. All above-mentioned makes impossible the long use of this preparation. From this point of view, Plaferon LB with its anti-oxidant, immuno-modulatory and anti-inflammatory characteristics has no side effects. This fact is approved by 18-year practice of using this preparation for treatment of different diseases. In this respect the main goal of our work was to research mechanisms of protective effect of ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 July/September, Volume 3, Issue 3 Long-Term Botulinum Toxin Treatment of Cranial Dystonia Marina Shishniashvili Center of Child Neurology and Neurorehabilitation, Tbilisi, Georgia Abstract We report the results of an open trial of botulinum toxin (Botox) in the treatment of 46 patients with cranial dystonia (38 patients with blepharospasm and 8 patients with Meige syndrome). The average age of the patients was 55,8 years, and duration of symptoms was 10,6 years. The blepharospasm involuntary movement (BIM) scale was used to asses clinical severity at baseline before BoNT/A injections and at two follow up visits after 6 and 12 weeks covering one BoNT/A treatment period with maximum effect size at the firs follow up.The average latency from injection to response was 6,8 days, and the average ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 October/December, Volume 3, Issue 4 286 Health Assessment and Problems of Implementation of Drug Prescriptions by Physicians in Georgia Natia Kvizhinadze Department of Social and Clinical Pharmacy, Department of Public Health and Health Management, Tbilisi State Medical University, Georgia ABSTRACT Health assessment recognized as a potentially powerful tool in achievement of progress in public-health system. In the period of political, social and economic changes in Georgia, the need for an integrated approach to health assessment of population becomes even more urgent. Health assessment may apply to individual, whole country and even world population. Processes could be assessed for short, middle and long- term periods. It could involve esthetic solution as well. The present ...